MSANTD5

Summary

MSANTD5 (Myb/SANT DNA binding domain containing 5, HGNC:55184) is a protein-coding gene on chromosome 5q35.3, encoding Uncharacterized protein MSANTD5 (A0A3B3IT52).

At a glance

• MANE Select transcript: NM_001395436

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:55184
Approved symbol	MSANTD5
Name	Myb/SANT DNA binding domain containing 5
Location	5q35.3
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000285891
Ensembl biotype	protein_coding
Entrez	102724657

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000648368

RefSeq mRNA: 1 — MANE Select: NM_001395436 NM_001395436

CCDS: CCDS93835

Canonical transcript exons

ENST00000648368 — 4 exons

Exon	Start	End
ENSE00003833532	178696097	178696181
ENSE00003833924	178695287	178695598
ENSE00003838117	178697586	178697761
ENSE00003978333	178694572	178694947

Expression profiles

Bgee: expression breadth broad, 44 present calls, max score 88.87.

Top tissues by expression

93 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	88.87	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	67.39	gold quality
left testis	UBERON:0004533	57.47	gold quality
right testis	UBERON:0004534	57.16	gold quality
testis	UBERON:0000473	56.45	gold quality
apex of heart	UBERON:0002098	45.14	gold quality
lower esophagus mucosa	UBERON:0035834	42.76	silver quality
prefrontal cortex	UBERON:0000451	41.37	gold quality
cortical plate	UBERON:0005343	40.88	silver quality
blood	UBERON:0000178	38.72	silver quality
ganglionic eminence	UBERON:0004023	37.68	silver quality
hindlimb stylopod muscle	UBERON:0004252	37.59	silver quality
adrenal tissue	UBERON:0018303	37.34	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
calcaneal tendon	UBERON:0003701	36.83	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
frontal cortex	UBERON:0001870	36.12	gold quality
sural nerve	UBERON:0015488	35.57	gold quality
bone marrow	UBERON:0002371	35.22	gold quality
temporal lobe	UBERON:0001871	34.81	gold quality
Ammon’s horn	UBERON:0001954	34.57	gold quality
mucosa of stomach	UBERON:0001199	34.51	gold quality
amygdala	UBERON:0001876	34.46	gold quality
muscle of leg	UBERON:0001383	34.23	silver quality
cerebral cortex	UBERON:0000956	33.83	gold quality
duodenum	UBERON:0002114	33.66	silver quality
gastrocnemius	UBERON:0001388	33.23	silver quality
dorsolateral prefrontal cortex	UBERON:0009834	33.08	gold quality
Brodmann (1909) area 9	UBERON:0013540	32.30	silver quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-GEOD-36552	yes	1038.49
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

16 orthologs

Organism	Symbol	Gene ID
mus_musculus	Msantd5l	ENSMUSG00000045942
mus_musculus	Msantd5	ENSMUSG00000061469
mus_musculus	Msantd5f6	ENSMUSG00000066137
mus_musculus	Msantd5f9	ENSMUSG00000093962
mus_musculus	Msantd5f5	ENSMUSG00000094116
mus_musculus	Msantd5f2	ENSMUSG00000095048
mus_musculus	Msantd5f1	ENSMUSG00000095341
mus_musculus	Msantd5f3	ENSMUSG00000095935
mus_musculus	Msantd5f10	ENSMUSG00000096333
mus_musculus	Msantd5f7	ENSMUSG00000096530
mus_musculus	Msantd5f4	ENSMUSG00000096700
mus_musculus	Msantd5f8	ENSMUSG00000096750
mus_musculus	Gm38423	ENSMUSG00000121585
rattus_norvegicus	Msantd5	ENSRNOG00000022555
rattus_norvegicus	Msantd5l1	ENSRNOG00000058960
rattus_norvegicus		ENSRNOG00000064786

Protein

Protein identifiers

Uncharacterized protein MSANTD5 — A0A3B3IT52 (reviewed: A0A3B3IT52)

Alternative names: Myb/SANT DNA binding domain-containing protein 5

All UniProt accessions (1): A0A3B3IT52

RefSeq proteins (1): NP_001382365* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR044822	Myb_DNA-bind_4	Domain

Pfam: PF13837

UniProt features (1 total): chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A0A3B3IT52-F1	68.38	0.31

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 6 (showing top): GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP, MADAN_DPPA4_TARGETS, FOSTER_KDM1A_TARGETS_UP, GSE7219_UNSTIM_VS_LPS_AND_ANTI_CD40_STIM_DC_UP, chr5q35

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

2 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MSANTD5	TMEM92	Q6UXU6	155

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A1W2PPF3, A0A3B3IT52, E9Q3T6, O02747, O13161, O42173, O57374, O73622, O95238, P01103, P01104, P09632, P0C7M4, P10242, P14837, P17278, P30561, P31538, P41738, P46200, Q1KKS8, Q28G02, Q32NH9, Q4JM65, Q5REX1, Q5WM45, Q66IG8, Q68EH7, Q6U8D7, Q6ZTZ1, Q7T1K4, Q8BIL2, Q8BKE5, Q8CFH6, Q8IWB6, Q8JIT7, Q8NHV9, Q8R4S2, Q8R4S4, Q8R4S5

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

1397 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
5:178695447:C:A	K81N	0.990
5:178695447:C:G	K81N	0.990
5:178695545:A:G	W49R	0.989
5:178695545:A:T	W49R	0.989
5:178695469:A:G	L74P	0.986
5:178695543:C:A	W49C	0.986
5:178695543:C:G	W49C	0.986
5:178695434:A:G	C86R	0.985
5:178695432:A:C	C86W	0.983
5:178695556:A:G	F45S	0.983
5:178695322:A:G	I123T	0.982
5:178695581:A:G	W37R	0.982
5:178695581:A:T	W37R	0.982
5:178695553:A:G	L46P	0.981
5:178695421:A:G	L90P	0.980
5:178695579:C:A	W37C	0.976
5:178695579:C:G	W37C	0.976
5:178695401:A:C	Y97D	0.975
5:178695350:A:G	C114R	0.974
5:178695544:C:G	W49S	0.974
5:178695555:G:C	F45L	0.967
5:178695555:G:T	F45L	0.967
5:178695557:A:G	F45L	0.967
5:178695322:A:C	I123S	0.966
5:178695396:G:C	F98L	0.965
5:178695396:G:T	F98L	0.965
5:178695398:A:G	F98L	0.965
5:178695412:A:G	L93S	0.964
5:178695449:T:C	K81E	0.964
5:178695383:C:G	A103P	0.963

dbSNP variants (sampled 300 via entrez): RS1000057 (5:178695516 C>A,G,T), RS1000148617 (5:178693607 A>G), RS1000361024 (5:178708922 G>A), RS1000683304 (5:178704511 C>T), RS1000789558 (5:178704880 G>A), RS1000798321 (5:178701085 T>C), RS1000915773 (5:178699645 A>C,G), RS1001026907 (5:178706375 G>A), RS1001035795 (5:178694764 G>A), RS1001449722 (5:178702556 C>T), RS1001576736 (5:178697341 C>G,T), RS1001655960 (5:178696705 A>G), RS1001712033 (5:178692689 C>T), RS1001764349 (5:178707390 T>C), RS1001812334 (5:178702297 T>A,C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.