MT-TR

Summary

MT-TR (mitochondrially encoded tRNA-Arg (CGN), HGNC:7496) is a mitochondrial tRNA gene on chromosome mitochondria.

At a glance

• Gene type: non-coding (Mt_tRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:7496
Approved symbol	MT-TR
Name	mitochondrially encoded tRNA-Arg (CGN)
Location	mitochondria
Locus type	RNA, transfer
Status	Approved
Aliases	trnR
Ensembl gene	ENSG00000210174
Ensembl biotype	Mt_tRNA
OMIM	590005
Entrez	4573
RNAcentral	URS00005983A6 — tRNA, 65 nt, 6 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 Mt_tRNA

ENST00000387439

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000387439 — 1 exons

Exon	Start	End
ENSE00001544482	10405	10469

Expression profiles

Bgee: expression breadth ubiquitous, 116 present calls, max score 99.49.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.3811 / max 55.5352, expressed in 117 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
194923	0.3811	117

Top tissues by expression

116 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	99.49	gold quality
skeletal muscle tissue	UBERON:0001134	99.20	gold quality
apex of heart	UBERON:0002098	99.01	gold quality
caudate nucleus	UBERON:0001873	97.68	gold quality
putamen	UBERON:0001874	97.62	gold quality
amygdala	UBERON:0001876	97.60	gold quality
substantia nigra	UBERON:0002038	97.27	gold quality
Ammon’s horn	UBERON:0001954	97.22	gold quality
nucleus accumbens	UBERON:0001882	96.95	gold quality
hypothalamus	UBERON:0001898	96.79	gold quality
right frontal lobe	UBERON:0002810	96.13	gold quality
heart left ventricle	UBERON:0002084	96.06	gold quality
frontal cortex	UBERON:0001870	95.98	gold quality
anterior cingulate cortex	UBERON:0009835	95.87	gold quality
prefrontal cortex	UBERON:0000451	95.13	gold quality
adult mammalian kidney	UBERON:0000082	94.69	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	94.29	gold quality
cerebral cortex	UBERON:0000956	94.12	gold quality
right adrenal gland cortex	UBERON:0035827	93.42	gold quality
brain	UBERON:0000955	92.86	gold quality
heart	UBERON:0000948	91.63	gold quality
right adrenal gland	UBERON:0001233	91.34	gold quality
adrenal gland	UBERON:0002369	90.66	gold quality
kidney	UBERON:0002113	90.52	gold quality
left adrenal gland	UBERON:0001234	90.45	gold quality
bone marrow	UBERON:0002371	90.41	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	90.29	gold quality
left adrenal gland cortex	UBERON:0035825	90.03	gold quality
placenta	UBERON:0001987	89.99	gold quality
right hemisphere of cerebellum	UBERON:0014890	89.96	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• A novel mitochondrial tRNA Arg mutation resulting in an anticodon swap in a patient with mitochondrial encephalomyopathy. (PMID:22781096)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.