MRTO4

Summary

MRTO4 (MRT4 homolog, ribosome maturation factor, HGNC:18477) is a protein-coding gene on chromosome 1p36.13, encoding mRNA turnover protein 4 homolog (Q9UKD2). Component of the ribosome assembly machinery. It is a common-essential gene (DepMap: required in 93.0% of cancer cell lines).

This gene encodes a protein sharing a low level of sequence similarity with ribosomal protein P0. While the precise function of the encoded protein is currently unknown, it appears to be involved in mRNA turnover and ribosome assembly.

Source: NCBI Gene 51154 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 50 total
• Druggable target: yes
• Cancer dependency (DepMap): dependent in 93.0% of screened cell lines (common-essential)
• MANE Select transcript: NM_016183

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:18477
Approved symbol	MRTO4
Name	MRT4 homolog, ribosome maturation factor
Location	1p36.13
Locus type	gene with protein product
Status	Approved
Aliases	dJ657E11.4, MRT4
Ensembl gene	ENSG00000053372
Ensembl biotype	protein_coding
OMIM	620476
Entrez	51154

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 3 protein_coding, 2 protein_coding_CDS_not_defined

ENST00000330263, ENST00000479559, ENST00000493700, ENST00000857508, ENST00000933910

RefSeq mRNA: 1 — MANE Select: NM_016183 NM_016183

CCDS: CCDS191

Canonical transcript exons

ENST00000330263 — 8 exons

Exon	Start	End
ENSE00000754852	19255948	19256051
ENSE00000754853	19257064	19257145
ENSE00000754855	19257454	19257521
ENSE00000754856	19257833	19257984
ENSE00001336766	19251805	19251863
ENSE00001465998	19258681	19260128
ENSE00003569483	19258477	19258553
ENSE00003637786	19254782	19254840

Expression profiles

Bgee: expression breadth ubiquitous, 260 present calls, max score 93.13.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 25.6237 / max 156.1556, expressed in 1802 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
1058	25.6237	1802

Top tissues by expression

280 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
oocyte	CL:0000023	93.13	gold quality
right lobe of liver	UBERON:0001114	91.85	gold quality
body of pancreas	UBERON:0001150	91.78	gold quality
prefrontal cortex	UBERON:0000451	89.99	gold quality
anterior cingulate cortex	UBERON:0009835	89.84	gold quality
body of stomach	UBERON:0001161	89.76	gold quality
cingulate cortex	UBERON:0003027	89.69	gold quality
lower esophagus mucosa	UBERON:0035834	89.64	gold quality
right frontal lobe	UBERON:0002810	89.47	gold quality
small intestine Peyer’s patch	UBERON:0003454	89.46	gold quality
stromal cell of endometrium	CL:0002255	89.31	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	89.20	gold quality
secondary oocyte	CL:0000655	89.14	gold quality
esophagus mucosa	UBERON:0002469	89.09	gold quality
mucosa of transverse colon	UBERON:0004991	88.82	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	88.65	gold quality
cortical plate	UBERON:0005343	88.60	gold quality
pancreas	UBERON:0001264	88.20	gold quality
left uterine tube	UBERON:0001303	88.19	gold quality
left adrenal gland cortex	UBERON:0035825	88.07	gold quality
ganglionic eminence	UBERON:0004023	88.03	gold quality
left adrenal gland	UBERON:0001234	87.94	gold quality
skin of leg	UBERON:0001511	87.77	gold quality
Brodmann (1909) area 9	UBERON:0013540	87.76	gold quality
small intestine	UBERON:0002108	87.61	gold quality
gastrocnemius	UBERON:0001388	87.59	gold quality
neocortex	UBERON:0001950	87.56	gold quality
amygdala	UBERON:0001876	87.49	gold quality
esophagus	UBERON:0001043	87.42	gold quality
ventricular zone	UBERON:0003053	87.40	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	7.06

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

35 targeting MRTO4, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-4482-3P	99.98	72.50	3147
HSA-MIR-551B-5P	99.96	71.28	3493
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-495-3P	99.96	72.81	4197
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-6845-3P	99.94	66.88	1439
HSA-MIR-627-3P	99.90	71.42	3316
HSA-MIR-6780A-5P	99.88	66.69	2776
HSA-MIR-4492	99.87	68.25	3611
HSA-MIR-3913-5P	99.78	67.26	968
HSA-MIR-7154-5P	99.69	70.52	1900
HSA-MIR-762	99.58	66.61	1994
HSA-MIR-4328	99.57	71.06	4094
HSA-MIR-3122	99.50	66.33	821
HSA-MIR-4498	99.47	67.42	2360
HSA-MIR-4284	99.36	65.25	1293
HSA-MIR-4263	99.18	69.25	2236
HSA-MIR-5001-5P	99.05	66.76	1972
HSA-MIR-1228-3P	99.00	66.53	857
HSA-MIR-6876-3P	98.97	65.69	765
HSA-MIR-626	98.89	66.21	762
HSA-MIR-1302	97.92	67.27	844
HSA-MIR-3670	97.88	64.39	763
HSA-MIR-3620-3P	97.78	64.88	772
HSA-MIR-4433A-3P	97.75	62.82	1435
HSA-MIR-3652	97.71	65.43	1890
HSA-MIR-3144-5P	97.64	65.45	646
HSA-MIR-665	97.60	65.64	1781
HSA-MIR-630	97.50	66.38	921

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 93.0% of screened cell lines, common-essential.

Literature-anchored findings (GeneRIF, showing 3)

• characterization of Mrt4; findings show Mrt4 is a trans-acting factor involved in ribosome maturation, with nucleus-cytoplasm shuttling capacity (PMID:20083226)
• Human Mrt4 undergoes phosphorylation in vivo and serines S229, S233, and S235 are phosphorylated by CK2 kinase in vitro. (PMID:26494001)
• MRTO4 Enhances Glycolysis to Facilitate HCC Progression by Inhibiting ALDOB. (PMID:38778508)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	mrto4	ENSDARG00000007130
mus_musculus	Mrto4	ENSMUSG00000028741
rattus_norvegicus	Mrto4	ENSRNOG00000017979

Protein

Protein identifiers

mRNA turnover protein 4 homolog — Q9UKD2 (reviewed: Q9UKD2)

Alternative names: Ribosome assembly factor MRTO4

All UniProt accessions (1): Q9UKD2

UniProt curated annotations — full annotation on UniProt →

Function. Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.

Subunit / interactions. Associates with the pre-60S ribosomal particle. Interacts with MINAS-60 (product of an alternative open reading frame of RBM10).

Subcellular location. Nucleus. Nucleolus. Cytoplasm.

Similarity. Belongs to the universal ribosomal protein uL10 family.

RefSeq proteins (1): NP_057267* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001790	Ribosomal_uL10_N	Domain
IPR033867	Mrt4	Family
IPR040637	Ribosomal_uL10-like_insert	Domain
IPR043141	Ribosomal_uL10-like_sf	Homologous_superfamily
IPR043164	Ribosomal_uL10-like_insert_sf	Homologous_superfamily
IPR051742	Ribosome_Assembly_uL10	Family

Pfam: PF00466, PF17777

UniProt features (8 total): modified residue 3, sequence conflict 2, chain 1, region of interest 1, compositionally biased region 1

Structure

Experimental structures (PDB)

35 structures, top 30 by resolution.

PDB	Method	Resolution (Å)
8FKV	ELECTRON MICROSCOPY	2.47
8FLE	ELECTRON MICROSCOPY	2.48
8FKW	ELECTRON MICROSCOPY	2.5
8FL3	ELECTRON MICROSCOPY	2.53
8FL7	ELECTRON MICROSCOPY	2.55
8FLB	ELECTRON MICROSCOPY	2.55
8FLD	ELECTRON MICROSCOPY	2.58
8FKX	ELECTRON MICROSCOPY	2.59
8FL6	ELECTRON MICROSCOPY	2.62
8FLA	ELECTRON MICROSCOPY	2.63
8FLF	ELECTRON MICROSCOPY	2.65
8FKY	ELECTRON MICROSCOPY	2.67
8FL2	ELECTRON MICROSCOPY	2.67
8FL9	ELECTRON MICROSCOPY	2.75
8FLC	ELECTRON MICROSCOPY	2.76
8IDT	ELECTRON MICROSCOPY	2.8
8FKT	ELECTRON MICROSCOPY	2.81
8FKU	ELECTRON MICROSCOPY	2.82
8RL2	ELECTRON MICROSCOPY	2.84
8FKS	ELECTRON MICROSCOPY	2.88
8FKR	ELECTRON MICROSCOPY	2.89
8FL4	ELECTRON MICROSCOPY	2.89
8FL0	ELECTRON MICROSCOPY	2.91
8IDY	ELECTRON MICROSCOPY	3
8INF	ELECTRON MICROSCOPY	3
8FKZ	ELECTRON MICROSCOPY	3.04
9QIW	ELECTRON MICROSCOPY	3.04
8INE	ELECTRON MICROSCOPY	3.2
8INK	ELECTRON MICROSCOPY	3.2
8IPD	ELECTRON MICROSCOPY	3.2

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9UKD2-F1	89.84	0.84

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (3): 225, 229, 233

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 191 (showing top): GSE45365_NK_CELL_VS_CD11B_DC_DN, GOBP_RIBOSOME_BIOGENESIS, RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, GOBP_RIBOSOME_ASSEMBLY, WEI_MYCN_TARGETS_WITH_E_BOX, GOBP_RIBOSOMAL_LARGE_SUBUNIT_ASSEMBLY, GOBP_PROTEIN_RNA_COMPLEX_ORGANIZATION, GOBP_ORGANELLE_ASSEMBLY, LIAO_METASTASIS, HIF1_Q3, BERTUCCI_MEDULLARY_VS_DUCTAL_BREAST_CANCER_UP, FISCHER_DREAM_TARGETS, GRYDER_PAX3FOXO1_ENHANCERS_IN_TADS, DANG_BOUND_BY_MYC

GO Biological Process (5): ribosomal large subunit assembly (GO:0000027), nuclear-transcribed mRNA catabolic process (GO:0000956), rRNA processing (GO:0006364), ribosomal large subunit biogenesis (GO:0042273), ribosome biogenesis (GO:0042254)

GO Molecular Function (2): RNA binding (GO:0003723), protein binding (GO:0005515)

GO Cellular Component (4): nucleolus (GO:0005730), cytoplasm (GO:0005737), preribosome, large subunit precursor (GO:0030687), nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
ribosome biogenesis	2
ribonucleoprotein complex biogenesis	2
protein-RNA complex assembly	1
ribosome assembly	1
ribosomal large subunit biogenesis	1
mRNA catabolic process	1
RNA processing	1
rRNA metabolic process	1
nucleic acid binding	1
binding	1
nuclear lumen	1
intracellular membraneless organelle	1
intracellular anatomical structure	1
cellular anatomical structure	1
preribosome	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

4754 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MRTO4	NSA2	O95478	928
MRTO4	ST3GAL3	Q11203	901
MRTO4	RSL24D1	Q9UHA3	848
MRTO4	ALX3	O95076	827
MRTO4	RPF2	Q9H7B2	827
MRTO4	RBM15	Q96T37	819
MRTO4	NMD3	Q96D46	811
MRTO4	GTPBP4	Q9BZE4	802
MRTO4	GNL2	Q13823	760
MRTO4	DUSP12	Q9UNI6	731
MRTO4	LSG1	Q9H089	723
MRTO4	EIF6	P56537	698
MRTO4	WDR12	Q9GZL7	663
MRTO4	RCL1	Q9Y2P8	632
MRTO4	RPL3	P39023	631

IntAct

111 interactions, top by confidence:

A	B	Type	Score
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
MAGEB10	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MACROH2A2	PPM1G	psi-mi:“MI:0914”(association)	0.530
ZFP41	LRP4	psi-mi:“MI:0914”(association)	0.530
MRTO4	H1-2	psi-mi:“MI:0914”(association)	0.530
ERBB2	HAX1	psi-mi:“MI:0914”(association)	0.530
MRTO4	TERF2IP	psi-mi:“MI:0915”(physical association)	0.510
RAB11A	LANCL1	psi-mi:“MI:2364”(proximity)	0.420
MRTO4	CCDC86	psi-mi:“MI:0915”(physical association)	0.400
Mki67	PPP1CA	psi-mi:“MI:0915”(physical association)	0.400
Rpl35	RPS6	psi-mi:“MI:0914”(association)	0.350
RPL10	RPS6	psi-mi:“MI:0914”(association)	0.350
Rrbp1	PIPSL	psi-mi:“MI:0914”(association)	0.350
NOP56	C12orf43	psi-mi:“MI:0914”(association)	0.350
HNRNPU		psi-mi:“MI:0914”(association)	0.350
RRP1B	ZNF785	psi-mi:“MI:0914”(association)	0.350
MKI67	ARHGAP10	psi-mi:“MI:0914”(association)	0.350
		psi-mi:“MI:0914”(association)	0.350
NUDCD1	TUBAL3	psi-mi:“MI:0914”(association)	0.350
Mecom	ESYT2	psi-mi:“MI:0914”(association)	0.350
RAB27A	DKC1	psi-mi:“MI:0914”(association)	0.350
TCF7L2	LOC401309	psi-mi:“MI:0914”(association)	0.350
CAND1	GTPBP10	psi-mi:“MI:0914”(association)	0.350
CUL2	ANXA2P2	psi-mi:“MI:0914”(association)	0.350
CUL3	PXDNL	psi-mi:“MI:0914”(association)	0.350
LRRK2		psi-mi:“MI:0914”(association)	0.350
ZFP41	AGRN	psi-mi:“MI:0914”(association)	0.350

BioGRID (227): MRTO4 (Affinity Capture-MS), MRTO4 (Affinity Capture-MS), MRTO4 (Affinity Capture-MS), MRTO4 (Affinity Capture-MS), MRTO4 (Affinity Capture-MS), MRTO4 (Affinity Capture-MS), BRIX1 (Co-fractionation), DDX24 (Co-fractionation), EFTUD2 (Co-fractionation), EIF2S2 (Co-fractionation), FBL (Co-fractionation), FTSJ3 (Co-fractionation), GNL2 (Co-fractionation), GTPBP4 (Co-fractionation), KIAA0020 (Co-fractionation)

ESM2 similar proteins: A4FUD3, A4FV84, F4JGR5, G1TUB8, O08810, O80526, O95045, P11497, P21343, P42932, P50990, P62913, P62914, Q13085, Q15029, Q28559, Q29205, Q2QNG7, Q2QZ86, Q2YDN6, Q3T087, Q3ZCI9, Q4R5J0, Q5F3X4, Q5M939, Q5R6E0, Q5R8Q7, Q5R8T5, Q5RAP1, Q5RC11, Q5RCW2, Q5SWU9, Q5XGS8, Q5XK67, Q5ZID6, Q5ZJ08, Q6EE31, Q6QMZ8, Q80YV4, Q80Z29

Diamond homologs: A4FV84, G0S616, P33201, Q6FJ04, Q75DK9, Q7S302, Q86HD3, Q9D0I8, Q9UKD2, Q9USZ6, P05317, P47826, P50346, P15825

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 148 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

GO biological processes:

GO term	Partners	Fold	FDR
peptidyl-tyrosine phosphorylation	5	16.6×	2e-03
negative regulation of gene expression, epigenetic	5	15.8×	2e-03
cell surface receptor protein tyrosine kinase signaling pathway	10	13.7×	2e-06
substrate adhesion-dependent cell spreading	5	13.5×	4e-03
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	14	8.6×	1e-06
positive regulation of MAPK cascade	13	8.2×	3e-06
protein autophosphorylation	7	8.0×	4e-03
rRNA processing	7	7.8×	4e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

50 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	37
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

728 predictions. Top by Δscore:

Variant	Effect	Δscore
1:19254780:A:AG	acceptor_gain	1.0000
1:19254781:G:GA	acceptor_gain	1.0000
1:19254781:GTCT:G	acceptor_gain	1.0000
1:19254781:GTCTC:G	acceptor_gain	1.0000
1:19255945:CAGC:C	acceptor_loss	1.0000
1:19255946:A:AG	acceptor_gain	1.0000
1:19255946:A:T	acceptor_loss	1.0000
1:19255947:G:GT	acceptor_gain	1.0000
1:19255947:GC:G	acceptor_gain	1.0000
1:19255947:GCT:G	acceptor_gain	1.0000
1:19255947:GCTT:G	acceptor_gain	1.0000
1:19255947:GCTTC:G	acceptor_gain	1.0000
1:19256040:G:GT	donor_gain	1.0000
1:19256047:AGCCG:A	donor_gain	1.0000
1:19256048:GCCG:G	donor_gain	1.0000
1:19256048:GCCGG:G	donor_gain	1.0000
1:19256049:CCGGT:C	donor_loss	1.0000
1:19256050:CGG:C	donor_loss	1.0000
1:19256052:G:GG	donor_gain	1.0000
1:19256053:T:G	donor_loss	1.0000
1:19257054:T:A	acceptor_gain	1.0000
1:19257058:T:TA	acceptor_gain	1.0000
1:19257059:G:A	acceptor_gain	1.0000
1:19257059:GGTA:G	acceptor_loss	1.0000
1:19257060:GTAG:G	acceptor_loss	1.0000
1:19257061:TAGG:T	acceptor_loss	1.0000
1:19257062:A:AG	acceptor_gain	1.0000
1:19257062:AG:A	acceptor_gain	1.0000
1:19257062:AGGAT:A	acceptor_gain	1.0000
1:19257063:G:A	acceptor_gain	1.0000

AlphaMissense

1586 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:19256006:G:T	R49M	1.000
1:19257075:G:A	G68D	1.000
1:19257952:G:C	R154T	1.000
1:19257952:G:T	R154M	1.000
1:19251851:C:A	R6S	0.999
1:19251851:C:T	R6C	0.999
1:19254822:A:C	K23N	0.999
1:19254822:A:T	K23N	0.999
1:19254830:T:C	L26P	0.999
1:19256006:G:C	R49T	0.999
1:19256007:G:C	R49S	0.999
1:19256007:G:T	R49S	0.999
1:19256018:T:C	L53P	0.999
1:19256030:G:C	R57P	0.999
1:19257099:C:A	A76D	0.999
1:19257104:G:C	G78R	0.999
1:19257105:G:A	G78D	0.999
1:19257105:G:T	G78V	0.999
1:19257482:G:A	G101D	0.999
1:19257949:T:A	L153H	0.999
1:19257949:T:C	L153P	0.999
1:19257953:G:C	R154S	0.999
1:19257953:G:T	R154S	0.999
1:19257964:T:C	L158P	0.999
1:19257976:T:A	L162H	0.999
1:19258510:G:A	C176Y	0.999
1:19258511:C:G	C176W	0.999
1:19258542:G:C	A187P	0.999
1:19258552:T:C	L190P	0.999
1:19258708:T:C	F200L	0.999

dbSNP variants (sampled 300 via entrez): RS1000261098 (1:19252229 T>A), RS1000311749 (1:19253195 T>A), RS1000592160 (1:19252379 C>T), RS1001047817 (1:19252026 AAAAC>A), RS1001198351 (1:19258730 T>C), RS1001304258 (1:19252670 G>A), RS1001596244 (1:19254154 C>T), RS1002379643 (1:19252468 C>A), RS1002602280 (1:19255342 A>G), RS1003162922 (1:19249980 G>C), RS1003223886 (1:19259336 G>A,T), RS1003298317 (1:19260550 A>G), RS1003313578 (1:19255728 G>A), RS1003384688 (1:19253884 A>G), RS1003852650 (1:19259554 G>A)

Disease associations

OMIM: gene MIM:620476 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST007001_1	Cerebrospinal AB1-42 levels in normal cognition	5.000000e-07

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004670	beta-amyloid 1-42 measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6066484 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

2 potent at pChembl≥5 of 4 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
6.51	Kd	311.1	nM	CHEMBL5653589
6.51	ED50	311.1	nM	CHEMBL5653589

PubChem BioAssay actives

1 with measured affinity, of 4 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2148783: Binding affinity to human MRTO4 incubated for 45 mins by Kinobead based pull down assay	kd	0.3111	uM

CTD chemical–gene interactions

46 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	affects methylation, decreases expression, affects cotreatment, increases abundance, increases expression	5
bisphenol A	decreases expression, decreases methylation	3
Nickel	increases expression	2
Plant Extracts	affects cotreatment, increases expression, decreases expression	2
Smoke	decreases expression	2
Valproic Acid	affects expression, increases expression	2
Cyclosporine	decreases expression, increases expression	2
GSK-J4	decreases expression	1
afuresertib	decreases expression	1
alpha phellandrene	decreases expression	1
deoxynivalenol	increases expression	1
sodium arsenate	decreases expression	1
trichostatin A	affects expression	1
mono-(2-ethylhexyl)phthalate	increases expression	1
cobaltous chloride	decreases expression	1
manganese chloride	increases abundance, increases expression, affects cotreatment	1
di-n-butylphosphoric acid	affects expression	1
perfluoro-n-nonanoic acid	increases expression	1
2-palmitoylglycerol	increases expression	1
K 7174	decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
LDN 193189	affects cotreatment, decreases expression	1
(+)-JQ1 compound	decreases expression	1
Resveratrol	increases expression, affects cotreatment	1
Sunitinib	increases expression	1
Arsenic	affects cotreatment, increases abundance, increases expression	1
Atrazine	decreases expression	1
Benzo(a)pyrene	affects methylation	1
Dichlorodiphenyl Dichloroethylene	increases expression	1
Dimethyl Sulfoxide	decreases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5651825	Binding	Binding affinity to human MRTO4 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.