MRPS9

Summary

MRPS9 (mitochondrial ribosomal protein S9, HGNC:14501) is a protein-coding gene on chromosome 2q12.1, encoding Small ribosomal subunit protein uS9m (P82933). It is a selective cancer dependency (DepMap: 43.0% of cell lines).

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein.

Source: NCBI Gene 64965 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 71 total
• Druggable target: yes
• Cancer dependency (DepMap): dependent in 43.0% of screened cell lines
• MANE Select transcript: NM_182640

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14501
Approved symbol	MRPS9
Name	mitochondrial ribosomal protein S9
Location	2q12.1
Locus type	gene with protein product
Status	Approved
Aliases	RPMS9, MRP-S9, S9mt, uS9m
Ensembl gene	ENSG00000135972
Ensembl biotype	protein_coding
OMIM	611975
Entrez	64965

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 12 protein_coding, 1 nonsense_mediated_decay, 1 retained_intron

ENST00000258455, ENST00000413583, ENST00000472220, ENST00000886284, ENST00000886285, ENST00000886286, ENST00000886287, ENST00000886288, ENST00000886289, ENST00000925255, ENST00000925256, ENST00000925257, ENST00000925258, ENST00000925259

RefSeq mRNA: 1 — MANE Select: NM_182640 NM_182640

CCDS: CCDS2065

Canonical transcript exons

ENST00000258455 — 11 exons

Exon	Start	End
ENSE00000804379	105049171	105049350
ENSE00001071850	105071313	105071375
ENSE00001071851	105088984	105089069
ENSE00001071852	105071459	105071489
ENSE00001071854	105038069	105038227
ENSE00001071855	105089920	105089995
ENSE00001071856	105099670	105099960
ENSE00001227995	105079983	105080062
ENSE00003558300	105093530	105093638
ENSE00003637653	105092401	105092569
ENSE00003638767	105097155	105097324

Expression profiles

Bgee: expression breadth ubiquitous, 254 present calls, max score 97.95.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 35.3129 / max 455.4540, expressed in 1812 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
21803	34.8275	1811
21802	0.4854	253

Top tissues by expression

257 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left ventricle myocardium	UBERON:0006566	97.95	gold quality
gastrocnemius	UBERON:0001388	95.77	gold quality
muscle of leg	UBERON:0001383	95.67	gold quality
deltoid	UBERON:0001476	95.62	gold quality
skeletal muscle organ	UBERON:0014892	95.54	gold quality
tibialis anterior	UBERON:0001385	95.47	gold quality
quadriceps femoris	UBERON:0001377	95.44	gold quality
vastus lateralis	UBERON:0001379	95.27	gold quality
heart left ventricle	UBERON:0002084	95.12	gold quality
hindlimb stylopod muscle	UBERON:0004252	95.04	gold quality
cardiac ventricle	UBERON:0002082	95.02	gold quality
skeletal muscle tissue	UBERON:0001134	94.80	gold quality
apex of heart	UBERON:0002098	94.42	gold quality
mucosa of transverse colon	UBERON:0004991	94.41	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	94.39	gold quality
myocardium	UBERON:0002349	94.35	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	94.35	gold quality
muscle tissue	UBERON:0002385	94.33	gold quality
right atrium auricular region	UBERON:0006631	94.21	gold quality
cardiac atrium	UBERON:0002081	94.14	gold quality
biceps brachii	UBERON:0001507	94.06	gold quality
heart	UBERON:0000948	94.01	gold quality
cardiac muscle of right atrium	UBERON:0003379	93.75	gold quality
right adrenal gland	UBERON:0001233	93.61	gold quality
right adrenal gland cortex	UBERON:0035827	93.60	gold quality
calcaneal tendon	UBERON:0003701	93.54	gold quality
rectum	UBERON:0001052	93.08	gold quality
left adrenal gland	UBERON:0001234	92.95	gold quality
adrenal tissue	UBERON:0018303	92.85	gold quality
left adrenal gland cortex	UBERON:0035825	92.61	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ENAD-17	no	285.93
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

11 targeting MRPS9, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-370-5P	99.78	66.81	706
HSA-MIR-10393-3P	99.72	66.56	961
HSA-MIR-6801-5P	99.72	66.50	981
HSA-MIR-4699-3P	99.71	70.15	3142
HSA-MIR-543	99.52	69.03	2595
HSA-MIR-7111-3P	97.80	66.75	1467
HSA-MIR-562	97.66	65.63	698
HSA-MIR-6131	97.22	66.72	960
HSA-MIR-346	97.01	66.97	662

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 43.0% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 1)

• MRPS9-Mediated Regulation of the PI3K/Akt/mTOR Pathway Inhibits Neuron Apoptosis and Protects Ischemic Stroke. (PMID:38381220)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	mrps9	ENSDARG00000061505
mus_musculus	Mrps9	ENSMUSG00000060679
rattus_norvegicus	Mrps9	ENSRNOG00000016201
drosophila_melanogaster	mRpS9	FBGN0037529
caenorhabditis_elegans		WBGENE00017319

Paralogs (1): RPS16 (ENSG00000105193)

Protein

Protein identifiers

Small ribosomal subunit protein uS9m — P82933 (reviewed: P82933)

Alternative names: 28S ribosomal protein S9, mitochondrial

All UniProt accessions (2): P82933, H7BZC4

UniProt curated annotations — full annotation on UniProt →

Subunit / interactions. Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

Subcellular location. Mitochondrion.

Similarity. Belongs to the universal ribosomal protein uS9 family.

RefSeq proteins (1): NP_872578* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000754	Ribosomal_uS9	Family
IPR014721	Ribsml_uS5_D2-typ_fold_subgr	Homologous_superfamily
IPR020568	Ribosomal_Su5_D2-typ_SF	Homologous_superfamily
IPR020574	Ribosomal_uS9_CS	Conserved_site
IPR023035	Ribosomal_uS9_bact_plastid	Family

Pfam: PF00380

UniProt features (29 total): helix 15, strand 9, transit peptide 1, chain 1, region of interest 1, modified residue 1, sequence variant 1

Structure

Experimental structures (PDB)

77 structures, top 30 by resolution.

PDB	Method	Resolution (Å)
7QI4	ELECTRON MICROSCOPY	2.21
8CSS	ELECTRON MICROSCOPY	2.36
7P2E	ELECTRON MICROSCOPY	2.4
8RRI	ELECTRON MICROSCOPY	2.4
9OLF	ELECTRON MICROSCOPY	2.46
9OJM	ELECTRON MICROSCOPY	2.5
8CSQ	ELECTRON MICROSCOPY	2.54
8CSR	ELECTRON MICROSCOPY	2.54
6ZM6	ELECTRON MICROSCOPY	2.59
7QI5	ELECTRON MICROSCOPY	2.63
8CSP	ELECTRON MICROSCOPY	2.66
7PNX	ELECTRON MICROSCOPY	2.76
8ANY	ELECTRON MICROSCOPY	2.85
8CST	ELECTRON MICROSCOPY	2.85
6ZM5	ELECTRON MICROSCOPY	2.89
7PO0	ELECTRON MICROSCOPY	2.9
8K2A	ELECTRON MICROSCOPY	2.9
9PGL	ELECTRON MICROSCOPY	2.9
7PO1	ELECTRON MICROSCOPY	2.92
7PO3	ELECTRON MICROSCOPY	2.92
9PGF	ELECTRON MICROSCOPY	2.93
6VMI	ELECTRON MICROSCOPY	2.96
6RW4	ELECTRON MICROSCOPY	2.97
6VLZ	ELECTRON MICROSCOPY	2.97
7QI6	ELECTRON MICROSCOPY	2.98
8QRN	ELECTRON MICROSCOPY	2.98
9PSM	ELECTRON MICROSCOPY	2.98
8OIS	ELECTRON MICROSCOPY	3
9G5C	ELECTRON MICROSCOPY	3
9G5D	ELECTRON MICROSCOPY	3

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P82933-F1	82.49	0.67

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 287

Function

Pathways and Gene Ontology

Reactome pathways

7 pathways

ID	Pathway
R-HSA-5368286	Mitochondrial translation initiation
R-HSA-5389840	Mitochondrial translation elongation
R-HSA-5419276	Mitochondrial translation termination
R-HSA-9937383	Mitochondrial ribosome-associated quality control
R-HSA-392499	Metabolism of proteins
R-HSA-5368287	Mitochondrial translation
R-HSA-72766	Translation

MSigDB gene sets: 64 (showing top): RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP, chr2q12, GOBP_MITOCHONDRIAL_TRANSLATION, GOBP_TRANSLATION, GOMF_STRUCTURAL_CONSTITUENT_OF_RIBOSOME, GOCC_MITOCHONDRIAL_ENVELOPE, GOCC_RIBOSOME, GOCC_SMALL_RIBOSOMAL_SUBUNIT, GOCC_ORGANELLAR_RIBOSOME, GOCC_MITOCHONDRIAL_MATRIX, GOCC_ORGANELLE_INNER_MEMBRANE, GOCC_RIBOSOMAL_SUBUNIT, GOCC_RIBONUCLEOPROTEIN_COMPLEX, GOCC_MITOCHONDRIAL_PROTEIN_CONTAINING_COMPLEX, GOMF_STRUCTURAL_MOLECULE_ACTIVITY

GO Biological Process (2): mitochondrial translation (GO:0032543), translation (GO:0006412)

GO Molecular Function (3): RNA binding (GO:0003723), structural constituent of ribosome (GO:0003735), protein binding (GO:0005515)

GO Cellular Component (7): nucleolus (GO:0005730), mitochondrion (GO:0005739), mitochondrial inner membrane (GO:0005743), mitochondrial small ribosomal subunit (GO:0005763), ribosome (GO:0005840), intracellular organelle lumen (GO:0070013), ribonucleoprotein complex (GO:1990904)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Mitochondrial translation	4
Translation	1
Metabolism of proteins	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
intracellular membraneless organelle	2
mitochondrion	1
translation	1
mitochondrial gene expression	1
peptidyltransferase activity	1
translational initiation	1
translational elongation	1
translational termination	1
macromolecule biosynthetic process	1
protein metabolic process	1
protein biosynthetic process	1
nucleic acid binding	1
structural molecule activity	1
ribosome	1
binding	1
nuclear lumen	1
cytoplasm	1
intracellular membrane-bounded organelle	1
organelle inner membrane	1
mitochondrial membrane	1
organellar small ribosomal subunit	1
mitochondrial ribosome	1
mitochondrial protein-containing complex	1
intracellular organelle	1
organelle lumen	1
protein-containing complex	1

Protein interactions and networks

STRING

3088 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MRPS9	MRPS5	P82675	773
MRPS9	MRPS16	Q9Y3D3	676
MRPS9	MRPS10	P82664	625
MRPS9	MRPS14	O60783	607
MRPS9	MRPS30	Q9NP92	599
MRPS9	MRPS11	P82912	578
MRPS9	MRPS23	Q9Y3D9	560
MRPS9	MRPL24	Q96A35	559
MRPS9	MRPS15	P82914	558
MRPS9	MRPL12	P52815	547
MRPS9	MRPL20	Q9BYC9	544
MRPS9	MRPS18C	Q9Y3D5	542
MRPS9	MRPL46	Q9H2W6	539
MRPS9	MRPS7	Q9Y2R9	517
MRPS9	MRPS26	Q9BYN8	502

IntAct

339 interactions, top by confidence:

A	B	Type	Score
NAPA	SNAP23	psi-mi:“MI:0914”(association)	0.780
KBTBD7	METTL15	psi-mi:“MI:0914”(association)	0.730
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
ATP6V1C2	ATP6V1G1	psi-mi:“MI:0914”(association)	0.640
NOP53	RRP8	psi-mi:“MI:0914”(association)	0.640
NOL12	RRP8	psi-mi:“MI:0914”(association)	0.640
MRPS27	MRPS14	psi-mi:“MI:0914”(association)	0.640
BCCIP	MRPS9	psi-mi:“MI:0915”(physical association)	0.560
MRPS9	BCCIP	psi-mi:“MI:0915”(physical association)	0.560
NP	KPNA6	psi-mi:“MI:0914”(association)	0.550
RPS6	IPO7	psi-mi:“MI:0914”(association)	0.530
ZNF169	ZNF316	psi-mi:“MI:0914”(association)	0.530
ZNF707	ZNF316	psi-mi:“MI:0914”(association)	0.530
ZNF331	USP9Y	psi-mi:“MI:0914”(association)	0.530
ZNF2	MPHOSPH10	psi-mi:“MI:0914”(association)	0.530
RPL18	NOP56	psi-mi:“MI:0914”(association)	0.530
ZBTB48	ZBTB24	psi-mi:“MI:0914”(association)	0.530
E4F1	ZBTB24	psi-mi:“MI:0914”(association)	0.530
MRPS15	MRPS14	psi-mi:“MI:0914”(association)	0.530
RPL6	MRPS14	psi-mi:“MI:0914”(association)	0.530
TRMT10B	MRPS14	psi-mi:“MI:0914”(association)	0.530
PDGFB	DKC1	psi-mi:“MI:0914”(association)	0.530
BHLHA15	RPLP0	psi-mi:“MI:0914”(association)	0.530
ZNF223	PPM1G	psi-mi:“MI:0914”(association)	0.530
MRPS18B	MRPS14	psi-mi:“MI:0914”(association)	0.530
MRPL2	GTPBP10	psi-mi:“MI:0914”(association)	0.530

BioGRID (525): MRPS9 (Affinity Capture-MS), MRPS9 (Affinity Capture-MS), MRPS9 (Affinity Capture-MS), MRPS9 (Affinity Capture-MS), MRPS9 (Affinity Capture-MS), MRPS9 (Affinity Capture-MS), MRPS9 (Affinity Capture-MS), MRPS9 (Affinity Capture-MS), MRPS9 (Affinity Capture-MS), MRPS9 (Affinity Capture-MS), MRPS9 (Affinity Capture-MS), MRPS9 (Affinity Capture-MS), MRPS9 (Affinity Capture-MS), MRPS9 (Affinity Capture-MS), MRPS9 (Affinity Capture-MS)

ESM2 similar proteins: A2BHB7, A3KP74, A8PJJ2, B0W041, B0WGN4, B0WV73, B0XHW8, B3MN22, B4GX14, B4HXA6, B4JCX8, B4KEN8, B4M8L8, B4MVR2, B4P3Q9, B4Q572, B5DFW7, B5DK05, B7PZ18, B9INH0, B9RRX2, C3XVM1, C5DHL6, D3ZY68, D7STK2, E1FU46, E2RK33, E3MIE2, E3WSB5, O43716, P53260, P82933, Q16Q94, Q2KIF1, Q3B8B2, Q3ZBC2, Q4R5K7, Q4RSW7, Q58DQ5, Q5R4W7

Diamond homologs: A0ALT2, A1U3H7, A9EYT5, B8DB44, C1A3Z4, C1KZ11, C4XNQ1, O67723, P34388, P82933, Q03PZ0, Q1AU64, Q31IG5, Q47LM6, Q58DQ5, Q6FL25, Q71WI2, Q8Y459, Q927P3, Q9D7N3, A0LIV3, A0R8L3, A4QBS4, A4YVP2, A5CU75, A5EKC6, A5VPX4, A6GWU3, A6L0V0, A6X1V5, A7GK54, A7HXB2, A7INH2, A8I7Z9, A9MAG7, A9VPB1, A9W606, A9WMF9, B0RB77, B0T0S3

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
MRPS9	“form complex”	“28S mitochondrial small ribosomal subunit”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 236 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Mitochondrial translation	15	13.3×	2e-10
Mitochondrial translation initiation	15	12.3×	2e-10
Mitochondrial translation elongation	15	12.3×	2e-10
Mitochondrial ribosome-associated quality control	15	11.9×	3e-10
Mitochondrial translation termination	15	10.6×	1e-09
Peptide chain elongation	10	8.2×	2e-05
Viral mRNA Translation	10	8.2×	2e-05
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	10	8.1×	2e-05

GO biological processes:

GO term	Partners	Fold	FDR
mitochondrial translation	16	13.5×	6e-11
cytoplasmic translation	10	9.0×	7e-05
RNA processing	8	8.5×	1e-03
translation	17	8.5×	1e-08
ribosomal small subunit biogenesis	7	7.7×	6e-03
mRNA splicing, via spliceosome	12	5.3×	8e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

71 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	50
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2469 predictions. Top by Δscore:

Variant	Effect	Δscore
2:105049154:T:G	acceptor_gain	1.0000
2:105049157:A:AG	acceptor_gain	1.0000
2:105049158:T:G	acceptor_gain	1.0000
2:105049159:A:AG	acceptor_gain	1.0000
2:105049165:T:A	acceptor_gain	1.0000
2:105049346:TTGAC:T	donor_gain	1.0000
2:105049347:TGAC:T	donor_gain	1.0000
2:105049348:GAC:G	donor_gain	1.0000
2:105049348:GACG:G	donor_gain	1.0000
2:105049349:AC:A	donor_gain	1.0000
2:105049350:CG:C	donor_loss	1.0000
2:105049351:G:GG	donor_gain	1.0000
2:105049351:GTAA:G	donor_loss	1.0000
2:105049352:TA:T	donor_loss	1.0000
2:105049353:AA:A	donor_loss	1.0000
2:105071457:A:AG	acceptor_gain	1.0000
2:105071458:G:GG	acceptor_gain	1.0000
2:105071458:GC:G	acceptor_gain	1.0000
2:105088983:GGAT:G	acceptor_gain	1.0000
2:105089065:ACCAG:A	donor_gain	1.0000
2:105089068:AGGT:A	donor_loss	1.0000
2:105089069:GGT:G	donor_loss	1.0000
2:105089070:GTA:G	donor_loss	1.0000
2:105089071:T:G	donor_loss	1.0000
2:105089512:G:GT	donor_gain	1.0000
2:105089531:T:G	donor_gain	1.0000
2:105089993:GAT:G	donor_gain	1.0000
2:105092397:GCA:G	acceptor_loss	1.0000
2:105092399:A:AG	acceptor_gain	1.0000
2:105092399:AGT:A	acceptor_loss	1.0000

AlphaMissense

2587 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:105099747:T:A	W393R	0.993
2:105099747:T:C	W393R	0.993
2:105099749:G:C	W393C	0.991
2:105099749:G:T	W393C	0.991
2:105049301:C:A	A89D	0.989
2:105099741:T:C	F391L	0.989
2:105099743:T:A	F391L	0.989
2:105099743:T:G	F391L	0.989
2:105089939:T:A	W199R	0.987
2:105089939:T:C	W199R	0.987
2:105071316:G:C	A107P	0.986
2:105080007:G:C	R145P	0.984
2:105080024:T:C	F151L	0.984
2:105080026:C:A	F151L	0.984
2:105080026:C:G	F151L	0.984
2:105097259:G:C	R345P	0.983
2:105049298:T:C	L88S	0.982
2:105099756:C:A	R396S	0.982
2:105049300:G:C	A89P	0.981
2:105097252:G:C	A343P	0.981
2:105099732:C:A	R388S	0.981
2:105099676:T:C	L369P	0.980
2:105093550:G:C	A281P	0.979
2:105089958:T:C	L205P	0.978
2:105097270:G:C	A349P	0.978
2:105049276:T:C	F81L	0.976
2:105049278:C:A	F81L	0.976
2:105049278:C:G	F81L	0.976
2:105097324:G:C	A367P	0.976
2:105093537:A:C	R276S	0.975

dbSNP variants (sampled 300 via entrez): RS1000013088 (2:105056057 T>C,G), RS1000028147 (2:105046587 T>C,G), RS1000031865 (2:105089363 G>C,T), RS1000032730 (2:105098609 G>A,T), RS1000048040 (2:105053112 A>G), RS1000081826 (2:105056380 G>A), RS1000093153 (2:105097487 C>G,T), RS1000094755 (2:105048009 G>A), RS1000138528 (2:105096997 G>A), RS1000185133 (2:105092405 T>C,G), RS1000257756 (2:105041973 C>G), RS1000272594 (2:105060538 C>T), RS1000290737 (2:105083250 G>A), RS1000311756 (2:105048798 C>T), RS1000319740 (2:105092685 A>G)

Disease associations

OMIM: gene MIM:611975 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST005951_42	Body mass index	1.000000e-08
GCST009391_1642	Metabolite levels	7.000000e-06

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004340	body mass index
EFO:0007787	plasma betaine measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6067104 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
5.33	Kd	4630	nM	CHEMBL5653589
5.33	ED50	4630	nM	CHEMBL5653589

PubChem BioAssay actives

1 with measured affinity, of 2 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2148782: Binding affinity to human MRPS9 incubated for 45 mins by Kinobead based pull down assay	kd	4.6297	uM

CTD chemical–gene interactions

25 total (human), top 25 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Acetaminophen	decreases expression, increases expression	3
sodium arsenite	increases abundance, increases expression, decreases expression, affects cotreatment	2
bisphenol F	increases expression	1
triphenyl phosphate	affects expression	1
ferric ammonium citrate	increases expression, decreases reaction	1
arsenite	affects binding, increases reaction	1
manganese chloride	increases expression, affects cotreatment, increases abundance	1
2,3,5-(triglutathion-S-yl)hydroquinone	increases ADP-ribosylation	1
ICG 001	decreases expression	1
bisphenol AF	increases expression	1
Resveratrol	affects cotreatment, increases expression	1
Fulvestrant	decreases methylation	1
Air Pollutants	increases abundance, increases expression	1
Arsenic	affects cotreatment, increases abundance, increases expression	1
Benzo(a)pyrene	affects methylation	1
Deferoxamine	increases expression, decreases reaction	1
Ivermectin	decreases expression	1
Manganese	increases abundance, increases expression, affects cotreatment	1
Plant Extracts	affects cotreatment, increases expression	1
Ribonucleotides	affects binding	1
Rotenone	increases expression	1
Smoke	increases abundance, increases expression	1
Tretinoin	decreases expression	1
Valproic Acid	affects expression	1
Cadmium Chloride	increases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5651824	Binding	Binding affinity to human MRPS9 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.