MRPS21

Summary

MRPS21 (mitochondrial ribosomal protein S21, HGNC:14046) is a protein-coding gene on chromosome 1q21.2, encoding Small ribosomal subunit protein bS21m (P82921). It is a common-essential gene (DepMap: required in 97.4% of cancer cell lines).

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S21P family. Pseudogenes corresponding to this gene are found on chromosomes 1p, 1q, 9p, 10p, 10q, 16q, and 17q. Available sequence data analyses identified splice variants that differ in the 5’ UTR; both transcripts encode the same protein.

Source: NCBI Gene 54460 — RefSeq curated summary.

At a glance

• GWAS associations: 19
• Clinical variants (ClinVar): 25 total
• Cancer dependency (DepMap): dependent in 97.4% of screened cell lines (common-essential)
• MANE Select transcript: NM_031901

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14046
Approved symbol	MRPS21
Name	mitochondrial ribosomal protein S21
Location	1q21.2
Locus type	gene with protein product
Status	Approved
Aliases	bS21m
Ensembl gene	ENSG00000266472
Ensembl biotype	protein_coding
OMIM	611984
Entrez	54460

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 14 protein_coding

ENST00000581066, ENST00000614145, ENST00000877736, ENST00000877737, ENST00000877738, ENST00000877739, ENST00000935111, ENST00000935112, ENST00000935113, ENST00000935114, ENST00000935115, ENST00000935116, ENST00000935117, ENST00000935118

RefSeq mRNA: 2 — MANE Select: NM_031901 NM_018997, NM_031901

CCDS: CCDS950

Canonical transcript exons

ENST00000614145 — 3 exons

Exon	Start	End
ENSE00002710928	150308048	150308979
ENSE00003716402	150293861	150293898
ENSE00003734455	150294335	150294449

Expression profiles

Bgee: expression breadth ubiquitous, 255 present calls, max score 98.66.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 84.5425 / max 1019.3506, expressed in 1824 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
5089	84.0442	1824
5090	0.4983	254

Top tissues by expression

256 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cardiac muscle of right atrium	UBERON:0003379	98.66	gold quality
left ventricle myocardium	UBERON:0006566	98.60	gold quality
lateral nuclear group of thalamus	UBERON:0002736	98.43	gold quality
pons	UBERON:0000988	98.37	gold quality
sperm	CL:0000019	98.30	gold quality
myocardium	UBERON:0002349	98.21	gold quality
pancreatic ductal cell	CL:0002079	98.14	gold quality
epithelial cell of pancreas	CL:0000083	98.06	gold quality
kidney epithelium	UBERON:0004819	98.06	gold quality
upper arm skin	UBERON:0004263	97.98	gold quality
Brodmann (1909) area 23	UBERON:0013554	97.53	gold quality
renal medulla	UBERON:0000362	97.51	gold quality
lateral globus pallidus	UBERON:0002476	97.40	gold quality
adult organism	UBERON:0007023	97.38	gold quality
cerebellar vermis	UBERON:0004720	97.37	gold quality
superior vestibular nucleus	UBERON:0007227	97.36	gold quality
vena cava	UBERON:0004087	97.35	gold quality
seminal vesicle	UBERON:0000998	97.32	gold quality
substantia nigra pars compacta	UBERON:0001965	97.32	gold quality
substantia nigra pars reticulata	UBERON:0001966	97.21	gold quality
hypothalamus	UBERON:0001898	97.15	gold quality
ventral tegmental area	UBERON:0002691	97.10	gold quality
middle temporal gyrus	UBERON:0002771	97.09	gold quality
pharyngeal mucosa	UBERON:0000355	97.03	gold quality
trachea	UBERON:0003126	97.03	gold quality
layer of synovial tissue	UBERON:0007616	97.03	gold quality
superior surface of tongue	UBERON:0007371	96.98	gold quality
anterior cingulate cortex	UBERON:0009835	96.98	gold quality
body of tongue	UBERON:0011876	96.96	gold quality
tongue	UBERON:0001723	96.95	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-MTAB-8559	no	1029.92
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

30 targeting MRPS21, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-4425	100.00	67.59	1049
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-4534	99.99	66.58	1907
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-493-5P	99.96	72.47	2382
HSA-LET-7C-3P	99.95	73.42	2862
HSA-MIR-4659A-3P	99.80	72.62	4248
HSA-MIR-4659B-3P	99.80	72.62	4248
HSA-MIR-2052	99.79	69.37	2031
HSA-MIR-4306	99.72	70.50	3630
HSA-MIR-561-3P	99.64	70.90	3647
HSA-MIR-185-5P	99.35	68.60	2497
HSA-MIR-4644	99.35	69.12	2514
HSA-MIR-3678-3P	99.31	67.10	1432
HSA-MIR-504-3P	99.30	67.18	1745
HSA-MIR-1273H-3P	99.29	67.55	980
HSA-MIR-5693	99.24	66.67	1106
HSA-MIR-619-5P	98.57	64.97	1988
HSA-MIR-5089-5P	98.45	66.06	1388
HSA-MIR-3166	98.24	66.63	1223
HSA-MIR-660-5P	98.16	68.27	680
HSA-MIR-197-3P	98.09	69.23	1004
HSA-MIR-4443	98.02	66.25	1928
HSA-MIR-5000-5P	97.40	66.11	1055
HSA-MIR-3664-5P	96.74	66.56	770
HSA-MIR-4790-3P	96.63	67.08	806
HSA-MIR-1298-3P	94.05	64.84	620

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 97.4% of screened cell lines, common-essential.

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mrps21	ENSMUSG00000054312
rattus_norvegicus	Mrps21	ENSRNOG00000024845

Protein

Protein identifiers

Small ribosomal subunit protein bS21m — P82921 (reviewed: P82921)

Alternative names: 28S ribosomal protein S21, mitochondrial

All UniProt accessions (1): P82921

UniProt curated annotations — full annotation on UniProt →

Subunit / interactions. Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

Subcellular location. Mitochondrion.

Similarity. Belongs to the bacterial ribosomal protein bS21 family.

RefSeq proteins (2): NP_061870, NP_114107* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001911	Ribosomal_bS21	Family
IPR038380	Ribosomal_bS21_sf	Homologous_superfamily

Pfam: PF01165

UniProt features (11 total): helix 4, strand 3, sequence variant 2, chain 1, turn 1

Structure

Experimental structures (PDB)

71 structures, top 30 by resolution.

PDB	Method	Resolution (Å)
8CSS	ELECTRON MICROSCOPY	2.36
7P2E	ELECTRON MICROSCOPY	2.4
8RRI	ELECTRON MICROSCOPY	2.4
9OLF	ELECTRON MICROSCOPY	2.46
9OJM	ELECTRON MICROSCOPY	2.5
8CSQ	ELECTRON MICROSCOPY	2.54
8CSR	ELECTRON MICROSCOPY	2.54
6ZM6	ELECTRON MICROSCOPY	2.59
8CSP	ELECTRON MICROSCOPY	2.66
7PNX	ELECTRON MICROSCOPY	2.76
8ANY	ELECTRON MICROSCOPY	2.85
8CST	ELECTRON MICROSCOPY	2.85
6ZM5	ELECTRON MICROSCOPY	2.89
7PO0	ELECTRON MICROSCOPY	2.9
8K2A	ELECTRON MICROSCOPY	2.9
9PGL	ELECTRON MICROSCOPY	2.9
7PO1	ELECTRON MICROSCOPY	2.92
7PO3	ELECTRON MICROSCOPY	2.92
9PGF	ELECTRON MICROSCOPY	2.93
6VMI	ELECTRON MICROSCOPY	2.96
6RW4	ELECTRON MICROSCOPY	2.97
6VLZ	ELECTRON MICROSCOPY	2.97
8QRN	ELECTRON MICROSCOPY	2.98
9PSM	ELECTRON MICROSCOPY	2.98
8OIS	ELECTRON MICROSCOPY	3
9G5C	ELECTRON MICROSCOPY	3
9G5D	ELECTRON MICROSCOPY	3
9H54	ELECTRON MICROSCOPY	3
9HFM	ELECTRON MICROSCOPY	3
9PGI	ELECTRON MICROSCOPY	3.02

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P82921-F1	96.48	0.96

Function

Pathways and Gene Ontology

Reactome pathways

7 pathways

ID	Pathway
R-HSA-5368286	Mitochondrial translation initiation
R-HSA-5389840	Mitochondrial translation elongation
R-HSA-5419276	Mitochondrial translation termination
R-HSA-9937383	Mitochondrial ribosome-associated quality control
R-HSA-392499	Metabolism of proteins
R-HSA-5368287	Mitochondrial translation
R-HSA-72766	Translation

MSigDB gene sets: 115 (showing top): PAL_PRMT5_TARGETS_UP, GOBP_MITOCHONDRIAL_TRANSLATION, TGACCTY_ERR1_Q2, SRF_Q5_01, GOBP_TRANSLATION, CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1, WANG_LMO4_TARGETS_DN, GGAANCGGAANY_UNKNOWN, GOMF_STRUCTURAL_CONSTITUENT_OF_RIBOSOME, GOCC_MITOCHONDRIAL_ENVELOPE, GOCC_RIBOSOME, chr1q21, GOCC_SMALL_RIBOSOMAL_SUBUNIT, GOCC_ORGANELLAR_RIBOSOME, GOCC_MITOCHONDRIAL_MATRIX

GO Biological Process (2): translation (GO:0006412), mitochondrial translation (GO:0032543)

GO Molecular Function (2): RNA binding (GO:0003723), structural constituent of ribosome (GO:0003735)

GO Cellular Component (5): mitochondrion (GO:0005739), mitochondrial inner membrane (GO:0005743), mitochondrial small ribosomal subunit (GO:0005763), ribosome (GO:0005840), ribonucleoprotein complex (GO:1990904)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Mitochondrial translation	4
Translation	1
Metabolism of proteins	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
peptidyltransferase activity	1
translational initiation	1
translational elongation	1
translational termination	1
macromolecule biosynthetic process	1
protein metabolic process	1
protein biosynthetic process	1
mitochondrion	1
translation	1
mitochondrial gene expression	1
nucleic acid binding	1
structural molecule activity	1
ribosome	1
cytoplasm	1
intracellular membrane-bounded organelle	1
organelle inner membrane	1
mitochondrial membrane	1
organellar small ribosomal subunit	1
mitochondrial ribosome	1
mitochondrial protein-containing complex	1
intracellular membraneless organelle	1
protein-containing complex	1

Protein interactions and networks

STRING

1615 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MRPS21	MRPL51	Q4U2R6	625
MRPS21	MRPS15	P82914	588
MRPS21	MRPL12	P52815	583
MRPS21	MRPL52	Q86TS9	578
MRPS21	RBM23	Q86U06	571
MRPS21	MRPS33	Q9Y291	555
MRPS21	GADD45GIP1	Q8TAE8	549
MRPS21	MRPL11	Q9Y3B7	543
MRPS21	MRPL10	Q7Z7H8	510
MRPS21	MRPL45	Q9BRJ2	508
MRPS21	MRPL37	Q9BZE1	505
MRPS21	ERAL1	O75616	503
MRPS21	MRPS6	P82932	496
MRPS21	MRPL53	Q96EL3	491
MRPS21	DAP3	P51398	485

IntAct

117 interactions, top by confidence:

A	B	Type	Score
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
USP44	CETN2	psi-mi:“MI:0914”(association)	0.690
MRPS27	MRPS14	psi-mi:“MI:0914”(association)	0.640
FAM120A	SYNCRIP	psi-mi:“MI:0914”(association)	0.640
NP	KPNA6	psi-mi:“MI:0914”(association)	0.550
MRPS15	MRPS14	psi-mi:“MI:0914”(association)	0.530
RPL6	MRPS14	psi-mi:“MI:0914”(association)	0.530
TRMT10B	MRPS14	psi-mi:“MI:0914”(association)	0.530
MRPS18B	MRPS14	psi-mi:“MI:0914”(association)	0.530
CCDC59	GAPDHS	psi-mi:“MI:0914”(association)	0.530
MRPS34	ZZEF1	psi-mi:“MI:0914”(association)	0.530
MRPS18C	MRPS14	psi-mi:“MI:0914”(association)	0.530
MRPS15	PRKACG	psi-mi:“MI:0914”(association)	0.530
MRPS27	YBX1	psi-mi:“MI:0914”(association)	0.530
MRPS26	MRPS10	psi-mi:“MI:0914”(association)	0.530
MRPL2	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MRPS34	MRPS12	psi-mi:“MI:0914”(association)	0.530
MRPS11	MRPS14	psi-mi:“MI:0914”(association)	0.530
SRSF3	CASC3	psi-mi:“MI:0914”(association)	0.530
AURKAIP1	NRDC	psi-mi:“MI:0914”(association)	0.480
Ttll12	TPM1	psi-mi:“MI:0914”(association)	0.350
LDHD	METTL8	psi-mi:“MI:0914”(association)	0.350
NP	HNRNPDL	psi-mi:“MI:0914”(association)	0.350

BioGRID (143): MRPS21 (Affinity Capture-RNA), MRPS21 (Affinity Capture-RNA), MRPS21 (Affinity Capture-RNA), MRPS21 (Affinity Capture-MS), MRPS21 (Affinity Capture-MS), MRPS21 (Affinity Capture-MS), MRPS21 (Affinity Capture-MS), MRPS21 (Affinity Capture-MS), MRPS21 (Affinity Capture-MS), MRPS21 (Co-fractionation), MRPS21 (Affinity Capture-MS), MRPS21 (Affinity Capture-MS), MRPS21 (Affinity Capture-MS), MRPS21 (Affinity Capture-MS), MRPS21 (Affinity Capture-MS)

ESM2 similar proteins: A0A1D8PEY9, A0L8J0, A2Y0T4, A9HS49, O01692, O42984, O80929, O94658, O96647, P02407, P14127, P47964, P58059, P82920, P82921, P93847, P9WEU2, Q08770, Q0DKF0, Q2JLR9, Q2JVE0, Q3T040, Q3T0J3, Q498Z6, Q4MYY1, Q4PM12, Q502B0, Q5I0K8, Q5M818, Q5R7L3, Q5RAZ9, Q5U4Z8, Q5ZMU0, Q6DDY9, Q6DJI4, Q6INF3, Q7SF85, Q80X85, Q92365, Q93VT9

Diamond homologs: A0L8J0, A1B4B5, A1URM1, A3PMA9, A4WVB1, A5CC57, A5FVG6, A5VVM8, A6WYQ4, A7HUU8, A8EY51, A8GP98, A8GT12, A8LLI5, A9B119, A9HS49, A9IM39, A9MCP6, A9WVX6, B0BUK2, B0U7F9, B2A1N7, B2IDB5, B2SD64, B3CTW5, B3DXV4, B3E615, B5YET6, B6ITS4, B6JC20, B8E0F9, B8EIA0, B8INF6, B9KLR1, C0RMB1, C1A4B1, C3PP58, C4K2S8, P66514, P66515

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
MRPS21	“form complex”	“28S mitochondrial small ribosomal subunit”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 127 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Mitochondrial translation	23	34.8×	4e-28
Mitochondrial ribosome-associated quality control	25	33.7×	8e-30
Mitochondrial translation initiation	24	33.5×	7e-29
Mitochondrial translation elongation	24	33.5×	7e-29
Mitochondrial translation termination	24	29.0×	2e-27
Translation	26	17.7×	5e-24
mRNA 3’-end processing	5	10.8×	3e-03
Transport of Mature mRNA derived from an Intron-Containing Transcript	5	8.4×	8e-03

GO biological processes:

GO term	Partners	Fold	FDR
mitochondrial translation	24	38.6×	2e-29
translation	13	12.4×	1e-08
mRNA splicing, via spliceosome	8	6.8×	3e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

25 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	12
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

416 predictions. Top by Δscore:

Variant	Effect	Δscore
1:150294445:AACAG:A	donor_loss	1.0000
1:150294446:ACAGG:A	donor_loss	1.0000
1:150294447:CAGG:C	donor_loss	1.0000
1:150294448:AGG:A	donor_loss	1.0000
1:150294449:GGTA:G	donor_loss	1.0000
1:150294450:G:A	donor_loss	1.0000
1:150294451:T:G	donor_loss	1.0000
1:150308042:A:AG	acceptor_gain	1.0000
1:150308044:A:AG	acceptor_gain	1.0000
1:150308045:C:G	acceptor_gain	1.0000
1:150308046:A:AG	acceptor_gain	1.0000
1:150308046:AGA:A	acceptor_loss	1.0000
1:150308047:G:GT	acceptor_gain	1.0000
1:150308047:GA:G	acceptor_gain	1.0000
1:150308047:GAA:G	acceptor_gain	1.0000
1:150308047:GAAT:G	acceptor_gain	1.0000
1:150308047:GAATC:G	acceptor_gain	1.0000
1:150294333:A:AG	acceptor_gain	0.9900
1:150294334:G:GG	acceptor_gain	0.9900
1:150295547:T:TA	donor_gain	0.9900
1:150295548:A:AA	donor_gain	0.9900
1:150308035:T:TA	acceptor_gain	0.9900
1:150308043:T:G	acceptor_gain	0.9900
1:150293879:C:G	donor_gain	0.9800
1:150294332:TAGGC:T	acceptor_loss	0.9800
1:150294333:AG:A	acceptor_gain	0.9800
1:150294334:GG:G	acceptor_gain	0.9800
1:150294412:G:GT	donor_gain	0.9800
1:150294334:GGC:G	acceptor_gain	0.9700
1:150295535:G:GT	donor_gain	0.9700

AlphaMissense

578 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:150294385:T:C	F7L	0.935
1:150294387:C:A	F7L	0.935
1:150294387:C:G	F7L	0.935
1:150308184:T:C	F74L	0.867
1:150308186:C:A	F74L	0.867
1:150308186:C:G	F74L	0.867
1:150294431:C:A	A22E	0.804
1:150308053:T:C	L30P	0.789
1:150308126:G:C	R54S	0.783
1:150308126:G:T	R54S	0.783
1:150308177:G:C	K71N	0.779
1:150308177:G:T	K71N	0.779
1:150294401:T:A	V12E	0.777
1:150308119:G:C	R52P	0.758
1:150308102:G:C	E46D	0.750
1:150308102:G:T	E46D	0.750
1:150308216:G:C	W84C	0.742
1:150308216:G:T	W84C	0.742
1:150294396:G:C	R10S	0.741
1:150294396:G:T	R10S	0.741
1:150308105:G:C	K47N	0.734
1:150308105:G:T	K47N	0.734
1:150308173:G:C	R70P	0.718
1:150308149:G:C	R62P	0.716
1:150308168:G:A	M68I	0.714
1:150308168:G:C	M68I	0.714
1:150308168:G:T	M68I	0.714
1:150294398:C:T	T11I	0.713
1:150308214:T:A	W84R	0.690
1:150308214:T:C	W84R	0.690

dbSNP variants (sampled 300 via entrez): RS1000089259 (1:150293124 G>A), RS1000249835 (1:150292875 G>C), RS1000606297 (1:150309154 G>A), RS1000758770 (1:150302640 C>T), RS1000910292 (1:150297170 A>G), RS1000941731 (1:150302333 C>T), RS1001467394 (1:150292308 G>A), RS1002042691 (1:150302035 T>A,C,G), RS1002110025 (1:150308633 A>C), RS1002195444 (1:150296783 A>C), RS1002260289 (1:150302274 T>C), RS1002290939 (1:150308369 A>G), RS1002737577 (1:150296521 T>A,G), RS1002892562 (1:150306849 C>G,T), RS1003047549 (1:150300641 G>A,C)

Disease associations

OMIM: gene MIM:611984 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

19 associations (top):

Study	Trait	p-value
GCST003184_1	Atopic dermatitis	5.000000e-09
GCST003184_11	Atopic dermatitis	1.000000e-07
GCST004946_24	Schizophrenia	5.000000e-09
GCST005038_31	Allergic disease (asthma, hay fever or eczema)	1.000000e-09
GCST008059_93	Estimated glomerular filtration rate	3.000000e-19
GCST008745_86	Estimated glomerular filtration rate in non-diabetics	5.000000e-09
GCST008747_130	Estimated glomerular filtration rate	3.000000e-10
GCST010002_366	Refractive error	3.000000e-15
GCST010696_11	Cortical thickness (min-P)	2.000000e-23
GCST010697_17	Cortical surface area (min-P)	9.000000e-09
GCST010698_23	Subcortical volume (min-P)	2.000000e-08
GCST010699_48	Brain morphology (min-P)	3.000000e-08
GCST010700_28	Cortical thickness (MOSTest)	8.000000e-38
GCST010701_113	Cortical surface area (MOSTest)	9.000000e-12
GCST010702_126	Subcortical volume (MOSTest)	4.000000e-09
GCST010703_244	Brain morphology (MOSTest)	9.000000e-12
GCST011352_16	Alanine aminotransferase levels	2.000000e-08
GCST012332_47	Multisite chronic pain	1.000000e-10
GCST90020028_621	Hip circumference adjusted for BMI	9.000000e-11

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0004346	neuroimaging measurement
EFO:0004840	cortical thickness
EFO:0010100	multisite chronic pain
EFO:0008039	BMI-adjusted hip circumference

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

25 total (human), top 25 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
chloropicrin	affects expression, decreases expression	2
Leflunomide	decreases expression	2
Acetaminophen	increases expression, affects cotreatment, decreases expression	2
bisphenol A	decreases expression	1
arsenite	increases reaction, affects binding	1
methylparaben	decreases expression	1
sodium arsenite	decreases expression	1
isobutyl alcohol	affects cotreatment, decreases expression, increases abundance	1
CGP 52608	affects binding, increases reaction	1
jinfukang	increases expression	1
Temozolomide	increases expression	1
Atrazine	decreases expression	1
Benzo(a)pyrene	increases methylation	1
Estradiol	decreases expression	1
Gasoline	affects cotreatment, decreases expression, increases abundance	1
Ivermectin	decreases expression	1
Lipopolysaccharides	affects cotreatment, decreases expression	1
Phthalic Acids	increases methylation	1
Polycyclic Aromatic Hydrocarbons	decreases expression, increases abundance, affects cotreatment	1
Ribonucleotides	affects binding	1
Smoke	decreases expression	1
Tretinoin	decreases expression	1
Aflatoxin B1	increases methylation	1
Lactic Acid	decreases expression	1
Particulate Matter	affects cotreatment, decreases expression, increases abundance	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.