MT-TS2

Summary

MT-TS2 (mitochondrially encoded tRNA-Ser (AGU/C) 2, HGNC:7498) is a mitochondrial tRNA gene on chromosome mitochondria.

At a glance

• Gene type: non-coding (Mt_tRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:7498
Approved symbol	MT-TS2
Name	mitochondrially encoded tRNA-Ser (AGU/C) 2
Location	mitochondria
Locus type	RNA, transfer
Status	Approved
Aliases	TRNS2, RP8
Ensembl gene	ENSG00000210184
Ensembl biotype	Mt_tRNA
OMIM	590085
Entrez	4575
RNAcentral	URS00002C130C — tRNA, 59 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 Mt_tRNA

ENST00000387449

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000387449 — 1 exons

Exon	Start	End
ENSE00001544479	12207	12265

Expression profiles

Bgee: expression breadth ubiquitous, 116 present calls, max score 99.85.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 35.4668 / max 10692.0082, expressed in 1648 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
194974	35.4668	1648

Top tissues by expression

116 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	99.85	gold quality
apex of heart	UBERON:0002098	99.78	gold quality
prefrontal cortex	UBERON:0000451	99.10	gold quality
right adrenal gland cortex	UBERON:0035827	98.85	gold quality
putamen	UBERON:0001874	98.82	gold quality
caudate nucleus	UBERON:0001873	98.70	gold quality
nucleus accumbens	UBERON:0001882	98.33	gold quality
skeletal muscle tissue	UBERON:0001134	98.22	gold quality
amygdala	UBERON:0001876	98.20	gold quality
substantia nigra	UBERON:0002038	98.12	gold quality
heart left ventricle	UBERON:0002084	98.02	gold quality
vermiform appendix	UBERON:0001154	97.97	gold quality
Ammon’s horn	UBERON:0001954	97.83	gold quality
adrenal tissue	UBERON:0018303	97.77	gold quality
hypothalamus	UBERON:0001898	97.69	gold quality
anterior cingulate cortex	UBERON:0009835	97.12	gold quality
duodenum	UBERON:0002114	96.86	gold quality
right adrenal gland	UBERON:0001233	96.64	gold quality
adrenal gland	UBERON:0002369	96.07	gold quality
cerebral cortex	UBERON:0000956	95.94	gold quality
mucosa of transverse colon	UBERON:0004991	95.89	gold quality
frontal cortex	UBERON:0001870	95.88	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	95.76	gold quality
endometrium	UBERON:0001295	95.75	gold quality
left adrenal gland	UBERON:0001234	95.67	gold quality
right frontal lobe	UBERON:0002810	95.64	gold quality
granulocyte	CL:0000094	95.63	gold quality
left adrenal gland cortex	UBERON:0035825	95.39	gold quality
lymph node	UBERON:0000029	95.29	gold quality
adult mammalian kidney	UBERON:0000082	95.25	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-MTAB-9543	yes	2316.56
E-HCAD-30	no	276.06
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• MTTS2 mutations are an important cause of retinal and syndromic auditory impairment. (PMID:22378285)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.