MT-TD

Summary

MT-TD (mitochondrially encoded tRNA-Asp (GAU/C), HGNC:7478) is a mitochondrial tRNA gene on chromosome mitochondria.

At a glance

• Gene type: non-coding (Mt_tRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:7478
Approved symbol	MT-TD
Name	mitochondrially encoded tRNA-Asp (GAU/C)
Location	mitochondria
Locus type	RNA, transfer
Status	Approved
Aliases	trnD
Ensembl gene	ENSG00000210154
Ensembl biotype	Mt_tRNA
OMIM	590015
Entrez	4555
RNAcentral	URS00001FC4D3 — tRNA, 68 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 Mt_tRNA

ENST00000387419

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000387419 — 1 exons

Exon	Start	End
ENSE00001544486	7518	7585

Expression profiles

Bgee: expression breadth ubiquitous, 116 present calls, max score 99.35.

FANTOM5 (CAGE): breadth broad, TPM avg 1.0234 / max 79.6809, expressed in 467 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
194882	1.0234	467

Top tissues by expression

116 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
apex of heart	UBERON:0002098	99.35	gold quality
sural nerve	UBERON:0015488	99.26	gold quality
skeletal muscle tissue	UBERON:0001134	99.16	gold quality
caudate nucleus	UBERON:0001873	98.45	gold quality
putamen	UBERON:0001874	98.42	gold quality
amygdala	UBERON:0001876	98.22	gold quality
substantia nigra	UBERON:0002038	97.69	gold quality
right frontal lobe	UBERON:0002810	97.66	gold quality
frontal cortex	UBERON:0001870	97.63	gold quality
nucleus accumbens	UBERON:0001882	97.58	gold quality
anterior cingulate cortex	UBERON:0009835	97.38	gold quality
adult mammalian kidney	UBERON:0000082	97.36	gold quality
Ammon’s horn	UBERON:0001954	97.35	gold quality
prefrontal cortex	UBERON:0000451	97.19	gold quality
heart left ventricle	UBERON:0002084	96.87	gold quality
hypothalamus	UBERON:0001898	96.64	gold quality
cerebral cortex	UBERON:0000956	95.61	gold quality
kidney	UBERON:0002113	95.29	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	95.28	gold quality
brain	UBERON:0000955	94.35	gold quality
right hemisphere of cerebellum	UBERON:0014890	94.13	gold quality
right adrenal gland cortex	UBERON:0035827	93.87	gold quality
cerebellar hemisphere	UBERON:0002245	93.15	gold quality
duodenum	UBERON:0002114	92.82	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	92.47	gold quality
right adrenal gland	UBERON:0001233	92.37	gold quality
left adrenal gland cortex	UBERON:0035825	92.27	gold quality
heart	UBERON:0000948	92.25	gold quality
left adrenal gland	UBERON:0001234	91.76	gold quality
adrenal gland	UBERON:0002369	91.56	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.48

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• role of nucleotide 9 in the network of 3D tertiary interactions (PMID:19535463)
• A deafness-associated m.7551A > G mutation in the mt-tRNAAsp gene reduced mitochondrial ATP production and increased the production of oxidative reactive species. (PMID:27536005)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.