MT-TE

Summary

MT-TE (mitochondrially encoded tRNA-Glu (GAA/G), HGNC:7479) is a mitochondrial tRNA gene on chromosome mitochondria.

At a glance

• Gene type: non-coding (Mt_tRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:7479
Approved symbol	MT-TE
Name	mitochondrially encoded tRNA-Glu (GAA/G)
Location	mitochondria
Locus type	RNA, transfer
Status	Approved
Aliases	trnE
Ensembl gene	ENSG00000210194
Ensembl biotype	Mt_tRNA
OMIM	590025
Entrez	4556
RNAcentral	URS000034E9D0 — tRNA, 69 nt, 12 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 Mt_tRNA

ENST00000387459

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000387459 — 1 exons

Exon	Start	End
ENSE00001544476	14674	14742

Expression profiles

Bgee: expression breadth ubiquitous, 118 present calls, max score 99.88.

FANTOM5 (CAGE): breadth broad, TPM avg 3.9828 / max 759.8381, expressed in 784 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
195273	3.9828	784

Top tissues by expression

118 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	99.88	gold quality
sural nerve	UBERON:0015488	99.85	gold quality
apex of heart	UBERON:0002098	99.82	gold quality
duodenum	UBERON:0002114	99.80	gold quality
caudate nucleus	UBERON:0001873	99.76	gold quality
putamen	UBERON:0001874	99.74	gold quality
vermiform appendix	UBERON:0001154	99.73	gold quality
nucleus accumbens	UBERON:0001882	99.66	gold quality
adrenal tissue	UBERON:0018303	99.64	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	99.58	gold quality
prefrontal cortex	UBERON:0000451	99.53	gold quality
amygdala	UBERON:0001876	99.47	gold quality
body of stomach	UBERON:0001161	99.46	gold quality
frontal cortex	UBERON:0001870	99.44	gold quality
mucosa of stomach	UBERON:0001199	99.43	gold quality
right frontal lobe	UBERON:0002810	99.43	gold quality
stomach	UBERON:0000945	99.42	gold quality
heart left ventricle	UBERON:0002084	99.41	gold quality
fundus of stomach	UBERON:0001160	99.39	gold quality
granulocyte	CL:0000094	99.38	gold quality
right lung	UBERON:0002167	99.34	gold quality
adult mammalian kidney	UBERON:0000082	99.25	gold quality
hypothalamus	UBERON:0001898	99.25	gold quality
Ammon’s horn	UBERON:0001954	99.24	gold quality
placenta	UBERON:0001987	99.20	gold quality
small intestine	UBERON:0002108	99.19	gold quality
smooth muscle tissue	UBERON:0001135	99.18	gold quality
right hemisphere of cerebellum	UBERON:0014890	99.17	gold quality
rectum	UBERON:0001052	99.14	gold quality
left uterine tube	UBERON:0001303	99.13	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	14.61

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• We report 2 siblings with the m.14709T>C mutation in the mitochondrial tRNA(Glu) gene. The first patient showed hydrops fetalis, a new presentation within the clinical spectrum of this mutation, and the other a known presentation namely mild myopathy. (PMID:17161635)
• The m.14709T>C mutation in the tRNA(Glu) gene could be a cause of mitochondrial diabetes in Tunisian affected families. (PMID:20045353)
• A novel homoplasmic mt-tRNA(Glu) m.14701C>T variant presenting with a partially reversible infantile respiratory chain deficiency. (PMID:34400372)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.