MRPS35

Summary

MRPS35 (mitochondrial ribosomal protein S35, HGNC:16635) is a protein-coding gene on chromosome 12p11.22, encoding Small ribosomal subunit protein mS35 (P82673).

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that has had confusing nomenclature in the literature. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Pseudogenes corresponding to this gene are found on chromosomes 3p, 5q, and 10q.

Source: NCBI Gene 60488 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 57 total
• Druggable target: yes
• MANE Select transcript: NM_021821

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16635
Approved symbol	MRPS35
Name	mitochondrial ribosomal protein S35
Location	12p11.22
Locus type	gene with protein product
Status	Approved
Aliases	MRPS28, MDS023, mS35
Ensembl gene	ENSG00000061794
Ensembl biotype	protein_coding
OMIM	611995
Entrez	60488

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 11 protein_coding, 2 nonsense_mediated_decay

ENST00000081029, ENST00000536569, ENST00000538315, ENST00000542199, ENST00000542791, ENST00000898975, ENST00000898976, ENST00000898977, ENST00000898978, ENST00000939666, ENST00000939667, ENST00000939668, ENST00000942831

RefSeq mRNA: 2 — MANE Select: NM_021821 NM_001190864, NM_021821

CCDS: CCDS53769, CCDS8714

Canonical transcript exons

ENST00000081029 — 8 exons

Exon	Start	End
ENSE00001008073	27714780	27714820
ENSE00001008074	27710832	27710955
ENSE00002273609	27755181	27756295
ENSE00003469386	27719808	27719868
ENSE00003591582	27724047	27724186
ENSE00003641578	27737539	27737608
ENSE00003653513	27735447	27735556
ENSE00003664214	27716291	27716458

Expression profiles

Bgee: expression breadth ubiquitous, 287 present calls, max score 96.49.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 56.9035 / max 717.7711, expressed in 1820 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
124844	56.9035	1820

Top tissues by expression

291 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
rectum	UBERON:0001052	96.49	gold quality
mucosa of transverse colon	UBERON:0004991	95.81	gold quality
calcaneal tendon	UBERON:0003701	95.72	gold quality
adrenal tissue	UBERON:0018303	95.61	gold quality
tibialis anterior	UBERON:0001385	95.39	gold quality
muscle of leg	UBERON:0001383	95.34	gold quality
gastrocnemius	UBERON:0001388	95.27	gold quality
ileal mucosa	UBERON:0000331	95.16	gold quality
deltoid	UBERON:0001476	95.07	gold quality
muscle organ	UBERON:0001630	94.91	gold quality
skeletal muscle organ	UBERON:0014892	94.91	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	94.84	gold quality
right adrenal gland	UBERON:0001233	94.56	gold quality
right adrenal gland cortex	UBERON:0035827	94.41	gold quality
hindlimb stylopod muscle	UBERON:0004252	94.40	gold quality
islet of Langerhans	UBERON:0000006	94.36	gold quality
left adrenal gland	UBERON:0001234	94.20	gold quality
ventricular zone	UBERON:0003053	94.04	gold quality
quadriceps femoris	UBERON:0001377	93.95	gold quality
mucosa of sigmoid colon	UBERON:0004993	93.95	gold quality
vastus lateralis	UBERON:0001379	93.92	gold quality
colonic mucosa	UBERON:0000317	93.77	gold quality
left adrenal gland cortex	UBERON:0035825	93.71	gold quality
adrenal gland	UBERON:0002369	93.70	gold quality
adult mammalian kidney	UBERON:0000082	93.68	gold quality
cortical plate	UBERON:0005343	93.67	gold quality
skeletal muscle tissue	UBERON:0001134	93.65	gold quality
triceps brachii	UBERON:0001509	93.65	gold quality
ganglionic eminence	UBERON:0004023	93.58	gold quality
transverse colon	UBERON:0001157	93.47	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

49 targeting MRPS35, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-200B-3P	100.00	73.31	2693
HSA-MIR-200C-3P	100.00	73.35	2685
HSA-MIR-429	100.00	73.44	2698
HSA-MIR-302C-5P	99.97	72.56	3642
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-1250-3P	99.96	70.04	4038
HSA-MIR-551B-5P	99.96	71.28	3493
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-3143	99.93	71.96	3104
HSA-MIR-6508-5P	99.92	70.67	2465
HSA-MIR-12119	99.87	68.35	1653
HSA-MIR-8067	99.86	69.59	2260
HSA-MIR-3151-5P	99.86	63.83	1069
HSA-MIR-4503	99.85	71.45	1869
HSA-MIR-4447	99.85	67.81	2900
HSA-MIR-6739-5P	99.80	67.87	2806
HSA-MIR-6764-5P	99.75	67.89	2304
HSA-MIR-6733-5P	99.74	67.94	2759
HSA-MIR-3934-5P	99.67	64.04	846
HSA-MIR-4666B	99.64	68.69	1282
HSA-MIR-1915-3P	99.58	66.79	1988
HSA-MIR-3153	99.55	67.59	2337
HSA-MIR-6083	99.47	68.73	2393
HSA-MIR-5690	99.25	67.58	1012
HSA-MIR-5584-3P	99.23	68.79	1351
HSA-MIR-544B	99.18	67.41	1632
HSA-MIR-491-5P	99.13	65.98	1468
HSA-MIR-4758-3P	99.12	63.96	869
HSA-MIR-10524-5P	99.05	66.08	963

Literature-anchored findings (GeneRIF, showing 1)

• Circular RNA circMRPS35 represses malignant progression in osteosarcoma cells via targeting miR-105-5p/FOXO1. (PMID:39103205)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	mrps35	ENSDARG00000038456
mus_musculus	Mrps35	ENSMUSG00000040112
rattus_norvegicus	Mrps35	ENSRNOG00000001842
drosophila_melanogaster	mRpS35	FBGN0035374
caenorhabditis_elegans		WBGENE00012697

Protein

Protein identifiers

Small ribosomal subunit protein mS35 — P82673 (reviewed: P82673)

Alternative names: 28S ribosomal protein S28, mitochondrial, 28S ribosomal protein S35, mitochondrial

All UniProt accessions (4): P82673, F5H612, H0YFD1, H0YG82

UniProt curated annotations — full annotation on UniProt →

Subunit / interactions. Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

Subcellular location. Mitochondrion.

Similarity. Belongs to the mitochondrion-specific ribosomal protein mS35 family.

Isoforms (2)

UniProt ID	Names	Canonical?
P82673-1	1	yes
P82673-2	2

RefSeq proteins (2): NP_001177793, NP_068593* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR019349	Ribosomal_mS35_mit	Domain
IPR039848	Ribosomal_mS35_mt	Family

Pfam: PF10213

UniProt features (35 total): helix 16, strand 8, turn 4, splice variant 2, transit peptide 1, chain 1, region of interest 1, coiled-coil region 1, sequence variant 1

Structure

Experimental structures (PDB)

77 structures, top 30 by resolution.

PDB	Method	Resolution (Å)
7QI4	ELECTRON MICROSCOPY	2.21
8CSS	ELECTRON MICROSCOPY	2.36
7P2E	ELECTRON MICROSCOPY	2.4
8RRI	ELECTRON MICROSCOPY	2.4
9OLF	ELECTRON MICROSCOPY	2.46
9OJM	ELECTRON MICROSCOPY	2.5
8CSQ	ELECTRON MICROSCOPY	2.54
8CSR	ELECTRON MICROSCOPY	2.54
6ZM6	ELECTRON MICROSCOPY	2.59
7QI5	ELECTRON MICROSCOPY	2.63
8CSP	ELECTRON MICROSCOPY	2.66
7PNX	ELECTRON MICROSCOPY	2.76
8ANY	ELECTRON MICROSCOPY	2.85
8CST	ELECTRON MICROSCOPY	2.85
6ZM5	ELECTRON MICROSCOPY	2.89
7PO0	ELECTRON MICROSCOPY	2.9
8K2A	ELECTRON MICROSCOPY	2.9
9PGL	ELECTRON MICROSCOPY	2.9
7PO1	ELECTRON MICROSCOPY	2.92
7PO3	ELECTRON MICROSCOPY	2.92
9PGF	ELECTRON MICROSCOPY	2.93
6VMI	ELECTRON MICROSCOPY	2.96
6RW4	ELECTRON MICROSCOPY	2.97
6VLZ	ELECTRON MICROSCOPY	2.97
7QI6	ELECTRON MICROSCOPY	2.98
8QRN	ELECTRON MICROSCOPY	2.98
9PSM	ELECTRON MICROSCOPY	2.98
8OIS	ELECTRON MICROSCOPY	3
9G5C	ELECTRON MICROSCOPY	3
9G5D	ELECTRON MICROSCOPY	3

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P82673-F1	85.25	0.68

Function

Pathways and Gene Ontology

Reactome pathways

7 pathways

ID	Pathway
R-HSA-5368286	Mitochondrial translation initiation
R-HSA-5389840	Mitochondrial translation elongation
R-HSA-5419276	Mitochondrial translation termination
R-HSA-9937383	Mitochondrial ribosome-associated quality control
R-HSA-392499	Metabolism of proteins
R-HSA-5368287	Mitochondrial translation
R-HSA-72766	Translation

MSigDB gene sets: 304 (showing top): GSE18804_BRAIN_VS_COLON_TUMORAL_MACROPHAGE_DN, TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_MONOCYTE_UP, STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GOBP_MITOCHONDRIAL_TRANSLATION, TGACCTY_ERR1_Q2, GOBP_TRANSLATION, chr12p11, WEI_MYCN_TARGETS_WITH_E_BOX, ONKEN_UVEAL_MELANOMA_UP, WANG_LMO4_TARGETS_DN, GOMF_STRUCTURAL_CONSTITUENT_OF_RIBOSOME, GOCC_MITOCHONDRIAL_ENVELOPE, HNF4_01, NIKOLSKY_BREAST_CANCER_8Q12_Q22_AMPLICON

GO Biological Process (1): mitochondrial translation (GO:0032543)

GO Molecular Function (3): RNA binding (GO:0003723), structural constituent of ribosome (GO:0003735), protein binding (GO:0005515)

GO Cellular Component (7): mitochondrion (GO:0005739), mitochondrial inner membrane (GO:0005743), mitochondrial small ribosomal subunit (GO:0005763), cytosol (GO:0005829), sperm head-tail coupling apparatus (GO:0120212), ribosome (GO:0005840), ribonucleoprotein complex (GO:1990904)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Mitochondrial translation	4
Translation	1
Metabolism of proteins	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cytoplasm	2
cellular anatomical structure	2
mitochondrion	1
translation	1
mitochondrial gene expression	1
nucleic acid binding	1
structural molecule activity	1
ribosome	1
binding	1
intracellular membrane-bounded organelle	1
organelle inner membrane	1
mitochondrial membrane	1
organellar small ribosomal subunit	1
mitochondrial ribosome	1
mitochondrial protein-containing complex	1
intracellular membraneless organelle	1
protein-containing complex	1

Protein interactions and networks

STRING

1940 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MRPS35	MIX23	Q4VC31	601
MRPS35	MRPS11	P82912	572
MRPS35	SNX30	Q5VWJ9	541
MRPS35	KAT7	O95251	462
MRPS35	KGD4	P82909	417
MRPS35	MRPS22	P82650	409
MRPS35	H3BQ15	H3BQ15	403
MRPS35	AMDHD2	Q9Y303	396
MRPS35	SCCPDH	Q8NBX0	389
MRPS35	TMEM63A	O94886	382
MRPS35	VDAC1	P21796	382
MRPS35	MRPL21	Q7Z2W9	374
MRPS35	MRPS5	P82675	350
MRPS35	BUD31	P41223	349
MRPS35	TM7SF3	Q9NS93	349
MRPS35	INTS13	Q9NVM9	349

IntAct

209 interactions, top by confidence:

A	B	Type	Score
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
ESR1	TRIM24	psi-mi:“MI:0914”(association)	0.640
LIN28A	IGF2BP3	psi-mi:“MI:0914”(association)	0.640
DAP3	MRPS35	psi-mi:“MI:0915”(physical association)	0.560
NP	KPNA6	psi-mi:“MI:0914”(association)	0.550
MRPS18B	MRPS14	psi-mi:“MI:0914”(association)	0.530
MRPL2	GTPBP10	psi-mi:“MI:0914”(association)	0.530
ZNF169	ZNF316	psi-mi:“MI:0914”(association)	0.530
SNRNP70	GTPBP1	psi-mi:“MI:0914”(association)	0.530
ZNF331	USP9Y	psi-mi:“MI:0914”(association)	0.530
PPAN	PPM1G	psi-mi:“MI:0914”(association)	0.530
MRPS34	ZZEF1	psi-mi:“MI:0914”(association)	0.530
ZBTB48	ZBTB24	psi-mi:“MI:0914”(association)	0.530
E4F1	ZBTB24	psi-mi:“MI:0914”(association)	0.530
MRPS18C	MRPS14	psi-mi:“MI:0914”(association)	0.530
TRMT10B	MRPS14	psi-mi:“MI:0914”(association)	0.530
PDGFB	DKC1	psi-mi:“MI:0914”(association)	0.530
IGF2BP3	PTCD1	psi-mi:“MI:0914”(association)	0.530
DAP3	PNMA6A	psi-mi:“MI:0914”(association)	0.530
MRPS15	PRKACG	psi-mi:“MI:0914”(association)	0.530
MRPS27	YBX1	psi-mi:“MI:0914”(association)	0.530
MRPS26	MRPS10	psi-mi:“MI:0914”(association)	0.530
ZNF764	SH3PXD2B	psi-mi:“MI:0914”(association)	0.530
MRPL18	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MRPS34	MRPS12	psi-mi:“MI:0914”(association)	0.530
MRPS11	MRPS14	psi-mi:“MI:0914”(association)	0.530
ABT1	ZNF316	psi-mi:“MI:0914”(association)	0.530

BioGRID (404): MRPS35 (Affinity Capture-MS), MRPS35 (Affinity Capture-MS), MRPS35 (Affinity Capture-MS), MRPS35 (Affinity Capture-MS), MRPS35 (Affinity Capture-MS), MRPS35 (Affinity Capture-MS), MRPS35 (Affinity Capture-MS), MRPS35 (Affinity Capture-MS), MRPS35 (Affinity Capture-MS), MRPS35 (Affinity Capture-MS), ATP1B1 (Co-fractionation), DAP3 (Co-fractionation), MRPS18B (Co-fractionation), MRPS23 (Co-fractionation), MRPS31 (Co-fractionation)

ESM2 similar proteins: A4IHS0, A5WUX7, A6ZND9, B1P1W2, B3LIY9, B4KPG8, B5XAM2, D2HD32, E7EXT2, O44568, O94443, P25642, P34511, P82673, Q05863, Q08230, Q08DT6, Q08DU1, Q09691, Q12322, Q14197, Q2KI45, Q3T116, Q3UFY8, Q497V5, Q498P2, Q5RDI0, Q5U2R4, Q60R52, Q7JUX9, Q80VP5, Q8C1Z8, Q8K2Y7, Q8MT06, Q8N5C6, Q8R035, Q8VCE1, Q95Q11, Q9BRU9, Q9BVP2

Diamond homologs: P82673, Q2YDF6, Q498P2, Q8BJZ4

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
MRPS35	“form complex”	“28S mitochondrial small ribosomal subunit”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 234 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Mitochondrial translation	27	24.8×	6e-29
Mitochondrial ribosome-associated quality control	29	23.7×	5e-30
Mitochondrial translation initiation	28	23.7×	3e-29
Mitochondrial translation elongation	28	23.7×	3e-29
Mitochondrial translation termination	28	20.5×	2e-27
Translation	33	13.7×	1e-26
Peptide chain elongation	11	9.3×	1e-06
Viral mRNA Translation	11	9.3×	1e-06

GO biological processes:

GO term	Partners	Fold	FDR
mitochondrial translation	29	24.5×	1e-29
cytoplasmic translation	13	11.7×	3e-08
translation	22	11.0×	4e-14
regulation of alternative mRNA splicing, via spliceosome	7	8.3×	6e-03
ribosomal small subunit biogenesis	7	7.7×	8e-03
RNA processing	7	7.4×	8e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

57 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	34
Likely benign	8
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

2099 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
12:27716333:T:A	W66R	0.992
12:27716333:T:C	W66R	0.992
12:27724061:T:A	W133R	0.992
12:27724061:T:C	W133R	0.992
12:27737560:T:A	N218K	0.992
12:27737560:T:G	N218K	0.992
12:27716335:G:C	W66C	0.990
12:27716335:G:T	W66C	0.990
12:27716443:T:A	N102K	0.989
12:27716443:T:G	N102K	0.989
12:27719816:T:A	N110K	0.989
12:27719816:T:G	N110K	0.989
12:27719817:T:C	F111L	0.988
12:27719819:T:A	F111L	0.988
12:27719819:T:G	F111L	0.988
12:27716391:T:A	V85D	0.987
12:27724063:G:C	W133C	0.986
12:27724063:G:T	W133C	0.986
12:27737603:T:C	S233P	0.986
12:27716363:T:C	F76L	0.985
12:27716365:T:A	F76L	0.985
12:27716365:T:G	F76L	0.985
12:27755193:T:A	W239R	0.985
12:27755193:T:C	W239R	0.985
12:27737580:T:C	L225P	0.983
12:27755195:G:C	W239C	0.983
12:27755195:G:T	W239C	0.983
12:27716458:G:C	K107N	0.982
12:27716458:G:T	K107N	0.982
12:27719818:T:C	F111S	0.982

dbSNP variants (sampled 300 via entrez): RS1000010454 (12:27741512 G>A), RS1000022731 (12:27750347 A>G), RS1000210355 (12:27746380 C>T), RS1000218549 (12:27722725 A>G,T), RS1000233666 (12:27710227 C>T), RS1000236280 (12:27739072 A>G), RS1000265670 (12:27739473 GAA>G,GA,GAAA), RS1000273961 (12:27715883 T>G), RS1000338833 (12:27739795 A>C), RS1000483230 (12:27754977 G>A), RS1000488575 (12:27709787 A>C), RS1000491672 (12:27731749 A>G), RS1000622126 (12:27725075 C>T), RS1000821268 (12:27731501 T>A), RS1000912601 (12:27734306 G>A)

Disease associations

OMIM: gene MIM:611995 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6066392 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
8.14	Kd	7.233	nM	CHEMBL5653589
8.14	ED50	7.233	nM	CHEMBL5653589

PubChem BioAssay actives

1 with measured affinity, of 2 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2148780: Binding affinity to human MRPS35 incubated for 45 mins by Kinobead based pull down assay	kd	0.0072	uM

CTD chemical–gene interactions

34 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Acetaminophen	affects cotreatment, decreases expression	3
aristolochic acid I	decreases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	decreases expression	1
arsenite	affects binding, increases reaction	1
sodium arsenite	affects cotreatment, increases abundance, increases expression	1
manganese chloride	increases abundance, increases expression, affects cotreatment	1
aflatoxin B2	decreases methylation	1
di-n-butylphosphoric acid	affects expression	1
2,3,5-(triglutathion-S-yl)hydroquinone	increases ADP-ribosylation	1
K 7174	increases expression	1
ICG 001	increases expression	1
bisphenol B	increases expression	1
bisphenol S	increases methylation	1
bisphenol AF	increases expression	1
Sunitinib	increases expression	1
Air Pollutants	decreases expression, increases abundance	1
Arsenic	affects cotreatment, increases abundance, increases expression	1
Atrazine	decreases expression	1
Benzo(a)pyrene	affects methylation	1
Doxorubicin	increases expression	1
Enzyme Inhibitors	decreases activity, increases O-linked glycosylation	1
Hydrogen Peroxide	affects expression	1
Ivermectin	decreases expression	1
Lipopolysaccharides	decreases expression, affects cotreatment	1
Manganese	increases expression, affects cotreatment, increases abundance	1
Ribonucleotides	affects binding	1
Rotenone	decreases expression	1
Testosterone	decreases expression	1
Valproic Acid	affects expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5651822	Binding	Binding affinity to human MRPS35 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.