MT-TT

Summary

MT-TT (mitochondrially encoded tRNA-Thr (ACN), HGNC:7499) is a mitochondrial tRNA gene on chromosome mitochondria.

Predicted to enable triplet codon-amino acid adaptor activity. Predicted to be involved in translation.

Source: NCBI Gene 4576 — RefSeq curated summary.

At a glance

• Gene type: non-coding (Mt_tRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:7499
Approved symbol	MT-TT
Name	mitochondrially encoded tRNA-Thr (ACN)
Location	mitochondria
Locus type	RNA, transfer
Status	Approved
Aliases	trnT
Ensembl gene	ENSG00000210195
Ensembl biotype	Mt_tRNA
OMIM	590090
Entrez	4576
RNAcentral	URS00000FCDE9 — tRNA, 66 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 Mt_tRNA

ENST00000387460

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000387460 — 1 exons

Exon	Start	End
ENSE00001544475	15888	15953

Expression profiles

Bgee: expression breadth ubiquitous, 118 present calls, max score 99.40.

FANTOM5 (CAGE): breadth broad, TPM avg 3.6321 / max 2116.6920, expressed in 609 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
195072	1.2047	137
195070	1.0074	156
195069	0.8276	269
195071	0.5924	148

Top tissues by expression

118 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	99.40	gold quality
sural nerve	UBERON:0015488	99.34	gold quality
substantia nigra	UBERON:0002038	99.00	gold quality
apex of heart	UBERON:0002098	98.81	gold quality
caudate nucleus	UBERON:0001873	98.71	gold quality
putamen	UBERON:0001874	98.70	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	98.55	gold quality
amygdala	UBERON:0001876	98.47	gold quality
hypothalamus	UBERON:0001898	98.44	gold quality
Ammon’s horn	UBERON:0001954	98.43	gold quality
nucleus accumbens	UBERON:0001882	98.29	gold quality
duodenum	UBERON:0002114	97.97	gold quality
right frontal lobe	UBERON:0002810	97.64	gold quality
anterior cingulate cortex	UBERON:0009835	97.58	gold quality
mucosa of stomach	UBERON:0001199	97.57	gold quality
frontal cortex	UBERON:0001870	97.52	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	97.39	gold quality
rectum	UBERON:0001052	96.94	gold quality
cerebral cortex	UBERON:0000956	96.92	gold quality
corpus callosum	UBERON:0002336	96.38	gold quality
prefrontal cortex	UBERON:0000451	95.86	gold quality
monocyte	CL:0000576	95.66	gold quality
leukocyte	CL:0000738	95.63	gold quality
right hemisphere of cerebellum	UBERON:0014890	95.40	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	95.34	gold quality
brain	UBERON:0000955	95.28	gold quality
bone marrow	UBERON:0002371	95.00	gold quality
heart left ventricle	UBERON:0002084	94.92	gold quality
cerebellar hemisphere	UBERON:0002245	94.81	gold quality
vermiform appendix	UBERON:0001154	94.30	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.46

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• the mitochondrial tRNA(Thr) A15951G mutation might be involved in the pathogenesis of Leber’s hereditary optic neuropathy in the two families. (PMID:21983721)
• the tRNAThr 15927G > A mutation, identified in a large cohort of LHON subjects, decreased the activities of mitochondrial complexes I and III, markedly diminished mitochondrial ATP levels, and increased the production of reactive oxygen species in the mutant cells. (PMID:29225014)
• A coronary artery disease-associated tRNAThr mutation altered mitochondrial function, apoptosis and angiogenesis. (PMID:30541130)
• Maternally Inherited Diabetes Mellitus Associated with a Novel m.15897G>A Mutation in Mitochondrial tRNA(Thr) Gene. (PMID:32083134)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.