MT-TH

Summary

MT-TH (mitochondrially encoded tRNA-His (CAU/C), HGNC:7487) is a mitochondrial tRNA gene on chromosome mitochondria.

Predicted to enable triplet codon-amino acid adaptor activity. Predicted to be involved in translation.

Source: NCBI Gene 4564 — RefSeq curated summary.

At a glance

• Gene type: non-coding (Mt_tRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:7487
Approved symbol	MT-TH
Name	mitochondrially encoded tRNA-His (CAU/C)
Location	mitochondria
Locus type	RNA, transfer
Status	Approved
Aliases	trnH
Ensembl gene	ENSG00000210176
Ensembl biotype	Mt_tRNA
OMIM	590040
Entrez	4564
RNAcentral	URS00001FBD75 — tRNA, 69 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 Mt_tRNA

ENST00000387441

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000387441 — 1 exons

Exon	Start	End
ENSE00001544480	12138	12206

Expression profiles

Bgee: expression breadth ubiquitous, 118 present calls, max score 99.83.

FANTOM5 (CAGE): breadth broad, TPM avg 4.2637 / max 597.0157, expressed in 733 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
194972	4.2637	733

Top tissues by expression

118 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	99.83	gold quality
apex of heart	UBERON:0002098	99.49	gold quality
putamen	UBERON:0001874	98.76	gold quality
caudate nucleus	UBERON:0001873	98.55	gold quality
nucleus accumbens	UBERON:0001882	98.28	gold quality
amygdala	UBERON:0001876	98.05	gold quality
substantia nigra	UBERON:0002038	97.88	gold quality
skeletal muscle tissue	UBERON:0001134	97.66	gold quality
Ammon’s horn	UBERON:0001954	97.64	gold quality
hypothalamus	UBERON:0001898	97.61	gold quality
heart left ventricle	UBERON:0002084	97.57	gold quality
right adrenal gland cortex	UBERON:0035827	97.37	gold quality
vermiform appendix	UBERON:0001154	97.33	gold quality
anterior cingulate cortex	UBERON:0009835	97.04	gold quality
prefrontal cortex	UBERON:0000451	96.93	gold quality
mucosa of stomach	UBERON:0001199	96.74	gold quality
adult mammalian kidney	UBERON:0000082	96.55	gold quality
left adrenal gland cortex	UBERON:0035825	96.23	gold quality
right adrenal gland	UBERON:0001233	96.18	gold quality
endometrium	UBERON:0001295	95.95	gold quality
duodenum	UBERON:0002114	95.81	gold quality
adrenal gland	UBERON:0002369	95.50	gold quality
cerebral cortex	UBERON:0000956	95.49	gold quality
left adrenal gland	UBERON:0001234	95.37	gold quality
frontal cortex	UBERON:0001870	95.31	gold quality
right frontal lobe	UBERON:0002810	95.17	gold quality
adrenal tissue	UBERON:0018303	94.67	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	94.59	gold quality
brain	UBERON:0000955	94.07	gold quality
kidney	UBERON:0002113	94.01	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.91

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• The findings demonstrate the pathogenic mechanism leading to an impaired oxidative phosphorylation in cybrid cell lines carrying the deafness-associated tRNAHis 12201T>C mutation. (PMID:24920829)
• We also detected in 4 asthenospermic patients a double novels mutations, the first was found in COXII gene (m.8021 G/A) that was absent in normospermic infertile men. (PMID:24931671)
• Whole mitochondrial genome analysis in Chinese patients with keratoconus. (PMID:34012229)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.