MYADM

Summary

MYADM (myeloid associated differentiation marker, HGNC:7544) is a protein-coding gene on chromosome 19q13.42, encoding Myeloid-associated differentiation marker (Q96S97).

Involved in several processes, including negative regulation of actin filament polymerization; negative regulation of heterotypic cell-cell adhesion; and positive regulation of substrate adhesion-dependent cell spreading. Located in several cellular components, including cortical actin cytoskeleton; membrane raft; and ruffle.

Source: NCBI Gene 91663 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 57 total
• Druggable target: yes
• MANE Select transcript: NM_138373

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:7544
Approved symbol	MYADM
Name	myeloid associated differentiation marker
Location	19q13.42
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000179820
Ensembl biotype	protein_coding
OMIM	609959
Entrez	91663

Gene structure

Transcript identifiers

Ensembl transcripts: 24 — 23 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000336967, ENST00000391768, ENST00000391769, ENST00000391770, ENST00000391771, ENST00000414489, ENST00000421337, ENST00000422045, ENST00000439000, ENST00000448420, ENST00000651087, ENST00000882280, ENST00000882281, ENST00000882282, ENST00000882283, ENST00000882284, ENST00000882285, ENST00000921584, ENST00000921585, ENST00000921586, ENST00000921587, ENST00000921588, ENST00000921589, ENST00000959436

RefSeq mRNA: 12 — MANE Select: NM_138373 NM_001020818, NM_001020819, NM_001020820, NM_001020821, NM_001290188, NM_001290189, NM_001290190, NM_001290191, NM_001290192, NM_001290193, NM_001290194, NM_138373

CCDS: CCDS12866

Canonical transcript exons

ENST00000391770 — 3 exons

Exon	Start	End
ENSE00001245940	53869754	53869838
ENSE00001509692	53867883	53867943
ENSE00001914413	53873528	53876435

Expression profiles

Bgee: expression breadth ubiquitous, 256 present calls, max score 99.39.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 319.7561 / max 5091.3022, expressed in 1809 samples.

FANTOM5 promoters (31 alternative TSS)

Promoter ID	TPM avg	Samples expressed
177399	251.5698	1805
177405	39.4658	1774
177396	7.6150	1453
177413	2.1872	1040
177414	1.9093	937
177393	1.7671	406
177394	1.7517	497
177418	1.5661	896
177411	1.4039	774
177416	1.2079	695

Top tissues by expression

256 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
oviduct epithelium	UBERON:0004804	99.39	gold quality
saphenous vein	UBERON:0007318	99.27	gold quality
vena cava	UBERON:0004087	99.22	gold quality
cauda epididymis	UBERON:0004360	98.95	gold quality
synovial joint	UBERON:0002217	98.93	gold quality
layer of synovial tissue	UBERON:0007616	98.76	gold quality
left uterine tube	UBERON:0001303	98.66	gold quality
skin of hip	UBERON:0001554	98.64	gold quality
decidua	UBERON:0002450	98.59	gold quality
myometrium	UBERON:0001296	98.58	gold quality
urethra	UBERON:0000057	98.55	gold quality
right coronary artery	UBERON:0001625	98.49	gold quality
trachea	UBERON:0003126	98.43	gold quality
nipple	UBERON:0002030	98.39	gold quality
mucosa of stomach	UBERON:0001199	98.30	gold quality
smooth muscle tissue	UBERON:0001135	98.29	gold quality
tendon of biceps brachii	UBERON:0008188	98.27	gold quality
body of uterus	UBERON:0009853	98.23	gold quality
gall bladder	UBERON:0002110	98.14	gold quality
epithelium of mammary gland	UBERON:0003244	98.14	gold quality
ileal mucosa	UBERON:0000331	98.12	gold quality
mammary duct	UBERON:0001765	98.12	gold quality
thoracic aorta	UBERON:0001515	98.11	gold quality
aorta	UBERON:0000947	98.08	gold quality
ascending aorta	UBERON:0001496	98.08	gold quality
popliteal artery	UBERON:0002250	98.05	gold quality
cardiac muscle of right atrium	UBERON:0003379	98.04	gold quality
upper leg skin	UBERON:0004262	98.04	gold quality
tibial artery	UBERON:0007610	98.04	gold quality
adult organism	UBERON:0007023	98.02	gold quality

Single-cell (SCXA)

Detected in 14 experiment(s), a significant marker in 11.

Experiment	Marker?	Max mean expression
E-MTAB-11011	yes	1201.11
E-CURD-88	yes	51.21
E-CURD-122	yes	34.38
E-CURD-46	yes	33.65
E-HCAD-1	yes	28.59
E-ANND-3	yes	17.85
E-GEOD-135922	yes	8.86
E-MTAB-9801	yes	8.15
E-GEOD-134144	yes	7.99
E-HCAD-9	yes	5.75
E-MTAB-10553	yes	5.67
E-HCAD-11	no	1495.36
E-CURD-10	no	413.29
E-MTAB-6678	no	3.73

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

1 targets.

Target	Regulation
ICAM1	Repression

Upstream regulators (CollecTRI, top): MYB

miRNA regulators (miRDB)

96 targeting MYADM, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-4747-5P	100.00	67.90	2681
HSA-MIR-5196-5P	100.00	67.98	2761
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-4533	100.00	69.48	2758
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-3134	100.00	66.43	777
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-4455	100.00	65.48	1587
HSA-MIR-6748-5P	100.00	65.81	1057
HSA-MIR-3924	100.00	72.09	2394
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-4514	99.99	67.10	1870
HSA-LET-7F-2-3P	99.98	70.98	2588
HSA-MIR-1185-1-3P	99.98	71.04	2593
HSA-MIR-1185-2-3P	99.98	71.04	2593
HSA-MIR-4789-5P	99.98	70.76	2721
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-6768-5P	99.92	67.36	1942
HSA-MIR-124-3P	99.89	73.74	3043
HSA-MIR-506-3P	99.89	73.55	3057
HSA-MIR-3065-3P	99.87	70.25	1407
HSA-MIR-3919	99.87	69.45	2489

Literature-anchored findings (GeneRIF, showing 9)

• Cloning and characterization of human MYADM gene whose expression was up-regulated in NB4 cells induced by all-trans retinoic acid. (PMID:12075932)
• Myeloid-associated differentiation marker (MYADM) regulates Rac1 targeting to ordered membranes required for cell spreading and migration. (PMID:21325632)
• MYADM controls endothelial barrier function through ERM-dependent regulation of ICAM-1 expression. (PMID:23264465)
• MYADM gene expression is significantly associated with long-term changes in Blood Pressure, providing a link between gene expression and Blood Pressure. (PMID:28784648)
• miR-182-3p/Myadm contribute to pulmonary artery hypertension vascular remodeling via a KLF4/p21-dependent mechanism. (PMID:32373233)
• Myeloid-associated differentiation marker is a novel SP-A-associated transmembrane protein whose expression on airway epithelial cells correlates with asthma severity. (PMID:34862427)
• Myeloid-associated differentiation marker is an essential host factor for human parechovirus PeV-A3 entry. (PMID:37002207)
• MYADM binds human parechovirus 1 and is essential for viral entry. (PMID:38658526)
• Smooth Muscle Ythdf2 Abrogation Ameliorates Pulmonary Vascular Remodeling by Regulating Myadm Transcript Stability. (PMID:38832511)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	myadmb	ENSDARG00000038709
danio_rerio	myadma	ENSDARG00000086815
mus_musculus	Myadm	ENSMUSG00000068566
rattus_norvegicus	Myadm	ENSRNOG00000053450

Paralogs (1): MYADML2 (ENSG00000185105)

Protein

Protein identifiers

Myeloid-associated differentiation marker — Q96S97 (reviewed: Q96S97)

Alternative names: Protein SB135

All UniProt accessions (6): A0A494C017, A0A499FIY8, C9JC07, C9JJV6, C9JZL8, Q96S97

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Membrane.

Tissue specificity. Widely expressed. Not detected in thymus.

Similarity. Belongs to the MAL family.

RefSeq proteins (12): NP_001018654, NP_001018655, NP_001018656, NP_001018657, NP_001277117, NP_001277118, NP_001277119, NP_001277120, NP_001277121, NP_001277122, NP_001277123, NP_612382* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR008253	Marvel	Domain
IPR047123	MYADM-like	Family

Pfam: PF01284

UniProt features (16 total): transmembrane region 8, domain 2, sequence conflict 2, chain 1, region of interest 1, compositionally biased region 1, modified residue 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96S97-F1	86.14	0.60

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 22

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 365 (showing top): GOBP_ENDOTHELIAL_CELL_DEVELOPMENT, GOBP_NEGATIVE_REGULATION_OF_PROTEIN_CONTAINING_COMPLEX_ASSEMBLY, GOBP_EPITHELIUM_DEVELOPMENT, GOBP_REGULATION_OF_PROTEIN_POLYMERIZATION, GOBP_EPITHELIAL_CELL_DEVELOPMENT, GOBP_REGULATION_OF_HETEROTYPIC_CELL_CELL_ADHESION, GOBP_NEGATIVE_REGULATION_OF_PROTEIN_POLYMERIZATION, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GOBP_NEGATIVE_REGULATION_OF_CELL_CELL_ADHESION, GOBP_CELLULAR_COMPONENT_MAINTENANCE, TGACCTY_ERR1_Q2, GOCC_RUFFLE, GOBP_MEMBRANE_RAFT_ORGANIZATION, GOBP_POSITIVE_REGULATION_OF_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING, GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS

GO Biological Process (9): negative regulation of gene expression (GO:0010629), positive regulation of cell migration (GO:0030335), negative regulation of actin filament polymerization (GO:0030837), membrane raft organization (GO:0031579), negative regulation of heterotypic cell-cell adhesion (GO:0034115), intracellular signal transduction (GO:0035556), protein localization to plasma membrane raft (GO:0044860), establishment of endothelial barrier (GO:0061028), positive regulation of substrate adhesion-dependent cell spreading (GO:1900026)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (6): ruffle (GO:0001726), plasma membrane (GO:0005886), cell-cell junction (GO:0005911), cortical actin cytoskeleton (GO:0030864), membrane raft (GO:0045121), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
gene expression	1
regulation of gene expression	1
negative regulation of macromolecule biosynthetic process	1
cell migration	1
regulation of cell migration	1
positive regulation of cell motility	1
actin filament polymerization	1
regulation of actin filament polymerization	1
negative regulation of protein polymerization	1
negative regulation of cytoskeleton organization	1
negative regulation of supramolecular fiber organization	1
membrane organization	1
negative regulation of cell-cell adhesion	1
heterotypic cell-cell adhesion	1
regulation of heterotypic cell-cell adhesion	1
regulation of cell-cell adhesion involved in gastrulation	1
intracellular anatomical structure	1
signal transduction	1
protein localization to membrane raft	1
protein localization to cell periphery	1
endothelial cell development	1
positive regulation of cell-substrate adhesion	1
substrate adhesion-dependent cell spreading	1
regulation of substrate adhesion-dependent cell spreading	1
binding	1
cell leading edge	1
plasma membrane bounded cell projection	1
membrane	1
cell periphery	1
anchoring junction	1
actin cytoskeleton	1
cortical cytoskeleton	1
membrane microdomain	1
cellular anatomical structure	1

Protein interactions and networks

STRING

908 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MYADM	PLLP	Q9Y342	915
MYADM	TAGAP	Q8N103	532
MYADM	KIT	P10721	520
MYADM	IL3	P08700	490
MYADM	ZNF554	Q86TJ5	477
MYADM	CKLF	Q9UBR5	457
MYADM	MAN2B2	Q9Y2E5	433
MYADM	DDX25	Q9UHL0	418
MYADM	LRP11	Q86VZ4	416
MYADM	ANXA2	P07355	416
MYADM	AATK	Q6ZMQ8	409
MYADM	ACOT13	Q9NPJ3	404
MYADM	GSTM4	Q03013	401
MYADM	LAYN	Q6UX15	400
MYADM	ANXA1	P04083	396

IntAct

141 interactions, top by confidence:

A	B	Type	Score
TMEM9B	DNAJC13	psi-mi:“MI:0914”(association)	0.640
PDGFRB	PIK3R2	psi-mi:“MI:0914”(association)	0.610
MYADM	ARF6	psi-mi:“MI:0915”(physical association)	0.560
MYADM	FNDC9	psi-mi:“MI:0915”(physical association)	0.560
FNDC9	MYADM	psi-mi:“MI:0915”(physical association)	0.560
MYADM	TMEM106C	psi-mi:“MI:0915”(physical association)	0.560
FIMP	MYADM	psi-mi:“MI:0915”(physical association)	0.560
PDZK1IP1	MYADM	psi-mi:“MI:0915”(physical association)	0.560
MUC1	MYADM	psi-mi:“MI:0915”(physical association)	0.560
FAM209A	MYADM	psi-mi:“MI:0915”(physical association)	0.560
MYADM	ERGIC3	psi-mi:“MI:0915”(physical association)	0.560
PLP1	MYADM	psi-mi:“MI:0915”(physical association)	0.560
CD79A	MYADM	psi-mi:“MI:0915”(physical association)	0.560
MYADM	F11R	psi-mi:“MI:0915”(physical association)	0.560
CFTR	MYADM	psi-mi:“MI:0915”(physical association)	0.550
HAVCR2	TCAF2	psi-mi:“MI:0914”(association)	0.530
LAMP3	METTL15	psi-mi:“MI:0914”(association)	0.530
NCR3LG1	FAM171A2	psi-mi:“MI:0914”(association)	0.530
PTGER3	PIK3R2	psi-mi:“MI:0914”(association)	0.530
TGFBR2	PIK3R2	psi-mi:“MI:0914”(association)	0.530
FZD10	NRP1	psi-mi:“MI:0914”(association)	0.530
CD83	BTAF1	psi-mi:“MI:0914”(association)	0.530
IL20RB	B4GALT5	psi-mi:“MI:0914”(association)	0.530
CD7	MYADM	psi-mi:“MI:0914”(association)	0.530
MRAP2	GOLIM4	psi-mi:“MI:0914”(association)	0.530

BioGRID (153): MYADM (Affinity Capture-MS), MYADM (Affinity Capture-MS), ARF6 (Affinity Capture-MS), MYADM (Affinity Capture-MS), MYADM (Affinity Capture-MS), MYADM (Affinity Capture-MS), MYADM (Two-hybrid), MYADM (Affinity Capture-MS), MYADM (Affinity Capture-MS), MYADM (Affinity Capture-MS), MYADM (Affinity Capture-MS), MYADM (Affinity Capture-MS), MYADM (Affinity Capture-MS), MYADM (Affinity Capture-MS), MYADM (Affinity Capture-MS)

ESM2 similar proteins: A1A4P6, A1A5B4, A5PK40, A6NDV4, A6NFX1, A6NGC4, A6QL84, A6QLK4, B1AWJ5, B6ID01, E1BY51, P58749, Q2TA01, Q2YDG0, Q32PG7, Q3T9M1, Q4R7X9, Q5HZE5, Q5JZQ7, Q5R6H1, Q5RBY7, Q60HE8, Q6AY05, Q6AYM9, Q6PHN7, Q6TCG5, Q6UX01, Q6UXD7, Q7RTT9, Q7Z403, Q80ZE4, Q8CE47, Q8R139, Q8TBR7, Q96FZ5, Q96HE8, Q96S97, Q9BSA9, Q9BZW5, Q9CQC4

Diamond homologs: A6NDP7, B2RZ87, O35682, Q08AU7, Q08DL4, Q5R6H1, Q5XGR0, Q63ZU3, Q6DFR5, Q6VBQ5, Q96S97

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 152 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Cell surface interactions at the vascular wall	7	7.5×	8e-03

GO biological processes:

GO term	Partners	Fold	FDR
negative regulation of T cell proliferation	5	12.4×	9e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

57 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	46
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

566 predictions. Top by Δscore:

Variant	Effect	Δscore
19:53866413:GCGCG:G	donor_gain	1.0000
19:53866415:GCG:G	donor_gain	1.0000
19:53866416:CGGTG:C	donor_loss	1.0000
19:53866418:G:GG	donor_gain	1.0000
19:53869835:GCTG:G	donor_gain	1.0000
19:53869837:TGGT:T	donor_loss	1.0000
19:53869839:G:GG	donor_gain	1.0000
19:53873524:GCAGC:G	acceptor_loss	1.0000
19:53873525:CA:C	acceptor_loss	1.0000
19:53873526:A:AG	acceptor_gain	1.0000
19:53873526:AG:A	acceptor_loss	1.0000
19:53873527:G:GA	acceptor_gain	1.0000
19:53873527:GC:G	acceptor_gain	1.0000
19:53873527:GCC:G	acceptor_gain	1.0000
19:53873527:GCCA:G	acceptor_gain	1.0000
19:53873527:GCCAT:G	acceptor_gain	1.0000
19:53866414:CGCG:C	donor_gain	0.9900
19:53866415:GCGG:G	donor_gain	0.9900
19:53866419:TGAG:T	donor_loss	0.9900
19:53869834:CGCTG:C	donor_gain	0.9900
19:53869835:GCTGG:G	donor_gain	0.9900
19:53869837:TG:T	donor_gain	0.9900
19:53869838:GG:G	donor_gain	0.9900
19:53869842:A:AG	donor_gain	0.9900
19:53869843:G:GG	donor_gain	0.9900
19:53873523:T:A	acceptor_gain	0.9900
19:53866416:CG:C	donor_gain	0.9800
19:53866417:GG:G	donor_gain	0.9800
19:53869836:CTG:C	donor_gain	0.9800
19:53873523:TGCAG:T	acceptor_gain	0.9700

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000084182 (19:53870495 T>TATAGG), RS1000331964 (19:53864935 A>G), RS1000697174 (19:53876784 A>C,G), RS1000858226 (19:53871751 G>A), RS1001063307 (19:53865696 A>G), RS1001412276 (19:53865489 A>T), RS1001588192 (19:53876303 A>T), RS1001686005 (19:53870616 G>T), RS1001729917 (19:53876551 A>G), RS1001738216 (19:53870929 C>T), RS1001790619 (19:53871185 C>A,T), RS1002029964 (19:53871844 G>A), RS1002039200 (19:53876467 C>T), RS1002076992 (19:53872087 C>A,T), RS1002209997 (19:53865846 G>A)

Disease associations

OMIM: gene MIM:609959 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6067449 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
5.04	Kd	9169	nM	CHEMBL5653589
5.04	ED50	9169	nM	CHEMBL5653589

PubChem BioAssay actives

1 with measured affinity, of 2 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2148801: Binding affinity to human MYADM incubated for 45 mins by Kinobead based pull down assay	kd	9.1686	uM

CTD chemical–gene interactions

67 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, increases abundance, increases expression, increases methylation	6
(+)-JQ1 compound	decreases expression	3
Dronabinol	increases expression	3
Cadmium Chloride	increases expression, decreases expression, increases abundance	3
Acetaminophen	increases expression, affects response to substance	2
Benzo(a)pyrene	affects methylation, decreases methylation, increases expression, increases methylation	2
Estradiol	decreases expression, decreases reaction, increases expression	2
Tobacco Smoke Pollution	affects expression, increases expression	2
Valproic Acid	increases expression	2
Cyclosporine	increases expression	2
Particulate Matter	decreases expression, increases abundance, affects cotreatment, increases expression	2
bisphenol F	increases expression	1
dicrotophos	increases expression	1
alpha phellandrene	increases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	increases expression	1
lead acetate	increases expression	1
mono-(2-ethylhexyl)phthalate	decreases expression	1
cobaltous chloride	decreases expression	1
nickel sulfate	decreases expression	1
isobutyl alcohol	increases abundance, increases expression, affects cotreatment	1
beta-methylcholine	affects expression	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	decreases expression	1
K 7174	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	decreases expression, affects cotreatment	1
erucylphospho-N,N,N-trimethylpropylammonium	increases expression	1
ICG 001	increases expression	1
bisphenol B	increases expression	1
abrine	decreases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5651843	Binding	Binding affinity to human MYADM incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.