MTMR7

Summary

MTMR7 (myotubularin related protein 7, HGNC:7454) is a protein-coding gene on chromosome 8p22, encoding Phosphatidylinositol-3-phosphate phosphatase MTMR7 (Q9Y216). Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate (PtdIns(3)P) and inositol 1,3-bisphosphate (Ins(1,3)P2).

This gene encodes a member of the myotubularin family of tyrosine/dual-specificity phosphatases. The encoded protein is characterized by four distinct domains that are conserved among all members of the myotubularin family: the glucosyltransferase, Rab-like GTPase activator and myotubularins domain, the Rac-induced recruitment domain, the protein tyrosine phosphatases and dual-specificity phosphatases domain and the suppressor of variegation 3-9, enhancer-of-zeste, and trithorax interaction domain. This protein dephosphorylates the target substrates phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate. A pseudogene of this gene is found on chromosome 5.

Source: NCBI Gene 9108 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 151 total
• MANE Select transcript: NM_004686

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:7454
Approved symbol	MTMR7
Name	myotubularin related protein 7
Location	8p22
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000003987
Ensembl biotype	protein_coding
OMIM	603562
Entrez	9108

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 5 protein_coding, 4 protein_coding_CDS_not_defined, 2 retained_intron, 1 nonsense_mediated_decay

ENST00000180173, ENST00000517317, ENST00000518272, ENST00000519122, ENST00000519590, ENST00000519763, ENST00000521177, ENST00000521857, ENST00000523571, ENST00000879805, ENST00000915631, ENST00000915632

RefSeq mRNA: 1 — MANE Select: NM_004686 NM_004686

CCDS: CCDS34851

Canonical transcript exons

ENST00000180173 — 14 exons

Exon	Start	End
ENSE00001146456	17313292	17313401
ENSE00001307828	17302154	17302280
ENSE00001490209	17361117	17361274
ENSE00001490212	17371037	17371199
ENSE00001490213	17373118	17373240
ENSE00002112952	17296794	17300224
ENSE00003478821	17331150	17331282
ENSE00003489376	17304379	17304519
ENSE00003603009	17341363	17341497
ENSE00003605216	17309277	17309326
ENSE00003606042	17311511	17311636
ENSE00003641877	17305757	17305957
ENSE00003669577	17348953	17349081
ENSE00003850239	17413269	17413351

Expression profiles

Bgee: expression breadth ubiquitous, 180 present calls, max score 85.75.

FANTOM5 (CAGE): breadth broad, TPM avg 2.4078 / max 157.8898, expressed in 315 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
91992	1.0278	224
91991	0.9432	246
91993	0.2800	71
91994	0.1568	57

Top tissues by expression

288 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
islet of Langerhans	UBERON:0000006	85.75	gold quality
cortical plate	UBERON:0005343	84.26	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	82.58	gold quality
cerebellar hemisphere	UBERON:0002245	82.18	gold quality
cerebellar cortex	UBERON:0002129	82.04	gold quality
prefrontal cortex	UBERON:0000451	82.02	gold quality
right hemisphere of cerebellum	UBERON:0014890	81.87	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.76	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	80.30	gold quality
Brodmann (1909) area 9	UBERON:0013540	79.88	gold quality
cerebellum	UBERON:0002037	79.53	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	78.56	gold quality
right frontal lobe	UBERON:0002810	78.34	gold quality
spinal cord	UBERON:0002240	78.25	gold quality
ganglionic eminence	UBERON:0004023	78.20	gold quality
cingulate cortex	UBERON:0003027	77.70	gold quality
anterior cingulate cortex	UBERON:0009835	77.53	gold quality
frontal cortex	UBERON:0001870	76.54	gold quality
neocortex	UBERON:0001950	76.29	gold quality
nucleus accumbens	UBERON:0001882	76.08	gold quality
adenohypophysis	UBERON:0002196	75.68	gold quality
pituitary gland	UBERON:0000007	74.93	gold quality
secondary oocyte	CL:0000655	74.65	gold quality
caudate nucleus	UBERON:0001873	74.61	gold quality
mucosa of stomach	UBERON:0001199	74.54	gold quality
cerebral cortex	UBERON:0000956	74.40	gold quality
calcaneal tendon	UBERON:0003701	73.92	gold quality
amygdala	UBERON:0001876	73.90	gold quality
telencephalon	UBERON:0001893	73.78	gold quality
central nervous system	UBERON:0001017	73.71	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-GEOD-83139	yes	8.02
E-ANND-3	no	5.71

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

131 targeting MTMR7, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-3924	100.00	72.09	2394
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-512-3P	99.97	67.35	1049
HSA-MIR-1229-3P	99.97	66.49	906
HSA-MIR-6793-5P	99.97	65.95	758
HSA-MIR-548AT-5P	99.96	70.83	2666
HSA-MIR-551B-5P	99.96	71.28	3493
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-767-5P	99.95	70.85	993
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-7-1-3P	99.91	71.53	4384
HSA-MIR-7-2-3P	99.91	71.40	4394
HSA-MIR-8063	99.91	69.76	3146
HSA-MIR-6499-3P	99.90	66.38	1212
HSA-MIR-153-5P	99.89	73.86	6317
HSA-MIR-4302	99.89	67.94	1187
HSA-MIR-548E-5P	99.89	72.73	4486
HSA-MIR-95-5P	99.89	72.17	3973
HSA-MIR-6857-5P	99.87	65.32	985
HSA-MIR-629-3P	99.85	67.99	1875
HSA-MIR-4698	99.84	71.41	4303

Literature-anchored findings (GeneRIF, showing 2)

• The MTMR7 gene is linked to variant Creutzfeldt-Jakob risk in a genome-wide study. (PMID:22137330)
• MTMR7 has a role inhibiting insulin signaling in colorectal cancer (PMID:27409167)

Cross-species orthologs

16 orthologs

Organism	Symbol	Gene ID
danio_rerio	mtmr7a	ENSDARG00000037101
danio_rerio	mtmr7b	ENSDARG00000070412
mus_musculus	Mtmr7	ENSMUSG00000039431
rattus_norvegicus	Mtmr7	ENSRNOG00000011420
drosophila_melanogaster	mtm	FBGN0025742
drosophila_melanogaster	Sbf	FBGN0025802
drosophila_melanogaster	Mtmr6	FBGN0028497
drosophila_melanogaster	CG14411	FBGN0030582
drosophila_melanogaster	CG3632	FBGN0030735
drosophila_melanogaster	CG5026	FBGN0035945
caenorhabditis_elegans	mtm-1	WBGENE00003475
caenorhabditis_elegans		WBGENE00003476
caenorhabditis_elegans		WBGENE00003477
caenorhabditis_elegans		WBGENE00003478
caenorhabditis_elegans		WBGENE00003479
caenorhabditis_elegans	mtm-10	WBGENE00021683

Paralogs (13): MTMR11 (ENSG00000014914), MTMR1 (ENSG00000063601), MTMR2 (ENSG00000087053), SBF1 (ENSG00000100241), MTMR3 (ENSG00000100330), MTMR8 (ENSG00000102043), MTMR9 (ENSG00000104643), MTMR4 (ENSG00000108389), SBF2 (ENSG00000133812), MTMR6 (ENSG00000139505), MTMR12 (ENSG00000150712), MTMR10 (ENSG00000166912), MTM1 (ENSG00000171100)

Protein

Protein identifiers

Phosphatidylinositol-3-phosphate phosphatase MTMR7 — Q9Y216 (reviewed: Q9Y216)

Alternative names: Inositol 1,3-bisphosphate phosphatase, Myotubularin-related protein 7

All UniProt accessions (2): Q9Y216, E5RK11

UniProt curated annotations — full annotation on UniProt →

Function. Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate (PtdIns(3)P) and inositol 1,3-bisphosphate (Ins(1,3)P2).

Subunit / interactions. Heterodimer (via C-terminus) with MTMR9 (via coiled coil domain); the interaction enhances MTMR7 catalytic activity. Does not homodimerize. Interacts with RAB1B (in GDP-bound form).

Subcellular location. Cytoplasm. Endomembrane system.

Tissue specificity. Expressed specifically in brain.

Activity regulation. Interaction with MTMR9 increases phosphatase activity.

Similarity. Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9Y216-1	1	yes
Q9Y216-2	2

RefSeq proteins (1): NP_004677* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000387	Tyr_Pase_dom	Domain
IPR003595	Tyr_Pase_cat	Domain
IPR010569	Myotubularin-like_Pase_dom	Domain
IPR011993	PH-like_dom_sf	Homologous_superfamily
IPR016130	Tyr_Pase_AS	Active_site
IPR029021	Prot-tyrosine_phosphatase-like	Homologous_superfamily
IPR030564	Myotubularin	Family
IPR030572	MTMR7_PTP	Domain
IPR036003	MTMR7_PH-GRAM	Domain
IPR048994	PH-GRAM_MTMR6-9	Domain

Pfam: PF06602, PF21098

Catalyzed reactions (Rhea), 2 shown:

• a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate (RHEA:12316)
• 1D-myo-inositol 1,3-bisphosphate + H2O = 1D-myo-inositol 1-phosphate + phosphate (RHEA:57840)

UniProt features (26 total): binding site 10, sequence conflict 4, splice variant 2, sequence variant 2, compositionally biased region 2, chain 1, domain 1, modified residue 1, region of interest 1, coiled-coil region 1, active site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9Y216-F1	84.56	0.72

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 338 (phosphocysteine intermediate)

Ligand- & substrate-binding residues (10): 339; 340; 341; 342; 343; 344; 384; 250; 275; 276

Post-translational modifications (1): 578

Function

Pathways and Gene Ontology

Reactome pathways

7 pathways

ID	Pathway
R-HSA-1660517	Synthesis of PIPs at the late endosome membrane
R-HSA-1855183	Synthesis of IP2, IP, and Ins in the cytosol
R-HSA-1430728	Metabolism
R-HSA-1483249	Inositol phosphate metabolism
R-HSA-1483255	PI Metabolism
R-HSA-1483257	Phospholipid metabolism
R-HSA-556833	Metabolism of lipids

MSigDB gene sets: 153 (showing top): GOBP_LIPID_MODIFICATION, BROWNE_HCMV_INFECTION_4HR_UP, GOBP_PHOSPHOLIPID_METABOLIC_PROCESS, GOBP_PHOSPHATIDYLINOSITOL_METABOLIC_PROCESS, GCM_GSPT1, GOBP_PHOSPHOLIPID_DEPHOSPHORYLATION, GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS, GOBP_ORGANOPHOSPHATE_BIOSYNTHETIC_PROCESS, GOBP_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS, GOBP_GLYCEROLIPID_METABOLIC_PROCESS, FOSTER_TOLERANT_MACROPHAGE_UP, GOBP_GLYCEROLIPID_BIOSYNTHETIC_PROCESS, GCM_NUMA1, GOBP_GLYCEROPHOSPHOLIPID_METABOLIC_PROCESS, GOBP_PHOSPHATIDYLINOSITOL_DEPHOSPHORYLATION

GO Biological Process (6): protein dephosphorylation (GO:0006470), phosphatidylinositol biosynthetic process (GO:0006661), phosphatidylinositol dephosphorylation (GO:0046856), lipid metabolic process (GO:0006629), dephosphorylation (GO:0016311), phosphatidylinositol metabolic process (GO:0046488)

GO Molecular Function (8): phosphatidylinositol-3-phosphate phosphatase activity (GO:0004438), protein tyrosine phosphatase activity (GO:0004725), inositol bisphosphate phosphatase activity (GO:0016312), phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity (GO:0052629), phosphatidylinositol-3,5-bisphosphate phosphatase activity (GO:0106018), protein binding (GO:0005515), hydrolase activity (GO:0016787), phosphatidylinositol phosphate phosphatase activity (GO:0052866)

GO Cellular Component (4): cytoplasm (GO:0005737), cytosol (GO:0005829), endomembrane system (GO:0012505), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-5 pathways:

Category	Pathways
Metabolism	2
PI Metabolism	1
Inositol phosphate metabolism	1
Phospholipid metabolism	1
Metabolism of lipids	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	4
phosphatidylinositol metabolic process	2
dephosphorylation	1
protein modification process	1
biosynthetic process	1
phospholipid dephosphorylation	1
primary metabolic process	1
phosphate-containing compound metabolic process	1
phosphorus metabolic process	1
phosphatidylinositol monophosphate phosphatase activity	1
phosphoprotein phosphatase activity	1
inositol phosphate phosphatase activity	1
phosphatidylinositol-3,5-bisphosphate phosphatase activity	1
phosphatidylinositol bisphosphate phosphatase activity	1
binding	1
catalytic activity	1
phosphatase activity	1
intracellular anatomical structure	1
cytoplasm	1
vacuole	1
plasma membrane	1

Protein interactions and networks

STRING

1001 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MTMR7	FAM167A	Q96KS9	714
MTMR7	MTMR14	Q8NCE2	629
MTMR7	PIK3C3	Q8NEB9	490
MTMR7	ZMYM2	Q9UBW7	423
MTMR7	MRPL35	Q9NZE8	421
MTMR7	TPTE2	Q6XPS3	410
MTMR7	TPTE	P56180	401
MTMR7	MAMLD1	Q13495	390
MTMR7	OOSP1	A8MZH6	386
MTMR7	SBF1	O95248	380
MTMR7	ELP5	Q8TE02	377
MTMR7	BEAN1	Q3B7T3	343
MTMR7	FAM222A	Q5U5X8	342
MTMR7	SYNJ1	O43426	339
MTMR7	SYNJ2	O15056	336
MTMR7	CBLN3	Q6UW01	336

IntAct

24 interactions, top by confidence:

A	B	Type	Score
MTMR7	MTMR9	psi-mi:“MI:0915”(physical association)	0.940
MTMR9	MTMR7	psi-mi:“MI:0915”(physical association)	0.940
CCNH	MTMR7	psi-mi:“MI:0915”(physical association)	0.740
MTMR7	CCNH	psi-mi:“MI:0914”(association)	0.740
MTMR7	MTMR9	psi-mi:“MI:0915”(physical association)	0.370
MTMR9	APOD	psi-mi:“MI:0914”(association)	0.350
MTMR7	HNRNPC	psi-mi:“MI:0914”(association)	0.350
MTMR7	STXBP3	psi-mi:“MI:0914”(association)	0.350
MTMR9	DSP	psi-mi:“MI:0914”(association)	0.350
MTMR7	RALGAPA2	psi-mi:“MI:0914”(association)	0.350
MTMR7	CALML3	psi-mi:“MI:0914”(association)	0.350
MTMR7	MTMR9	psi-mi:“MI:0915”(physical association)	0.000
MTMR7	CCNH	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (93): MTMR9 (Two-hybrid), VIPAS39 (Affinity Capture-MS), CCNH (Affinity Capture-MS), MTMR9 (Affinity Capture-MS), STXBP3 (Affinity Capture-MS), VPS33B (Affinity Capture-MS), YEATS4 (Affinity Capture-MS), MTMR7 (Affinity Capture-MS), MTMR7 (Affinity Capture-MS), YEATS4 (Affinity Capture-MS), CYTH2 (Affinity Capture-MS), XRCC4 (Affinity Capture-MS), CAMSAP3 (Affinity Capture-MS), CDC42BPB (Affinity Capture-MS), CORO1B (Affinity Capture-MS)

ESM2 similar proteins: A0A0G2JXT6, A0JMF6, A0JMK5, A2ALK8, A2BGG1, A6QLT4, A7MB43, G5ED68, O13819, O14830, P26045, P33402, P51432, Q09M05, Q13496, Q13613, Q15111, Q3USB7, Q4KWH5, Q4R6N0, Q4U2V3, Q52KU6, Q5EB32, Q5F452, Q5R6F6, Q5R9S3, Q5U581, Q62688, Q6AXQ4, Q6NU08, Q6TEL0, Q6XPS3, Q7TPM9, Q7ZXF1, Q8K394, Q8NCE2, Q8VE11, Q8VEL2, Q96EF0, Q96MI9

Diamond homologs: A0A0G2JXT6, A0JMK5, A2BGG1, A4FU01, A6QLT2, A6QLT4, A7MB43, E9PXF8, F4J3T8, F4JWB3, G5ED68, O13819, P47147, Q13496, Q13613, Q13614, Q13615, Q22712, Q2KJ24, Q3V1L6, Q52KU6, Q54GQ1, Q55E58, Q5EB32, Q5F452, Q5PQT2, Q5R6F6, Q5R9S3, Q5REB9, Q5U581, Q5ZIV1, Q6AXQ4, Q6NTN5, Q6NU08, Q6TEL0, Q7TPM9, Q7ZXF1, Q80TA6, Q8K296, Q8VE11

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

151 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	136
Likely benign	5
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

3116 predictions. Top by Δscore:

Variant	Effect	Δscore
8:17302148:TCTTA:T	donor_loss	1.0000
8:17302149:CTTAC:C	donor_loss	1.0000
8:17302150:TTA:T	donor_loss	1.0000
8:17302151:TA:T	donor_loss	1.0000
8:17302152:A:AC	donor_gain	1.0000
8:17302152:ACTT:A	donor_gain	1.0000
8:17302153:C:CG	donor_gain	1.0000
8:17302153:CTT:C	donor_gain	1.0000
8:17302153:CTTC:C	donor_gain	1.0000
8:17302155:T:TA	donor_gain	1.0000
8:17302158:T:TA	donor_gain	1.0000
8:17302176:T:TA	donor_gain	1.0000
8:17302281:C:CC	acceptor_gain	1.0000
8:17304377:A:AC	donor_gain	1.0000
8:17304378:C:CC	donor_gain	1.0000
8:17304421:C:A	donor_gain	1.0000
8:17305750:CACTT:C	donor_loss	1.0000
8:17305751:ACTT:A	donor_loss	1.0000
8:17305753:TTACT:T	donor_loss	1.0000
8:17305754:TAC:T	donor_loss	1.0000
8:17305755:A:AC	donor_gain	1.0000
8:17305755:ACTT:A	donor_loss	1.0000
8:17305756:C:CG	donor_gain	1.0000
8:17305756:CT:C	donor_gain	1.0000
8:17305756:CTT:C	donor_gain	1.0000
8:17305756:CTTG:C	donor_gain	1.0000
8:17305756:CTTGA:C	donor_gain	1.0000
8:17305953:CATAT:C	acceptor_gain	1.0000
8:17305955:TAT:T	acceptor_gain	1.0000
8:17305957:TC:T	acceptor_loss	1.0000

AlphaMissense

4400 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
8:17309308:A:G	W374R	1.000
8:17309308:A:T	W374R	1.000
8:17311580:C:A	R344S	1.000
8:17311580:C:G	R344S	1.000
8:17311581:C:A	R344M	1.000
8:17311581:C:G	R344T	1.000
8:17311584:T:A	D343V	1.000
8:17311584:T:G	D343A	1.000
8:17311585:C:G	D343H	1.000
8:17311588:A:G	W342R	1.000
8:17311588:A:T	W342R	1.000
8:17311590:C:A	G341V	1.000
8:17311590:C:T	G341D	1.000
8:17311591:C:A	G341C	1.000
8:17311591:C:G	G341R	1.000
8:17311593:T:A	D340V	1.000
8:17311598:A:C	C338W	1.000
8:17311600:A:G	C338R	1.000
8:17313342:A:G	W309R	1.000
8:17313342:A:T	W309R	1.000
8:17331176:C:A	R280M	1.000
8:17331186:G:C	H277D	1.000
8:17331190:G:C	N275K	1.000
8:17331190:G:T	N275K	1.000
8:17331205:A:C	F270L	1.000
8:17331205:A:T	F270L	1.000
8:17331207:A:G	F270L	1.000
8:17331248:C:T	G256D	1.000
8:17331249:C:G	G256R	1.000
8:17331260:G:T	A252D	1.000

dbSNP variants (sampled 300 via entrez): RS1000017661 (8:17409318 G>C), RS1000027250 (8:17363785 C>G,T), RS1000031599 (8:17302096 G>A), RS1000033426 (8:17307212 A>G), RS1000055281 (8:17323477 C>T), RS1000063887 (8:17333761 A>C), RS1000111900 (8:17399144 A>AG), RS1000170259 (8:17345690 C>A), RS1000181221 (8:17330884 A>G), RS1000202500 (8:17378546 G>A), RS1000210122 (8:17337119 C>A), RS1000224113 (8:17298960 A>C), RS1000256827 (8:17382244 C>A,G,T), RS1000277331 (8:17413626 C>G,T), RS1000280909 (8:17350647 C>T)

Disease associations

OMIM: gene MIM:603562 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST001334_5	Creutzfeldt-Jakob disease (variant)	2.000000e-08
GCST004946_93	Schizophrenia	3.000000e-12

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

21 total (human), top 21 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	affects cotreatment, increases abundance, increases expression	2
Methotrexate	decreases expression	2
bisphenol A	affects methylation, affects cotreatment, decreases methylation	1
trichostatin A	increases expression	1
aflatoxin B2	increases methylation	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	increases reaction, affects binding	1
bisphenol S	decreases methylation	1
jinfukang	decreases expression	1
Fulvestrant	affects cotreatment, decreases methylation	1
Microplastics	affects cotreatment, increases abundance, increases expression	1
Atrazine	decreases expression	1
Benzo(a)pyrene	affects methylation, increases methylation	1
Cycloheximide	increases expression, affects cotreatment	1
Phthalic Acids	affects methylation	1
Polystyrenes	increases expression, affects cotreatment, increases abundance	1
Tetrachlorodibenzodioxin	affects cotreatment, increases expression	1
Thiram	increases expression	1
Tobacco Smoke Pollution	increases expression	1
Tretinoin	increases expression	1
Aflatoxin B1	increases methylation	1

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_SZ33	HAP1 MTMR7 (-) 1	Cancer cell line	Male
CVCL_SZ34	HAP1 MTMR7 (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.