MT-TN

Summary

MT-TN (mitochondrially encoded tRNA-Asn (AAU/C), HGNC:7493) is a mitochondrial tRNA gene on chromosome mitochondria.

Predicted to enable triplet codon-amino acid adaptor activity. Predicted to be involved in translation.

Source: NCBI Gene 4570 — RefSeq curated summary.

At a glance

• Gene type: non-coding (Mt_tRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:7493
Approved symbol	MT-TN
Name	mitochondrially encoded tRNA-Asn (AAU/C)
Location	mitochondria
Locus type	RNA, transfer
Status	Approved
Aliases	trnN
Ensembl gene	ENSG00000210135
Ensembl biotype	Mt_tRNA
OMIM	590010
Entrez	4570
RNAcentral	URS00004206E2 — tRNA, 73 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 Mt_tRNA

ENST00000387400

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000387400 — 1 exons

Exon	Start	End
ENSE00001544490	5657	5729

Expression profiles

Bgee: expression breadth ubiquitous, 118 present calls, max score 99.97.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2885 / max 17.6979, expressed in 94 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
195157	0.2885	94

Top tissues by expression

118 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
duodenum	UBERON:0002114	99.97	gold quality
skeletal muscle tissue	UBERON:0001134	99.96	gold quality
vermiform appendix	UBERON:0001154	99.96	gold quality
adrenal tissue	UBERON:0018303	99.96	gold quality
right uterine tube	UBERON:0001302	99.95	gold quality
apex of heart	UBERON:0002098	99.95	gold quality
granulocyte	CL:0000094	99.92	gold quality
fundus of stomach	UBERON:0001160	99.90	gold quality
mucosa of stomach	UBERON:0001199	99.90	gold quality
rectum	UBERON:0001052	99.88	gold quality
right coronary artery	UBERON:0001625	99.88	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	99.87	gold quality
amygdala	UBERON:0001876	99.86	gold quality
right adrenal gland	UBERON:0001233	99.85	gold quality
right adrenal gland cortex	UBERON:0035827	99.85	gold quality
stomach	UBERON:0000945	99.84	gold quality
body of stomach	UBERON:0001161	99.84	gold quality
left uterine tube	UBERON:0001303	99.80	gold quality
skin of leg	UBERON:0001511	99.79	gold quality
muscle of leg	UBERON:0001383	99.78	gold quality
zone of skin	UBERON:0000014	99.77	gold quality
smooth muscle tissue	UBERON:0001135	99.77	gold quality
transverse colon	UBERON:0001157	99.77	gold quality
gastrocnemius	UBERON:0001388	99.77	gold quality
placenta	UBERON:0001987	99.76	gold quality
skin of abdomen	UBERON:0001416	99.75	gold quality
Ammon’s horn	UBERON:0001954	99.75	gold quality
prefrontal cortex	UBERON:0000451	99.73	gold quality
putamen	UBERON:0001874	99.73	gold quality
nucleus accumbens	UBERON:0001882	99.71	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Progressive external ophthalmoplegia associated with novel MT-TN mutations. (PMID:32869280)
• MT-TN mutations lead to progressive mitochondrial encephalopathy and promotes mitophagy. (PMID:38320662)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.