MYHAS

Summary

MYHAS (myosin heavy chain gene cluster antisense RNA, HGNC:50609) is a long non-coding RNA gene on chromosome 17p13.1.

Predicted to enable primary miRNA binding activity. Predicted to be involved in response to muscle activity and skeletal muscle fiber development. Predicted to act upstream of or within with a positive effect on gene expression. Predicted to be located in cytoplasm and nucleus.

Source: NCBI Gene 100128560 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50609
Approved symbol	MYHAS
Name	myosin heavy chain gene cluster antisense RNA
Location	17p13.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	linc-MYH
Ensembl gene	ENSG00000272975
Ensembl biotype	lncRNA
Entrez	100128560
RNAcentral	URS00007E4CFC — lncRNA, 3952 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 32 — 32 lncRNA

ENST00000399342, ENST00000577181, ENST00000577743, ENST00000579914, ENST00000581304, ENST00000581947, ENST00000584139, ENST00000585303, ENST00000587182, ENST00000609088, ENST00000715354, ENST00000715355, ENST00000715356, ENST00000762682, ENST00000781812, ENST00000781813, ENST00000781814, ENST00000781815, ENST00000781816, ENST00000781817, ENST00000789820, ENST00000789821, ENST00000789822, ENST00000789823, ENST00000789824, ENST00000789825, ENST00000789826, ENST00000789827, ENST00000789828, ENST00000789829, ENST00000789830, ENST00000850668

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000399342 — 4 exons

Exon	Start	End
ENSE00001537663	10537650	10537862
ENSE00002708034	10533324	10533487
ENSE00002723078	10383132	10383207
ENSE00002728951	10406148	10406277

Expression profiles

Bgee: expression breadth broad, 65 present calls, max score 87.38.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0232 / max 9.9239, expressed in 7 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
159578	0.0232	7

Top tissues by expression

65 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	87.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	81.08	gold quality
muscle of leg	UBERON:0001383	77.55	gold quality
gastrocnemius	UBERON:0001388	75.05	gold quality
smooth muscle tissue	UBERON:0001135	61.94	gold quality
thyroid gland	UBERON:0002046	61.60	gold quality
tibial nerve	UBERON:0001323	56.70	gold quality
multicellular organism	UBERON:0000468	51.58	gold quality
apex of heart	UBERON:0002098	51.46	gold quality
calcaneal tendon	UBERON:0003701	51.07	silver quality
minor salivary gland	UBERON:0001830	50.24	gold quality
prefrontal cortex	UBERON:0000451	49.94	silver quality
esophagogastric junction muscularis propria	UBERON:0035841	49.87	gold quality
ectocervix	UBERON:0012249	49.37	gold quality
lower esophagus muscularis layer	UBERON:0035833	49.31	gold quality
pancreas	UBERON:0001264	48.98	gold quality
gall bladder	UBERON:0002110	48.76	gold quality
islet of Langerhans	UBERON:0000006	48.73	gold quality
thoracic mammary gland	UBERON:0005200	48.49	gold quality
tibial artery	UBERON:0007610	47.59	gold quality
endocervix	UBERON:0000458	47.44	gold quality
endometrium	UBERON:0001295	46.81	silver quality
blood	UBERON:0000178	46.79	gold quality
myometrium	UBERON:0001296	46.35	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	46.32	silver quality
body of uterus	UBERON:0009853	46.19	gold quality
placenta	UBERON:0001987	46.03	silver quality
heart	UBERON:0000948	45.94	gold quality
right atrium auricular region	UBERON:0006631	45.86	gold quality
left lobe of thyroid gland	UBERON:0001120	45.77	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.94

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Linc-MYH configures INO80 to regulate muscle stem cell numbers and skeletal muscle hypertrophy. (PMID:32960481)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.