MTUS2

Summary

MTUS2 (microtubule associated scaffold protein 2, HGNC:20595) is a protein-coding gene on chromosome 13q12.3, encoding Microtubule-associated tumor suppressor candidate 2 (Q5JR59). Binds microtubules.

Enables microtubule binding activity and protein homodimerization activity. Located in centrosome; cytoplasmic microtubule; and intercellular bridge. Part of nucleus.

Source: NCBI Gene 23281 — RefSeq curated summary.

At a glance

• GWAS associations: 6
• Clinical variants (ClinVar): 88 total — 1 likely-pathogenic
• MANE Select transcript: NM_001033602

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:20595
Approved symbol	MTUS2
Name	microtubule associated scaffold protein 2
Location	13q12.3
Locus type	gene with protein product
Status	Approved
Aliases	TIP150, CAZIP, ICIS
Ensembl gene	ENSG00000132938
Ensembl biotype	protein_coding
OMIM	619358
Entrez	23281

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 4 protein_coding, 2 protein_coding_CDS_not_defined, 1 retained_intron

ENST00000255289, ENST00000380808, ENST00000400542, ENST00000467990, ENST00000542829, ENST00000612955, ENST00000948542

RefSeq mRNA: 6 — MANE Select: NM_001033602 NM_001033602, NM_001366650, NM_001366651, NM_001384605, NM_001384606, NM_015233

CCDS: CCDS41874, CCDS45022

Canonical transcript exons

ENST00000612955 — 16 exons

Exon	Start	End
ENSE00000906642	29033885	29034125
ENSE00001132221	29492646	29492719
ENSE00001132224	29487900	29488005
ENSE00001132234	29439983	29440049
ENSE00001132241	29359262	29359473
ENSE00001132250	29324613	29324711
ENSE00001132257	29281704	29281865
ENSE00003481621	29480150	29480364
ENSE00003504164	29501097	29501194
ENSE00003509890	29497238	29497336
ENSE00003544958	29100773	29100970
ENSE00003554653	29498418	29498537
ENSE00003720590	29024457	29026903
ENSE00003730700	28820339	28820611
ENSE00003739288	28839778	28839850
ENSE00003739860	29502993	29505947

Expression profiles

Bgee: expression breadth ubiquitous, 194 present calls, max score 94.68.

FANTOM5 (CAGE): breadth broad, TPM avg 1.6785 / max 184.7703, expressed in 313 samples.

FANTOM5 promoters (12 alternative TSS)

Promoter ID	TPM avg	Samples expressed
134587	0.6598	159
134594	0.2826	113
134588	0.2195	70
134586	0.1515	71
134595	0.1489	49
134598	0.0835	27
206990	0.0378	10
134590	0.0362	20
134596	0.0190	9
134597	0.0188	10

Top tissues by expression

280 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
heart right ventricle	UBERON:0002080	94.68	gold quality
left ventricle myocardium	UBERON:0006566	94.03	gold quality
myocardium	UBERON:0002349	92.49	gold quality
cardiac ventricle	UBERON:0002082	91.65	gold quality
apex of heart	UBERON:0002098	91.58	gold quality
heart left ventricle	UBERON:0002084	91.56	gold quality
cardiac muscle of right atrium	UBERON:0003379	90.60	gold quality
cardiac atrium	UBERON:0002081	89.64	gold quality
right atrium auricular region	UBERON:0006631	89.32	gold quality
heart	UBERON:0000948	89.00	gold quality
Brodmann (1909) area 23	UBERON:0013554	85.45	gold quality
ascending aorta	UBERON:0001496	85.16	gold quality
thoracic aorta	UBERON:0001515	85.04	gold quality
primary visual cortex	UBERON:0002436	84.25	gold quality
descending thoracic aorta	UBERON:0002345	84.08	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.00	gold quality
body of pancreas	UBERON:0001150	82.79	gold quality
cortical plate	UBERON:0005343	82.13	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.50	gold quality
middle temporal gyrus	UBERON:0002771	80.67	gold quality
pancreas	UBERON:0001264	80.32	gold quality
occipital lobe	UBERON:0002021	79.85	gold quality
buccal mucosa cell	CL:0002336	79.63	silver quality
islet of Langerhans	UBERON:0000006	78.64	gold quality
lateral nuclear group of thalamus	UBERON:0002736	78.17	gold quality
secondary oocyte	CL:0000655	77.08	gold quality
right hemisphere of cerebellum	UBERON:0014890	76.35	gold quality
right frontal lobe	UBERON:0002810	76.30	gold quality
pituitary gland	UBERON:0000007	76.24	gold quality
cerebellar cortex	UBERON:0002129	76.05	gold quality

Single-cell (SCXA)

Detected in 5 experiment(s), a significant marker in 4.

Experiment	Marker?	Max mean expression
E-HCAD-35	yes	1413.18
E-MTAB-5061	yes	15.22
E-GEOD-83139	yes	8.91
E-ANND-3	yes	5.70
E-ENAD-27	no	129.93

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

102 targeting MTUS2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-150-5P	99.99	66.69	1976
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-4482-3P	99.98	72.50	3147
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-495-3P	99.96	72.81	4197
HSA-MIR-6721-5P	99.93	68.92	2981
HSA-MIR-4778-3P	99.93	70.40	1818
HSA-MIR-5680	99.91	69.83	3421
HSA-MIR-589-3P	99.91	69.62	2088
HSA-MIR-6499-3P	99.90	66.38	1212
HSA-MIR-6783-3P	99.89	67.92	2059
HSA-MIR-1343-3P	99.89	66.78	1815
HSA-MIR-137-3P	99.87	74.74	2401
HSA-MIR-7978	99.86	66.90	856
HSA-MIR-5582-3P	99.86	72.48	4221
HSA-MIR-383-3P	99.85	65.84	1359
HSA-MIR-548AR-3P	99.85	71.26	3889
HSA-MIR-4447	99.85	67.81	2900
HSA-MIR-5010-3P	99.83	70.60	2357
HSA-MIR-548AZ-3P	99.82	70.56	3549
HSA-MIR-548BC	99.82	70.61	3524
HSA-MIR-548E-3P	99.82	70.59	3514
HSA-MIR-548F-3P	99.82	70.59	3540
HSA-MIR-4659A-3P	99.80	72.62	4248
HSA-MIR-4659B-3P	99.80	72.62	4248
HSA-MIR-34B-5P	99.78	67.56	1175

Literature-anchored findings (GeneRIF, showing 6)

• TIP150 facilitates the EB1-dependent loading of MCAK onto MT plus ends and orchestrates the dynamics at the plus end of MTs. (PMID:19543227)
• These results suggest a role for CAZIP in development and function of the heart and nervous system in vertebrates. (PMID:19806667)
• TIP150-EB1 interaction governs kinetochore microtubule plus-end plasticity and establish that the temporal control of the TIP150-EB1 interaction by PCAF acetylation ensures chromosome stability in mitosis. (PMID:23595990)
• A dynamic interaction of MCAK-TIP150 orchestrated by Aurora A-mediated phosphorylation governs entosis via regulating microtubule plus-end dynamics and cell rigidity. (PMID:24847103)
• a dynamic TIP150-cortactin interaction orchestrates directional cell migration via coupling dynamic microtubule plus ends to the cortical cytoskeleton. (PMID:27451391)
• Whole genome-wide sequence analysis of long-lived families (Long-Life Family Study) identifies MTUS2 gene associated with late-onset Alzheimer’s disease. (PMID:38380866)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	mtus2a	ENSDARG00000062347
danio_rerio		ENSDARG00000074984
mus_musculus	Mtus2	ENSMUSG00000029651
rattus_norvegicus	Mtus2	ENSRNOG00000032410

Paralogs (2): MTUS1 (ENSG00000129422), CCDC69 (ENSG00000198624)

Protein

Protein identifiers

Microtubule-associated tumor suppressor candidate 2 — Q5JR59 (reviewed: Q5JR59)

Alternative names: Cardiac zipper protein, Microtubule plus-end tracking protein TIP150

All UniProt accessions (1): Q5JR59

UniProt curated annotations — full annotation on UniProt →

Function. Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip.

Subunit / interactions. Homodimer. Interacts with KIF2C and MAPRE1; the interaction is direct and probably targets MTUS2 and KIF2C to microtubules.

Subcellular location. Cytoplasm. Cytoskeleton.

Tissue specificity. Detected in embryonic stem cells differentiating to cardiomyocytes.

Similarity. In the C-terminal section; belongs to the MTUS1 family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q5JR59-2	1	yes
Q5JR59-3	2
Q5JR59-4	3

RefSeq proteins (6): NP_001028774, NP_001353579, NP_001353580, NP_001371534, NP_001371535, NP_056048 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR051293	MTUS1/CCDC69	Family

UniProt features (24 total): region of interest 10, compositionally biased region 6, splice variant 3, sequence variant 2, chain 1, coiled-coil region 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q5JR59-F1	52.20	0.21

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 90 (showing top): YAGI_AML_WITH_INV_16_TRANSLOCATION, GAUSSMANN_MLL_AF4_FUSION_TARGETS_E_UP, GOCC_MICROTUBULE_ORGANIZING_CENTER, GOCC_CENTROSOME, GOCC_INTERCELLULAR_BRIDGE, GOCC_CYTOPLASMIC_MICROTUBULE, GOMF_PROTEIN_DIMERIZATION_ACTIVITY, GOMF_PROTEIN_HOMODIMERIZATION_ACTIVITY, GOMF_CYTOSKELETAL_PROTEIN_BINDING, MEISSNER_NPC_HCP_WITH_H3K4ME2, GOCC_SUPRAMOLECULAR_COMPLEX, GOCC_POLYMERIC_CYTOSKELETAL_FIBER, ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY, PTEN_DN.V1_DN, GSE5503_MLN_DC_VS_SPLEEN_DC_ACTIVATED_ALLOGENIC_TCELL_UP

GO Biological Process (0):

GO Molecular Function (3): microtubule binding (GO:0008017), protein homodimerization activity (GO:0042803), protein binding (GO:0005515)

GO Cellular Component (8): nucleus (GO:0005634), microtubule (GO:0005874), microtubule cytoskeleton (GO:0015630), intercellular bridge (GO:0045171), cytoplasm (GO:0005737), centrosome (GO:0005813), cytoskeleton (GO:0005856), cytoplasmic microtubule (GO:0005881)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
tubulin binding	1
identical protein binding	1
protein dimerization activity	1
binding	1
intracellular membrane-bounded organelle	1
microtubule cytoskeleton	1
polymeric cytoskeletal fiber	1
cytoskeleton	1
intracellular anatomical structure	1
centriole	1
microtubule organizing center	1
intracellular membraneless organelle	1
cytoplasm	1
microtubule	1

Protein interactions and networks

STRING

2121 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MTUS2	CTLA4	P16410	926
MTUS2	CD274	Q9NZQ7	909
MTUS2	PDCD1	Q15116	884
MTUS2	HAVCR2	Q8TDQ0	817
MTUS2	CD4	P01730	803
MTUS2	TIGIT	Q495A1	784
MTUS2	CD8A	P01732	782
MTUS2	LAG3	P18627	728
MTUS2	PDCD1LG2	Q9BQ51	720
MTUS2	EGFR	P00533	713
MTUS2	ALK	Q9UM73	699
MTUS2	BRAF	P15056	626
MTUS2	IFNG	P01579	624
MTUS2	IDO1	P14902	621
MTUS2	KIF2C	Q99661	596

IntAct

572 interactions, top by confidence:

A	B	Type	Score
PSMA1	MTUS2	psi-mi:“MI:0915”(physical association)	0.760
MTUS2	PSMA1	psi-mi:“MI:0915”(physical association)	0.760
MTUS2	PLSCR4	psi-mi:“MI:0915”(physical association)	0.740
MTUS2	ZNF490	psi-mi:“MI:0915”(physical association)	0.740
ZNF785	MTUS2	psi-mi:“MI:0915”(physical association)	0.670
FCHSD2	MTUS2	psi-mi:“MI:0915”(physical association)	0.670
MTUS2	SLC25A6	psi-mi:“MI:0915”(physical association)	0.670
ZNF136	MTUS2	psi-mi:“MI:0915”(physical association)	0.670
MTUS2	ODF1	psi-mi:“MI:0915”(physical association)	0.670
MTUS2	TSGA10IP	psi-mi:“MI:0915”(physical association)	0.670
ZC2HC1C	MTUS2	psi-mi:“MI:0915”(physical association)	0.670
MTUS2	CCDC60	psi-mi:“MI:0915”(physical association)	0.670
MTUS2	CCDC116	psi-mi:“MI:0915”(physical association)	0.670
MTUS2	ZNF439	psi-mi:“MI:0915”(physical association)	0.670
MTUS2	C1orf216	psi-mi:“MI:0915”(physical association)	0.670
MTUS2	LNX1	psi-mi:“MI:0915”(physical association)	0.670
RHPN1	MTUS2	psi-mi:“MI:0915”(physical association)	0.670
MTUS2	PKP2	psi-mi:“MI:0915”(physical association)	0.670
MTUS2	ZNF581	psi-mi:“MI:0915”(physical association)	0.670
MTUS2	NDOR1	psi-mi:“MI:0915”(physical association)	0.670
DCTN4	MTUS2	psi-mi:“MI:0915”(physical association)	0.670
SPG7	MTUS2	psi-mi:“MI:0915”(physical association)	0.670
MTUS2	FCHSD2	psi-mi:“MI:0915”(physical association)	0.670
MTUS2	TSHZ3	psi-mi:“MI:0915”(physical association)	0.560
TRIM42	MTUS2	psi-mi:“MI:0915”(physical association)	0.560
MTUS2	ZNF572	psi-mi:“MI:0915”(physical association)	0.560
DCDC2B	MTUS2	psi-mi:“MI:0915”(physical association)	0.560
GTPBP10	MTUS2	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (513): MTUS2 (Two-hybrid), MTUS2 (Two-hybrid), MTUS2 (Two-hybrid), MTUS2 (Two-hybrid), MTUS2 (Two-hybrid), MTUS2 (Two-hybrid), MTUS2 (Two-hybrid), MTUS2 (Two-hybrid), MTUS2 (Two-hybrid), MTUS2 (Two-hybrid), MTUS2 (Two-hybrid), MTUS2 (Two-hybrid), MTUS2 (Two-hybrid), MTUS2 (Two-hybrid), MTUS2 (Two-hybrid)

ESM2 similar proteins: A2A995, A2ALU4, A4IGN8, A6NMK8, D3ZUI5, E1C2Q8, F1QGH6, O54931, O75128, O75363, O75410, O95425, P24275, P24588, P51827, Q1LWM5, Q1RMS0, Q1W617, Q3UHI0, Q3UMF0, Q3ZB98, Q499V8, Q53SF7, Q5JR59, Q5NBX1, Q5VWT5, Q5ZJ26, Q62394, Q66KC9, Q673G8, Q69ZL1, Q6GQV1, Q6INC4, Q6QZN6, Q6WKZ4, Q6Y685, Q7TP36, Q7TS75, Q80YN3, Q8BI29

Diamond homologs: A0JMQ7, A6NI79, A6QNP9, A7MC22, Q08AV7, Q0IHN7, Q17QT2, Q3TCJ8, Q3UHD3, Q5HZI1, Q5JR59, Q5R9I1, Q6DCD4, Q6IMY1, Q7SZL5, Q9ULD2

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 149 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Regulation of TP53 Activity through Phosphorylation	7	9.5×	2e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

88 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	1
Uncertain significance	67
Likely benign	4
Benign	4

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
979362	GRCh37/hg19 13q12.12-12.3(chr13:23775339-30534624)x3	Likely pathogenic

SpliceAI

1775 predictions. Top by Δscore:

Variant	Effect	Δscore
13:29492640:TTCCA:T	acceptor_loss	1.0000
13:29492641:TCCAG:T	acceptor_loss	1.0000
13:29492642:CCA:C	acceptor_loss	1.0000
13:29492643:CAGAA:C	acceptor_loss	1.0000
13:29492644:A:AG	acceptor_gain	1.0000
13:29492644:A:T	acceptor_loss	1.0000
13:29492645:G:GC	acceptor_loss	1.0000
13:29492645:G:GG	acceptor_gain	1.0000
13:29492645:GA:G	acceptor_gain	1.0000
13:29492645:GAAT:G	acceptor_gain	1.0000
13:29492645:GAATT:G	acceptor_gain	1.0000
13:29492716:GCAG:G	donor_gain	1.0000
13:29492718:AGGT:A	donor_loss	1.0000
13:29492719:GGT:G	donor_loss	1.0000
13:29492720:G:C	donor_loss	1.0000
13:29492721:T:A	donor_loss	1.0000
13:29497312:G:GT	donor_gain	1.0000
13:29497334:G:GT	donor_gain	1.0000
13:29497371:G:GT	donor_gain	1.0000
13:29497449:G:GT	donor_gain	1.0000
13:29497526:GCT:G	donor_gain	1.0000
13:29497543:C:G	donor_gain	1.0000
13:29501092:T:TA	acceptor_gain	1.0000
13:29501095:A:AG	acceptor_gain	1.0000
13:29501095:AG:A	acceptor_gain	1.0000
13:29501096:G:A	acceptor_loss	1.0000
13:29501096:G:GT	acceptor_gain	1.0000
13:29501096:GG:G	acceptor_gain	1.0000
13:29501096:GGC:G	acceptor_gain	1.0000
13:29501096:GGCA:G	acceptor_gain	1.0000

AlphaMissense

8960 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
13:29026629:T:C	I644T	0.999
13:29026629:T:G	I644S	0.999
13:29026632:T:A	I645N	0.999
13:29497254:T:C	L1199P	0.999
13:29501158:T:C	L1287P	0.999
13:29502998:T:C	L1301P	0.999
13:29503019:T:C	L1308P	0.999
13:29503082:T:C	L1329P	0.999
13:29026632:T:C	I645T	0.998
13:29026632:T:G	I645S	0.998
13:29492703:T:C	L1188P	0.998
13:29492706:G:C	R1189P	0.998
13:29492709:T:C	L1190P	0.998
13:29497242:A:C	Q1195P	0.998
13:29497286:G:C	A1210P	0.998
13:29497304:G:C	A1216P	0.998
13:29498464:T:C	L1242P	0.998
13:29501137:T:C	L1280P	0.998
13:29503012:G:C	A1306P	0.998
13:29503061:T:C	L1322S	0.998
13:29503067:G:C	R1324P	0.998
13:29026621:G:C	R641S	0.997
13:29026621:G:T	R641S	0.997
13:29026644:G:C	R649T	0.997
13:29026644:G:T	R649M	0.997
13:29026645:G:C	R649S	0.997
13:29026645:G:T	R649S	0.997
13:29492718:A:C	Q1193P	0.997
13:29497275:T:C	L1206P	0.997
13:29497295:T:C	F1213L	0.997

dbSNP variants (sampled 300 via entrez): RS1000000306 (13:29280743 G>A), RS1000000488 (13:29006246 T>C), RS1000004691 (13:29000776 C>T), RS1000008285 (13:29124870 G>A), RS1000008877 (13:29053276 C>T), RS1000009060 (13:28965113 A>G), RS1000015001 (13:29368953 T>C), RS1000016991 (13:29242210 C>G,T), RS1000024531 (13:29497306 C>T), RS1000044602 (13:28839082 A>G), RS1000045832 (13:29004734 C>G), RS1000049565 (13:29241990 C>T), RS1000058268 (13:29320510 G>A), RS1000062772 (13:29053512 A>G), RS1000064625 (13:29286798 C>T)

Disease associations

OMIM: gene MIM:619358 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

6 associations (top):

Study	Trait	p-value
GCST000523_3	Methotrexate pharmacokinetics (acute lymphoblastic leukemia)	6.000000e-06
GCST001586_6	Insomnia (caffeine-induced)	4.000000e-06
GCST001762_818	Obesity-related traits	8.000000e-06
GCST003008_8	Triptolide cytotoxicity	7.000000e-06
GCST011743_54	HDL cholesterol levels in HIV infection	3.000000e-06
GCST012100_3	Hypertrophic cardiomyopathy (sarcomere positive)	2.000000e-08

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0007876	insomnia measurement
EFO:0005134	amino acid measurement
EFO:0006952	cytotoxicity measurement
EFO:0004612	high density lipoprotein cholesterol measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

23 total (human), top 23 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression, increases methylation	6
sodium arsenite	affects methylation, decreases expression, increases expression	3
Cadmium	increases abundance, increases expression, decreases expression	2
bisphenol A	affects cotreatment, decreases methylation, affects methylation	1
N-acetyl-4-benzoquinoneimine	affects response to substance	1
aflatoxin B2	increases methylation	1
entinostat	decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
dorsomorphin	affects cotreatment, increases expression	1
(+)-JQ1 compound	increases expression	1
Resveratrol	decreases expression, affects cotreatment	1
Fulvestrant	affects cotreatment, decreases methylation	1
Arsenic	affects methylation	1
Benzo(a)pyrene	affects methylation, decreases methylation	1
Copper	affects cotreatment, decreases expression	1
Diethylhexyl Phthalate	decreases expression	1
Silicon Dioxide	decreases expression	1
Dihydrotestosterone	increases expression	1
Thiram	increases expression	1
Tobacco Smoke Pollution	decreases expression	1
Triclosan	decreases expression	1
Cyclosporine	increases methylation	1
Cadmium Chloride	increases abundance, increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.