MRPS30-DT

Summary

MRPS30-DT (MRPS30 divergent transcript, HGNC:53420) is a long non-coding RNA gene on chromosome 5p12.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53420
Approved symbol	MRPS30-DT
Name	MRPS30 divergent transcript
Location	5p12
Locus type	RNA, long non-coding
Status	Approved
Aliases	BRCAT54, BRCAT107
Ensembl gene	ENSG00000251141
Ensembl biotype	lncRNA
Entrez	100506674
RNAcentral	URS000075EF58 — lncRNA, 1395 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 32 — 32 lncRNA

ENST00000503179, ENST00000503452, ENST00000505302, ENST00000505401, ENST00000505637, ENST00000505706, ENST00000508123, ENST00000508945, ENST00000510758, ENST00000514597, ENST00000656315, ENST00000659161, ENST00000671607, ENST00000715752, ENST00000715753, ENST00000807629, ENST00000807630, ENST00000807631, ENST00000807632, ENST00000807633, ENST00000807634, ENST00000807635, ENST00000807636, ENST00000807637, ENST00000807638, ENST00000807639, ENST00000807640, ENST00000807641, ENST00000807642, ENST00000807643, ENST00000807644, ENST00000850656

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000503179 — 3 exons

Exon	Start	End
ENSE00002076778	44777909	44777992
ENSE00004027810	44808642	44808802
ENSE00004201927	44776756	44777328

Expression profiles

Bgee: expression breadth ubiquitous, 206 present calls, max score 86.58.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 4.3911 / max 478.6520, expressed in 955 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
61591	4.2768	947
61589	0.0648	14
61590	0.0495	13

Top tissues by expression

248 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	86.58	gold quality
primary visual cortex	UBERON:0002436	86.21	gold quality
Brodmann (1909) area 9	UBERON:0013540	85.26	gold quality
Brodmann (1909) area 23	UBERON:0013554	84.92	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.38	gold quality
prefrontal cortex	UBERON:0000451	84.15	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	84.09	gold quality
occipital lobe	UBERON:0002021	82.86	gold quality
anterior cingulate cortex	UBERON:0009835	82.54	gold quality
endothelial cell	CL:0000115	82.45	silver quality
right frontal lobe	UBERON:0002810	82.26	gold quality
frontal cortex	UBERON:0001870	82.13	gold quality
neocortex	UBERON:0001950	82.06	gold quality
nucleus accumbens	UBERON:0001882	82.03	gold quality
caudate nucleus	UBERON:0001873	81.83	gold quality
tendon	UBERON:0000043	81.64	gold quality
corpus callosum	UBERON:0002336	81.64	gold quality
skin of leg	UBERON:0001511	81.48	gold quality
cerebral cortex	UBERON:0000956	80.78	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	80.72	gold quality
skin of abdomen	UBERON:0001416	80.70	gold quality
right ovary	UBERON:0002118	80.35	gold quality
forebrain	UBERON:0001890	80.03	gold quality
putamen	UBERON:0001874	79.99	gold quality
left ovary	UBERON:0002119	79.97	gold quality
right hemisphere of cerebellum	UBERON:0014890	79.93	gold quality
cerebellar hemisphere	UBERON:0002245	79.79	gold quality
cerebellar cortex	UBERON:0002129	79.74	gold quality
pituitary gland	UBERON:0000007	79.64	gold quality
ventricular zone	UBERON:0003053	79.56	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.50

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• LncRNA BRCAT54 inhibits the tumorigenesis of non-small cell lung cancer by binding to RPS9 to transcriptionally regulate JAK-STAT and calcium pathway genes. (PMID:32459848)
• Long non-coding RNA BRCAT54 sponges microRNA-21 in vestibular schwannoma to suppress cell proliferation. (PMID:35137654)
• Long non-coding RNA breast cancer-associated transcript 54 sponges microRNA-1269b to suppress the proliferation of hemangioma-derived endothelial cells. (PMID:35200096)
• LncRNA BRCAT54 is downregulated and inhibits cancer cell proliferation by downregulating miR-130b-3p through methylation in prostate cancer. (PMID:37888834)
• In silico identification and in vitro evaluation of MRPS30-DT lncRNA and MRPS30 gene expression in breast cancer. (PMID:38886335)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.