MYCNUT

Summary

MYCNUT (MYCN upstream transcript, HGNC:32684) is a long non-coding RNA gene on chromosome 2p24.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32684
Approved symbol	MYCNUT
Name	MYCN upstream transcript
Location	2p24.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	lncUSMycN
Ensembl gene	ENSG00000223850
Ensembl biotype	lncRNA
OMIM	615968
Entrez	103752554
RNAcentral	URS00007E3A80 — lncRNA, 1040 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 15 — 15 lncRNA

ENST00000433810, ENST00000817294, ENST00000817295, ENST00000817296, ENST00000817297, ENST00000817298, ENST00000817299, ENST00000817300, ENST00000817301, ENST00000817302, ENST00000817303, ENST00000817304, ENST00000817305, ENST00000817306, ENST00000817307

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000433810 — 3 exons

Exon	Start	End
ENSE00001706546	15920399	15921063
ENSE00001750039	15935774	15936017
ENSE00001802862	15921568	15921697

Expression profiles

Bgee: expression breadth broad, 17 present calls, max score 95.38.

Top tissues by expression

170 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
anterior cingulate cortex	UBERON:0009835	95.38	gold quality
buccal mucosa cell	CL:0002336	68.32	gold quality
ganglionic eminence	UBERON:0004023	61.77	gold quality
cortical plate	UBERON:0005343	60.89	gold quality
ventricular zone	UBERON:0003053	60.67	gold quality
placenta	UBERON:0001987	56.73	gold quality
jejunal mucosa	UBERON:0000399	53.61	gold quality
cerebellar vermis	UBERON:0004720	53.46	gold quality
decidua	UBERON:0002450	53.21	silver quality
skin of hip	UBERON:0001554	50.72	silver quality
jejunum	UBERON:0002115	49.91	gold quality
upper leg skin	UBERON:0004262	48.10	silver quality
prefrontal cortex	UBERON:0000451	47.52	silver quality
lateral globus pallidus	UBERON:0002476	46.67	gold quality
upper lobe of lung	UBERON:0008948	45.89	silver quality
lower lobe of lung	UBERON:0008949	45.82	silver quality
muscle of leg	UBERON:0001383	45.79	silver quality
lateral nuclear group of thalamus	UBERON:0002736	45.70	gold quality
urinary bladder	UBERON:0001255	45.51	silver quality
female reproductive system	UBERON:0000474	44.16	gold quality
right frontal lobe	UBERON:0002810	44.03	silver quality
thymus	UBERON:0002370	43.72	gold quality
small intestine	UBERON:0002108	43.64	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	43.37	gold quality
pharyngeal mucosa	UBERON:0000355	43.09	gold quality
adrenal cortex	UBERON:0001235	43.05	gold quality
putamen	UBERON:0001874	42.63	gold quality
subcutaneous adipose tissue	UBERON:0002190	42.63	gold quality
adrenal gland	UBERON:0002369	42.59	gold quality
secondary oocyte	CL:0000655	42.57	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• The data demonstrates the important roles of lncUSMycN in regulating N-Myc expression and neuroblastoma oncogenesis. (PMID:24906397)
• The findings highlight the pivotal role of lncUSMycN in tumorigenesis, providing a new potential target for breast cancer therapy. (PMID:31102367)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.