MSRB3-AS1

Summary

MSRB3-AS1 (MSRB3 antisense RNA 1, HGNC:53386) is a long non-coding RNA gene on chromosome 12q14.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53386
Approved symbol	MSRB3-AS1
Name	MSRB3 antisense RNA 1
Location	12q14.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	RP11-230G5.2
Ensembl gene	ENSG00000250748
Ensembl biotype	lncRNA
Entrez	100507065
RNAcentral	URS000075EA83 — lncRNA, 867 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 11 lncRNA

ENST00000355869, ENST00000511935, ENST00000535315, ENST00000537250, ENST00000537298, ENST00000538294, ENST00000539653, ENST00000540652, ENST00000544557, ENST00000546198, ENST00000799621

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000355869 — 2 exons

Exon	Start	End
ENSE00001733641	65608471	65609293
ENSE00002252262	65613179	65613229

Expression profiles

Bgee: expression breadth ubiquitous, 144 present calls, max score 66.41.

Top tissues by expression

235 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cortical plate	UBERON:0005343	66.41	gold quality
stromal cell of endometrium	CL:0002255	65.47	gold quality
tibial artery	UBERON:0007610	64.53	gold quality
popliteal artery	UBERON:0002250	64.50	gold quality
ventricular zone	UBERON:0003053	64.14	gold quality
ganglionic eminence	UBERON:0004023	63.95	gold quality
aorta	UBERON:0000947	62.40	gold quality
hindlimb stylopod muscle	UBERON:0004252	61.20	gold quality
descending thoracic aorta	UBERON:0002345	60.89	gold quality
lower esophagus	UBERON:0013473	60.61	gold quality
right coronary artery	UBERON:0001625	60.57	gold quality
lower esophagus muscularis layer	UBERON:0035833	60.57	gold quality
thoracic aorta	UBERON:0001515	59.90	gold quality
ascending aorta	UBERON:0001496	59.89	gold quality
smooth muscle tissue	UBERON:0001135	59.87	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	59.43	gold quality
muscle of leg	UBERON:0001383	59.38	gold quality
gastrocnemius	UBERON:0001388	59.11	gold quality
mucosa of stomach	UBERON:0001199	58.96	gold quality
muscle layer of sigmoid colon	UBERON:0035805	58.93	gold quality
lower esophagus mucosa	UBERON:0035834	58.93	gold quality
left coronary artery	UBERON:0001626	58.13	gold quality
coronary artery	UBERON:0001621	57.34	gold quality
body of uterus	UBERON:0009853	56.24	gold quality
rectum	UBERON:0001052	55.84	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	55.81	gold quality
heart left ventricle	UBERON:0002084	54.93	gold quality
esophagus	UBERON:0001043	54.89	gold quality
heart	UBERON:0000948	54.50	gold quality
cardiac ventricle	UBERON:0002082	54.39	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.15

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Higher ENS-653 (LOC100507065, ENST00000539653.1) expression was observed in papillary thyroid cancer (PTC) tissue samples versus adjacent normal tissues, and was associated with a larger tumor size and a more advanced clinical stage. ENS-653 downregulation reduced the proliferation of PTC cells and led to G1-S arrest. ENS-653 downregulation also inactivated ERK1/2 and ERK5, causing partial MAPK cascade suppression. (PMID:30940124)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.