MXRA8

Summary

MXRA8 (matrix remodeling associated 8, HGNC:7542) is a protein-coding gene on chromosome 1p36.33, encoding Matrix remodeling-associated protein 8 (Q9BRK3). Transmembrane protein which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3.

Predicted to be involved in establishment of glial blood-brain barrier. Located in extracellular exosome.

Source: NCBI Gene 54587 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 106 total — 1 likely-pathogenic
• MANE Select transcript: NM_032348

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:7542
Approved symbol	MXRA8
Name	matrix remodeling associated 8
Location	1p36.33
Locus type	gene with protein product
Status	Approved
Aliases	DKFZp586E2023
Ensembl gene	ENSG00000162576
Ensembl biotype	protein_coding
OMIM	617293
Entrez	54587

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 8 protein_coding, 6 retained_intron

ENST00000309212, ENST00000342753, ENST00000445648, ENST00000460473, ENST00000464351, ENST00000473097, ENST00000474033, ENST00000476718, ENST00000477278, ENST00000478517, ENST00000897927, ENST00000953649, ENST00000953650, ENST00000953651

RefSeq mRNA: 5 — MANE Select: NM_032348 NM_001282582, NM_001282583, NM_001282584, NM_001282585, NM_032348

CCDS: CCDS24, CCDS59950, CCDS59951, CCDS59952

Canonical transcript exons

ENST00000309212 — 10 exons

Exon	Start	End
ENSE00001066499	1354354	1354509
ENSE00001130277	1355244	1355345
ENSE00001208985	1355450	1355752
ENSE00001224365	1354682	1355152
ENSE00001224378	1356681	1356704
ENSE00001829673	1358456	1358555
ENSE00001829761	1352691	1353629
ENSE00003469474	1354193	1354232
ENSE00003558812	1354030	1354106
ENSE00003672275	1353848	1353928

Expression profiles

Bgee: expression breadth ubiquitous, 270 present calls, max score 99.32.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 51.9366 / max 856.3660, expressed in 1167 samples.

FANTOM5 promoters (10 alternative TSS)

Promoter ID	TPM avg	Samples expressed
9770	49.2188	1134
9766	0.5725	352
9767	0.3829	201
9763	0.3521	149
9765	0.3071	172
9762	0.3012	163
9768	0.2505	122
9764	0.2474	127
9769	0.2102	113
9771	0.0939	36

Top tissues by expression

289 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
stromal cell of endometrium	CL:0002255	99.32	gold quality
tibial nerve	UBERON:0001323	99.19	gold quality
decidua	UBERON:0002450	99.08	gold quality
endocervix	UBERON:0000458	98.93	gold quality
body of uterus	UBERON:0009853	98.91	gold quality
right coronary artery	UBERON:0001625	98.87	gold quality
right ovary	UBERON:0002118	98.80	gold quality
gall bladder	UBERON:0002110	98.79	gold quality
ascending aorta	UBERON:0001496	98.68	gold quality
left ovary	UBERON:0002119	98.68	gold quality
thoracic aorta	UBERON:0001515	98.67	gold quality
descending thoracic aorta	UBERON:0002345	98.59	gold quality
mucosa of stomach	UBERON:0001199	98.55	gold quality
left coronary artery	UBERON:0001626	98.26	gold quality
left uterine tube	UBERON:0001303	98.22	gold quality
coronary artery	UBERON:0001621	98.14	gold quality
aorta	UBERON:0000947	98.12	gold quality
right lobe of thyroid gland	UBERON:0001119	98.12	gold quality
left lobe of thyroid gland	UBERON:0001120	98.12	gold quality
ectocervix	UBERON:0012249	98.07	gold quality
subcutaneous adipose tissue	UBERON:0002190	97.91	gold quality
muscle layer of sigmoid colon	UBERON:0035805	97.82	gold quality
apex of heart	UBERON:0002098	97.77	gold quality
popliteal artery	UBERON:0002250	97.77	gold quality
tibial artery	UBERON:0007610	97.77	gold quality
omental fat pad	UBERON:0010414	97.41	gold quality
peritoneum	UBERON:0002358	97.35	gold quality
adipose tissue of abdominal region	UBERON:0007808	97.20	gold quality
periodontal ligament	UBERON:0008266	97.06	gold quality
calcaneal tendon	UBERON:0003701	96.97	gold quality

Single-cell (SCXA)

Detected in 17 experiment(s), a significant marker in 16.

Experiment	Marker?	Max mean expression
E-GEOD-114530	yes	2219.60
E-GEOD-124472	yes	1263.42
E-MTAB-6701	yes	559.07
E-ANND-5	yes	490.70
E-GEOD-135922	yes	337.76
E-MTAB-6678	yes	266.08
E-MTAB-10287	yes	119.80
E-HCAD-1	yes	82.75
E-MTAB-8410	yes	52.88
E-GEOD-134144	yes	37.20
E-ANND-3	yes	32.03
E-HCAD-13	yes	27.03
E-HCAD-10	yes	22.44
E-CURD-112	yes	17.67
E-GEOD-81547	yes	7.97

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

24 targeting MXRA8, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-4447	99.85	67.81	2900
HSA-MIR-4530	99.69	66.47	1509
HSA-MIR-3175	99.65	66.30	2031
HSA-MIR-486-3P	99.51	66.82	1901
HSA-MIR-4480	99.42	66.02	735
HSA-MIR-4786-3P	99.36	68.35	1390
HSA-MIR-6846-5P	98.81	65.86	1121
HSA-MIR-6848-5P	98.81	65.49	1126
HSA-MIR-6852-3P	98.54	67.60	1468
HSA-MIR-6810-5P	98.29	66.21	975
HSA-MIR-4664-5P	98.17	65.07	1020
HSA-MIR-1972	97.67	67.38	1172
HSA-MIR-6862-5P	97.48	64.84	713
HSA-MIR-194-3P	97.36	65.96	1027
HSA-MIR-148B-5P	97.29	66.30	992
HSA-MIR-6874-3P	97.29	66.34	975
HSA-MIR-342-5P	97.25	64.10	817
HSA-MIR-4652-5P	96.46	64.22	553
HSA-MIR-6782-5P	96.45	64.42	612
HSA-MIR-152-5P	96.42	66.59	960
HSA-MIR-6747-5P	96.17	64.99	743
HSA-MIR-365A-5P	94.91	63.72	471
HSA-MIR-365B-5P	94.91	63.79	470

Literature-anchored findings (GeneRIF, showing 8)

• new member of the transmembrane-type immunoglobulin superfamily and designated limitrin, localizing selectively to glia limitans in mouse brain (PMID:14603461)
• MXRA8 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells. (PMID:21555518)
• exogenous expression of DICAM in human umbilical vein endothelial cells suppressed angiogenesis in vitro Matrigel and in vivo plug assays, and conversely, DICAM knockdown enhanced angiogenesis (PMID:23386276)
• studies provide insight into how Mxra8 binds CHIKV and creates a path for developing alphavirus entry inhibitors. (PMID:31080061)
• the stalk region of MXRA8 is critical for CHIKV virus entry. (PMID:31080063)
• Elevated Expression of miR-200c/141 in MDA-MB-231 Cells Suppresses MXRA8 Levels and Impairs Breast Cancer Growth and Metastasis In Vivo. (PMID:35456497)
• Loss of MXRA8 Delays Mammary Tumor Development and Impairs Metastasis. (PMID:37762032)
• Single-cell RNA combined with bulk RNA analysis to explore oxidative stress and energy metabolism factors and found a new prostate cancer oncogene MXRA8. (PMID:38441550)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	mxra8b	ENSDARG00000062129
danio_rerio	mxra8a	ENSDARG00000062222
mus_musculus	Mxra8	ENSMUSG00000029070
rattus_norvegicus	Mxra8	ENSRNOG00000019244

Paralogs (14): VSIG2 (ENSG00000019102), VSIG1 (ENSG00000101842), VSIR (ENSG00000107738), GPA33 (ENSG00000143167), IGSF11 (ENSG00000144847), ESAM (ENSG00000149564), CXADR (ENSG00000154639), JAM2 (ENSG00000154721), F11R (ENSG00000158769), JAM3 (ENSG00000166086), CLMP (ENSG00000166250), MUC15 (ENSG00000169550), VSTM2B (ENSG00000187135), VSIG8 (ENSG00000243284)

Protein

Protein identifiers

Matrix remodeling-associated protein 8 — Q9BRK3 (reviewed: Q9BRK3)

Alternative names: Limitrin

All UniProt accessions (1): Q9BRK3

UniProt curated annotations — full annotation on UniProt →

Function. Transmembrane protein which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3. Mediates heterophilic cell-cell interactions in vitro. Inhibits osteoclastogenesis downstream of TNFSF11/RANKL and CSF1, where it may function by attenuating signaling via integrin ITGB3 and MAP kinase p38. Plays a role in cartilage formation where it promotes proliferation and maturation of growth plate chondrocytes. Stimulates formation of primary cilia in chondrocytes. Enhances expression of genes involved in the hedgehog signaling pathway in chondrocytes, including the hedgehog signaling molecule IHH; may also promote signaling via the PTHLH/PTHrP pathway. Plays a role in angiogenesis where it suppresses migration of endothelial cells and also promotes their apoptosis. Inhibits VEGF-induced activation of AKT and p38 MAP kinase in endothelial cells. Also inhibits VTN (vitronectin)-mediated integrin ITGAV:ITGB3 signaling and activation of PTK2/FAK. May play a role in the maturation and maintenance of the blood-brain barrier. (Microbial infection) Contributes to arthritogenic alphavirus pathogenesis and acts as a receptor for these viruses.

Subunit / interactions. Homodimer in cis. Does not appear to form trans-homodimers. Interacts with ITGB3; the interaction inhibits ITGAV:ITGB3 heterodimer formation. (Microbial infection) Interacts with chikungunya virus spike glycoproteins E2 and E1. The interaction involves 2 adjacent E2-E1 heterodimers.

Subcellular location. Cell membrane. Cell junction. Tight junction. Cytoplasm. Cell projection. Cilium membrane. Nucleus.

Tissue specificity. Detected in endothelial cells in mammary tissue, in both large vessels (left internal mammary artery) and small capillaries (vasa vasorum of the adventitia).

Domain organisation. The RGD motif is involved in integrin ITGAV:ITGB3 binding.

Induction. Up-regulated in vein endothelial cells (HUVECs) in response to VEGF signaling.

Isoforms (4)

UniProt ID	Names	Canonical?
Q9BRK3-1	1	yes
Q9BRK3-2	2
Q9BRK3-3	3
Q9BRK3-4	4

RefSeq proteins (5): NP_001269511, NP_001269512, NP_001269513, NP_001269514, NP_115724* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003599	Ig_sub	Domain
IPR007110	Ig-like_dom	Domain
IPR013106	Ig_V-set	Domain
IPR013783	Ig-like_fold	Homologous_superfamily
IPR036179	Ig-like_dom_sf	Homologous_superfamily
IPR042472	MXRA8	Family

Pfam: PF07686

UniProt features (50 total): strand 18, turn 7, splice variant 4, helix 4, glycosylation site 2, disulfide bond 2, topological domain 2, domain 2, signal peptide 1, chain 1, modified residue 1, sequence variant 1, sequence conflict 1, transmembrane region 1, region of interest 1, short sequence motif 1, site 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
6JO8	X-RAY DIFFRACTION	3.5

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9BRK3-F1	76.46	0.48

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 325–326 (cleavage)

Post-translational modifications (1): 228

Disulfide bonds (2): 54–137, 186–272

Glycosylation sites (2): 119, 306

Function

Pathways and Gene Ontology

Reactome pathways

4 pathways

ID	Pathway
R-HSA-381426	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275	Post-translational protein phosphorylation
R-HSA-392499	Metabolism of proteins
R-HSA-597592	Post-translational protein modification

MSigDB gene sets: 148 (showing top): BERTUCCI_MEDULLARY_VS_DUCTAL_BREAST_CANCER_DN, MODULE_255, GOBP_GLIAL_CELL_DEVELOPMENT, MODULE_317, GOCC_CELL_SURFACE, GOBP_NEUROGENESIS, FOXO1_01, LIEN_BREAST_CARCINOMA_METAPLASTIC, FERREIRA_EWINGS_SARCOMA_UNSTABLE_VS_STABLE_DN, LI_WILMS_TUMOR_VS_FETAL_KIDNEY_1_UP, KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_DN, HFH8_01, TGACATY_UNKNOWN, ATF3_Q6, HFH1_01

GO Biological Process (3): cell adhesion (GO:0007155), cell differentiation (GO:0030154), establishment of glial blood-brain barrier (GO:0060857)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (11): nucleus (GO:0005634), endoplasmic reticulum lumen (GO:0005788), bicellular tight junction (GO:0005923), cell surface (GO:0009986), ciliary membrane (GO:0060170), extracellular exosome (GO:0070062), cytoplasm (GO:0005737), plasma membrane (GO:0005886), membrane (GO:0016020), cell projection (GO:0042995), anchoring junction (GO:0070161)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Metabolism of proteins	2
Post-translational protein modification	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	4
cellular process	1
cellular developmental process	1
glial cell development	1
establishment of blood-brain barrier	1
binding	1
intracellular membrane-bounded organelle	1
endoplasmic reticulum	1
intracellular organelle lumen	1
apical junction complex	1
tight junction	1
cilium	1
cell projection membrane	1
bounding membrane of organelle	1
extracellular vesicle	1
intracellular anatomical structure	1
membrane	1
cell periphery	1
cell junction	1

Protein interactions and networks

STRING

1016 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MXRA8	BACE1	P56817	583
MXRA8	RHO	P08100	578
MXRA8	JAG2	Q9Y219	568
MXRA8	ADRB2	P07550	566
MXRA8	NAPSA	O96009	541
MXRA8	MXRA7	P84157	537
MXRA8	ARG2	P78540	535
MXRA8	FAM20A	Q96MK3	525
MXRA8	VIP	P01282	505
MXRA8	LDLRAD3	Q86YD5	495
MXRA8	AASDHPPT	Q9NRN7	484
MXRA8	TPM3	P06753	476
MXRA8	PHB1	P35232	465
MXRA8	PRSS23	O95084	452
MXRA8	ADRA2A	P08913	451

IntAct

50 interactions, top by confidence:

A	B	Type	Score
IL13RA2	CHEK1	psi-mi:“MI:0914”(association)	0.640
TRDN	TMEM223	psi-mi:“MI:0914”(association)	0.640
CABP2	MXRA8	psi-mi:“MI:0915”(physical association)	0.560
DTX2	MXRA8	psi-mi:“MI:0915”(physical association)	0.560
GMEB2	MXRA8	psi-mi:“MI:0915”(physical association)	0.560
MXRA8	GMEB2	psi-mi:“MI:0915”(physical association)	0.560
MXRA8	CABP2	psi-mi:“MI:0915”(physical association)	0.560
MXRA8	ANKRD11	psi-mi:“MI:0915”(physical association)	0.560
TTC19	MXRA8	psi-mi:“MI:0915”(physical association)	0.560
NTAQ1	MXRA8	psi-mi:“MI:0915”(physical association)	0.560
CCT8L2	ACSL4	psi-mi:“MI:0914”(association)	0.530
CLEC4A	SEMA7A	psi-mi:“MI:0914”(association)	0.530
EVA1C	STK25	psi-mi:“MI:0914”(association)	0.530
LPAR1	TMEM223	psi-mi:“MI:0914”(association)	0.530
SLC7A1	STXBP3	psi-mi:“MI:0914”(association)	0.530
TNFSF8	LGALS8	psi-mi:“MI:0914”(association)	0.530
		psi-mi:“MI:0914”(association)	0.350
	ESYT2	psi-mi:“MI:0914”(association)	0.350
	HAX1	psi-mi:“MI:0914”(association)	0.350
CELA3A	PIK3C2A	psi-mi:“MI:0914”(association)	0.350
CLGN	TMEM131L	psi-mi:“MI:0914”(association)	0.350
CUEDC1	WWP2	psi-mi:“MI:0914”(association)	0.350
GDPD5	TMEM120B	psi-mi:“MI:0914”(association)	0.350

BioGRID (17): MXRA8 (Affinity Capture-MS), MXRA8 (Proximity Label-MS), MXRA8 (Two-hybrid), MXRA8 (Two-hybrid), MXRA8 (Two-hybrid), MXRA8 (Two-hybrid), ANKRD11 (Two-hybrid), CABP2 (Two-hybrid), MXRA8 (Affinity Capture-RNA), MXRA8 (Affinity Capture-MS), MXRA8 (Affinity Capture-MS), MXRA8 (Negative Genetic), MXRA8 (Affinity Capture-MS), MXRA8 (Proximity Label-MS), MXRA8 (Proximity Label-MS)

ESM2 similar proteins: A0A140LHF2, A0JPB1, A2AJ76, A7LCJ3, A8E0Y8, E7FF10, O00241, O60500, P01874, P03988, P04221, P0DOX2, P0DOX3, P0DOX4, P0DOX6, P0DP72, P32507, P35590, P43121, P50895, Q06805, Q06806, Q148M6, Q15109, Q5TFQ8, Q5U5A3, Q5XI43, Q62230, Q62786, Q8HW98, Q8NDA2, Q8R2Y2, Q92154, Q923P0, Q93033, Q95KI3, Q96MS0, Q9BRK3, Q9BZZ2, Q9DBV4

Diamond homologs: Q148M6, Q5XI43, Q7T0R0, Q90WI4, Q9BRK3, Q9DBV4

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

106 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	1
Uncertain significance	78
Likely benign	12
Benign	3

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
402162	NM_032348.4(MXRA8):c.1238T>A (p.Ile413Asn)	Likely pathogenic

SpliceAI

1037 predictions. Top by Δscore:

Variant	Effect	Δscore
1:1353924:GTAAT:G	acceptor_gain	1.0000
1:1353925:TAAT:T	acceptor_gain	1.0000
1:1353925:TAATC:T	acceptor_loss	1.0000
1:1353926:AAT:A	acceptor_gain	1.0000
1:1353927:AT:A	acceptor_gain	1.0000
1:1353928:TCTGT:T	acceptor_loss	1.0000
1:1353929:C:CC	acceptor_gain	1.0000
1:1353930:T:C	acceptor_loss	1.0000
1:1354025:CTCAC:C	donor_loss	1.0000
1:1354026:TCA:T	donor_loss	1.0000
1:1354028:ACCTA:A	donor_loss	1.0000
1:1354029:CCTAG:C	donor_gain	1.0000
1:1354033:G:C	donor_gain	1.0000
1:1354046:ACT:A	donor_gain	1.0000
1:1354047:CTC:C	donor_gain	1.0000
1:1354351:CA:C	donor_loss	1.0000
1:1354352:ACC:A	donor_loss	1.0000
1:1354353:C:CA	donor_loss	1.0000
1:1354506:GGGTC:G	acceptor_loss	1.0000
1:1354507:GGTC:G	acceptor_loss	1.0000
1:1354509:TCT:T	acceptor_loss	1.0000
1:1354510:C:CA	acceptor_loss	1.0000
1:1354510:C:CC	acceptor_gain	1.0000
1:1354511:T:A	acceptor_loss	1.0000
1:1355343:CCG:C	acceptor_gain	1.0000
1:1355344:CGC:C	acceptor_gain	1.0000
1:1355346:C:CC	acceptor_gain	1.0000
1:1355355:C:T	acceptor_gain	1.0000
1:1358454:A:AC	donor_gain	1.0000
1:1358455:C:CC	donor_gain	1.0000

AlphaMissense

2824 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:1355010:C:A	W207C	1.000
1:1355010:C:G	W207C	1.000
1:1355012:A:G	W207R	1.000
1:1355012:A:T	W207R	1.000
1:1355052:C:A	W193C	1.000
1:1355052:C:G	W193C	1.000
1:1354795:C:T	C279Y	0.999
1:1354810:A:G	L274P	0.999
1:1354815:G:C	C272W	0.999
1:1354816:C:G	C272S	0.999
1:1354816:C:T	C272Y	0.999
1:1354817:A:G	C272R	0.999
1:1354817:A:T	C272S	0.999
1:1354820:A:G	S271P	0.999
1:1354823:A:C	Y270D	0.999
1:1354882:A:C	F250C	0.999
1:1355011:C:G	W207S	0.999
1:1355290:G:C	C144W	0.999
1:1355291:C:A	C144F	0.999
1:1355291:C:G	C144S	0.999
1:1355291:C:T	C144Y	0.999
1:1355292:A:T	C144S	0.999
1:1355311:G:C	C137W	0.999
1:1355312:C:G	C137S	0.999
1:1355312:C:T	C137Y	0.999
1:1355313:A:T	C137S	0.999
1:1355319:A:C	Y135D	0.999
1:1355482:A:C	F115C	0.999
1:1355601:C:A	W75C	0.999
1:1355601:C:G	W75C	0.999

dbSNP variants (sampled 300 via entrez): RS1000015240 (1:1362918 C>T), RS1000102657 (1:1364390 C>T), RS1000610776 (1:1358208 C>T), RS1000784544 (1:1360285 GGGGGCAGCTGACCCCCAT>G), RS1000806936 (1:1364428 G>A), RS1000911771 (1:1354666 G>A,C,T), RS1001047036 (1:1354970 G>A,T), RS1001390176 (1:1354017 A>C), RS1001649313 (1:1362079 C>A), RS1001678785 (1:1361875 A>G), RS1001986381 (1:1361176 A>T), RS1002098834 (1:1357607 G>A), RS1002101488 (1:1352269 A>G), RS1002357556 (1:1361333 G>C), RS1002626981 (1:1355587 G>A,C)

Disease associations

OMIM: gene MIM:617293 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST004131_103	Inflammatory bowel disease	2.000000e-07
GCST004133_40	Ulcerative colitis	3.000000e-06
GCST005580_249	Intraocular pressure	1.000000e-10
GCST005580_72	Intraocular pressure	1.000000e-11

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004695	intraocular pressure measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

35 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, decreases expression, increases expression, increases methylation	5
Tetrachlorodibenzodioxin	affects expression, increases expression	3
Benzo(a)pyrene	decreases methylation, increases expression, affects methylation	2
aristolochic acid I	increases expression	1
FR900359	increases phosphorylation	1
bisphenol F	affects cotreatment, increases expression	1
bisphenol A	decreases methylation	1
perfluorooctane sulfonic acid	decreases expression	1
entinostat	increases expression	1
bisphenol S	increases expression	1
MT19c compound	decreases expression	1
bisphenol AF	increases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Sunitinib	decreases expression	1
Acetaminophen	decreases expression	1
Calcitriol	decreases expression	1
Dexamethasone	affects cotreatment, increases expression	1
Doxorubicin	increases expression	1
Folic Acid	decreases expression	1
Formaldehyde	decreases expression	1
Indomethacin	affects cotreatment, increases expression	1
Plant Extracts	affects cotreatment, decreases expression	1
Potassium Dichromate	increases expression	1
Rotenone	increases expression	1
Smoke	decreases expression	1
Testosterone	increases expression	1
Thimerosal	decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Tretinoin	decreases expression	1
1-Methyl-3-isobutylxanthine	affects cotreatment, increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.