MSH2-OT1

Summary

MSH2-OT1 (MSH2 overlapping transcript 1, HGNC:40319) is a long non-coding RNA gene on chromosome 2p16.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40319
Approved symbol	MSH2-OT1
Name	MSH2 overlapping transcript 1
Location	2p16.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000235760
Ensembl biotype	lncRNA
Entrez	644093
RNAcentral	URS00002A8FBA — lncRNA, 434 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000435331, ENST00000439182, ENST00000648301

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000435331 — 3 exons

Exon	Start	End
ENSE00001722816	47529067	47529164
ENSE00001747824	47528301	47528368
ENSE00001784299	47527537	47527804

Expression profiles

Bgee: expression breadth ubiquitous, 122 present calls, max score 89.60.

Top tissues by expression

122 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	89.60	gold quality
sural nerve	UBERON:0015488	73.24	gold quality
right hemisphere of cerebellum	UBERON:0014890	69.34	gold quality
cerebellar hemisphere	UBERON:0002245	68.88	gold quality
cerebellar cortex	UBERON:0002129	68.78	gold quality
cerebellum	UBERON:0002037	68.74	gold quality
left testis	UBERON:0004533	68.55	gold quality
ventricular zone	UBERON:0003053	68.16	gold quality
testis	UBERON:0000473	68.00	gold quality
right testis	UBERON:0004534	67.65	gold quality
corpus callosum	UBERON:0002336	67.04	gold quality
cortical plate	UBERON:0005343	66.85	gold quality
nucleus accumbens	UBERON:0001882	64.65	gold quality
hindlimb stylopod muscle	UBERON:0004252	64.20	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	64.17	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	63.26	gold quality
ganglionic eminence	UBERON:0004023	62.66	gold quality
hypothalamus	UBERON:0001898	61.87	gold quality
tonsil	UBERON:0002372	61.74	gold quality
putamen	UBERON:0001874	61.31	gold quality
substantia nigra	UBERON:0002038	61.06	gold quality
brain	UBERON:0000955	60.94	gold quality
caudate nucleus	UBERON:0001873	60.37	gold quality
right frontal lobe	UBERON:0002810	60.19	gold quality
pituitary gland	UBERON:0000007	59.72	gold quality
frontal cortex	UBERON:0001870	59.71	gold quality
vermiform appendix	UBERON:0001154	59.65	gold quality
prefrontal cortex	UBERON:0000451	59.62	gold quality
superior frontal gyrus	UBERON:0002661	59.32	gold quality
tibial nerve	UBERON:0001323	59.27	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.30

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.