MT-TC

Summary

MT-TC (mitochondrially encoded tRNA-Cys (UGU/C), HGNC:7477) is a mitochondrial tRNA gene on chromosome mitochondria.

At a glance

• Gene type: non-coding (Mt_tRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:7477
Approved symbol	MT-TC
Name	mitochondrially encoded tRNA-Cys (UGU/C)
Location	mitochondria
Locus type	RNA, transfer
Status	Approved
Aliases	trnC
Ensembl gene	ENSG00000210140
Ensembl biotype	Mt_tRNA
OMIM	590020
Entrez	4511
RNAcentral	URS000018E119 — tRNA, 66 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 Mt_tRNA

ENST00000387405

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000387405 — 1 exons

Exon	Start	End
ENSE00001544489	5761	5826

Expression profiles

Bgee: expression breadth ubiquitous, 118 present calls, max score 99.98.

Top tissues by expression

118 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	99.98	gold quality
duodenum	UBERON:0002114	99.98	gold quality
adrenal tissue	UBERON:0018303	99.98	gold quality
vermiform appendix	UBERON:0001154	99.97	gold quality
right uterine tube	UBERON:0001302	99.96	gold quality
granulocyte	CL:0000094	99.95	gold quality
apex of heart	UBERON:0002098	99.95	gold quality
mucosa of stomach	UBERON:0001199	99.92	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	99.92	gold quality
fundus of stomach	UBERON:0001160	99.91	gold quality
rectum	UBERON:0001052	99.89	gold quality
right coronary artery	UBERON:0001625	99.89	gold quality
amygdala	UBERON:0001876	99.89	gold quality
stomach	UBERON:0000945	99.86	gold quality
right adrenal gland	UBERON:0001233	99.86	gold quality
body of stomach	UBERON:0001161	99.85	gold quality
right adrenal gland cortex	UBERON:0035827	99.85	gold quality
sural nerve	UBERON:0015488	99.82	gold quality
smooth muscle tissue	UBERON:0001135	99.80	gold quality
left uterine tube	UBERON:0001303	99.80	gold quality
skin of leg	UBERON:0001511	99.80	gold quality
hypothalamus	UBERON:0001898	99.80	gold quality
transverse colon	UBERON:0001157	99.79	gold quality
Ammon’s horn	UBERON:0001954	99.79	gold quality
zone of skin	UBERON:0000014	99.78	gold quality
muscle of leg	UBERON:0001383	99.78	gold quality
putamen	UBERON:0001874	99.78	gold quality
gastrocnemius	UBERON:0001388	99.77	gold quality
placenta	UBERON:0001987	99.77	gold quality
skin of abdomen	UBERON:0001416	99.76	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-9543	yes	1683.02
E-ANND-3	yes	10.20

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• two novel variants, KAL1 (c.146G>T (p.Cys49Phe)) and mitochondrial tRNAcys (m.5800A>G), were identified in a large Han Chinese family with inherited Kallmann syndrome; although two variants can’t exert obvious effects on the migration of GnRH neurons, they show a synergistic effect, which can account for the occurrence of the disorder in this family (PMID:26278626)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.