MXD3

Summary

MXD3 (MAX dimerization protein 3, HGNC:14008) is a protein-coding gene on chromosome 5q35.3, encoding Max dimerization protein 3 (Q9BW11). Transcriptional repressor.

This gene encodes a member of the Myc superfamily of basic helix-loop-helix leucine zipper transcriptional regulators. The encoded protein forms a heterodimer with the cofactor MAX which binds specific E-box DNA motifs in the promoters of target genes and regulates their transcription. Disruption of the MAX-MXD3 complex is associated with uncontrolled cell proliferation and tumorigenesis. Transcript variants of this gene encoding different isoforms have been described.

Source: NCBI Gene 83463 — RefSeq curated summary.

At a glance

• GWAS associations: 25
• Clinical variants (ClinVar): 62 total
• MANE Select transcript: NM_031300

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14008
Approved symbol	MXD3
Name	MAX dimerization protein 3
Location	5q35.3
Locus type	gene with protein product
Status	Approved
Aliases	MAD3, bHLHc13
Ensembl gene	ENSG00000213347
Ensembl biotype	protein_coding
OMIM	609450
Entrez	83463

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 10 protein_coding, 3 retained_intron

ENST00000423571, ENST00000427908, ENST00000439742, ENST00000502529, ENST00000503473, ENST00000503782, ENST00000509339, ENST00000513063, ENST00000513169, ENST00000927425, ENST00000927426, ENST00000927427, ENST00000927428

RefSeq mRNA: 4 — MANE Select: NM_031300 NM_001142935, NM_001394986, NM_001394987, NM_031300

CCDS: CCDS4416, CCDS47347

Canonical transcript exons

ENST00000439742 — 6 exons

Exon	Start	End
ENSE00001157956	177311379	177311484
ENSE00001742468	177307210	177307703
ENSE00002061389	177311761	177311898
ENSE00003491608	177310668	177310697
ENSE00003557719	177310426	177310540
ENSE00003587221	177307781	177307964

Expression profiles

Bgee: expression breadth ubiquitous, 199 present calls, max score 94.09.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 13.2626 / max 342.1206, expressed in 1433 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
65074	12.3581	1403
65073	0.9045	83

Top tissues by expression

258 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ventricular zone	UBERON:0003053	94.09	gold quality
granulocyte	CL:0000094	93.37	gold quality
diaphragm	UBERON:0001103	92.85	gold quality
monocyte	CL:0000576	92.22	gold quality
superficial temporal artery	UBERON:0001614	92.11	silver quality
mononuclear cell	CL:0000842	92.04	gold quality
lower esophagus mucosa	UBERON:0035834	91.81	gold quality
leukocyte	CL:0000738	91.34	gold quality
blood	UBERON:0000178	90.76	gold quality
ganglionic eminence	UBERON:0004023	90.34	gold quality
spleen	UBERON:0002106	90.05	gold quality
embryo	UBERON:0000922	88.78	gold quality
bone marrow	UBERON:0002371	88.45	gold quality
mucosa of transverse colon	UBERON:0004991	87.68	gold quality
trabecular bone tissue	UBERON:0002483	86.84	silver quality
mucosa of stomach	UBERON:0001199	86.82	gold quality
right uterine tube	UBERON:0001302	85.93	gold quality
bone marrow cell	CL:0002092	85.78	gold quality
right lobe of liver	UBERON:0001114	85.58	gold quality
left uterine tube	UBERON:0001303	85.40	gold quality
esophagus mucosa	UBERON:0002469	85.05	gold quality
mucosa of paranasal sinus	UBERON:0005030	85.04	gold quality
periodontal ligament	UBERON:0008266	84.60	silver quality
transverse colon	UBERON:0001157	84.54	gold quality
muscle layer of sigmoid colon	UBERON:0035805	84.53	gold quality
small intestine Peyer’s patch	UBERON:0003454	84.52	gold quality
olfactory bulb	UBERON:0002264	84.39	silver quality
cerebellar vermis	UBERON:0004720	84.39	gold quality
body of pancreas	UBERON:0001150	84.29	gold quality
esophagus	UBERON:0001043	84.24	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-9543	yes	29.89
E-ANND-3	yes	9.07

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): E2F1, TP63

miRNA regulators (miRDB)

105 targeting MXD3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4283	100.00	66.42	2097
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-302E	99.96	70.74	2669
HSA-MIR-6721-5P	99.93	68.92	2981
HSA-MIR-497-5P	99.92	71.83	2674
HSA-MIR-15A-5P	99.90	72.80	2787
HSA-MIR-15B-5P	99.90	72.78	2798
HSA-MIR-16-5P	99.90	72.80	2780
HSA-MIR-195-5P	99.90	72.81	2805
HSA-MIR-95-5P	99.89	72.17	3973
HSA-MIR-302A-3P	99.89	71.23	1777
HSA-MIR-302B-3P	99.89	71.23	1777
HSA-MIR-302C-3P	99.89	71.20	1778
HSA-MIR-302D-3P	99.89	71.25	1777
HSA-MIR-6838-5P	99.89	71.94	2690
HSA-MIR-424-5P	99.89	71.90	2641
HSA-MIR-4492	99.87	68.25	3611
HSA-MIR-182-5P	99.87	74.03	2589
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-373-3P	99.84	70.68	1668
HSA-MIR-520E-3P	99.84	70.55	1698
HSA-MIR-372-3P	99.83	70.58	1691
HSA-MIR-520A-3P	99.83	70.59	1687
HSA-MIR-520B-3P	99.83	70.56	1699
HSA-MIR-520C-3P	99.83	70.56	1699
HSA-MIR-520D-3P	99.83	70.78	1676
HSA-MIR-6785-5P	99.82	68.68	4428
HSA-MIR-4713-5P	99.78	67.80	1794
HSA-MIR-5002-5P	99.76	70.84	1763
HSA-MIR-149-3P	99.72	68.22	3963

Literature-anchored findings (GeneRIF, showing 5)

• Increased level and/or duration of MXD3 expression ultimately reduces cell numbers via increased cell death and cell cycle arrest in medulloblastoma cells. (PMID:22808009)
• Acute MXD3 activation results in a transient increase in DAOY cell proliferation while persistent activation of MXD3 results in an overall decrease in cell number, suggesting that the time course of MXD3 expression dictates the cellular outcome. (PMID:25053245)
• The results suggest that MXD3 is important for survival of Reh preB ALL cells, possibly as an anti-apoptotic factor. (PMID:25554682)
• results indicate that MXD3 is a potential new target and that the use of MXD3 siRNA nanocomplexes is a novel therapeutic approach for neuroblastoma (PMID:28419087)
• MXD3 Promotes Obesity and the Androgen Receptor Signaling Pathway in Gender-Disparity Hepatocarcinogenesis. (PMID:34943942)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	mxd3	ENSDARG00000098350
mus_musculus	Mxd3	ENSMUSG00000021485
rattus_norvegicus	Mxd3	ENSRNOG00000070523
caenorhabditis_elegans		WBGENE00003163

Paralogs (4): MXD1 (ENSG00000059728), MNT (ENSG00000070444), MXI1 (ENSG00000119950), MXD4 (ENSG00000123933)

Protein

Protein identifiers

Max dimerization protein 3 — Q9BW11 (reviewed: Q9BW11)

Alternative names: Class C basic helix-loop-helix protein 13, Max-associated protein 3, Max-interacting transcriptional repressor MAD3, Myx

All UniProt accessions (3): D6RD21, D6RED4, Q9BW11

UniProt curated annotations — full annotation on UniProt →

Function. Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5’-CAC[GA]TG-3’. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation.

Subunit / interactions. Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with SIN3A AND SIN3B. Interacts with RNF17.

Subcellular location. Nucleus.

Isoforms (4)

UniProt ID	Names	Canonical?
Q9BW11-1	1	yes
Q9BW11-2	2
Q9BW11-3	3
Q9BW11-4	4

RefSeq proteins (4): NP_001136407, NP_001381915, NP_001381916, NP_112590* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR011598	bHLH_dom	Domain
IPR036638	HLH_DNA-bd_sf	Homologous_superfamily

Pfam: PF00010

UniProt features (13 total): sequence conflict 4, region of interest 3, splice variant 3, chain 1, domain 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9BW11-F1	74.64	0.40

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 215 (showing top): E2F_Q4, E2F_Q4_01, TGCGCANK_UNKNOWN, E2F4DP1_01, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP, GOLDRATH_ANTIGEN_RESPONSE, IRF7_01, E2F1DP1_01, E2F_Q3, E2F1DP2_01, DOANE_RESPONSE_TO_ANDROGEN_DN, MYB_Q3, AFFAR_YY1_TARGETS_DN, E2F1_Q3

GO Biological Process (3): regulation of transcription by RNA polymerase II (GO:0006357), negative regulation of transcription by RNA polymerase II (GO:0000122), negative regulation of DNA-templated transcription (GO:0045892)

GO Molecular Function (7): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227), protein dimerization activity (GO:0046983), RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977), DNA binding (GO:0003677), protein binding (GO:0005515)

GO Cellular Component (3): chromatin (GO:0000785), RNA polymerase II transcription regulator complex (GO:0090575), nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA polymerase II transcription regulatory region sequence-specific DNA binding	3
regulation of DNA-templated transcription	2
transcription by RNA polymerase II	2
regulation of transcription by RNA polymerase II	2
negative regulation of DNA-templated transcription	1
DNA-templated transcription	1
negative regulation of RNA biosynthetic process	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
negative regulation of transcription by RNA polymerase II	1
DNA-binding transcription factor activity, RNA polymerase II-specific	1
DNA-binding transcription repressor activity	1
protein binding	1
transcription cis-regulatory region binding	1
nucleic acid binding	1
binding	1
chromosome	1
cellular anatomical structure	1
transcription regulator complex	1
nuclear protein-containing complex	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

674 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MXD3	MLXIP	Q9HAP2	519
MXD3	TEX26	Q8N6G2	496
MXD3	ESRRA	P11474	456
MXD3	MAX	P25912	449
MXD3	SYNGR4	O95473	437
MXD3	LTC4S	Q16873	412
MXD3	MGA	Q8IWI9	402
MXD3	MLXIPL	Q9NP71	398
MXD3	KIAA1191	Q96A73	393
MXD3	NOMO2	Q5JPE7	392
MXD3	MLX	Q9UH92	388
MXD3	PLEKHB1	Q9UF11	386
MXD3	PREB	Q9HCU5	383
MXD3	NOMO3	P69849	379
MXD3	HMGN4	O00479	376

IntAct

36 interactions, top by confidence:

A	B	Type	Score
MAX	E2F6	psi-mi:“MI:0914”(association)	0.710
MXD3	NOTCH2NLA	psi-mi:“MI:0915”(physical association)	0.670
MXD3	TFIP11	psi-mi:“MI:0915”(physical association)	0.670
MXD3	KRTAP10-7	psi-mi:“MI:0915”(physical association)	0.560
KRTAP10-7	MXD3	psi-mi:“MI:0915”(physical association)	0.560
KRT31	MXD3	psi-mi:“MI:0915”(physical association)	0.560
CYSRT1	MXD3	psi-mi:“MI:0915”(physical association)	0.560
NOTCH2NLC	MXD3	psi-mi:“MI:0915”(physical association)	0.560
KRTAP1-3	MXD3	psi-mi:“MI:0915”(physical association)	0.560
KRTAP1-1	MXD3	psi-mi:“MI:0915”(physical association)	0.560
MXD3	KRTAP3-3	psi-mi:“MI:0915”(physical association)	0.560
NUP62	MXD3	psi-mi:“MI:0915”(physical association)	0.560
MAGEA11	MXD3	psi-mi:“MI:0915”(physical association)	0.370
MXD3	SAP30	psi-mi:“MI:0914”(association)	0.350
MXD3	PCK1	psi-mi:“MI:0914”(association)	0.350
MXD3	KRT31	psi-mi:“MI:0915”(physical association)	0.000
MXD3	CYSRT1	psi-mi:“MI:0915”(physical association)	0.000
MXD3	NOTCH2NLC	psi-mi:“MI:0915”(physical association)	0.000
MXD3	NUP62	psi-mi:“MI:0915”(physical association)	0.000
MXD3	TFIP11	psi-mi:“MI:0915”(physical association)	0.000
MXD3	KRTAP1-3	psi-mi:“MI:0915”(physical association)	0.000
MXD3	KRTAP1-1	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (74): KRTAP10-7 (Two-hybrid), NOTCH2NL (Two-hybrid), MXD3 (Two-hybrid), MNT (Affinity Capture-MS), SIN3A (Affinity Capture-MS), SAP30L (Affinity Capture-MS), SUDS3 (Affinity Capture-MS), ARID4B (Affinity Capture-MS), SAP130 (Affinity Capture-MS), ING2 (Affinity Capture-MS), BRMS1L (Affinity Capture-MS), TSPYL2 (Affinity Capture-MS), NUP62CL (Affinity Capture-MS), TFIP11 (Affinity Capture-MS), KIF20B (Affinity Capture-MS)

ESM2 similar proteins: A4IFK0, A6NI15, D2CLZ9, O15040, O55208, P10158, P11939, P15407, P23050, P29176, P39881, P97303, P97432, Q14596, Q3TVI4, Q4KMA0, Q501R9, Q53GL0, Q5BJM5, Q5F3F2, Q5R802, Q5RA50, Q5RC94, Q5SUE8, Q62912, Q66HA2, Q68CJ9, Q6AI12, Q6AY70, Q6PKU1, Q6QB00, Q6QHK4, Q7TS99, Q80US8, Q861R7, Q86V42, Q86YI8, Q8BQR4, Q8K2W6, Q90ZL1

Diamond homologs: G5EG44, O09015, P50538, P50539, P50540, P50541, Q05195, Q0VFI9, Q0VH33, Q0VH34, Q14582, Q28DB3, Q60948, Q62912, Q7SX95, Q80US8, Q9BW11, O08789, P28574, P52162, P52164, P61244, P61245, Q07016, Q0VH32, Q99583, A1YG22, A2T7L5, B8XIA5, P01106, P01108, P01109, P01110, P03966, P04198, P06171, P06646, P09416, P0C0N8, P0C0N9

SIGNOR signaling

2 interactions.

A	Effect	B	Mechanism
MAX	“up-regulates activity”	MXD3	binding
SMC3	“down-regulates activity”	MXD3	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 15 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Keratinization	5	21.4×	1e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

62 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	45
Likely benign	6
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

3213 predictions. Top by Δscore:

Variant	Effect	Δscore
5:177302395:A:AC	donor_gain	1.0000
5:177302396:C:CC	donor_gain	1.0000
5:177302396:CTGT:C	donor_gain	1.0000
5:177302406:A:AC	donor_gain	1.0000
5:177302417:T:TA	donor_gain	1.0000
5:177302492:CAGCC:C	acceptor_gain	1.0000
5:177302495:CC:C	acceptor_gain	1.0000
5:177302496:CC:C	acceptor_gain	1.0000
5:177302496:CCTGA:C	acceptor_loss	1.0000
5:177302497:C:CG	acceptor_loss	1.0000
5:177302654:CGGCA:C	acceptor_gain	1.0000
5:177302655:G:T	acceptor_gain	1.0000
5:177302657:C:CT	acceptor_gain	1.0000
5:177302658:A:AC	acceptor_gain	1.0000
5:177302658:A:C	acceptor_gain	1.0000
5:177302661:C:CT	acceptor_gain	1.0000
5:177303003:ACTT:A	donor_loss	1.0000
5:177303005:TTA:T	donor_loss	1.0000
5:177303006:T:TG	donor_loss	1.0000
5:177303007:A:AC	donor_gain	1.0000
5:177303007:AC:A	donor_gain	1.0000
5:177303008:C:CC	donor_gain	1.0000
5:177303008:CC:C	donor_gain	1.0000
5:177303074:TGGT:T	acceptor_gain	1.0000
5:177303075:GGTCT:G	acceptor_loss	1.0000
5:177303077:TCTGC:T	acceptor_loss	1.0000
5:177303078:C:CC	acceptor_gain	1.0000
5:177303078:CTG:C	acceptor_loss	1.0000
5:177303079:T:G	acceptor_loss	1.0000
5:177303084:C:CT	acceptor_gain	1.0000

AlphaMissense

1309 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
5:177310668:C:A	R69M	0.998
5:177310466:G:A	T94I	0.997
5:177310529:A:G	L73S	0.997
5:177310537:C:A	R70S	0.997
5:177310537:C:G	R70S	0.997
5:177310676:C:A	E66D	0.997
5:177310676:C:G	E66D	0.997
5:177310442:G:T	A102D	0.996
5:177310538:C:A	R70M	0.996
5:177310540:C:A	R69S	0.996
5:177310540:C:G	R69S	0.996
5:177310668:C:G	R69T	0.996
5:177310451:A:G	L99P	0.995
5:177310508:A:G	L80P	0.995
5:177310673:C:A	K67N	0.995
5:177310673:C:G	K67N	0.995
5:177310443:C:G	A102P	0.994
5:177310454:A:G	L98P	0.994
5:177310538:C:G	R70T	0.994
5:177310690:G:C	H62D	0.994
5:177307960:A:G	L109P	0.993
5:177310451:A:T	L99Q	0.993
5:177310504:C:A	K81N	0.992
5:177310504:C:G	K81N	0.992
5:177310677:T:A	E66V	0.992
5:177310678:C:T	E66K	0.992
5:177311780:G:C	F17L	0.992
5:177311780:G:T	F17L	0.992
5:177311782:A:G	F17L	0.992
5:177311787:G:T	A15D	0.992

dbSNP variants (sampled 300 via entrez): RS1000246353 (5:177312479 C>T), RS1000480379 (5:177311708 G>A,C), RS1000526900 (5:177313943 T>G), RS1000584174 (5:177312159 C>A,G,T), RS1001044130 (5:177308321 T>A), RS1001095149 (5:177308076 C>A,G), RS1001208636 (5:177311508 C>A,G,T), RS1001261160 (5:177311356 C>A,T), RS1002048416 (5:177307431 A>G), RS1002435258 (5:177314598 A>C,G), RS1002763570 (5:177309068 C>T), RS1003201377 (5:177313247 CAT>C), RS1003376149 (5:177308036 A>G), RS1003420728 (5:177313430 C>A), RS1003551935 (5:177310342 C>G,T)

Disease associations

OMIM: gene MIM:609450 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

25 associations (top):

Study	Trait	p-value
GCST001574_7	Activated partial thromboplastin time	6.000000e-88
GCST001762_35	Obesity-related traits	2.000000e-06
GCST001762_798	Obesity-related traits	2.000000e-06
GCST004632_116	Lymphocyte percentage of white cells	3.000000e-13
GCST004633_56	Neutrophil percentage of white cells	1.000000e-11
GCST005956_15	Waist-to-hip ratio adjusted for BMI	1.000000e-07
GCST005957_13	Waist-to-hip ratio adjusted for BMI (age <50)	3.000000e-07
GCST005962_42	Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test)	1.000000e-08
GCST006627_61	Diastolic blood pressure	9.000000e-10
GCST007485_3	Anthropometric traits	3.000000e-67
GCST007490_8	Anthropometric traits (multi-trait analysis)	2.000000e-36
GCST007725_20	Serum uric acid levels	4.000000e-08
GCST007733_28	Serum uric acid levels	3.000000e-07
GCST012226_74	Waist circumference adjusted for body mass index	3.000000e-13
GCST012228_120	Waist-hip index	6.000000e-11
GCST012228_122	Waist-hip index	2.000000e-12
GCST012229_96	Hip index	3.000000e-08
GCST012230_19	Waist-to-hip ratio adjusted for BMI	5.000000e-10
GCST012230_22	Waist-to-hip ratio adjusted for BMI	2.000000e-10
GCST90002389_273	Lymphocyte percentage of white cells	1.000000e-25
GCST90002399_432	Neutrophil percentage of white cells	8.000000e-22
GCST90002400_656	Plateletcrit	5.000000e-09
GCST90002402_716	Platelet count	5.000000e-13
GCST90020029_1504	Waist circumference adjusted for body mass index	6.000000e-09
GCST90020029_1507	Waist circumference adjusted for body mass index	6.000000e-12

EFO canonical traits (13, from GWAS)

EFO ID	Trait name
EFO:0004730	hormone measurement
EFO:0007993	lymphocyte percentage of leukocytes
EFO:0007990	neutrophil percentage of leukocytes
EFO:0007788	BMI-adjusted waist-hip ratio
EFO:0008007	age at assessment
EFO:0008343	sex interaction measurement
EFO:0006336	diastolic blood pressure
EFO:0004324	body weights and measures
EFO:0004761	uric acid measurement
EFO:0007789	BMI-adjusted waist circumference
EFO:0008039	BMI-adjusted hip circumference
EFO:0007985	platelet crit
EFO:0004309	platelet count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

40 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Air Pollutants	affects cotreatment, increases abundance, increases expression, affects expression, decreases expression	3
sodium arsenite	decreases expression	2
Curcumin	decreases expression	2
Estradiol	decreases expression	2
Ozone	affects cotreatment, increases expression, increases abundance, affects expression	2
Tobacco Smoke Pollution	decreases expression	2
dicrotophos	decreases expression	1
triphenyl phosphate	affects expression	1
alpha-pinene	increases expression, increases abundance, affects cotreatment	1
propionaldehyde	decreases expression	1
titanium dioxide	decreases methylation	1
beta-lapachone	decreases expression	1
butyraldehyde	decreases expression	1
perfluorooctanoic acid	decreases expression	1
methacrylaldehyde	increases abundance, affects cotreatment, increases expression	1
diallyl trisulfide	decreases expression	1
abrine	decreases expression	1
NSC668394	decreases expression	1
Sunitinib	decreases expression	1
Troglitazone	decreases expression	1
Acrolein	affects cotreatment, increases expression, increases abundance	1
Arsenic	affects expression	1
Benzo(a)pyrene	increases methylation	1
Calcitriol	decreases expression, affects cotreatment	1
Cycloheximide	affects cotreatment, increases expression	1
Cytarabine	increases expression	1
Dichlorodiphenyl Dichloroethylene	increases expression	1
Diazinon	increases methylation	1
N-Nitrosopyrrolidine	decreases expression	1
Smoke	decreases expression	1

Cellosaurus cell lines

3 cell lines: 3 embryonic stem cell

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_A4G4	SEES3-1V human MXD3, clone1	Embryonic stem cell	Male
CVCL_A4G5	SEES3-1V human MXD3, clone2	Embryonic stem cell	Male
CVCL_A4G6	SEES3-1V human MXD3, clone3	Embryonic stem cell	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.