MSC-AS1

Summary

MSC-AS1 (MSC antisense RNA 1, HGNC:48724) is a long non-coding RNA gene on chromosome 8q13.3-q21.11.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48724
Approved symbol	MSC-AS1
Name	MSC antisense RNA 1
Location	8q13.3-q21.11
Locus type	RNA, long non-coding
Status	Approved
Aliases	MAT1
Ensembl gene	ENSG00000235531
Ensembl biotype	lncRNA
Entrez	100132891
RNAcentral	URS00007599B7 — lncRNA, 4802 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 25 — 25 lncRNA

ENST00000457356, ENST00000512290, ENST00000518700, ENST00000518916, ENST00000519068, ENST00000519751, ENST00000521467, ENST00000522519, ENST00000523133, ENST00000524152, ENST00000653074, ENST00000655314, ENST00000656742, ENST00000670333, ENST00000767640, ENST00000767641, ENST00000767642, ENST00000767643, ENST00000767644, ENST00000767645, ENST00000767646, ENST00000767647, ENST00000767648, ENST00000767649, ENST00000767650

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000457356 — 3 exons

Exon	Start	End
ENSE00002090111	72052539	72056312
ENSE00003755058	71962923	71963048
ENSE00003868796	71844039	71844422

Expression profiles

Bgee: expression breadth ubiquitous, 183 present calls, max score 91.24.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 12.5173 / max 489.7264, expressed in 1220 samples.

FANTOM5 promoters (7 alternative TSS)

Promoter ID	TPM avg	Samples expressed
89333	9.1655	1166
89332	0.9886	632
89336	0.8292	323
89334	0.6750	420
89331	0.4460	193
89335	0.3909	199
89330	0.0221	10

Top tissues by expression

249 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right coronary artery	UBERON:0001625	91.24	gold quality
stromal cell of endometrium	CL:0002255	90.20	gold quality
thoracic aorta	UBERON:0001515	88.80	gold quality
ascending aorta	UBERON:0001496	88.79	gold quality
descending thoracic aorta	UBERON:0002345	88.58	gold quality
left coronary artery	UBERON:0001626	88.21	gold quality
aorta	UBERON:0000947	87.73	gold quality
popliteal artery	UBERON:0002250	87.12	gold quality
tibial artery	UBERON:0007610	87.10	gold quality
coronary artery	UBERON:0001621	86.88	gold quality
sural nerve	UBERON:0015488	82.86	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.83	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.47	gold quality
gall bladder	UBERON:0002110	80.21	gold quality
colonic epithelium	UBERON:0000397	79.16	gold quality
islet of Langerhans	UBERON:0000006	79.01	gold quality
mucosa of stomach	UBERON:0001199	77.40	gold quality
right atrium auricular region	UBERON:0006631	76.16	gold quality
right ovary	UBERON:0002118	75.97	gold quality
endocervix	UBERON:0000458	75.47	gold quality
pancreas	UBERON:0001264	75.33	gold quality
smooth muscle tissue	UBERON:0001135	75.28	gold quality
adipose tissue	UBERON:0001013	74.92	gold quality
left ovary	UBERON:0002119	74.79	gold quality
omental fat pad	UBERON:0010414	74.65	gold quality
subcutaneous adipose tissue	UBERON:0002190	74.58	gold quality
peritoneum	UBERON:0002358	74.56	gold quality
adipose tissue of abdominal region	UBERON:0007808	74.43	gold quality
cardiac atrium	UBERON:0002081	74.37	gold quality
apex of heart	UBERON:0002098	74.33	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-CURD-119	yes	19.80
E-ANND-3	yes	5.37

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 11)

• we demonstrated that MSC-AS1/miR-29b-3p axis modulates the cell proliferation and GEM-induced cell apoptosis in PDAC cell lines through CDK14. We provided a novel experimental basis for PDAC treatment from the perspective of lncRNA-miRNA-mRNA network. (PMID:30915884)
• MSC-AS1 might promote the osteogenic differentiation of BMSCs through sponging microRNA-140-5p to up-regulate BMP2, thus alleviating the progression of osteoporosis (PMID:31551149)
• lncRNA MSC-AS1 activates Wnt/beta-catenin signaling pathway to modulate cell proliferation and migration in kidney renal clear cell carcinoma via miR-3924/WNT5A. (PMID:31916281)
• Downregulated Long Non-Coding RNA MSC-AS1 Inhibits Osteosarcoma Progression and Increases Sensitivity to Cisplatin by Binding to MicroRNA-142. (PMID:32155139)
• MSC-AS1 knockdown inhibits cell growth and temozolomide resistance by regulating miR-373-3p/CPEB4 axis in glioma through PI3K/Akt pathway. (PMID:33106913)
• Long non-coding RNA MSC-AS1 facilitates the proliferation and glycolysis of gastric cancer cells by regulating PFKFB3 expression. (PMID:33390824)
• Expression of lncRNA MSC-AS1 in hepatocellular carcinoma cell lines and its effect on proliferation, apoptosis, and migration. (PMID:33625998)
• MSC-AS1 induced cell growth and inflammatory mediators secretion through sponging miR-142-5p/DDX5 in gastric carcinoma. (PMID:33819916)
• LncRNA MSC-AS1 facilitates lung adenocarcinoma through sponging miR-33b-5p to up-regulate GPAM. (PMID:33821667)
• Role of hypermethylated-lncRNAs in the prognosis of bladder cancer patients. (PMID:34617815)
• LncRNA MSC-AS1, as an oncogene in melanoma, promotes the proliferation and glutaminolysis by regulating the miR-330-3p/ YAP1 axis. (PMID:36206100)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.