MSANTD7

Summary

MSANTD7 (Myb/SANT DNA binding domain containing 7, HGNC:56248) is a protein-coding gene on chromosome 10p13, encoding Myb/SANT-like DNA-binding domain-containing protein 7 (A0A1W2PQ72).

At a glance

• MANE Select transcript: NM_001378785

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:56248
Approved symbol	MSANTD7
Name	Myb/SANT DNA binding domain containing 7
Location	10p13
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000284024
Ensembl biotype	protein_coding
Entrez	100421372

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 2 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000493178, ENST00000640019, ENST00000645667

RefSeq mRNA: 2 — MANE Select: NM_001378785 NM_001378785, NM_001378790

CCDS: CCDS91215

Canonical transcript exons

ENST00000640019 — 5 exons

Exon	Start	End
ENSE00003803612	14839905	14839985
ENSE00003808176	14840075	14840157
ENSE00003808600	14838306	14838459
ENSE00003808636	14843371	14846999
ENSE00003810063	14842134	14842846

Expression profiles

Bgee: expression breadth ubiquitous, 231 present calls, max score 93.50.

Top tissues by expression

246 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
epithelial cell of pancreas	CL:0000083	93.50	gold quality
pancreatic ductal cell	CL:0002079	86.02	silver quality
secondary oocyte	CL:0000655	85.75	gold quality
ileal mucosa	UBERON:0000331	84.77	gold quality
cartilage tissue	UBERON:0002418	83.59	gold quality
amniotic fluid	UBERON:0000173	83.32	gold quality
tibialis anterior	UBERON:0001385	82.99	gold quality
ventricular zone	UBERON:0003053	82.62	gold quality
esophagus squamous epithelium	UBERON:0006920	82.56	gold quality
cortical plate	UBERON:0005343	82.38	gold quality
ganglionic eminence	UBERON:0004023	81.50	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	81.40	gold quality
palpebral conjunctiva	UBERON:0001812	81.20	gold quality
bone marrow	UBERON:0002371	80.97	gold quality
monocyte	CL:0000576	80.39	gold quality
leukocyte	CL:0000738	80.28	gold quality
oocyte	CL:0000023	79.68	gold quality
calcaneal tendon	UBERON:0003701	79.68	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.65	gold quality
placenta	UBERON:0001987	79.52	gold quality
islet of Langerhans	UBERON:0000006	79.48	gold quality
Brodmann (1909) area 23	UBERON:0013554	78.90	gold quality
stromal cell of endometrium	CL:0002255	78.77	gold quality
corpus epididymis	UBERON:0004359	78.72	gold quality
rectum	UBERON:0001052	78.62	gold quality
gall bladder	UBERON:0002110	78.46	gold quality
bone marrow cell	CL:0002092	78.37	gold quality
epithelium of nasopharynx	UBERON:0001951	78.04	gold quality
adrenal tissue	UBERON:0018303	77.93	gold quality
vermiform appendix	UBERON:0001154	77.58	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.24

Regulation

Is transcription factor: no

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	si:dkey-261j15.2	ENSDARG00000096411
mus_musculus	Msantd7	ENSMUSG00000051396
rattus_norvegicus	Msantd7	ENSRNOG00000065772
drosophila_melanogaster	meso18E	FBGN0040089

Paralogs (2): MSANTD2 (ENSG00000120458), UTF1 (ENSG00000171794)

Protein

Protein identifiers

Myb/SANT-like DNA-binding domain-containing protein 7 — A0A1W2PQ72 (reviewed: A0A1W2PQ72)

All UniProt accessions (2): A0A1W2PQ72, A0A2R8Y8B9

RefSeq proteins (2): NP_001365714, NP_001365719 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR044822	Myb_DNA-bind_4	Domain

Pfam: PF13837

UniProt features (6 total): region of interest 2, compositionally biased region 2, chain 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A0A1W2PQ72-F1	69.97	0.39

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 2 (showing top): chr10p13, GARY_CD5_TARGETS_DN

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A1W2PQ72, A7J1T0, A7J1T2, A7MBB4, A8MZ59, D3ZXW3, M0R5D6, O36371, O43283, O43310, O73622, O95073, P03177, P10242, P21705, P46200, Q0P4H6, Q1HKZ5, Q1HVD1, Q1LVK9, Q22811, Q2NKQ1, Q3KSQ2, Q3UPF5, Q535K8, Q562B4, Q567C6, Q5R8X7, Q5ZI27, Q6DGX3, Q6INH1, Q6J1H4, Q6PEE2, Q6ZTZ1, Q71M44, Q7SXL7, Q80T85, Q8BFX3, Q8BIL2, Q8BKE5

Diamond homologs: A0A1W2PQ72, B2KFW1, P17040, Q63HK3, Q8IWY8, Q9NX65, A1YEP8, A1YEQ3, A1YEV9, A1YFW2, A1YFW6, A1YG26, A1YG48, A1YG60, A1YGJ4, A2T6E3, A2T6V8, A2T6W2, A2T712, A2T736, A2T7D2, A2T7D7, A2T7F4, A2T7L7, A2T812, A6QNZ0, A6QPT6, O14709, O14771, O14978, O15535, O43309, O60304, O95125, P10073, P17022, P17028, P17029, P28698, P49910

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

989 predictions. Top by Δscore:

Variant	Effect	Δscore
10:14839899:CTCTA:C	acceptor_loss	1.0000
10:14839900:TCTA:T	acceptor_loss	1.0000
10:14839901:CTAG:C	acceptor_loss	1.0000
10:14839902:TAGGA:T	acceptor_loss	1.0000
10:14839903:A:AG	acceptor_gain	1.0000
10:14839903:A:AT	acceptor_loss	1.0000
10:14839903:AG:A	acceptor_gain	1.0000
10:14839903:AGGAT:A	acceptor_gain	1.0000
10:14839904:G:GG	acceptor_gain	1.0000
10:14839904:GG:G	acceptor_gain	1.0000
10:14839904:GGA:G	acceptor_gain	1.0000
10:14839904:GGAT:G	acceptor_gain	1.0000
10:14839904:GGATG:G	acceptor_gain	1.0000
10:14839983:G:GT	donor_gain	1.0000
10:14839983:GAG:G	donor_gain	1.0000
10:14839983:GAGG:G	donor_loss	1.0000
10:14839984:AGGTA:A	donor_loss	1.0000
10:14839986:G:GG	donor_gain	1.0000
10:14839986:GTACT:G	donor_loss	1.0000
10:14839987:T:A	donor_loss	1.0000
10:14840073:A:AG	acceptor_gain	1.0000
10:14840074:G:GG	acceptor_gain	1.0000
10:14840074:GATT:G	acceptor_gain	1.0000
10:14840154:GAAG:G	donor_gain	1.0000
10:14840155:AAGG:A	donor_loss	1.0000
10:14840156:AG:A	donor_loss	1.0000
10:14840157:GG:G	donor_loss	1.0000
10:14840158:G:GC	donor_loss	1.0000
10:14840159:T:A	donor_loss	1.0000
10:14838644:A:T	donor_gain	0.9900

AlphaMissense

2343 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
10:14842318:T:A	W12R	1.000
10:14842318:T:C	W12R	1.000
10:14842320:G:C	W12C	1.000
10:14842320:G:T	W12C	1.000
10:14842433:T:C	M50T	0.999
10:14842453:C:A	R57S	0.999
10:14842479:G:C	K65N	0.999
10:14842479:G:T	K65N	0.999
10:14842319:G:C	W12S	0.998
10:14842331:A:T	E16V	0.998
10:14842447:T:C	F55L	0.998
10:14842449:C:A	F55L	0.998
10:14842449:C:G	F55L	0.998
10:14842477:A:G	K65E	0.998
10:14842485:A:C	K67N	0.998
10:14842485:A:T	K67N	0.998
10:14842494:G:C	K70N	0.998
10:14842494:G:T	K70N	0.998
10:14842501:T:G	Y73D	0.998
10:14842558:T:C	F92L	0.998
10:14842560:T:A	F92L	0.998
10:14842560:T:G	F92L	0.998
10:14842330:G:A	E16K	0.997
10:14842332:G:C	E16D	0.997
10:14842332:G:T	E16D	0.997
10:14842411:T:C	Y43H	0.997
10:14842411:T:G	Y43D	0.997
10:14842448:T:C	F55S	0.997
10:14842468:T:C	C62R	0.997
10:14842471:C:A	R63S	0.997

dbSNP variants (sampled 300 via entrez): RS1000177458 (10:14843139 G>T), RS1000309553 (10:14837637 G>A), RS1000613070 (10:14843419 G>A,C), RS1000869763 (10:14839536 A>C), RS1000942756 (10:14839737 T>C), RS1001187308 (10:14837106 G>A), RS1001212931 (10:14838184 A>C), RS1001496676 (10:14845039 A>G), RS1001549786 (10:14846532 A>G,T), RS1001684775 (10:14842781 G>C), RS1001821908 (10:14836841 G>T), RS1001822972 (10:14844692 T>C), RS1002235502 (10:14839398 A>C), RS1002883171 (10:14836742 G>A,C), RS1003139589 (10:14847381 T>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

1 total (human), top 1 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Niclosamide	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.