MVB12A

Summary

MVB12A (multivesicular body subunit 12A, HGNC:25153) is a protein-coding gene on chromosome 19p13.11, encoding Multivesicular body subunit 12A (Q96EY5). Component of the ESCRT-I complex, a regulator of vesicular trafficking process.

Enables lipid binding activity and ubiquitin binding activity. Involved in regulation of epidermal growth factor receptor signaling pathway. Located in several cellular components, including centrosome; cytosol; and vesicle. Part of ESCRT I complex.

Source: NCBI Gene 93343 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 54 total
• MANE Select transcript: NM_138401

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25153
Approved symbol	MVB12A
Name	multivesicular body subunit 12A
Location	19p13.11
Locus type	gene with protein product
Status	Approved
Aliases	FLJ32495
Ensembl gene	ENSG00000141971
Ensembl biotype	protein_coding
Entrez	93343

Gene structure

Transcript identifiers

Ensembl transcripts: 16 — 10 protein_coding, 4 retained_intron, 2 protein_coding_CDS_not_defined

ENST00000317040, ENST00000524382, ENST00000526234, ENST00000528515, ENST00000528604, ENST00000528659, ENST00000528732, ENST00000528911, ENST00000528997, ENST00000529490, ENST00000529939, ENST00000594784, ENST00000600514, ENST00000875213, ENST00000875214, ENST00000919685

RefSeq mRNA: 2 — MANE Select: NM_138401 NM_001304547, NM_138401

CCDS: CCDS12359

Canonical transcript exons

ENST00000317040 — 9 exons

Exon	Start	End
ENSE00001256513	17422332	17422458
ENSE00002195423	17420047	17420225
ENSE00003070501	17424931	17425332
ENSE00003471511	17423498	17423617
ENSE00003585650	17424006	17424067
ENSE00003601886	17424621	17424677
ENSE00003615114	17420313	17420411
ENSE00003619294	17420538	17420634
ENSE00003787260	17423693	17423799

Expression profiles

Bgee: expression breadth ubiquitous, 208 present calls, max score 95.57.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 27.8641 / max 183.9830, expressed in 1809 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
174514	15.9954	1797
174515	11.8687	1771
174508	0.9785	429
174512	0.0802	20

Top tissues by expression

241 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right ovary	UBERON:0002118	95.57	gold quality
left ovary	UBERON:0002119	95.33	gold quality
right adrenal gland	UBERON:0001233	95.10	gold quality
lower esophagus mucosa	UBERON:0035834	95.01	gold quality
left adrenal gland cortex	UBERON:0035825	94.78	gold quality
left adrenal gland	UBERON:0001234	94.69	gold quality
right adrenal gland cortex	UBERON:0035827	94.60	gold quality
mucosa of transverse colon	UBERON:0004991	94.16	gold quality
right lobe of thyroid gland	UBERON:0001119	94.02	gold quality
right uterine tube	UBERON:0001302	93.79	gold quality
left lobe of thyroid gland	UBERON:0001120	93.78	gold quality
adrenal cortex	UBERON:0001235	93.60	gold quality
esophagus mucosa	UBERON:0002469	93.41	gold quality
granulocyte	CL:0000094	93.17	gold quality
left uterine tube	UBERON:0001303	92.68	gold quality
thyroid gland	UBERON:0002046	92.66	gold quality
skin of leg	UBERON:0001511	92.65	gold quality
adrenal gland	UBERON:0002369	92.58	gold quality
metanephros cortex	UBERON:0010533	92.53	gold quality
skin of abdomen	UBERON:0001416	92.49	gold quality
ascending aorta	UBERON:0001496	91.66	gold quality
thoracic aorta	UBERON:0001515	91.64	gold quality
ectocervix	UBERON:0012249	91.62	gold quality
omental fat pad	UBERON:0010414	91.59	gold quality
body of stomach	UBERON:0001161	91.57	gold quality
peritoneum	UBERON:0002358	91.53	gold quality
ovary	UBERON:0000992	91.52	gold quality
transverse colon	UBERON:0001157	91.28	gold quality
body of pancreas	UBERON:0001150	91.27	gold quality
left coronary artery	UBERON:0001626	91.19	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.86

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

11 targeting MVB12A, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-548AN	99.97	70.91	2817
HSA-MIR-6132	99.60	65.83	1554
HSA-MIR-6836-5P	99.60	65.62	1538
HSA-MIR-6752-5P	99.59	67.32	1243
HSA-MIR-10524-5P	99.05	66.08	963
HSA-MIR-6787-5P	97.54	63.85	457
HSA-MIR-514A-3P	96.43	67.77	1048
HSA-MIR-514B-3P	96.43	67.77	1048
HSA-MIR-10396B-5P	94.99	63.57	358
HSA-MIR-1908-5P	94.99	63.41	352
HSA-MIR-663A	94.99	63.54	378

Literature-anchored findings (GeneRIF, showing 3)

• CFBP is a novel tyrosine-phosphorylated protein that might function as a regulator of CIN85/CD2AP (PMID:16895919)
• These results suggest that the expression of MVB12B may be normally suppressed through the ubiquitin-proteasome pathway that simultaneously regulates the fate of MVB12A and the functions of ESCRT-I. (PMID:20654576)
• A helical assembly of human ESCRT-I scaffolds reverse-topology membrane scission. (PMID:32424346)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	mvb12a	ENSDARG00000099741
mus_musculus	Mvb12a	ENSMUSG00000031813
rattus_norvegicus	Mvb12a	ENSRNOG00000017949
drosophila_melanogaster	Mvb12	FBGN0030894
caenorhabditis_elegans		WBGENE00015508

Protein

Protein identifiers

Multivesicular body subunit 12A — Q96EY5 (reviewed: Q96EY5)

Alternative names: CIN85/CD2AP family-binding protein, ESCRT-I complex subunit MVB12A, Protein FAM125A

All UniProt accessions (6): E9PJW8, E9PLL0, E9PLZ8, E9PQA6, Q96EY5, M0QZK6

UniProt curated annotations — full annotation on UniProt →

Function. Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down-regulation of EGF receptor.

Subunit / interactions. Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoichiometry. Interacts with CD2AP and CIN85/SH3KBP1. Interacts with CD2AP (via one of the SH3 domains). Interacts with TSG101; the association appears to be mediated by the TSG101-VPS37 binary subcomplex. Interacts with VPS28. Interacts with VPS37B; the association appears to be mediated by the TSG101-VPS37 binary subcomplex. Interacts with VPS37C; the association appears to be mediated by the TSG101-VPS37 binary subcomplex. Interacts with VPS37D; the association appears to be mediated by the TSG101-VPS37 binary subcomplex. Interacts with CEP55.

Subcellular location. Cytoplasm. Nucleus. Endosome. Cytoskeleton. Microtubule organizing center. Centrosome. Late endosome membrane.

Tissue specificity. Ubiquitously expressed except in skeletal muscle.

Post-translational modifications. Phosphorylated on Tyr-204 upon EGF stimulation. Phosphorylation is required for interaction with CD2AP and CIN85/SH3KBP1.

Miscellaneous. Does not interact with CD2AP.

Similarity. Belongs to the MVB12 family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q96EY5-1	1	yes
Q96EY5-2	2, Delta 5
Q96EY5-3	3, Delta 8

RefSeq proteins (2): NP_001291476, NP_612410* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR018798
IPR023340	UMA	Domain
IPR023341	MABP	Domain
IPR040335	MVB12A	Family

Pfam: PF10240

UniProt features (21 total): modified residue 8, domain 2, splice variant 2, mutagenesis site 2, helix 2, chain 1, sequence variant 1, strand 1, region of interest 1, short sequence motif 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
6VME	X-RAY DIFFRACTION	2.19

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96EY5-F1	77.43	0.40

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (8): 204, 207, 232, 130, 163, 170, 195, 202

Mutagenesis-validated functional residues (2):

Position	Phenotype
204	mimics constitutively phosphorylated form and has the ability to interact with cd2ap and cin85/sh3kbp1 without egf treat
204	abolishes interaction with cd2ap and cin85/sh3kbp1.

Function

Pathways and Gene Ontology

Reactome pathways

17 pathways

ID	Pathway
R-HSA-162588	Budding and maturation of HIV virion
R-HSA-174490	Membrane binding and targetting of GAG proteins
R-HSA-917729	Endosomal Sorting Complex Required For Transport (ESCRT)
R-HSA-9610379	HCMV Late Events
R-HSA-9615710	Late endosomal microautophagy
R-HSA-162587	HIV Life Cycle
R-HSA-162599	Late Phase of HIV Life Cycle
R-HSA-162906	HIV Infection
R-HSA-1643685	Disease
R-HSA-174495	Synthesis And Processing Of GAG, GAGPOL Polyproteins
R-HSA-175474	Assembly Of The HIV Virion
R-HSA-199991	Membrane Trafficking
R-HSA-5653656	Vesicle-mediated transport
R-HSA-5663205	Infectious disease
R-HSA-9609646	HCMV Infection
R-HSA-9612973	Autophagy
R-HSA-9824446	Viral Infection Pathways

MSigDB gene sets: 185 (showing top): REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT, RRAGTTGT_UNKNOWN, GOBP_LYSOSOMAL_TRANSPORT, GOBP_REGULATION_OF_ERBB_SIGNALING_PATHWAY, GOBP_ENDOSOME_ORGANIZATION, GOBP_INTRACELLULAR_PROTEIN_TRANSPORT, GOBP_VESICLE_ORGANIZATION, GOBP_ENDOSOME_TO_LYSOSOME_TRANSPORT, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, GOBP_VACUOLAR_TRANSPORT, GOBP_VESICLE_MEDIATED_TRANSPORT, REACTOME_MEMBRANE_TRAFFICKING, GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ORGANELLE, GOCC_MICROTUBULE_ORGANIZING_CENTER, GOBP_MACROAUTOPHAGY

GO Biological Process (12): macroautophagy (GO:0016236), virus maturation (GO:0019075), endosome to lysosome transport via multivesicular body sorting pathway (GO:0032510), receptor catabolic process (GO:0032801), multivesicular body assembly (GO:0036258), viral budding via host ESCRT complex (GO:0039702), regulation of epidermal growth factor receptor signaling pathway (GO:0042058), ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162), protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043328), viral budding (GO:0046755), membrane fission (GO:0090148), protein transport (GO:0015031)

GO Molecular Function (4): lipid binding (GO:0008289), SH3 domain binding (GO:0017124), ubiquitin binding (GO:0043130), protein binding (GO:0005515)

GO Cellular Component (12): ESCRT I complex (GO:0000813), nucleus (GO:0005634), centrosome (GO:0005813), cytosol (GO:0005829), endosome membrane (GO:0010008), late endosome membrane (GO:0031902), vesicle (GO:0031982), extracellular exosome (GO:0070062), cytoplasm (GO:0005737), endosome (GO:0005768), cytoskeleton (GO:0005856), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-12 pathways:

Category	Pathways
Late Phase of HIV Life Cycle	2
Viral Infection Pathways	2
Synthesis And Processing Of GAG, GAGPOL Polyproteins	1
Membrane Trafficking	1
HCMV Infection	1
Autophagy	1
HIV Infection	1
HIV Life Cycle	1
Assembly Of The HIV Virion	1
Vesicle-mediated transport	1
Disease	1
Infectious disease	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
viral process	2
binding	2
endosome membrane	2
autophagosome assembly	1
autophagy	1
viral life cycle	1
endosome to lysosome transport	1
endosome transport via multivesicular body sorting pathway	1
macromolecule catabolic process	1
receptor metabolic process	1
multivesicular body organization	1
organelle assembly	1
viral budding	1
epidermal growth factor receptor signaling pathway	1
regulation of ERBB signaling pathway	1
ubiquitin-dependent protein catabolic process	1
protein catabolic process in the vacuole	1
multivesicular body sorting pathway	1
intracellular protein transport	1
late endosome to vacuole transport via multivesicular body sorting pathway	1
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	1
protein localization to vacuole	1
establishment of protein localization to vacuole	1
virion assembly	1
membrane organization	1
transport	1
intracellular protein localization	1
establishment of protein localization	1
protein domain specific binding	1
ubiquitin-like protein binding	1
ESCRT complex	1
membrane protein complex	1
intracellular membrane-bounded organelle	1
centriole	1
microtubule organizing center	1
cytoplasm	1
endosome	1
cytoplasmic vesicle membrane	1
bounding membrane of organelle	1

Protein interactions and networks

STRING

594 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MVB12A	VPS28	Q9UK41	985
MVB12A	TSG101	Q99816	978
MVB12A	VPS37A	Q8NEZ2	916
MVB12A	VPS37B	Q9H9H4	833
MVB12A	UBAP1	Q9NZ09	776
MVB12A	VPS36	Q86VN1	732
MVB12A	VPS37C	A5D8V6	728
MVB12A	VPS37D	Q86XT2	652
MVB12A	VPS25	Q9BRG1	572
MVB12A	CHMP6	Q96FZ7	568
MVB12A	CD2AP	Q9Y5K6	557
MVB12A	ZC3H7A	Q8IWR0	547
MVB12A	ZNHIT6	Q9NWK9	547
MVB12A	CHMP3	Q9Y3E7	544
MVB12A	A0A140T963	A0A140T963	544

IntAct

67 interactions, top by confidence:

A	B	Type	Score
GRB2	WIPF3	psi-mi:“MI:0914”(association)	0.730
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
VPS28	VPS37A	psi-mi:“MI:0914”(association)	0.640
CIDEB	MVB12A	psi-mi:“MI:0915”(physical association)	0.560
HSF2BP	MVB12A	psi-mi:“MI:0915”(physical association)	0.560
PPP1R27	MVB12A	psi-mi:“MI:0915”(physical association)	0.560
MANSC1	KLRG2	psi-mi:“MI:0914”(association)	0.530
SLC25A41	NUDT19	psi-mi:“MI:0914”(association)	0.530
CDK5R1	DENR	psi-mi:“MI:0914”(association)	0.530
GRB2	SH3PXD2B	psi-mi:“MI:0914”(association)	0.530
TAS2R7	ATP2B4	psi-mi:“MI:0914”(association)	0.500
MVB12A	OXTR	psi-mi:“MI:0915”(physical association)	0.370
Cep55	UMAD1	psi-mi:“MI:0914”(association)	0.350
Cd2ap		psi-mi:“MI:0914”(association)	0.350
Chmp4b		psi-mi:“MI:0914”(association)	0.350
Sec24c	SEC31A	psi-mi:“MI:0914”(association)	0.350
Spast		psi-mi:“MI:0914”(association)	0.350
Tsg101	VPS37C	psi-mi:“MI:0914”(association)	0.350
Vps28	UMAD1	psi-mi:“MI:0914”(association)	0.350
CHMP4B	ELOC	psi-mi:“MI:0914”(association)	0.350
Xpo1	IFT56	psi-mi:“MI:0914”(association)	0.350
TAS2R7	PRKCA	psi-mi:“MI:0914”(association)	0.350
VPS28	DCAF6	psi-mi:“MI:0914”(association)	0.350
UBE2U	MVB12A	psi-mi:“MI:0914”(association)	0.350
PDLIM7	VPS37C	psi-mi:“MI:0914”(association)	0.350

BioGRID (109): MVB12A (Affinity Capture-MS), MVB12A (Affinity Capture-MS), MVB12A (Affinity Capture-MS), MVB12A (Affinity Capture-MS), ARFIP1 (Co-fractionation), MVB12A (Co-fractionation), MVB12A (Co-fractionation), MVB12A (Co-fractionation), TSG101 (Co-fractionation), VPS28 (Co-fractionation), VPS37B (Co-fractionation), MVB12A (Affinity Capture-MS), MVB12A (Affinity Capture-MS), MVB12A (Affinity Capture-MS), MVB12A (Affinity Capture-MS)

ESM2 similar proteins: A2A9C3, A6QQV9, D4A039, D4AB98, F7EL49, O00750, O14525, P59240, Q1JPG0, Q1LZ89, Q2QL82, Q2QLG9, Q3T0N1, Q495M9, Q4V8Y7, Q5T011, Q5ZJX7, Q61137, Q62671, Q68DU8, Q6P549, Q6P777, Q78HU3, Q7L4E1, Q7SXX7, Q7ZYJ7, Q80TP3, Q80U93, Q86UW9, Q86XL3, Q8BK03, Q8BYR5, Q8BZI0, Q8C008, Q8CDG3, Q8CF97, Q8R3P2, Q8TED9, Q8VH46, Q92574

Diamond homologs: Q3T0N1, Q5ZJX7, Q6KAU4, Q6P777, Q78HU3, Q7SXX7, Q7ZYJ7, Q96EY5, Q9H7P6

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 71 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Endosomal Sorting Complex Required For Transport (ESCRT)	5	38.4×	4e-05
Late endosomal microautophagy	5	34.0×	5e-05
RET signaling	6	32.4×	1e-05
Signaling by SCF-KIT	5	25.9×	2e-04
RAF/MAP kinase cascade	6	7.6×	3e-03

GO biological processes:

GO term	Partners	Fold	FDR
multivesicular body assembly	5	45.4×	4e-05
membrane fission	5	35.4×	4e-05
macroautophagy	6	24.9×	4e-05

Disease & clinical

Clinical variants and AI predictions

ClinVar

54 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	39
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

990 predictions. Top by Δscore:

Variant	Effect	Δscore
19:17420221:GCGCG:G	donor_gain	1.0000
19:17420635:G:GG	donor_gain	1.0000
19:17420679:G:GT	donor_gain	1.0000
19:17422330:A:AG	acceptor_gain	1.0000
19:17422331:G:GG	acceptor_gain	1.0000
19:17422457:GG:G	donor_gain	1.0000
19:17422458:GG:G	donor_gain	1.0000
19:17423490:T:A	acceptor_gain	1.0000
19:17423688:TCCA:T	acceptor_loss	1.0000
19:17423689:CCAG:C	acceptor_loss	1.0000
19:17423691:A:AG	acceptor_gain	1.0000
19:17423691:A:T	acceptor_loss	1.0000
19:17423692:G:GT	acceptor_gain	1.0000
19:17423692:GT:G	acceptor_gain	1.0000
19:17423692:GTA:G	acceptor_gain	1.0000
19:17423692:GTAA:G	acceptor_gain	1.0000
19:17424004:A:AG	acceptor_gain	1.0000
19:17424005:G:GA	acceptor_gain	1.0000
19:17420409:GAG:G	donor_gain	0.9900
19:17420409:GAGGT:G	donor_loss	0.9900
19:17420411:GGTAA:G	donor_loss	0.9900
19:17420412:G:C	donor_loss	0.9900
19:17420530:A:AG	acceptor_gain	0.9900
19:17420531:C:G	acceptor_gain	0.9900
19:17420536:A:AG	acceptor_gain	0.9900
19:17420537:G:GG	acceptor_gain	0.9900
19:17420630:TTCCA:T	donor_gain	0.9900
19:17420631:TCCA:T	donor_gain	0.9900
19:17420633:CA:C	donor_gain	0.9900
19:17420633:CAGTA:C	donor_loss	0.9900

AlphaMissense

1751 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:17424943:T:C	F258L	1.000
19:17424945:C:A	F258L	1.000
19:17424945:C:G	F258L	1.000
19:17424954:G:C	E261D	1.000
19:17424954:G:T	E261D	1.000
19:17424018:T:A	V218D	0.999
19:17424023:T:C	F220L	0.999
19:17424024:T:C	F220S	0.999
19:17424025:C:A	F220L	0.999
19:17424025:C:G	F220L	0.999
19:17424944:T:C	F258S	0.999
19:17424953:A:T	E261V	0.999
19:17420184:T:A	W17R	0.998
19:17420184:T:C	W17R	0.998
19:17423520:T:A	W146R	0.998
19:17423520:T:C	W146R	0.998
19:17424024:T:G	F220C	0.998
19:17424653:G:C	K245N	0.998
19:17424653:G:T	K245N	0.998
19:17424667:T:A	I250N	0.998
19:17424937:T:C	Y256H	0.998
19:17424944:T:G	F258C	0.998
19:17424952:G:A	E261K	0.998
19:17422410:T:A	V122D	0.997
19:17422418:A:C	S125R	0.997
19:17422420:T:A	S125R	0.997
19:17422420:T:G	S125R	0.997
19:17424943:T:A	F258I	0.997
19:17423518:T:A	I145N	0.996
19:17424023:T:A	F220I	0.996

dbSNP variants (sampled 300 via entrez): RS1000102962 (19:17425059 C>A,G,T), RS1000157410 (19:17408539 G>A,T), RS1000554402 (19:17424320 G>A), RS1000906895 (19:17406000 C>G,T), RS1000937391 (19:17406221 C>G,T), RS1001013922 (19:17412837 C>T), RS1001224664 (19:17423741 A>G), RS1001369736 (19:17424319 C>T), RS1001471429 (19:17412110 A>C), RS1001694957 (19:17406924 G>T), RS1001726704 (19:17424005 G>T), RS1002035142 (19:17405696 G>C), RS1002420554 (19:17418179 G>A,T), RS1002733186 (19:17416379 G>A), RS1002849299 (19:17413489 G>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

34 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, increases expression	3
sodium arsenite	affects binding, increases reaction, increases expression	2
Panobinostat	affects cotreatment, decreases expression	2
Nickel	increases expression	2
Phenylmercuric Acetate	decreases expression, affects cotreatment	2
Tobacco Smoke Pollution	affects expression, decreases methylation	2
FR900359	affects phosphorylation	1
methylmercuric chloride	decreases expression	1
triphenyl phosphate	affects expression	1
propionaldehyde	decreases expression	1
sodium arsenate	decreases expression	1
beta-lapachone	decreases expression	1
cobaltous chloride	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
entinostat	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
jinfukang	increases expression	1
(+)-JQ1 compound	decreases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Temozolomide	increases expression	1
Arsenic	affects methylation	1
Benzo(a)pyrene	increases methylation	1
Caffeine	increases phosphorylation	1
Cytarabine	decreases expression	1
Doxorubicin	decreases expression	1
Plant Extracts	decreases expression, affects cotreatment	1
Smoke	decreases expression	1
Testosterone	increases expression	1
Thimerosal	decreases expression	1

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B1XY	Abcam HeLa MVB12A KO	Cancer cell line	Female
CVCL_F1P5	HyCyte HCT 116 KO-hMVB12A	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.