MTPN

Summary

MTPN (myotrophin, HGNC:15667) is a protein-coding gene on chromosome 7q33, encoding Myotrophin (P58546). Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity.

The transcript produced from this gene is bi-cistronic and can encode both myotrophin and leucine zipper protein 6. The myotrophin protein is associated with cardiac hypertrophy, where it is involved in the conversion of NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers. This protein also has a potential function in cerebellar morphogenesis, and it may be involved in the differentiation of cerebellar neurons, particularly of granule cells. A cryptic ORF at the 3’ end of this transcript uses a novel internal ribosome entry site and a non-AUG translation initiation codon to produce leucine zipper protein 6, a 6.4 kDa tumor antigen that is associated with myeloproliferative disease.

Source: NCBI Gene 136319 — RefSeq curated summary.

At a glance

• GWAS associations: 6
• Clinical variants (ClinVar): 1 total
• Druggable target: yes
• MANE Select transcript: NM_145808

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15667
Approved symbol	MTPN
Name	myotrophin
Location	7q33
Locus type	gene with protein product
Status	Approved
Aliases	MYOTROPHIN, GCDP, V-1
Ensembl gene	ENSG00000105887
Ensembl biotype	protein_coding
OMIM	606484
Entrez	136319

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 protein_coding

ENST00000393085, ENST00000435723, ENST00000874999

RefSeq mRNA: 1 — MANE Select: NM_145808 NM_145808

CCDS: CCDS5842

Canonical transcript exons

ENST00000393085 — 4 exons

Exon	Start	End
ENSE00000725079	135950599	135950682
ENSE00000725085	135951517	135951630
ENSE00001514152	135926760	135930012
ENSE00001627701	135977029	135977359

Expression profiles

Bgee: expression breadth ubiquitous, 256 present calls, max score 99.58.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 104.2523 / max 872.8772, expressed in 1827 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
86379	104.2523	1827
204784	0.4978	185

Top tissues by expression

256 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cardiac muscle of right atrium	UBERON:0003379	99.58	gold quality
upper arm skin	UBERON:0004263	99.50	gold quality
ileal mucosa	UBERON:0000331	99.44	gold quality
left ventricle myocardium	UBERON:0006566	99.08	gold quality
superficial temporal artery	UBERON:0001614	99.00	gold quality
kidney epithelium	UBERON:0004819	98.99	gold quality
monocyte	CL:0000576	98.97	gold quality
lower lobe of lung	UBERON:0008949	98.95	gold quality
trabecular bone tissue	UBERON:0002483	98.93	gold quality
Brodmann (1909) area 46	UBERON:0006483	98.93	gold quality
tibialis anterior	UBERON:0001385	98.89	gold quality
leukocyte	CL:0000738	98.87	gold quality
esophagus squamous epithelium	UBERON:0006920	98.85	gold quality
postcentral gyrus	UBERON:0002581	98.77	gold quality
oral cavity	UBERON:0000167	98.73	gold quality
cartilage tissue	UBERON:0002418	98.66	gold quality
myocardium	UBERON:0002349	98.63	gold quality
parietal lobe	UBERON:0001872	98.62	gold quality
nasal cavity epithelium	UBERON:0005384	98.53	gold quality
trigeminal ganglion	UBERON:0001675	98.49	gold quality
oviduct epithelium	UBERON:0004804	98.47	gold quality
dorsal root ganglion	UBERON:0000044	98.45	gold quality
upper leg skin	UBERON:0004262	98.45	gold quality
parietal pleura	UBERON:0002400	98.44	gold quality
superior frontal gyrus	UBERON:0002661	98.44	gold quality
cortical plate	UBERON:0005343	98.41	gold quality
adult organism	UBERON:0007023	98.40	gold quality
pharyngeal mucosa	UBERON:0000355	98.39	gold quality
decidua	UBERON:0002450	98.36	gold quality
lateral nuclear group of thalamus	UBERON:0002736	98.36	gold quality

Single-cell (SCXA)

Detected in 5 experiment(s), a significant marker in 4.

Experiment	Marker?	Max mean expression
E-CURD-122	yes	21.19
E-MTAB-9221	yes	19.06
E-HCAD-13	yes	7.54
E-MTAB-7606	no	798.36
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

188 targeting MTPN, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-7110-3P	100.00	73.18	2486
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-9-5P	100.00	72.28	2361
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-520G-5P	99.99	66.76	658
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-3185	99.99	68.12	1959
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-4514	99.99	67.10	1870
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-223-3P	99.99	70.14	1140
HSA-MIR-511-3P	99.99	68.85	1467
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-507	99.97	70.11	1915
HSA-MIR-4666A-3P	99.96	71.71	3434

Literature-anchored findings (GeneRIF, showing 8)

• myotrophin/V-1 is a regulatory protein for modulating the levels of activated NFkappaB dimers. (PMID:11971907)
• a novel internal ribosome entry site-mediated mechanism may be responsible for the translation of unconventional self-Ag MPD6 in response to IFN-alpha stimulation. (PMID:16982933)
• T allele of rs17168525 in the 3’-UTR of myotrophin influence the level of myotrophin protein by interfering with let-7 binding.The T allele of MTPN rs17168525 is not associated with the left ventricular hypertrophy risk in essential hypertension patients. (PMID:26274321)
• In our findings 9cRA emerges has a hormone with a regulatory action on miR-375 that in most cases interfere with Mtpn expression. (PMID:28300567)
• V-1 and CARMIL induce changes in both proteins’ binding sites on the surface of capping proteins, along with a set of internal residues. (PMID:29847807)
• Lysyl oxidase suppresses the inflammatory response in anterior cruciate ligament fibroblasts and promotes tissue regeneration by targeting myotrophin via the nuclear factor-kappa B pathway. (PMID:32483895)
• Crystal structure of human V-1 in the apo form. (PMID:33439151)
• The ATO/miRNA-885-5p/MTPN axis induces reversal of drug-resistance in cholangiocarcinoma. (PMID:34170484)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	mtpn	ENSDARG00000104018
mus_musculus	Mtpn	ENSMUSG00000029840
rattus_norvegicus	Mtpn	ENSRNOG00000011857

Paralogs (1): ANKRD7 (ENSG00000106013)

Protein

Protein identifiers

Myotrophin — P58546 (reviewed: P58546)

Alternative names: Protein V-1

All UniProt accessions (3): P58546, C9JL85, Q69YG1

UniProt curated annotations — full annotation on UniProt →

Function. Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity. Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy.

Subunit / interactions. Interacts with RELA. Interacts with the heterodimer formed by CAPZA1 and CAPZB.

Subcellular location. Cytoplasm. Nucleus. Perinuclear region.

Tissue specificity. Ubiquitous.

Induction. Up-regulated in heart left ventricle of patients with severe coronary artery disease and history of myocardial ischemia. Up-regulated in heart left ventricle of patients with dilated cardiomyopathy.

Miscellaneous. This protein is produced by a bicistronic gene which also produces the MPD6 protein from a non-overlapping reading frame. MPD6 belongs to a group of cryptic antigens without conventional genomic structure. It is encoded by a cryptic open reading frame located in the 3’-untranslated region of MTPN.

Similarity. Belongs to the myotrophin family.

RefSeq proteins (1): NP_665807* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR002110	Ankyrin_rpt	Repeat
IPR036770	Ankyrin_rpt-contain_sf	Homologous_superfamily

Pfam: PF12796

UniProt features (19 total): helix 8, modified residue 5, repeat 3, initiator methionine 1, chain 1, turn 1

Structure

Experimental structures (PDB)

4 structures.

PDB	Method	Resolution (Å)
3AAA	X-RAY DIFFRACTION	2.2
7DF7	X-RAY DIFFRACTION	2.3
7DSB	X-RAY DIFFRACTION	2.44
7DSA	X-RAY DIFFRACTION	2.8

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P58546-F1	88.22	0.42

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (5): 2, 4, 11, 24, 31

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 235 (showing top): GOBP_NEGATIVE_REGULATION_OF_PROTEIN_CONTAINING_COMPLEX_ASSEMBLY, AAGCAAT_MIR137, HORIUCHI_WTAP_TARGETS_DN, GOBP_REGULATION_OF_PROTEIN_POLYMERIZATION, GOBP_MUSCLE_TISSUE_DEVELOPMENT, TGCGCANK_UNKNOWN, MODULE_151, CHUNG_BLISTER_CYTOTOXICITY_DN, GOBP_NEGATIVE_REGULATION_OF_PROTEIN_POLYMERIZATION, GOBP_BARBED_END_ACTIN_FILAMENT_CAPPING, GOBP_GROWTH, GOBP_NEGATIVE_REGULATION_OF_ACTIN_FILAMENT_DEPOLYMERIZATION, GOBP_NEUROGENESIS, ATGCAGT_MIR217, GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS

GO Biological Process (10): regulation of translation (GO:0006417), regulation of cell size (GO:0008361), positive regulation of macromolecule biosynthetic process (GO:0010557), positive regulation of cardiac muscle hypertrophy (GO:0010613), regulation of striated muscle tissue development (GO:0016202), neuron differentiation (GO:0030182), positive regulation of cell growth (GO:0030307), obsolete positive regulation of NF-kappaB transcription factor activity (GO:0051092), positive regulation of protein metabolic process (GO:0051247), regulation of barbed-end actin filament capping (GO:2000812)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (5): nucleus (GO:0005634), cytoplasm (GO:0005737), cytosol (GO:0005829), F-actin capping protein complex (GO:0008290), perinuclear region of cytoplasm (GO:0048471)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
regulation of protein metabolic process	2
positive regulation of macromolecule metabolic process	2
cytoplasm	2
translation	1
post-transcriptional regulation of gene expression	1
regulation of cellular component size	1
macromolecule biosynthetic process	1
positive regulation of biosynthetic process	1
regulation of macromolecule biosynthetic process	1
cardiac muscle hypertrophy	1
regulation of cardiac muscle hypertrophy	1
positive regulation of muscle hypertrophy	1
striated muscle tissue development	1
regulation of muscle organ development	1
regulation of muscle tissue development	1
cell differentiation	1
generation of neurons	1
regulation of cell growth	1
cell growth	1
positive regulation of growth	1
positive regulation of cellular process	1
protein metabolic process	1
regulation of actin filament polymerization	1
regulation of actin filament depolymerization	1
barbed-end actin filament capping	1
binding	1
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1
actin cytoskeleton	1
protein-containing complex	1

Protein interactions and networks

STRING

1621 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MTPN	LUZP6	Q538Z0	925
MTPN	TMOD4	Q9NZQ9	721
MTPN	CAPZA1	P52907	602
MTPN	CAPZA2	P47755	596
MTPN	CARMIL1	Q5VZK9	505
MTPN	TLR3	O15455	474
MTPN	TLR8	Q9NR97	463
MTPN	ONECUT2	O95948	457
MTPN	SYTL4	Q96C24	434
MTPN	NFKB1	P19838	426
MTPN	INS	P01308	405
MTPN	NFKBIA	P25963	402
MTPN	RPH3AL	Q9UNE2	397
MTPN	ZFP90	Q8TF47	386
MTPN	BDNF	P23560	377
MTPN	WWP1	Q9H0M0	377

IntAct

59 interactions, top by confidence:

A	B	Type	Score
CAPZA1	CAPZB	psi-mi:“MI:0407”(direct interaction)	0.750
CAPZA1	CAPZB	psi-mi:“MI:0915”(physical association)	0.750
CFTR	ESYT2	psi-mi:“MI:0914”(association)	0.710
MTPN	CAPZA2	psi-mi:“MI:0914”(association)	0.530
CFTR	PLEKHG3	psi-mi:“MI:0914”(association)	0.480
HIF1AN	MTPN	psi-mi:“MI:0210”(hydroxylation reaction)	0.440
MTPN	AKTIP	psi-mi:“MI:0915”(physical association)	0.370
OTUB1		psi-mi:“MI:0914”(association)	0.350
OTUB1	EPM2A	psi-mi:“MI:0914”(association)	0.350
KSR1	FBLL1	psi-mi:“MI:0914”(association)	0.350
ORF69	PEPD	psi-mi:“MI:0914”(association)	0.350
SOD1	NPEPPSL1	psi-mi:“MI:0914”(association)	0.350
ARHGAP35	CSTB	psi-mi:“MI:0914”(association)	0.350
ARHGAP11B	RPN1	psi-mi:“MI:0914”(association)	0.350
TRIM24	DDTL	psi-mi:“MI:0914”(association)	0.350
	SHTN1	psi-mi:“MI:0914”(association)	0.350
HTRA4	PSMD12	psi-mi:“MI:0914”(association)	0.350
MAP3K7	ACOT7	psi-mi:“MI:0914”(association)	0.350
GABARAPL2		psi-mi:“MI:0914”(association)	0.350
MAPT	SHTN1	psi-mi:“MI:0914”(association)	0.350
CAPZB	ENAH	psi-mi:“MI:0914”(association)	0.350
G3BP2	RPS3A	psi-mi:“MI:0914”(association)	0.350
MTPN	PLCG1	psi-mi:“MI:0914”(association)	0.350
VCP	SHTN1	psi-mi:“MI:0914”(association)	0.350
VCP	FAM171A2	psi-mi:“MI:0914”(association)	0.350

BioGRID (169): DPY30 (Co-fractionation), GARS (Co-fractionation), MTPN (Co-fractionation), NPLOC4 (Co-fractionation), PIP4K2A (Co-fractionation), PIP4K2C (Co-fractionation), UBA1 (Co-fractionation), MTPN (Proximity Label-MS), MTPN (Proximity Label-MS), MTPN (Proximity Label-MS), MTPN (Proximity Label-MS), MTPN (Proximity Label-MS), MTPN (Proximity Label-MS), MTPN (Proximity Label-MS), MTPN (Proximity Label-MS)

ESM2 similar proteins: B0S794, O15084, O75832, P0A2U4, P0A2U5, P31968, P50086, P58546, P62774, P62775, P77736, Q0V9D9, Q10311, Q3T0F7, Q4R3S3, Q505D1, Q54HW1, Q54KH3, Q55FM5, Q5EA33, Q5FWY3, Q5RCK5, Q5TYQ3, Q5VYY1, Q5ZJJ9, Q62422, Q66KY0, Q6P1S6, Q6P686, Q6TGW5, Q6XJU9, Q7T0Q1, Q7T2B9, Q7ZYG4, Q83N02, Q83NH7, Q863Z4, Q8MJ49, Q8MJ50, Q8VE42

Diamond homologs: P58546, P62774, P62775, Q3T0F7, Q6P1S6, Q7T0Q1, Q7T2B9, Q863Z4, Q91955, O95271, Q3UES3, Q55FM5, Q6PFX9, Q8VD46, Q93650, Q9H2K2, Q9VBP3, Q54BA2

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 72 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Signaling by BRAF and RAF1 fusions	5	17.4×	2e-03
Loss of Nlp from mitotic centrosomes	5	16.2×	2e-03
Loss of proteins required for interphase microtubule organization from the centrosome	5	16.2×	2e-03
AURKA Activation by TPX2	5	15.5×	2e-03
Recruitment of mitotic centrosome proteins and complexes	5	13.9×	3e-03
Regulation of PLK1 Activity at G2/M Transition	5	12.9×	3e-03
Recruitment of NuMA to mitotic centrosomes	5	11.9×	4e-03
Anchoring of the basal body to the plasma membrane	5	11.5×	4e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

1 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	1
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

600 predictions. Top by Δscore:

Variant	Effect	Δscore
7:135930008:GCACC:G	acceptor_gain	1.0000
7:135930009:CACC:C	acceptor_gain	1.0000
7:135930009:CACCC:C	acceptor_gain	1.0000
7:135930010:ACC:A	acceptor_gain	1.0000
7:135930011:CC:C	acceptor_gain	1.0000
7:135930011:CCC:C	acceptor_gain	1.0000
7:135930012:CC:C	acceptor_gain	1.0000
7:135930013:C:CC	acceptor_gain	1.0000
7:135930013:C:CG	acceptor_loss	1.0000
7:135930013:C:T	acceptor_gain	1.0000
7:135930014:T:A	acceptor_loss	1.0000
7:135950680:AGCCT:A	acceptor_gain	1.0000
7:135950682:CC:C	acceptor_loss	1.0000
7:135950682:CCTA:C	acceptor_gain	1.0000
7:135950683:C:A	acceptor_loss	1.0000
7:135950684:T:G	acceptor_loss	1.0000
7:135951505:T:TA	donor_gain	1.0000
7:135951512:CGTA:C	donor_gain	1.0000
7:135951513:GTA:G	donor_loss	1.0000
7:135951514:TACAT:T	donor_loss	1.0000
7:135951515:A:AC	donor_gain	1.0000
7:135951516:C:CA	donor_gain	1.0000
7:135951516:CA:C	donor_gain	1.0000
7:135951516:CAT:C	donor_gain	1.0000
7:135951516:CATT:C	donor_gain	1.0000
7:135951516:CATTA:C	donor_gain	1.0000
7:135951627:CTCC:C	acceptor_gain	1.0000
7:135951629:CC:C	acceptor_gain	1.0000
7:135951630:CCTGA:C	acceptor_gain	1.0000
7:135951631:C:CC	acceptor_gain	1.0000

AlphaMissense

764 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
7:135950609:A:G	L87P	0.985
7:135950646:C:G	A75P	0.983
7:135950606:A:G	L88P	0.980
7:135951542:A:G	L54P	0.980
7:135951576:C:G	A43P	0.978
7:135950645:G:T	A75D	0.977
7:135951539:A:G	L55P	0.975
7:135950675:T:A	D65V	0.973
7:135950609:A:T	L87H	0.972
7:135929964:C:G	A107P	0.971
7:135950642:A:T	V76D	0.970
7:135951578:G:T	A42E	0.968
7:135950651:A:G	L73P	0.967
7:135950676:C:G	D65H	0.967
7:135951544:A:C	F53L	0.967
7:135951544:A:T	F53L	0.967
7:135951546:A:G	F53L	0.967
7:135951595:C:A	R36S	0.967
7:135951595:C:G	R36S	0.967
7:135977072:A:G	L10P	0.967
7:135950654:A:G	L72P	0.966
7:135950654:A:T	L72H	0.965
7:135950657:G:T	P71H	0.964
7:135950620:A:C	C83W	0.963
7:135977084:A:G	F6S	0.962
7:135950676:C:A	D65Y	0.961
7:135929933:A:G	L117P	0.960
7:135930009:C:G	A92P	0.960
7:135951575:G:T	A43E	0.959
7:135950649:A:G	S74P	0.956

dbSNP variants (sampled 300 via entrez): RS1000031670 (7:135977455 G>GTGCGCA), RS1000104844 (7:135977363 G>A,C), RS1000132480 (7:135964943 A>G), RS1000209192 (7:135960240 A>G), RS1000230659 (7:135971935 G>A), RS1000242953 (7:135958473 T>C), RS1000254504 (7:135965390 A>G), RS1000255845 (7:135952128 C>T), RS1000334399 (7:135964905 A>T), RS1000385848 (7:135952440 T>C), RS1000395179 (7:135977479 G>A,T), RS1000436545 (7:135958381 A>G), RS1000495128 (7:135960205 C>T), RS1000710150 (7:135966274 C>T), RS1000770163 (7:135959441 G>A)

Disease associations

OMIM: gene MIM:606484 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

6 associations (top):

Study	Trait	p-value
GCST004068_1	Venous thromboembolism adjusted for sickle cell variant rs77121243-T	9.000000e-06
GCST004603_73	Platelet count	6.000000e-09
GCST004616_192	Platelet distribution width	4.000000e-12
GCST004860_4	Alcoholic chronic pancreatitis	6.000000e-06
GCST90002395_704	Mean platelet volume	3.000000e-10
GCST90002401_495	Platelet distribution width	2.000000e-23

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004309	platelet count
EFO:0007984	platelet component distribution width

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6067232 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

21 total (human), top 21 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Tobacco Smoke Pollution	affects expression, increases expression	2
FR900359	increases phosphorylation	1
triphenyl phosphate	affects expression	1
bisphenol A	increases expression	1
decabromobiphenyl ether	increases expression	1
sodium arsenite	increases expression	1
chloropicrin	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
ICG 001	increases expression	1
LDN 193189	affects cotreatment, increases expression	1
bisphenol AF	increases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1
Resveratrol	decreases expression	1
Temozolomide	decreases expression	1
Doxorubicin	increases expression	1
Endosulfan	decreases expression	1
Enzyme Inhibitors	increases O-linked glycosylation, decreases activity	1
Tretinoin	increases expression	1
Valproic Acid	decreases methylation	1
Okadaic Acid	increases expression	1
Copper Sulfate	increases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5651840	Binding	Binding affinity to human MTPN incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.