MTERF4

Summary

MTERF4 (mitochondrial transcription termination factor 4, HGNC:28785) is a protein-coding gene on chromosome 2q37.3, encoding Transcription termination factor 4, mitochondrial (Q7Z6M4). Regulator of mitochondrial ribosome biogenesis and translation. It is a selective cancer dependency (DepMap: 13.7% of cell lines).

Enables rRNA binding activity. Predicted to be involved in mitochondrial ribosome assembly and mitochondrial transcription. Predicted to act upstream of or within several processes, including camera-type eye development; protein targeting to mitochondrion; and ribosome assembly. Located in cytosol and mitochondrion. Part of mitochondrial large ribosomal subunit.

Source: NCBI Gene 130916 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 273 total — 1 pathogenic
• Cancer dependency (DepMap): dependent in 13.7% of screened cell lines
• MANE Select transcript: NM_182501

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28785
Approved symbol	MTERF4
Name	mitochondrial transcription termination factor 4
Location	2q37.3
Locus type	gene with protein product
Status	Approved
Aliases	MGC61716
Ensembl gene	ENSG00000122085
Ensembl biotype	protein_coding
OMIM	615393
Entrez	130916

Gene structure

Transcript identifiers

Ensembl transcripts: 24 — 13 protein_coding, 6 protein_coding_CDS_not_defined, 4 retained_intron, 1 nonsense_mediated_decay

ENST00000241527, ENST00000391980, ENST00000401626, ENST00000406593, ENST00000407095, ENST00000414146, ENST00000424798, ENST00000434791, ENST00000439144, ENST00000449133, ENST00000455202, ENST00000460915, ENST00000464344, ENST00000475860, ENST00000476564, ENST00000479205, ENST00000480298, ENST00000488567, ENST00000493169, ENST00000495694, ENST00000496878, ENST00000614476, ENST00000902117, ENST00000923999

RefSeq mRNA: 3 — MANE Select: NM_182501 NM_001330179, NM_001330180, NM_182501

CCDS: CCDS2544, CCDS82584

Canonical transcript exons

ENST00000391980 — 4 exons

Exon	Start	End
ENSE00000827773	241099396	241099894
ENSE00001510314	241095571	241096438
ENSE00001601042	241102253	241102287
ENSE00003694390	241097243	241097427

Expression profiles

Bgee: expression breadth ubiquitous, 267 present calls, max score 96.25.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 28.6596 / max 361.1099, expressed in 1813 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
34879	28.6596	1813

Top tissues by expression

293 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right hemisphere of cerebellum	UBERON:0014890	96.25	gold quality
sural nerve	UBERON:0015488	96.25	gold quality
cerebellar hemisphere	UBERON:0002245	95.95	gold quality
cerebellar cortex	UBERON:0002129	95.76	gold quality
left lobe of thyroid gland	UBERON:0001120	95.71	gold quality
right lobe of thyroid gland	UBERON:0001119	95.67	gold quality
thyroid gland	UBERON:0002046	95.02	gold quality
left ovary	UBERON:0002119	94.18	gold quality
gastrocnemius	UBERON:0001388	93.89	gold quality
tendon of biceps brachii	UBERON:0008188	93.68	gold quality
right ovary	UBERON:0002118	93.57	gold quality
muscle of leg	UBERON:0001383	93.55	gold quality
parotid gland	UBERON:0001831	93.55	gold quality
hindlimb stylopod muscle	UBERON:0004252	93.52	gold quality
cerebellum	UBERON:0002037	93.40	gold quality
body of pancreas	UBERON:0001150	93.23	gold quality
lymph node	UBERON:0000029	93.20	gold quality
small intestine Peyer’s patch	UBERON:0003454	93.15	gold quality
body of uterus	UBERON:0009853	93.05	gold quality
right uterine tube	UBERON:0001302	92.87	gold quality
tibial nerve	UBERON:0001323	92.70	gold quality
left uterine tube	UBERON:0001303	92.41	gold quality
colonic epithelium	UBERON:0000397	92.39	gold quality
islet of Langerhans	UBERON:0000006	92.34	gold quality
minor salivary gland	UBERON:0001830	92.18	gold quality
esophagus mucosa	UBERON:0002469	92.12	gold quality
saliva-secreting gland	UBERON:0001044	92.08	gold quality
lower esophagus mucosa	UBERON:0035834	92.07	gold quality
right frontal lobe	UBERON:0002810	91.97	gold quality
endocervix	UBERON:0000458	91.89	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.43

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

30 targeting MTERF4, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-513B-5P	99.99	69.96	2150
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-1297	99.91	73.41	3162
HSA-MIR-26A-5P	99.78	73.52	2303
HSA-MIR-26B-5P	99.78	73.51	2305
HSA-MIR-4465	99.71	72.56	2096
HSA-MIR-580-3P	99.67	69.23	1841
HSA-MIR-7152-5P	99.60	69.33	2094
HSA-MIR-516A-3P	99.46	67.96	1378
HSA-MIR-516B-3P	99.46	67.96	1378
HSA-MIR-7162-5P	99.46	68.08	1368
HSA-MIR-653-5P	99.46	67.35	1300
HSA-MIR-4311	99.31	70.47	3041
HSA-MIR-1253	99.12	67.08	1688
HSA-MIR-548AS-3P	99.12	69.12	2294
HSA-MIR-4699-5P	98.99	67.50	1210
HSA-MIR-1288-5P	98.85	67.01	734
HSA-MIR-7705	98.69	67.47	543
HSA-MIR-548AT-3P	98.37	64.98	580
HSA-MIR-548AY-3P	98.37	65.14	562
HSA-MIR-506-5P	98.02	67.41	1065
HSA-MIR-125A-3P	97.04	66.92	902
HSA-MIR-711	96.60	65.75	528
HSA-MIR-554	95.20	66.98	341

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 13.7% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 2)

• analysis of the 3D crystal structure of the human MTERF4-NSUN4 complex (PMID:22949673)
• The overexpression of MTERF4 induced a significant increase in the levels of APP protein and secreted Abeta 42 in HEK293-APPswe cells compared with control cells these results suggest that MTERF4 promotes the amyloidogenic processing of APP by inhibiting ADAM10 in HEK293-APPswe cells; therefore, MTERF4 may play an important role in the pathogenesis of Alzheimer’s disease. (PMID:27894840)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	mterf4	ENSDARG00000079124
mus_musculus	Mterf4	ENSMUSG00000026273
rattus_norvegicus	Mterf4	ENSRNOG00000037376
drosophila_melanogaster	CG15390	FBGN0031419
caenorhabditis_elegans	mter-4	WBGENE00010771

Protein

Protein identifiers

Transcription termination factor 4, mitochondrial — Q7Z6M4 (reviewed: Q7Z6M4)

Alternative names: Mitochondrial transcription termination factor 4, mTERF domain-containing protein 2

All UniProt accessions (10): B4DFP7, B4DKD5, B5MBW3, C9JNJ7, C9JX74, E7EW93, Q7Z6M4, H7C1N9, H7C316, H7C3Q3

UniProt curated annotations — full annotation on UniProt →

Function. Regulator of mitochondrial ribosome biogenesis and translation. Binds to mitochondrial ribosomal RNAs 16S, 12S and 7S and targets NSUN4 RNA methyltransferase to the mitochondrial large ribosomal subunit (39S).

Subunit / interactions. Heterodimer with NSUN4; this interaction may be required for NSUN4 recruitment to the mitochondrial large ribosomal subunit.

Subcellular location. Mitochondrion.

Post-translational modifications. The mature mitochondrial protein exists in 2 forms differing at the level of their N-terminus, one is starting at residue 43 and the other at residue 48.

Domain organisation. The MTERF repeats form a half-donut shaped, right-handed superhelix, where the concave side displays a positively charged path for nucleic acid interaction.

Similarity. Belongs to the mTERF family.

RefSeq proteins (3): NP_001317108, NP_001317109, NP_872307* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003690	MTERF	Family
IPR038538	MTERF_sf	Homologous_superfamily

Pfam: PF02536

UniProt features (42 total): helix 18, sequence variant 5, repeat 5, sequence conflict 4, turn 3, chain 2, region of interest 2, transit peptide 1, compositionally biased region 1, strand 1

Structure

Experimental structures (PDB)

15 structures.

PDB	Method	Resolution (Å)
4FZV	X-RAY DIFFRACTION	2
7OF0	ELECTRON MICROSCOPY	2.2
7OF7	ELECTRON MICROSCOPY	2.5
7O9M	ELECTRON MICROSCOPY	2.6
7OF3	ELECTRON MICROSCOPY	2.7
4FP9	X-RAY DIFFRACTION	2.9
7ODR	ELECTRON MICROSCOPY	2.9
7OF5	ELECTRON MICROSCOPY	2.9
8QSJ	ELECTRON MICROSCOPY	3
8PK0	ELECTRON MICROSCOPY	3.03
7O9K	ELECTRON MICROSCOPY	3.1
7ODS	ELECTRON MICROSCOPY	3.1
7ODT	ELECTRON MICROSCOPY	3.1
7OIC	ELECTRON MICROSCOPY	3.1
7PD3	ELECTRON MICROSCOPY	3.4

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q7Z6M4-F1	77.13	0.60

Function

Pathways and Gene Ontology

Reactome pathways

4 pathways

ID	Pathway
R-HSA-6793080	rRNA modification in the mitochondrion
R-HSA-72312	rRNA processing
R-HSA-8868766	rRNA processing in the mitochondrion
R-HSA-8953854	Metabolism of RNA

MSigDB gene sets: 136 (showing top): GOBP_RIBOSOME_BIOGENESIS, GOBP_RIBOSOME_ASSEMBLY, GOBP_RIBOSOMAL_LARGE_SUBUNIT_ASSEMBLY, GOBP_PROTEIN_RNA_COMPLEX_ORGANIZATION, GOBP_ORGANELLE_ASSEMBLY, ZHOU_INFLAMMATORY_RESPONSE_LIVE_DN, CCAGGTT_MIR490, GOBP_SENSORY_ORGAN_DEVELOPMENT, GOBP_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS, GOBP_RIBOSOMAL_LARGE_SUBUNIT_BIOGENESIS, WANG_RESPONSE_TO_ANDROGEN_UP, GOBP_CIRCULATORY_SYSTEM_DEVELOPMENT, REACTOME_METABOLISM_OF_RNA, OSMAN_BLADDER_CANCER_DN, YAGI_AML_WITH_T_9_11_TRANSLOCATION

GO Biological Process (7): rRNA processing (GO:0006364), heart development (GO:0007507), camera-type eye development (GO:0043010), mitochondrial ribosome assembly (GO:0061668), mitochondrial large ribosomal subunit assembly (GO:1902775), regulation of mitochondrial transcription (GO:1903108), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (7): rRNA binding (GO:0019843), protein-RNA adaptor activity (GO:0140517), RNA folding chaperone (GO:0140691), nucleic acid binding (GO:0003676), double-stranded DNA binding (GO:0003690), RNA binding (GO:0003723), protein binding (GO:0005515)

GO Cellular Component (3): mitochondrion (GO:0005739), mitochondrial matrix (GO:0005759), cytosol (GO:0005829)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
rRNA processing in the mitochondrion	1
Metabolism of RNA	1
rRNA processing	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
binding	2
cytoplasm	2
RNA processing	1
rRNA metabolic process	1
ribosome biogenesis	1
animal organ development	1
circulatory system development	1
eye development	1
ribosome assembly	1
ribosomal large subunit assembly	1
mitochondrial ribosome assembly	1
regulation of DNA-templated transcription	1
mitochondrial transcription	1
regulation of mitochondrial gene expression	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
RNA binding	1
protein-macromolecule adaptor activity	1
molecular_function	1
RNA folding	1
DNA binding	1
nucleic acid binding	1
intracellular membrane-bounded organelle	1
mitochondrion	1
intracellular organelle lumen	1
cellular anatomical structure	1

Protein interactions and networks

STRING

1028 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MTERF4	NSUN4	Q96CB9	998
MTERF4	MALSU1	Q96EH3	829
MTERF4	MTG1	Q9BT17	811
MTERF4	MTERF1	Q99551	771
MTERF4	MTERF2	Q49AM1	769
MTERF4	MTG2	Q9H4K7	739
MTERF4	POLRMT	O00411	731
MTERF4	GTPBP10	A4D1E9	720
MTERF4	MRM2	Q9UI43	708
MTERF4	TFB1M	Q8WVM0	677
MTERF4	DDX28	Q9NUL7	667
MTERF4	NSUN3	Q9H649	663
MTERF4	MRM3	Q9HC36	652
MTERF4	MRM1	Q6IN84	644
MTERF4	GTPBP6	O43824	616

IntAct

54 interactions, top by confidence:

A	B	Type	Score
MTERF4	NSUN4	psi-mi:“MI:0915”(physical association)	0.760
MTERF4	NSUN4	psi-mi:“MI:0407”(direct interaction)	0.760
KBTBD7	METTL15	psi-mi:“MI:0914”(association)	0.730
CA10	WDHD1	psi-mi:“MI:0914”(association)	0.640
EMD	MTERF4	psi-mi:“MI:0915”(physical association)	0.560
MTERF4	BANP	psi-mi:“MI:0915”(physical association)	0.560
MTERF4	OSGIN1	psi-mi:“MI:0915”(physical association)	0.560
DGAT2L6	MTERF4	psi-mi:“MI:0915”(physical association)	0.560
MTERF4	CIDEB	psi-mi:“MI:0915”(physical association)	0.560
MTERF4	TNFRSF10D	psi-mi:“MI:0915”(physical association)	0.560
INSL3	GAPDHS	psi-mi:“MI:0914”(association)	0.530
KBTBD7	PLD2	psi-mi:“MI:0914”(association)	0.530
HDGFL2	CDC7	psi-mi:“MI:0914”(association)	0.530
NDUFAB1	MIEF1	psi-mi:“MI:0915”(physical association)	0.490
HSCB	RBP5	psi-mi:“MI:0914”(association)	0.350
MRPL12		psi-mi:“MI:0914”(association)	0.350
MND1	SPAG9	psi-mi:“MI:0914”(association)	0.350
KBTBD7	GTPBP10	psi-mi:“MI:0914”(association)	0.350

BioGRID (36): MTERF4 (Affinity Capture-MS), MTERF4 (Affinity Capture-MS), MTERF4 (Affinity Capture-MS), MTERF4 (Affinity Capture-MS), MTERF4 (Affinity Capture-MS), MTERF4 (Affinity Capture-MS), MTERF4 (Affinity Capture-MS), MTERF4 (Affinity Capture-MS), MTERF4 (Affinity Capture-RNA), MTERF4 (Two-hybrid), CIDEB (Two-hybrid), OSGIN1 (Two-hybrid), BANP (Two-hybrid), TNFRSF10D (Two-hybrid), DGAT2L6 (Two-hybrid)

ESM2 similar proteins: A1L3F5, A1L3L1, A2RT67, A6NFN9, A6QPR9, A7MBF6, B9EJ57, F4IHL3, H2LP95, O81916, P0C6R2, Q28CB1, Q29RL0, Q2HJ90, Q49AM1, Q4G078, Q4R683, Q5R6G1, Q5R9U8, Q5RD21, Q5RFI6, Q5XIE2, Q5ZJC8, Q6AUK6, Q6NXY1, Q6P6Q6, Q6ZRR7, Q7L8L6, Q7TMV3, Q7Z494, Q7Z6M4, Q80YS9, Q8BKY8, Q8BVN4, Q8CDN9, Q8CHZ9, Q8NEN0, Q8R3J4, Q8S8F2, Q8W519

Diamond homologs: Q4G078, Q7Z6M4, Q8BVN4

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
MTERF4	“form complex”	“MTERF4-NSUN4 mitochondiral ribosomal assembly complex”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 34 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Mitochondrial ribosome-associated quality control	5	26.7×	1e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

273 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	209
Likely benign	18
Benign	4

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
830538	NC_000002.11:g.(?241808273)(242708241_?)del	Pathogenic

SpliceAI

2700 predictions. Top by Δscore:

Variant	Effect	Δscore
2:241073361:GGAA:G	donor_gain	1.0000
2:241073362:G:GT	donor_gain	1.0000
2:241073362:GAA:G	donor_gain	1.0000
2:241073365:G:GG	donor_gain	1.0000
2:241096439:C:CC	acceptor_gain	1.0000
2:241097239:TCA:T	donor_loss	1.0000
2:241097240:CA:C	donor_loss	1.0000
2:241097241:ACCTG:A	donor_loss	1.0000
2:241097242:CCTG:C	donor_loss	1.0000
2:241102248:CTTA:C	donor_loss	1.0000
2:241102249:TTACC:T	donor_loss	1.0000
2:241102250:TACCT:T	donor_loss	1.0000
2:241081676:GAC:G	acceptor_gain	0.9900
2:241081789:GCTCG:G	donor_gain	0.9900
2:241081790:CTCGG:C	donor_loss	0.9900
2:241081791:TCGGT:T	donor_loss	0.9900
2:241081792:CGG:C	donor_loss	0.9900
2:241081793:GGT:G	donor_loss	0.9900
2:241081794:GT:G	donor_loss	0.9900
2:241081795:TAAGT:T	donor_loss	0.9900
2:241094275:ACCT:A	donor_gain	0.9900
2:241094276:CCTC:C	donor_gain	0.9900
2:241094278:T:TA	donor_gain	0.9900
2:241094343:A:C	donor_gain	0.9900
2:241094430:CTG:C	acceptor_gain	0.9900
2:241095953:T:A	donor_gain	0.9900
2:241095954:C:A	donor_gain	0.9900
2:241095988:T:TA	donor_gain	0.9900
2:241096002:T:TA	donor_gain	0.9900
2:241096005:T:TA	donor_gain	0.9900

AlphaMissense

2540 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:241096241:A:C	F301L	0.993
2:241096241:A:T	F301L	0.993
2:241096243:A:G	F301L	0.993
2:241096335:C:G	R270P	0.992
2:241096427:G:C	F239L	0.991
2:241096427:G:T	F239L	0.991
2:241096429:A:G	F239L	0.991
2:241097246:A:C	F234L	0.991
2:241097246:A:T	F234L	0.991
2:241097248:A:G	F234L	0.991
2:241096196:A:C	F316L	0.990
2:241096196:A:T	F316L	0.990
2:241096198:A:G	F316L	0.990
2:241096242:A:G	F301S	0.989
2:241096324:A:C	Y274D	0.989
2:241097328:A:G	F207S	0.989
2:241096188:A:G	L319P	0.985
2:241096341:A:G	L268P	0.985
2:241097247:A:G	F234S	0.984
2:241096352:T:A	R264S	0.982
2:241096352:T:G	R264S	0.982
2:241097327:G:C	F207L	0.982
2:241097327:G:T	F207L	0.982
2:241097329:A:G	F207L	0.982
2:241097335:A:G	C205R	0.982
2:241096323:T:G	Y274S	0.981
2:241099605:A:G	F104S	0.981
2:241096242:A:C	F301C	0.979
2:241096345:A:C	Y267D	0.978
2:241096336:G:T	R270S	0.977

dbSNP variants (sampled 300 via entrez): RS1000015077 (2:241076422 G>T), RS1000107414 (2:241090887 A>G), RS1000196783 (2:241075563 C>A), RS1000210579 (2:241061884 A>G), RS1000217825 (2:241045038 G>A), RS1000242987 (2:241081677 A>G,T), RS1000340659 (2:241087751 G>A), RS1000352817 (2:241070666 G>A), RS1000372052 (2:241087521 C>G), RS1000440430 (2:241044787 C>G), RS1000453581 (2:241065972 G>C), RS1000492617 (2:241071384 C>T), RS1000506931 (2:241056875 C>T), RS1000531170 (2:241074369 C>T), RS1000572298 (2:241081838 G>A)

Disease associations

OMIM: gene MIM:615393 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST001554_3	Sex hormone-binding globulin levels	3.000000e-06
GCST012227_981	Hip circumference adjusted for BMI	8.000000e-11

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004696	sex hormone-binding globulin measurement
EFO:0008039	BMI-adjusted hip circumference

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

24 total (human), top 24 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	increases expression, increases methylation	2
Acetaminophen	decreases expression, increases expression	2
alpha-pinene	affects cotreatment, increases oxidation, increases abundance	1
sodium arsenite	decreases expression	1
methacrylaldehyde	affects cotreatment, increases oxidation, increases abundance	1
di-n-butylphosphoric acid	affects expression	1
Zoledronic Acid	increases expression	1
Vorinostat	increases expression	1
Leflunomide	increases expression	1
Acrolein	affects cotreatment, increases oxidation, increases abundance	1
Air Pollutants	affects cotreatment, increases abundance, increases oxidation	1
Benzo(a)pyrene	decreases expression	1
Doxorubicin	decreases expression	1
Colforsin	decreases expression	1
Ozone	affects cotreatment, increases oxidation, increases abundance	1
Ribonucleotides	affects binding	1
Tretinoin	decreases expression	1
Valproic Acid	decreases expression	1
1-Methyl-4-phenylpyridinium	increases cleavage, decreases expression, decreases reaction	1
Metribolone	increases expression	1
Antirheumatic Agents	increases expression	1
Cadmium Chloride	decreases expression	1
Okadaic Acid	decreases expression	1
Volatile Organic Compounds	affects cotreatment, increases oxidation	1

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_KT78	HeLa SilenciX MTERFD2	Cancer cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.