MT-TQ

Summary

MT-TQ (mitochondrially encoded tRNA-Gln (CAA/G), HGNC:7495) is a mitochondrial tRNA gene on chromosome mitochondria.

Predicted to enable triplet codon-amino acid adaptor activity. Predicted to be involved in translation.

Source: NCBI Gene 4572 — RefSeq curated summary.

At a glance

• Gene type: non-coding (Mt_tRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:7495
Approved symbol	MT-TQ
Name	mitochondrially encoded tRNA-Gln (CAA/G)
Location	mitochondria
Locus type	RNA, transfer
Status	Approved
Aliases	trnQ
Ensembl gene	ENSG00000210107
Ensembl biotype	Mt_tRNA
OMIM	590030
Entrez	4572
RNAcentral	URS000019B78E — tRNA, 72 nt, 7 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 Mt_tRNA

ENST00000387372

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000387372 — 1 exons

Exon	Start	End
ENSE00001544494	4329	4400

Expression profiles

Bgee: expression breadth ubiquitous, 118 present calls, max score 99.82.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.6600 / max 379.9191, expressed in 148 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
195146	0.6600	148

Top tissues by expression

118 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	99.82	gold quality
sural nerve	UBERON:0015488	99.66	gold quality
apex of heart	UBERON:0002098	99.51	gold quality
prefrontal cortex	UBERON:0000451	99.46	gold quality
caudate nucleus	UBERON:0001873	99.37	gold quality
putamen	UBERON:0001874	99.31	gold quality
nucleus accumbens	UBERON:0001882	98.95	gold quality
frontal cortex	UBERON:0001870	98.73	gold quality
right frontal lobe	UBERON:0002810	98.73	gold quality
duodenum	UBERON:0002114	98.72	gold quality
heart left ventricle	UBERON:0002084	98.69	gold quality
amygdala	UBERON:0001876	98.61	gold quality
substantia nigra	UBERON:0002038	98.59	gold quality
Ammon’s horn	UBERON:0001954	98.52	gold quality
anterior cingulate cortex	UBERON:0009835	98.08	gold quality
rectum	UBERON:0001052	98.00	gold quality
vermiform appendix	UBERON:0001154	97.82	gold quality
hypothalamus	UBERON:0001898	97.65	gold quality
adult mammalian kidney	UBERON:0000082	97.36	gold quality
right adrenal gland cortex	UBERON:0035827	97.16	gold quality
cerebral cortex	UBERON:0000956	97.13	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	96.90	gold quality
adrenal tissue	UBERON:0018303	96.35	gold quality
right hemisphere of cerebellum	UBERON:0014890	96.34	gold quality
kidney	UBERON:0002113	96.19	gold quality
granulocyte	CL:0000094	95.94	gold quality
brain	UBERON:0000955	95.89	gold quality
muscle of leg	UBERON:0001383	95.76	gold quality
right adrenal gland	UBERON:0001233	95.70	gold quality
gastrocnemius	UBERON:0001388	95.68	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.11

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• The noncoding mitochondrial sequence alteration (A4401G) at the junction of tRNA(Met) and tRNA(Gln) alters mitochondrial function, implicating this mutation in the pathogenesis of left ventricular hypertrophy in Chinese hypertensives. (PMID:18701880)
• Data indicate that the 4329C> G point mutation in mitochondrial transfer RNA genes tRNA(Ile) and tRNA(Gln) probably contributed to the pathogenesis of hypertension, possibly in association with other modifying factors. (PMID:25297595)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.