MT-TG

Summary

MT-TG (mitochondrially encoded tRNA-Gly (GGN), HGNC:7486) is a mitochondrial tRNA gene on chromosome mitochondria.

At a glance

• Gene type: non-coding (Mt_tRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:7486
Approved symbol	MT-TG
Name	mitochondrially encoded tRNA-Gly (GGN)
Location	mitochondria
Locus type	RNA, transfer
Status	Approved
Aliases	trnG
Ensembl gene	ENSG00000210164
Ensembl biotype	Mt_tRNA
OMIM	590035
Entrez	4563
RNAcentral	URS00000C6674 — tRNA, 68 nt, 8 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 Mt_tRNA

ENST00000387429

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000387429 — 1 exons

Exon	Start	End
ENSE00001544483	9991	10058

Expression profiles

Bgee: expression breadth ubiquitous, 117 present calls, max score 99.57.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.7567 / max 325.6449, expressed in 180 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
194913	0.5805	149
194914	0.1763	56

Top tissues by expression

117 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
apex of heart	UBERON:0002098	99.57	gold quality
sural nerve	UBERON:0015488	99.49	gold quality
skeletal muscle tissue	UBERON:0001134	99.32	gold quality
putamen	UBERON:0001874	99.19	gold quality
caudate nucleus	UBERON:0001873	99.17	gold quality
amygdala	UBERON:0001876	99.08	gold quality
substantia nigra	UBERON:0002038	98.96	gold quality
Ammon’s horn	UBERON:0001954	98.95	gold quality
nucleus accumbens	UBERON:0001882	98.94	gold quality
hypothalamus	UBERON:0001898	98.85	gold quality
anterior cingulate cortex	UBERON:0009835	98.38	gold quality
right frontal lobe	UBERON:0002810	98.19	gold quality
heart left ventricle	UBERON:0002084	98.13	gold quality
frontal cortex	UBERON:0001870	97.86	gold quality
right adrenal gland cortex	UBERON:0035827	97.73	gold quality
cerebral cortex	UBERON:0000956	97.46	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	97.45	gold quality
prefrontal cortex	UBERON:0000451	97.23	gold quality
endometrium	UBERON:0001295	96.97	gold quality
right adrenal gland	UBERON:0001233	96.85	gold quality
vermiform appendix	UBERON:0001154	96.61	gold quality
left adrenal gland cortex	UBERON:0035825	96.39	gold quality
granulocyte	CL:0000094	96.37	gold quality
monocyte	CL:0000576	96.26	gold quality
leukocyte	CL:0000738	96.26	gold quality
lymph node	UBERON:0000029	96.22	gold quality
adult mammalian kidney	UBERON:0000082	96.21	gold quality
left adrenal gland	UBERON:0001234	96.12	gold quality
adrenal gland	UBERON:0002369	95.96	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	95.90	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.12

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Mitochondrial tRNA(Glu) variant modulate the phenotype of deafness-associated 12S rRNA A1555G mutation in Chinese family. (PMID:19376484)
• Molecular characterization of a Chinese pedigree carrying the hypertension-associated mitochondrial tRNAGln T4363C mutation has been reported. (PMID:28849157)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.