MUC5B-AS1

Summary

MUC5B-AS1 (MUC5B antisense RNA 1, HGNC:53936) is a long non-coding RNA gene on chromosome 11p15.5.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53936
Approved symbol	MUC5B-AS1
Name	MUC5B antisense RNA 1
Location	11p15.5
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000255177
Ensembl biotype	lncRNA
Entrez	112577518
RNAcentral	URS00000E9EFC — lncRNA, 434 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000532061

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000532061 — 2 exons

Exon	Start	End
ENSE00002159314	1249621	1249676
ENSE00002164645	1242261	1242638

Expression profiles

Bgee: expression breadth broad, 85 present calls, max score 81.87.

Top tissues by expression

85 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	81.87	gold quality
gall bladder	UBERON:0002110	80.48	gold quality
tonsil	UBERON:0002372	74.03	gold quality
uterine cervix	UBERON:0000002	66.95	silver quality
stomach	UBERON:0000945	65.38	gold quality
liver	UBERON:0002107	62.90	gold quality
rectum	UBERON:0001052	62.12	gold quality
lymph node	UBERON:0000029	61.89	gold quality
pancreas	UBERON:0001264	61.66	gold quality
islet of Langerhans	UBERON:0000006	61.08	gold quality
sural nerve	UBERON:0015488	60.97	gold quality
skeletal muscle tissue	UBERON:0001134	58.66	gold quality
cortex of kidney	UBERON:0001225	58.66	gold quality
smooth muscle tissue	UBERON:0001135	58.56	gold quality
vermiform appendix	UBERON:0001154	57.90	gold quality
ovary	UBERON:0000992	56.31	gold quality
bone marrow	UBERON:0002371	54.62	gold quality
muscle of leg	UBERON:0001383	52.21	gold quality
blood	UBERON:0000178	52.19	silver quality
intestine	UBERON:0000160	51.88	gold quality
colon	UBERON:0001155	51.42	gold quality
primary visual cortex	UBERON:0002436	50.47	gold quality
prefrontal cortex	UBERON:0000451	49.55	gold quality
thoracic mammary gland	UBERON:0005200	49.54	silver quality
gastrocnemius	UBERON:0001388	49.46	gold quality
multicellular organism	UBERON:0000468	49.45	gold quality
superior frontal gyrus	UBERON:0002661	48.97	gold quality
lung	UBERON:0002048	48.60	gold quality
myometrium	UBERON:0001296	48.14	silver quality
esophagus	UBERON:0001043	47.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• findings highlight MUC5B-AS1 functions as an oncogenic lncRNA in tumor metastasis and implicate MUC5B-AS1 as an attractive candidate target for lung adenocarcinoma treatment. (PMID:29670111)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.