MRPS10

Summary

MRPS10 (mitochondrial ribosomal protein S10, HGNC:14502) is a protein-coding gene on chromosome 6p21.1, encoding Small ribosomal subunit protein uS10m (P82664). It is a selective cancer dependency (DepMap: 60.1% of cell lines).

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S10P family. Pseudogenes corresponding to this gene are found on chromosomes 1q, 3p, and 9p.

Source: NCBI Gene 55173 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 34 total
• Cancer dependency (DepMap): dependent in 60.1% of screened cell lines
• MANE Select transcript: NM_018141

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14502
Approved symbol	MRPS10
Name	mitochondrial ribosomal protein S10
Location	6p21.1
Locus type	gene with protein product
Status	Approved
Aliases	FLJ10567, uS10m
Ensembl gene	ENSG00000048544
Ensembl biotype	protein_coding
OMIM	611976
Entrez	55173

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 7 protein_coding, 2 nonsense_mediated_decay

ENST00000053468, ENST00000718325, ENST00000718326, ENST00000718327, ENST00000896501, ENST00000896502, ENST00000896503, ENST00000934613, ENST00000934614

RefSeq mRNA: 1 — MANE Select: NM_018141 NM_018141

CCDS: CCDS4866

Canonical transcript exons

ENST00000053468 — 7 exons

Exon	Start	End
ENSE00000619063	42211781	42211917
ENSE00000751174	42208858	42208947
ENSE00000751201	42210488	42210596
ENSE00000751202	42214120	42214192
ENSE00000751226	42214280	42214344
ENSE00001138963	42217802	42217861
ENSE00004034784	42206807	42208372

Expression profiles

Bgee: expression breadth ubiquitous, 294 present calls, max score 98.80.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 31.8266 / max 642.6341, expressed in 1818 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
73602	31.8266	1818

Top tissues by expression

294 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	98.80	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	96.03	gold quality
body of tongue	UBERON:0011876	95.54	gold quality
vastus lateralis	UBERON:0001379	95.40	gold quality
biceps brachii	UBERON:0001507	95.04	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	94.93	gold quality
quadriceps femoris	UBERON:0001377	94.82	gold quality
pharyngeal mucosa	UBERON:0000355	94.55	gold quality
palpebral conjunctiva	UBERON:0001812	94.40	gold quality
tongue	UBERON:0001723	94.36	gold quality
superior surface of tongue	UBERON:0007371	94.30	gold quality
muscle organ	UBERON:0001630	94.02	gold quality
skeletal muscle organ	UBERON:0014892	94.02	gold quality
skeletal muscle tissue	UBERON:0001134	94.00	gold quality
hindlimb stylopod muscle	UBERON:0004252	93.99	gold quality
heart right ventricle	UBERON:0002080	93.92	gold quality
gastrocnemius	UBERON:0001388	93.88	gold quality
muscle of leg	UBERON:0001383	93.79	gold quality
lower esophagus mucosa	UBERON:0035834	93.61	gold quality
oral cavity	UBERON:0000167	93.45	gold quality
triceps brachii	UBERON:0001509	93.35	gold quality
visceral pleura	UBERON:0002401	93.22	gold quality
esophagus squamous epithelium	UBERON:0006920	93.16	gold quality
epithelium of esophagus	UBERON:0001976	92.98	gold quality
gingiva	UBERON:0001828	92.94	gold quality
muscle tissue	UBERON:0002385	92.92	gold quality
gingival epithelium	UBERON:0001949	92.85	gold quality
amniotic fluid	UBERON:0000173	92.66	gold quality
esophagus mucosa	UBERON:0002469	92.62	gold quality
jejunum	UBERON:0002115	92.52	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.70

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): YY1

miRNA regulators (miRDB)

61 targeting MRPS10, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-4482-3P	99.98	72.50	3147
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-495-3P	99.96	72.81	4197
HSA-MIR-10523-5P	99.91	69.22	2038
HSA-MIR-548AR-3P	99.85	71.26	3889
HSA-MIR-4698	99.84	71.41	4303
HSA-MIR-548AZ-3P	99.82	70.56	3549
HSA-MIR-548BC	99.82	70.61	3524
HSA-MIR-548E-3P	99.82	70.59	3514
HSA-MIR-548F-3P	99.82	70.59	3540
HSA-MIR-577	99.78	69.13	2479
HSA-MIR-548AG	99.77	69.25	1492
HSA-MIR-4645-3P	99.76	69.33	993
HSA-MIR-548A-3P	99.76	70.58	3524
HSA-MIR-378G	99.71	64.90	1106
HSA-MIR-548AI	99.69	69.24	1494
HSA-MIR-548BA	99.69	69.14	1514
HSA-MIR-570-5P	99.69	69.24	1494
HSA-MIR-561-3P	99.64	70.90	3647
HSA-MIR-1251-3P	99.64	67.21	1408
HSA-MIR-885-5P	99.59	68.59	879
HSA-MIR-888-3P	99.53	69.77	1057
HSA-MIR-3923	99.52	69.21	446
HSA-MIR-6081	99.48	66.07	1446

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 60.1% of screened cell lines.

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	mrps10	ENSDARG00000045913
mus_musculus	Mrps10	ENSMUSG00000034729
rattus_norvegicus	Mrps10	ENSRNOG00000022609
drosophila_melanogaster	mRpS10	FBGN0038307
caenorhabditis_elegans		WBGENE00012556

Protein

Protein identifiers

Small ribosomal subunit protein uS10m — P82664 (reviewed: P82664)

Alternative names: 28S ribosomal protein S10, mitochondrial

All UniProt accessions (1): P82664

UniProt curated annotations — full annotation on UniProt →

Subunit / interactions. Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

Subcellular location. Mitochondrion.

Similarity. Belongs to the universal ribosomal protein uS10 family.

RefSeq proteins (1): NP_060611* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR027486	Ribosomal_uS10_dom	Domain
IPR036838	Ribosomal_uS10_dom_sf	Homologous_superfamily
IPR040055	Ribosomal_uS10m	Family

Pfam: PF00338

UniProt features (11 total): strand 6, helix 3, chain 1, sequence conflict 1

Structure

Experimental structures (PDB)

77 structures, top 30 by resolution.

PDB	Method	Resolution (Å)
7QI4	ELECTRON MICROSCOPY	2.21
8CSS	ELECTRON MICROSCOPY	2.36
7P2E	ELECTRON MICROSCOPY	2.4
8RRI	ELECTRON MICROSCOPY	2.4
9OLF	ELECTRON MICROSCOPY	2.46
9OJM	ELECTRON MICROSCOPY	2.5
8CSQ	ELECTRON MICROSCOPY	2.54
8CSR	ELECTRON MICROSCOPY	2.54
6ZM6	ELECTRON MICROSCOPY	2.59
7QI5	ELECTRON MICROSCOPY	2.63
8CSP	ELECTRON MICROSCOPY	2.66
7PNX	ELECTRON MICROSCOPY	2.76
8ANY	ELECTRON MICROSCOPY	2.85
8CST	ELECTRON MICROSCOPY	2.85
6ZM5	ELECTRON MICROSCOPY	2.89
7PO0	ELECTRON MICROSCOPY	2.9
8K2A	ELECTRON MICROSCOPY	2.9
9PGL	ELECTRON MICROSCOPY	2.9
7PO1	ELECTRON MICROSCOPY	2.92
7PO3	ELECTRON MICROSCOPY	2.92
9PGF	ELECTRON MICROSCOPY	2.93
6VMI	ELECTRON MICROSCOPY	2.96
6RW4	ELECTRON MICROSCOPY	2.97
6VLZ	ELECTRON MICROSCOPY	2.97
7QI6	ELECTRON MICROSCOPY	2.98
8QRN	ELECTRON MICROSCOPY	2.98
9PSM	ELECTRON MICROSCOPY	2.98
8OIS	ELECTRON MICROSCOPY	3
9G5C	ELECTRON MICROSCOPY	3
9G5D	ELECTRON MICROSCOPY	3

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P82664-F1	79.46	0.58

Function

Pathways and Gene Ontology

Reactome pathways

8 pathways

ID	Pathway
R-HSA-5368286	Mitochondrial translation initiation
R-HSA-5389840	Mitochondrial translation elongation
R-HSA-5419276	Mitochondrial translation termination
R-HSA-9837999	Mitochondrial protein degradation
R-HSA-9937383	Mitochondrial ribosome-associated quality control
R-HSA-392499	Metabolism of proteins
R-HSA-5368287	Mitochondrial translation
R-HSA-72766	Translation

MSigDB gene sets: 110 (showing top): GOBP_MITOCHONDRIAL_TRANSLATION, GOBP_TRANSLATION, WCTCNATGGY_UNKNOWN, GOCC_MITOCHONDRIAL_ENVELOPE, BERENJENO_TRANSFORMED_BY_RHOA_UP, RIZKI_TUMOR_INVASIVENESS_3D_UP, GOCC_RIBOSOME, GOCC_SMALL_RIBOSOMAL_SUBUNIT, GOCC_ORGANELLAR_RIBOSOME, GOCC_MITOCHONDRIAL_MATRIX, GOCC_ORGANELLE_INNER_MEMBRANE, GOCC_RIBOSOMAL_SUBUNIT, BLALOCK_ALZHEIMERS_DISEASE_DN, GOCC_RIBONUCLEOPROTEIN_COMPLEX, GOCC_MITOCHONDRIAL_PROTEIN_CONTAINING_COMPLEX

GO Biological Process (1): mitochondrial translation (GO:0032543)

GO Molecular Function (0):

GO Cellular Component (6): mitochondrion (GO:0005739), mitochondrial inner membrane (GO:0005743), mitochondrial matrix (GO:0005759), mitochondrial small ribosomal subunit (GO:0005763), ribosome (GO:0005840), ribonucleoprotein complex (GO:1990904)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Mitochondrial translation	4
Metabolism of proteins	2
Translation	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
mitochondrion	2
translation	1
mitochondrial gene expression	1
cytoplasm	1
intracellular membrane-bounded organelle	1
organelle inner membrane	1
mitochondrial membrane	1
intracellular organelle lumen	1
organellar small ribosomal subunit	1
mitochondrial ribosome	1
mitochondrial protein-containing complex	1
intracellular membraneless organelle	1
protein-containing complex	1

Protein interactions and networks

STRING

5094 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MRPS10	MRPS27	Q92552	724
MRPS10	MRPL44	Q9H9J2	674
MRPS10	MRPL21	Q7Z2W9	647
MRPS10	DAP3	P51398	625
MRPS10	MRPS9	P82933	625
MRPS10	MRPL9	Q9BYD2	614
MRPS10	MRPS14	O60783	604
MRPS10	MRPS11	P82912	563
MRPS10	MRPS6	P82932	561
MRPS10	MRPL11	Q9Y3B7	558
MRPS10	MRPL40	Q9NQ50	550
MRPS10	MRPS5	P82675	533
MRPS10	MRPS15	P82914	531
MRPS10	MRPL36	Q9P0J6	513
MRPS10	MRPS2	Q9Y399	505

IntAct

166 interactions, top by confidence:

A	B	Type	Score
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
MRPS27	MRPS14	psi-mi:“MI:0914”(association)	0.640
IGF2BP1	IGF2BP3	psi-mi:“MI:0914”(association)	0.640
LIN28A	IGF2BP3	psi-mi:“MI:0914”(association)	0.640
NOP53	RRP8	psi-mi:“MI:0914”(association)	0.640
FAM120A	SYNCRIP	psi-mi:“MI:0914”(association)	0.640
NP	KPNA6	psi-mi:“MI:0914”(association)	0.550
MRPS6	STAT5A	psi-mi:“MI:0914”(association)	0.550
ZNF707	ZNF316	psi-mi:“MI:0914”(association)	0.530
RPL18	NOP56	psi-mi:“MI:0914”(association)	0.530
ZBTB48	ZBTB24	psi-mi:“MI:0914”(association)	0.530
MRPS15	MRPS14	psi-mi:“MI:0914”(association)	0.530
TRMT10B	MRPS14	psi-mi:“MI:0914”(association)	0.530
DAP3	PNMA6A	psi-mi:“MI:0914”(association)	0.530
MRPS18B	MRPS14	psi-mi:“MI:0914”(association)	0.530
SNRNP70	GTPBP1	psi-mi:“MI:0914”(association)	0.530
PPAN	PPM1G	psi-mi:“MI:0914”(association)	0.530
MRPS34	ZZEF1	psi-mi:“MI:0914”(association)	0.530
E4F1	ZBTB24	psi-mi:“MI:0914”(association)	0.530
MRPS18C	MRPS14	psi-mi:“MI:0914”(association)	0.530
MRPS15	PRKACG	psi-mi:“MI:0914”(association)	0.530
MRPS27	YBX1	psi-mi:“MI:0914”(association)	0.530
MRPS26	MRPS10	psi-mi:“MI:0914”(association)	0.530
MRPL18	GTPBP10	psi-mi:“MI:0914”(association)	0.530

BioGRID (266): MRPS10 (Affinity Capture-RNA), MRPS10 (Affinity Capture-RNA), MRPS10 (Affinity Capture-RNA), MRPS10 (Affinity Capture-MS), MRPS10 (Affinity Capture-MS), MRPS10 (Affinity Capture-MS), MRPS10 (Affinity Capture-MS), MRPS10 (Affinity Capture-MS), MRPS10 (Affinity Capture-MS), MRPS10 (Affinity Capture-MS), MRPS10 (Affinity Capture-MS), MRPS10 (Co-fractionation), MRPS10 (Co-fractionation), MRPS10 (Co-fractionation), MRPS10 (Co-fractionation)

ESM2 similar proteins: A6QPQ5, A9X1A9, O95707, P0C2C1, P82664, P82670, P82675, P82915, P82919, P82933, Q08BI9, Q0P5E7, Q0VFH6, Q2KIB9, Q2KID9, Q2KIJ6, Q2TBK2, Q2TBR2, Q3MHY7, Q3SYS0, Q3T040, Q58DQ5, Q58DV5, Q5C9Z4, Q5R7B0, Q5REJ1, Q5REY4, Q5RFM3, Q641X9, Q7Z2W9, Q7Z7H8, Q8N3Z3, Q8TCC3, Q924T2, Q99N85, Q99N87, Q99N94, Q9BSH4, Q9BYD2, Q9BYD6

Diamond homologs: A0ALW9, A0L5X2, A0LII9, A0Q4I2, A1AVJ9, A1B026, A3PGL0, A4WVK9, A4YSJ1, A5CXK3, A5ELM8, A5FZW6, A5VR07, A6U858, A6X0B7, A7HWR0, A7IFY0, A7Z0N7, A8F984, A8IAS9, A9IW28, A9M5Q1, B0CH33, B0SAF5, B0SSH8, B0UHX0, B1Y7H1, B2IK61, B2S680, B2SDY6, B3PWS0, B3QBY1, B5ZYT4, B6JET2, B8DB07, B8ELG4, B8IS84, B9JVN6, B9KL90, C0RJK2

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
MRPS10	“form complex”	“28S mitochondrial small ribosomal subunit”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 175 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Mitochondrial translation	26	32.8×	2e-31
Mitochondrial ribosome-associated quality control	29	32.7×	1e-34
Mitochondrial translation initiation	28	32.6×	9e-34
Mitochondrial translation elongation	28	32.6×	9e-34
Mitochondrial translation termination	28	28.2×	7e-32
Transport of Mature Transcript to Cytoplasm	5	17.5×	1e-04
Translation	30	17.1×	2e-27
Peptide chain elongation	10	11.6×	4e-07

GO biological processes:

GO term	Partners	Fold	FDR
mitochondrial translation	29	32.7×	9e-34
positive regulation of cytoplasmic translation	5	32.2×	5e-05
cytoplasmic translation	12	14.4×	9e-09
translation	21	14.0×	8e-16
regulation of alternative mRNA splicing, via spliceosome	7	11.1×	3e-04
negative regulation of translation	7	8.9×	1e-03
ribosomal small subunit biogenesis	6	8.9×	4e-03
RNA processing	6	8.5×	4e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

34 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	23
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

926 predictions. Top by Δscore:

Variant	Effect	Δscore
6:42208852:CTATA:C	donor_loss	1.0000
6:42208853:TATAC:T	donor_loss	1.0000
6:42208854:ATAC:A	donor_loss	1.0000
6:42208856:A:AT	donor_loss	1.0000
6:42208868:T:TA	donor_gain	1.0000
6:42208869:C:A	donor_gain	1.0000
6:42208944:CTAA:C	acceptor_gain	1.0000
6:42208945:TAA:T	acceptor_gain	1.0000
6:42208946:AA:A	acceptor_gain	1.0000
6:42208948:C:CC	acceptor_gain	1.0000
6:42210483:CTCA:C	donor_loss	1.0000
6:42210484:TCA:T	donor_loss	1.0000
6:42210485:CACC:C	donor_loss	1.0000
6:42210486:A:AC	donor_gain	1.0000
6:42210486:ACC:A	donor_loss	1.0000
6:42210487:C:CC	donor_gain	1.0000
6:42210487:CCT:C	donor_gain	1.0000
6:42210592:CATGT:C	acceptor_gain	1.0000
6:42210593:ATGT:A	acceptor_gain	1.0000
6:42210594:TGT:T	acceptor_gain	1.0000
6:42210594:TGTC:T	acceptor_loss	1.0000
6:42210595:GT:G	acceptor_gain	1.0000
6:42210595:GTC:G	acceptor_loss	1.0000
6:42210597:C:CA	acceptor_loss	1.0000
6:42210597:C:CC	acceptor_gain	1.0000
6:42210603:T:C	acceptor_gain	1.0000
6:42210603:T:TC	acceptor_gain	1.0000
6:42210606:A:AC	acceptor_gain	1.0000
6:42210606:A:C	acceptor_gain	1.0000
6:42211779:A:AC	donor_gain	1.0000

AlphaMissense

1301 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
6:42208895:C:G	R162P	0.994
6:42211808:G:T	A99D	0.987
6:42211871:A:T	V78D	0.986
6:42211809:C:G	A99P	0.985
6:42211834:A:C	S90R	0.985
6:42211834:A:T	S90R	0.985
6:42211836:T:G	S90R	0.985
6:42208875:C:G	A169P	0.984
6:42208923:C:G	A153P	0.980
6:42211811:G:T	A98D	0.980
6:42211822:A:C	F94L	0.980
6:42211822:A:T	F94L	0.980
6:42211824:A:G	F94L	0.980
6:42208914:A:C	Y156D	0.977
6:42208881:C:G	G167R	0.974
6:42208881:C:T	G167R	0.974
6:42211820:G:T	A95D	0.973
6:42211860:C:G	G82R	0.970
6:42210515:T:A	E135D	0.968
6:42210515:T:G	E135D	0.968
6:42211799:A:G	L102P	0.968
6:42211859:C:T	G82D	0.968
6:42208886:G:T	P165H	0.966
6:42211821:C:G	A95P	0.966
6:42210509:T:A	R137S	0.964
6:42210509:T:G	R137S	0.964
6:42208877:A:T	V168D	0.963
6:42210561:A:G	L120P	0.963
6:42208881:C:A	G167W	0.961
6:42208905:A:G	Y159H	0.961

dbSNP variants (sampled 300 via entrez): RS1000225370 (6:42212277 T>C), RS1000402020 (6:42214037 T>C), RS1000499655 (6:42209189 G>A), RS1001055629 (6:42208542 C>G), RS1001387618 (6:42206775 T>C), RS1001661268 (6:42214762 A>G), RS1001674983 (6:42212344 T>C), RS1002042249 (6:42212056 C>G,T), RS1002131193 (6:42218380 A>T), RS1002930114 (6:42216116 T>C), RS1003062831 (6:42209698 T>C), RS1003110363 (6:42209500 C>G), RS1003250447 (6:42217451 C>A,T), RS1003315493 (6:42211045 G>T), RS1003450685 (6:42211269 T>C)

Disease associations

OMIM: gene MIM:611976 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

24 total (human), top 24 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	increases expression, increases methylation	2
Acetaminophen	increases expression, affects cotreatment	2
Tretinoin	decreases expression	2
dicrotophos	decreases expression	1
triphenyl phosphate	affects expression	1
arsenite	affects binding, increases reaction	1
sodium arsenite	affects cotreatment, increases abundance, increases expression	1
di-n-butylphosphoric acid	affects expression	1
cylindrospermopsin	increases expression	1
abrine	increases expression	1
eprenetapopt	affects expression, affects reaction	1
bisphenol S	increases expression	1
Air Pollutants	decreases expression, increases abundance	1
Arsenic	affects cotreatment, increases abundance, increases expression	1
Atrazine	decreases expression	1
Cannabidiol	increases expression	1
Lead	affects expression	1
Lipopolysaccharides	increases expression, affects cotreatment	1
Ribonucleotides	affects binding	1
Valproic Acid	affects expression	1
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression	1
Cyclosporine	increases expression	1
Antirheumatic Agents	increases expression	1
Particulate Matter	increases abundance, decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.