MT-TL2

Summary

MT-TL2 (mitochondrially encoded tRNA-Leu (CUN) 2, HGNC:7491) is a mitochondrial tRNA gene on chromosome mitochondria.

At a glance

• Gene type: non-coding (Mt_tRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:7491
Approved symbol	MT-TL2
Name	mitochondrially encoded tRNA-Leu (CUN) 2
Location	mitochondria
Locus type	RNA, transfer
Status	Approved
Aliases	TRNL2
Ensembl gene	ENSG00000210191
Ensembl biotype	Mt_tRNA
OMIM	590055
Entrez	4568
RNAcentral	URS000056BD99 — tRNA, 71 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 Mt_tRNA

ENST00000387456

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000387456 — 1 exons

Exon	Start	End
ENSE00001544478	12266	12336

Expression profiles

Bgee: expression breadth ubiquitous, 118 present calls, max score 99.89.

FANTOM5 (CAGE): breadth broad, TPM avg 5.3912 / max 4450.4806, expressed in 537 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
194975	5.3912	537

Top tissues by expression

118 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
apex of heart	UBERON:0002098	99.89	gold quality
putamen	UBERON:0001874	99.32	gold quality
caudate nucleus	UBERON:0001873	99.27	gold quality
endometrium	UBERON:0001295	99.15	gold quality
amygdala	UBERON:0001876	99.10	gold quality
nucleus accumbens	UBERON:0001882	99.09	gold quality
skeletal muscle tissue	UBERON:0001134	99.08	gold quality
prefrontal cortex	UBERON:0000451	98.95	gold quality
substantia nigra	UBERON:0002038	98.89	gold quality
Ammon’s horn	UBERON:0001954	98.86	gold quality
hypothalamus	UBERON:0001898	98.85	gold quality
heart left ventricle	UBERON:0002084	98.80	gold quality
right adrenal gland cortex	UBERON:0035827	98.67	gold quality
vermiform appendix	UBERON:0001154	98.61	gold quality
sural nerve	UBERON:0015488	98.55	gold quality
anterior cingulate cortex	UBERON:0009835	98.41	gold quality
right adrenal gland	UBERON:0001233	98.40	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	98.38	gold quality
duodenum	UBERON:0002114	98.25	gold quality
monocyte	CL:0000576	98.08	gold quality
mucosa of stomach	UBERON:0001199	98.04	gold quality
granulocyte	CL:0000094	98.02	gold quality
leukocyte	CL:0000738	98.02	gold quality
frontal cortex	UBERON:0001870	97.93	gold quality
left adrenal gland cortex	UBERON:0035825	97.91	gold quality
right frontal lobe	UBERON:0002810	97.85	gold quality
adrenal gland	UBERON:0002369	97.69	gold quality
adrenal tissue	UBERON:0018303	97.61	gold quality
cerebral cortex	UBERON:0000956	97.57	gold quality
left adrenal gland	UBERON:0001234	97.51	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Significant reduction of total ATP and mitochondrial membrane potential and an increased production of reactive oxygen species were observed in a patient with mutation m.12300G>A in the mitochondrial tRNA(Leu(CUN)) gene. (PMID:22094595)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.