MRPS6

Summary

MRPS6 (mitochondrial ribosomal protein S6, HGNC:14051) is a protein-coding gene on chromosome 21q22.11, encoding Small ribosomal subunit protein bS6m (P82932). It is a selective cancer dependency (DepMap: 57.6% of cell lines).

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S6P family. Pseudogenes corresponding to this gene are found on chromosomes 1p and 12q.

Source: NCBI Gene 64968 — RefSeq curated summary.

At a glance

• GWAS associations: 5
• Clinical variants (ClinVar): 62 total
• Cancer dependency (DepMap): dependent in 57.6% of screened cell lines
• MANE Select transcript: NM_032476

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14051
Approved symbol	MRPS6
Name	mitochondrial ribosomal protein S6
Location	21q22.11
Locus type	gene with protein product
Status	Approved
Aliases	MRP-S6, RPMS6, bS6m
Ensembl gene	ENSG00000243927
Ensembl biotype	protein_coding
OMIM	611973
Entrez	64968

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 3 protein_coding_CDS_not_defined, 2 nonsense_mediated_decay, 1 protein_coding, 1 retained_intron

ENST00000362077, ENST00000399312, ENST00000477091, ENST00000482679, ENST00000483977, ENST00000488492, ENST00000715810

RefSeq mRNA: 1 — MANE Select: NM_032476 NM_032476

CCDS: CCDS33548

Canonical transcript exons

ENST00000399312 — 3 exons

Exon	Start	End
ENSE00001537488	34073578	34073745
ENSE00003491091	34142408	34143030
ENSE00003597756	34125341	34125480

Expression profiles

Bgee: expression breadth ubiquitous, 255 present calls, max score 99.51.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 4.5590 / max 44.3196, expressed in 1679 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
188911	96.7010	1828
188910	2.0997	1145
188909	2.0596	1205
188917	0.3997	208

Top tissues by expression

256 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
renal medulla	UBERON:0000362	99.51	gold quality
metanephros cortex	UBERON:0010533	98.26	gold quality
kidney epithelium	UBERON:0004819	98.15	gold quality
left lobe of thyroid gland	UBERON:0001120	97.90	gold quality
decidua	UBERON:0002450	97.90	gold quality
thyroid gland	UBERON:0002046	97.75	gold quality
metanephros	UBERON:0000081	97.54	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	97.46	gold quality
adult mammalian kidney	UBERON:0000082	97.44	gold quality
right lobe of thyroid gland	UBERON:0001119	97.42	gold quality
tibial artery	UBERON:0007610	97.31	gold quality
popliteal artery	UBERON:0002250	97.30	gold quality
right adrenal gland cortex	UBERON:0035827	97.29	gold quality
right coronary artery	UBERON:0001625	97.17	gold quality
tibial nerve	UBERON:0001323	97.13	gold quality
aorta	UBERON:0000947	97.12	gold quality
dorsal root ganglion	UBERON:0000044	97.11	gold quality
descending thoracic aorta	UBERON:0002345	97.11	gold quality
cortical plate	UBERON:0005343	97.11	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	97.05	gold quality
trigeminal ganglion	UBERON:0001675	97.03	gold quality
right adrenal gland	UBERON:0001233	96.96	gold quality
ascending aorta	UBERON:0001496	96.92	gold quality
thoracic aorta	UBERON:0001515	96.91	gold quality
calcaneal tendon	UBERON:0003701	96.86	gold quality
ventricular zone	UBERON:0003053	96.76	gold quality
left coronary artery	UBERON:0001626	96.69	gold quality
coronary artery	UBERON:0001621	96.55	gold quality
pigmented layer of retina	UBERON:0001782	96.52	gold quality
saphenous vein	UBERON:0007318	96.51	gold quality

Single-cell (SCXA)

Detected in 4 experiment(s), a significant marker in 3.

Experiment	Marker?	Max mean expression
E-MTAB-8142	yes	35.20
E-GEOD-125970	yes	14.31
E-MTAB-10485	no	712.91
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

39 targeting MRPS6, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-3692-3P	99.98	70.27	2139
HSA-MIR-548AN	99.97	70.91	2817
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-3912-5P	99.95	66.11	925
HSA-MIR-6768-5P	99.92	67.36	1942
HSA-MIR-5680	99.91	69.83	3421
HSA-MIR-10527-5P	99.91	72.28	3754
HSA-MIR-4697-3P	99.89	67.09	1123
HSA-MIR-369-3P	99.85	70.52	2264
HSA-MIR-202-3P	99.84	71.41	1290
HSA-MIR-6515-3P	99.82	68.19	1933
HSA-MIR-374C-5P	99.80	72.06	2910
HSA-MIR-655-3P	99.80	72.19	2909
HSA-MIR-548AJ-5P	99.78	71.12	3085
HSA-MIR-548F-5P	99.78	71.02	3093
HSA-MIR-548G-5P	99.78	71.12	3085
HSA-MIR-548X-5P	99.78	71.12	3085
HSA-MIR-556-3P	99.74	68.75	1203
HSA-MIR-3685	99.62	68.83	1621
HSA-MIR-425-5P	99.59	67.67	900
HSA-MIR-4672	99.50	71.58	2893
HSA-MIR-657	99.48	66.02	848
HSA-MIR-330-3P	99.41	69.95	2521
HSA-MIR-888-5P	99.30	70.15	1855
HSA-MIR-6768-3P	99.14	67.38	1319
HSA-MIR-8066	99.05	68.66	1532
HSA-MIR-3117-5P	99.04	67.93	618

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 57.6% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 2)

• Mitochondrial ribosomal small subunit proteins (MRPS) MRPS6 and MRPS23 show dysregulation in breast cancer affecting tumorigenic cellular processes. (PMID:33964376)
• MRPS6 modulates glucose-stimulated insulin secretion in mouse islet cells through mitochondrial unfolded protein response. (PMID:37758822)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	mrps6	ENSDARG00000039543
mus_musculus	Mrps6	ENSMUSG00000039680
rattus_norvegicus	Mrps6	ENSRNOG00000059381

Protein

Protein identifiers

Small ribosomal subunit protein bS6m — P82932 (reviewed: P82932)

Alternative names: 28S ribosomal protein S6, mitochondrial

All UniProt accessions (1): P82932

UniProt curated annotations — full annotation on UniProt →

Subunit / interactions. Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

Subcellular location. Mitochondrion.

Similarity. Belongs to the bacterial ribosomal protein bS6 family.

RefSeq proteins (1): NP_115865* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000529	Ribosomal_bS6	Family
IPR014717	Transl_elong_EF1B/ribsomal_bS6	Homologous_superfamily
IPR035980	Ribosomal_bS6_sf	Homologous_superfamily

Pfam: PF01250

UniProt features (9 total): strand 4, helix 3, chain 1, turn 1

Structure

Experimental structures (PDB)

77 structures, top 30 by resolution.

PDB	Method	Resolution (Å)
7QI4	ELECTRON MICROSCOPY	2.21
8CSS	ELECTRON MICROSCOPY	2.36
7P2E	ELECTRON MICROSCOPY	2.4
8RRI	ELECTRON MICROSCOPY	2.4
9OLF	ELECTRON MICROSCOPY	2.46
9OJM	ELECTRON MICROSCOPY	2.5
8CSQ	ELECTRON MICROSCOPY	2.54
8CSR	ELECTRON MICROSCOPY	2.54
6ZM6	ELECTRON MICROSCOPY	2.59
7QI5	ELECTRON MICROSCOPY	2.63
8CSP	ELECTRON MICROSCOPY	2.66
7PNX	ELECTRON MICROSCOPY	2.76
8ANY	ELECTRON MICROSCOPY	2.85
8CST	ELECTRON MICROSCOPY	2.85
6ZM5	ELECTRON MICROSCOPY	2.89
7PO0	ELECTRON MICROSCOPY	2.9
8K2A	ELECTRON MICROSCOPY	2.9
9PGL	ELECTRON MICROSCOPY	2.9
7PO1	ELECTRON MICROSCOPY	2.92
7PO3	ELECTRON MICROSCOPY	2.92
9PGF	ELECTRON MICROSCOPY	2.93
6VMI	ELECTRON MICROSCOPY	2.96
6RW4	ELECTRON MICROSCOPY	2.97
6VLZ	ELECTRON MICROSCOPY	2.97
7QI6	ELECTRON MICROSCOPY	2.98
8QRN	ELECTRON MICROSCOPY	2.98
9PSM	ELECTRON MICROSCOPY	2.98
8OIS	ELECTRON MICROSCOPY	3
9G5C	ELECTRON MICROSCOPY	3
9G5D	ELECTRON MICROSCOPY	3

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P82932-F1	92.50	0.81

Function

Pathways and Gene Ontology

Reactome pathways

7 pathways

ID	Pathway
R-HSA-5368286	Mitochondrial translation initiation
R-HSA-5389840	Mitochondrial translation elongation
R-HSA-5419276	Mitochondrial translation termination
R-HSA-9937383	Mitochondrial ribosome-associated quality control
R-HSA-392499	Metabolism of proteins
R-HSA-5368287	Mitochondrial translation
R-HSA-72766	Translation

MSigDB gene sets: 175 (showing top): HONMA_DOCETAXEL_RESISTANCE, GCANCTGNY_MYOD_Q6, GOBP_MITOCHONDRIAL_TRANSLATION, IVANOVA_HEMATOPOIESIS_LATE_PROGENITOR, CAGCTG_AP4_Q5, GOBP_TRANSLATION, NFKB_C, GOMF_STRUCTURAL_CONSTITUENT_OF_RIBOSOME, GGARNTKYCCA_UNKNOWN, SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_UP, GOCC_MITOCHONDRIAL_ENVELOPE, ZHOU_INFLAMMATORY_RESPONSE_LIVE_DN, AACTTT_UNKNOWN, DOUGLAS_BMI1_TARGETS_UP, chr21q22

GO Biological Process (2): translation (GO:0006412), mitochondrial translation (GO:0032543)

GO Molecular Function (4): structural constituent of ribosome (GO:0003735), small ribosomal subunit rRNA binding (GO:0070181), protein binding (GO:0005515), rRNA binding (GO:0019843)

GO Cellular Component (6): mitochondrion (GO:0005739), mitochondrial inner membrane (GO:0005743), mitochondrial small ribosomal subunit (GO:0005763), small ribosomal subunit (GO:0015935), ribosome (GO:0005840), ribonucleoprotein complex (GO:1990904)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Mitochondrial translation	4
Translation	1
Metabolism of proteins	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
peptidyltransferase activity	1
translational initiation	1
translational elongation	1
translational termination	1
macromolecule biosynthetic process	1
protein metabolic process	1
protein biosynthetic process	1
mitochondrion	1
translation	1
mitochondrial gene expression	1
structural molecule activity	1
ribosome	1
rRNA binding	1
binding	1
RNA binding	1
cytoplasm	1
intracellular membrane-bounded organelle	1
organelle inner membrane	1
mitochondrial membrane	1
organellar small ribosomal subunit	1
mitochondrial ribosome	1
mitochondrial protein-containing complex	1
ribosomal subunit	1
intracellular membraneless organelle	1
protein-containing complex	1

Protein interactions and networks

STRING

2369 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MRPS6	SLC5A3	P53794	637
MRPS6	TMEM50B	P56557	585
MRPS6	WDR12	Q9GZL7	580
MRPS6	PHACTR1	Q9C0D0	571
MRPS6	MRPS10	P82664	561
MRPS6	DONSON	Q9NYP3	559
MRPS6	MRPS18C	Q9Y3D5	555
MRPS6	MRPL22	Q9NWU5	552
MRPS6	MIA3	Q5JRA6	544
MRPS6	MRPL1	Q9BYD6	534
MRPS6	MRPS16	Q9Y3D3	530
MRPS6	MRPS5	P82675	517
MRPS6	DOP1B	Q9Y3R5	517
MRPS6	KCNE2	Q9Y6J6	507
MRPS6	MRPS14	O60783	504

IntAct

98 interactions, top by confidence:

A	B	Type	Score
FBL	NOP56	psi-mi:“MI:0914”(association)	0.800
STAT5B	MRPS6	psi-mi:“MI:0915”(physical association)	0.670
ESR1	TRIM24	psi-mi:“MI:0914”(association)	0.640
IGF2BP1	IGF2BP3	psi-mi:“MI:0914”(association)	0.640
MRPS6	MKRN3	psi-mi:“MI:0915”(physical association)	0.560
MKRN3	MRPS6	psi-mi:“MI:0915”(physical association)	0.560
MRPS6	LNX1	psi-mi:“MI:0915”(physical association)	0.560
MRPS6	tax	psi-mi:“MI:0915”(physical association)	0.560
tax	MRPS6	psi-mi:“MI:0915”(physical association)	0.560
NP	KPNA6	psi-mi:“MI:0914”(association)	0.550
STAT5A	MRPS6	psi-mi:“MI:0915”(physical association)	0.550
MRPS6	STAT5A	psi-mi:“MI:0914”(association)	0.550
RPS6	IPO7	psi-mi:“MI:0914”(association)	0.530
MRPS15	MRPS14	psi-mi:“MI:0914”(association)	0.530
MRPS18B	MRPS14	psi-mi:“MI:0914”(association)	0.530
MRPS34	MRPS12	psi-mi:“MI:0914”(association)	0.530
MRPS11	MRPS14	psi-mi:“MI:0914”(association)	0.530
SRPK2	MRPS6	psi-mi:“MI:0217”(phosphorylation reaction)	0.440
MRPS6		psi-mi:“MI:0915”(physical association)	0.370
MRPS6	CFAP418	psi-mi:“MI:0915”(physical association)	0.370
SREBF2	MRPS6	psi-mi:“MI:0915”(physical association)	0.370
MRPS6	RNF181	psi-mi:“MI:0915”(physical association)	0.370
MRPL50	MRPL43	psi-mi:“MI:0914”(association)	0.350
NP	KPNA6	psi-mi:“MI:0914”(association)	0.350

BioGRID (215): MRPS6 (Two-hybrid), MRPS6 (Affinity Capture-MS), MRPS6 (Affinity Capture-MS), MRPS18C (Co-fractionation), MRPS6 (Co-fractionation), MRPS6 (Affinity Capture-MS), MRPS6 (Affinity Capture-MS), MRPS6 (Affinity Capture-MS), MRPS6 (Affinity Capture-MS), MRPS6 (Affinity Capture-MS), MRPS6 (Affinity Capture-MS), MRPS6 (Affinity Capture-MS), MRPS6 (Affinity Capture-RNA), MRPS6 (Affinity Capture-MS), MRPS6 (Affinity Capture-MS)

ESM2 similar proteins: A4FUH0, A4FV08, A6QQL9, B5FWC0, D2K759, D2K760, D3K5L7, E1C6Q1, F1QH17, O22969, O94973, P16255, P35614, P35615, P46926, P50886, P50894, P58064, P62495, P62496, P62497, P62498, P82931, P82932, Q0VCK5, Q0VCX5, Q1RMS5, Q28IL6, Q3UA06, Q5R4C7, Q5R8T8, Q5R938, Q5U2Q7, Q5ZIJ2, Q5ZKQ6, Q64422, Q6P5R6, Q8BWY3, Q8CJ19, Q8LPJ4

Diamond homologs: P58064, P82931, P82932, Q5ZIJ2, Q9VZD5, Q7SB95, A8HVF1, P28778

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
MRPS6	“form complex”	“28S mitochondrial small ribosomal subunit”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 111 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Mitochondrial ribosome-associated quality control	22	34.6×	3e-26
Mitochondrial translation initiation	21	34.2×	3e-25
Mitochondrial translation elongation	21	34.2×	3e-25
Mitochondrial translation	19	33.5×	1e-22
Mitochondrial translation termination	21	29.6×	7e-24
Translation	20	15.9×	3e-17
Mitochondrial protein degradation	6	8.8×	3e-03

GO biological processes:

GO term	Partners	Fold	FDR
mitochondrial translation	22	39.8×	6e-27
translation	13	13.9×	3e-09
protein phosphorylation	8	5.7×	1e-02

Disease & clinical

Clinical variants and AI predictions

ClinVar

62 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	57
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1460 predictions. Top by Δscore:

Variant	Effect	Δscore
21:34073742:GCGG:G	donor_gain	1.0000
21:34073744:GG:G	donor_gain	1.0000
21:34073745:GG:G	donor_gain	1.0000
21:34073745:GGT:G	donor_loss	1.0000
21:34073746:G:C	donor_loss	1.0000
21:34073746:G:GG	donor_gain	1.0000
21:34073746:GTAA:G	donor_loss	1.0000
21:34073747:T:G	donor_loss	1.0000
21:34102909:G:GG	donor_gain	1.0000
21:34117659:T:G	donor_gain	1.0000
21:34125321:A:AG	acceptor_gain	1.0000
21:34125322:A:G	acceptor_gain	1.0000
21:34125327:A:AG	acceptor_gain	1.0000
21:34125328:C:G	acceptor_gain	1.0000
21:34142402:TTGCA:T	acceptor_loss	1.0000
21:34142405:CAG:C	acceptor_loss	1.0000
21:34142406:A:AG	acceptor_gain	1.0000
21:34142406:A:AT	acceptor_loss	1.0000
21:34142407:G:A	acceptor_loss	1.0000
21:34142407:G:GG	acceptor_gain	1.0000
21:34142407:GGT:G	acceptor_gain	1.0000
21:34073741:AGCGG:A	donor_gain	0.9900
21:34073742:GCGGG:G	donor_gain	0.9900
21:34073743:CGG:C	donor_gain	0.9900
21:34073744:GGG:G	donor_gain	0.9900
21:34125323:A:G	acceptor_gain	0.9900
21:34125324:A:AG	acceptor_gain	0.9900
21:34125325:A:G	acceptor_gain	0.9900
21:34125326:C:G	acceptor_gain	0.9900
21:34125329:A:AG	acceptor_gain	0.9900

AlphaMissense

807 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
21:34073717:T:C	L6P	0.973
21:34125366:G:C	R24P	0.973
21:34142412:T:C	F64L	0.973
21:34142414:C:A	F64L	0.973
21:34142414:C:G	F64L	0.973
21:34142475:G:C	D85H	0.970
21:34125477:G:A	G61D	0.968
21:34125402:T:A	V36E	0.967
21:34125360:T:C	L22S	0.966
21:34142413:T:C	F64S	0.963
21:34142476:A:C	D85A	0.963
21:34142476:A:T	D85V	0.962
21:34142419:T:A	V66E	0.960
21:34125435:T:A	L47H	0.958
21:34142409:T:G	Y63D	0.954
21:34142488:T:A	I89N	0.953
21:34073713:G:A	E5K	0.950
21:34125396:C:A	A34E	0.950
21:34125435:T:C	L47P	0.950
21:34142430:G:C	A70P	0.949
21:34125364:A:C	K23N	0.947
21:34125364:A:T	K23N	0.947
21:34125395:G:C	A34P	0.946
21:34125423:G:T	G43V	0.944
21:34142425:T:C	F68S	0.944
21:34073733:A:C	K11N	0.943
21:34073733:A:T	K11N	0.943
21:34125365:C:A	R24S	0.943
21:34142485:T:A	V88E	0.943
21:34125476:G:C	G61R	0.941

dbSNP variants (sampled 300 via entrez): RS1000064656 (21:34079990 T>C), RS1000090050 (21:34093571 A>G), RS1000156894 (21:34079854 T>G), RS1000190074 (21:34105135 G>A), RS1000196042 (21:34101557 C>G), RS1000204647 (21:34082853 T>A,C), RS1000282999 (21:34126893 G>A,T), RS1000299823 (21:34115620 C>T), RS1000362222 (21:34099044 A>C,G), RS1000373829 (21:34077518 A>G), RS1000517518 (21:34084485 A>G), RS1000566361 (21:34122531 G>A), RS1000637371 (21:34116753 A>G,T), RS1000651003 (21:34098717 A>ACTCTAACTTGACATGGCTTGGCACC), RS1000666878 (21:34116528 A>G)

Disease associations

OMIM: gene MIM:611973 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

5 associations (top):

Study	Trait	p-value
GCST000340_3	Myocardial infarction (early onset)	6.000000e-11
GCST000998_26	Coronary heart disease	4.000000e-10
GCST003998_10	Joint mobility (Beighton score)	2.000000e-09
GCST011364_31	Myocardial infarction	7.000000e-12
GCST011365_35	Myocardial infarction	3.000000e-22

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0007905	joint hypermobility measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

59 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	decreases methylation, increases expression	3
Acetaminophen	affects cotreatment, increases expression	2
Air Pollutants	affects cotreatment, increases abundance, increases oxidation, increases expression	2
Valproic Acid	decreases methylation, increases expression, affects expression	2
aristolochic acid I	increases expression	1
testosterone enanthate	affects expression	1
triphenyl phosphate	affects expression	1
alpha-pinene	affects cotreatment, increases oxidation, increases abundance	1
bisphenol A	increases expression	1
testosterone undecanoate	decreases expression, affects cotreatment	1
tris(2-butoxyethyl) phosphate	affects expression	1
arsenite	increases methylation	1
nickel chloride	decreases expression	1
nickel sulfate	decreases expression	1
methacrylaldehyde	affects cotreatment, increases oxidation, increases abundance	1
beta-methylcholine	affects expression	1
CGP 52608	affects binding, increases reaction	1
chloropicrin	increases expression	1
deguelin	decreases expression	1
corosolic acid	decreases expression	1
ICG 001	decreases expression	1
2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine	decreases expression, increases response to substance	1
bisphenol S	affects cotreatment, decreases expression	1
PCI 5002	affects cotreatment, increases expression	1
Resveratrol	affects cotreatment, increases expression	1
Sunitinib	increases expression	1
Acrolein	affects cotreatment, increases oxidation, increases abundance	1
Atrazine	decreases expression	1
Calcitriol	increases expression	1
Cisplatin	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.