MT-TF

Summary

MT-TF (mitochondrially encoded tRNA-Phe (UUU/C), HGNC:7481) is a mitochondrial tRNA gene on chromosome mitochondria.

Predicted to enable triplet codon-amino acid adaptor activity. Predicted to be involved in translation.

Source: NCBI Gene 4558 — RefSeq curated summary.

At a glance

• Gene type: non-coding (Mt_tRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:7481
Approved symbol	MT-TF
Name	mitochondrially encoded tRNA-Phe (UUU/C)
Location	mitochondria
Locus type	RNA, transfer
Status	Approved
Aliases	trnF
Ensembl gene	ENSG00000210049
Ensembl biotype	Mt_tRNA
OMIM	590070
Entrez	4558
RNAcentral	URS00003E8921 — tRNA, 71 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 Mt_tRNA

ENST00000387314

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000387314 — 1 exons

Exon	Start	End
ENSE00001544501	577	647

Expression profiles

Bgee: expression breadth ubiquitous, 118 present calls, max score 99.72.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 418.5871 / max 21897.5002, expressed in 1827 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
194814	398.4252	1827
194815	20.1619	1696

Top tissues by expression

118 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
prefrontal cortex	UBERON:0000451	99.72	gold quality
amygdala	UBERON:0001876	99.65	gold quality
skeletal muscle tissue	UBERON:0001134	99.62	gold quality
putamen	UBERON:0001874	99.54	gold quality
caudate nucleus	UBERON:0001873	99.53	gold quality
nucleus accumbens	UBERON:0001882	99.53	gold quality
substantia nigra	UBERON:0002038	99.52	gold quality
Ammon’s horn	UBERON:0001954	99.49	gold quality
frontal cortex	UBERON:0001870	99.44	gold quality
right frontal lobe	UBERON:0002810	99.41	gold quality
anterior cingulate cortex	UBERON:0009835	99.29	gold quality
hypothalamus	UBERON:0001898	99.27	gold quality
sural nerve	UBERON:0015488	99.17	gold quality
apex of heart	UBERON:0002098	99.00	gold quality
adult mammalian kidney	UBERON:0000082	98.97	gold quality
duodenum	UBERON:0002114	98.90	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	98.46	gold quality
mucosa of stomach	UBERON:0001199	98.41	gold quality
cerebral cortex	UBERON:0000956	98.23	gold quality
kidney	UBERON:0002113	98.18	gold quality
right hemisphere of cerebellum	UBERON:0014890	97.77	gold quality
cerebellar hemisphere	UBERON:0002245	97.54	gold quality
granulocyte	CL:0000094	97.50	gold quality
heart left ventricle	UBERON:0002084	97.29	gold quality
brain	UBERON:0000955	97.14	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	96.91	gold quality
metanephros cortex	UBERON:0010533	96.48	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	96.25	gold quality
rectum	UBERON:0001052	95.86	gold quality
adrenal tissue	UBERON:0018303	95.65	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.41

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• We report a novel heteroplasmic T–>C mutation at nt position 582 within the mitochondrial tRNA(Phe) gene of a 70-year-old woman with mitochondrial myopathy; This adds to the previously described four pathogenic mutations in the tRNA(Phe) gene (PMID:14659412)
• role of the point mutation at position 616 in the MT-TF gene (T>C or T>G)in severe epilepsy (PMID:20142618)
• Optic neuropathy, cardiomyopathy, and cognitive disability was found in patients with a homozygous mutation in the nuclear MTO1 and a mitochondrial MT-TF variant. (PMID:26061759)
• This is the 18th MT-TF point mutation associated with a mitochondrial disorder. The onset and the severity of the disease, however, is unique in this case and broadens the clinical picture related to mutations of mitochondrial tRNA-Phe. (PMID:31009750)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.