MYL10

Summary

MYL10 (myosin light chain 10, HGNC:29825) is a protein-coding gene on chromosome 7q22.1, encoding Myosin regulatory light chain 10 (Q9BUA6).

Predicted to enable calcium ion binding activity. Located in mitochondrion.

Source: NCBI Gene 93408 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 31 total
• MANE Select transcript: NM_138403

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:29825
Approved symbol	MYL10
Name	myosin light chain 10
Location	7q22.1
Locus type	gene with protein product
Status	Approved
Aliases	MGC3479, MYLC2PL, PLRLC
Ensembl gene	ENSG00000106436
Ensembl biotype	protein_coding
OMIM	617177
Entrez	93408

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 protein_coding

ENST00000223167, ENST00000642629, ENST00000706943

RefSeq mRNA: 1 — MANE Select: NM_138403 NM_138403

CCDS: CCDS34713

Canonical transcript exons

ENST00000223167 — 8 exons

Exon	Start	End
ENSE00000712529	101613662	101613710
ENSE00000712532	101616220	101616298
ENSE00001178070	101613330	101613573
ENSE00001371506	101623920	101624021
ENSE00001377435	101624172	101624264
ENSE00001516628	101629041	101629296
ENSE00002347299	101622997	101623072
ENSE00002390743	101622096	101622200

Expression profiles

Bgee: expression breadth ubiquitous, 216 present calls, max score 95.98.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0246 / max 14.8822, expressed in 9 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
85341	0.0246	9

Top tissues by expression

253 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
olfactory bulb	UBERON:0002264	95.98	silver quality
type B pancreatic cell	CL:0000169	95.30	silver quality
parotid gland	UBERON:0001831	95.25	gold quality
lateral nuclear group of thalamus	UBERON:0002736	95.20	gold quality
vena cava	UBERON:0004087	93.95	gold quality
lateral globus pallidus	UBERON:0002476	93.54	silver quality
triceps brachii	UBERON:0001509	93.42	silver quality
cerebellar vermis	UBERON:0004720	92.64	silver quality
substantia nigra pars compacta	UBERON:0001965	92.31	gold quality
tongue squamous epithelium	UBERON:0006919	92.15	gold quality
gluteal muscle	UBERON:0002000	91.86	gold quality
body of tongue	UBERON:0011876	91.83	silver quality
substantia nigra pars reticulata	UBERON:0001966	91.56	gold quality
pons	UBERON:0000988	91.27	gold quality
inferior olivary complex	UBERON:0002127	91.09	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	91.08	gold quality
cervix squamous epithelium	UBERON:0006922	91.01	silver quality
diaphragm	UBERON:0001103	90.78	silver quality
dorsal plus ventral thalamus	UBERON:0001897	90.57	silver quality
subthalamic nucleus	UBERON:0001906	90.37	silver quality
tongue	UBERON:0001723	89.88	silver quality
dorsal motor nucleus of vagus nerve	UBERON:0002870	89.19	gold quality
pylorus	UBERON:0001166	88.88	silver quality
inferior vagus X ganglion	UBERON:0005363	88.80	silver quality
medulla oblongata	UBERON:0001896	88.55	gold quality
vastus lateralis	UBERON:0001379	88.50	silver quality
left ventricle myocardium	UBERON:0006566	88.37	silver quality
heart right ventricle	UBERON:0002080	88.32	gold quality
quadriceps femoris	UBERON:0001377	88.21	silver quality
pharyngeal mucosa	UBERON:0000355	88.20	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.94

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

7 targeting MYL10, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4646-3P	98.65	66.98	693
HSA-MIR-210-5P	98.57	64.37	832
HSA-MIR-6882-3P	98.23	67.01	1119
HSA-MIR-1913	97.07	66.20	1417
HSA-MIR-339-5P	96.73	66.01	820
HSA-MIR-6889-5P	90.26	64.13	291
HSA-MIR-6777-5P	88.76	62.64	222

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	myl10	ENSDARG00000062592
mus_musculus	Myl10	ENSMUSG00000005474
rattus_norvegicus	Myl10	ENSRNOG00000028981
caenorhabditis_elegans		WBGENE00003369
caenorhabditis_elegans		WBGENE00003370

Paralogs (7): MYL9 (ENSG00000101335), MYL12A (ENSG00000101608), MYL7 (ENSG00000106631), MYL2 (ENSG00000111245), MYL12B (ENSG00000118680), MYL11 (ENSG00000180209), MYL5 (ENSG00000215375)

Protein

Protein identifiers

Myosin regulatory light chain 10 — Q9BUA6 (reviewed: Q9BUA6)

Alternative names: Myosin light chain 2, lymphocyte-specific, Precursor lymphocyte-specific regulatory light chain

All UniProt accessions (3): A0A2R8YDI2, A0A9L9PXJ4, Q9BUA6

UniProt curated annotations — full annotation on UniProt →

Subunit / interactions. Myosin is a hexamer of 2 heavy chains and 4 light chains.

Miscellaneous. This chain binds calcium.

RefSeq proteins (1): NP_612412* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR002048	EF_hand_dom	Domain
IPR011992	EF-hand-dom_pair	Homologous_superfamily
IPR018247	EF_Hand_1_Ca_BS	Binding_site
IPR050403	Myosin_RLC	Family

Pfam: PF13405

UniProt features (9 total): binding site 4, domain 3, chain 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9BUA6-F1	62.26	0.01

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (4): 97; 99; 101; 108

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-445355	Smooth Muscle Contraction
R-HSA-397014	Muscle contraction

MSigDB gene sets: 72 (showing top): KEGG_TIGHT_JUNCTION, REACTOME_SMOOTH_MUSCLE_CONTRACTION, KIM_GASTRIC_CANCER_CHEMOSENSITIVITY, GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN, ZHENG_IL22_SIGNALING_DN, KEGG_REGULATION_OF_ACTIN_CYTOSKELETON, KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION, SHEDDEN_LUNG_CANCER_GOOD_SURVIVAL_A12, HUANG_GATA2_TARGETS_UP, PTEN_DN.V2_UP, DCA_UP.V1_DN, ALK_DN.V1_DN, GSE5503_MLN_DC_VS_SPLEEN_DC_ACTIVATED_ALLOGENIC_TCELL_DN, SOX10_TARGET_GENES, GSE12845_IGD_NEG_BLOOD_VS_DARKZONE_GC_TONSIL_BCELL_UP

GO Biological Process (0):

GO Molecular Function (3): calcium ion binding (GO:0005509), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (3): cytoplasm (GO:0005737), mitochondrion (GO:0005739), cytosol (GO:0005829)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Muscle contraction	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
cytoplasm	2
metal ion binding	1
binding	1
cation binding	1
intracellular anatomical structure	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

1651 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MYL10	MYH1	P12882	571
MYL10	MYH7B	A7E2Y1	531
MYL10	MYH6	P13533	459
MYL10	MYL3	P08590	446
MYL10	ITPKA	P23677	422
MYL10	PPP1R12C	Q9BZL4	408
MYL10	TMEM143	Q96AN5	401
MYL10	MYL4	P11783	390
MYL10	ADGRG1	Q9Y653	387
MYL10	MYL2	P10916	379
MYL10	MICALL2	Q8IY33	353
MYL10	DYTN	A2CJ06	337
MYL10	DNTT	P04053	330
MYL10	MYL6	P16475	323
MYL10	MYBPC2	Q14324	320
MYL10	ARPC5L	Q9BPX5	320

IntAct

7 interactions, top by confidence:

A	B	Type	Score
ZNF76	MYL10	psi-mi:“MI:0915”(physical association)	0.560
MYL10	IQGAP1	psi-mi:“MI:0914”(association)	0.530
MYL10	BCKDK	psi-mi:“MI:0914”(association)	0.350
ZNF76	MYL10	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (32): IQGAP1 (Affinity Capture-MS), MYO19 (Affinity Capture-MS), IQGAP1 (Affinity Capture-MS), MYO19 (Affinity Capture-MS), MYL10 (Two-hybrid), IQGAP1 (Affinity Capture-MS), MYO19 (Affinity Capture-MS), ZMYND19 (Affinity Capture-MS), ADCK4 (Affinity Capture-MS), DCAF6 (Affinity Capture-MS), LARS2 (Affinity Capture-MS), NARS2 (Affinity Capture-MS), MCCC1 (Affinity Capture-MS), MIPEP (Affinity Capture-MS), CYP24A1 (Affinity Capture-MS)

ESM2 similar proteins: A0A5N6H279, A4D2B8, D3ZML2, O76081, O91531, P03327, P0C678, P0C733, P79348, Q00731, Q09PK2, Q13670, Q1HVB5, Q1ZZU3, Q4KL35, Q4R1S1, Q52993, Q5JLA7, Q5JN07, Q5MFW3, Q63553, Q64902, Q6DN03, Q6NUI1, Q6P050, Q6SW81, Q86UQ5, Q8AZJ3, Q8BG31, Q8BVZ5, Q8CE90, Q8CEZ0, Q8K3M5, Q8LN49, Q8N5Z5, Q8TE04, Q8VDU5, Q8WTX9, Q8WXT5, Q9BTV7

Diamond homologs: A0A096LPI5, A6NIU2, A6NJG6, F2Z398, P0DTE4, P51957, Q09FC8, Q5H9K5, Q5T7P6, Q68CZ1, Q6B4Z3, Q6UX73, Q86U02, Q8IV13, Q8N7M2, Q8N9N2, Q8NDZ0, Q8NEM8, Q8TDM0, Q92918, Q96J02, Q96MD7, Q9BUA6, Q9NXG0, A2WN93, A2WNH1, A2Y609, A3E3H0, A3E4D8, A3E4F9, A4IF97, A4UHC0, A8CEP3, A8I1Q0, B7SNI3, F1SSF9, O14950, O93409, O94739, P02597

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

31 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	30
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1330 predictions. Top by Δscore:

Variant	Effect	Δscore
7:101616214:ACTT:A	donor_loss	1.0000
7:101616215:CTTAC:C	donor_loss	1.0000
7:101616218:A:AC	donor_gain	1.0000
7:101616218:A:C	donor_loss	1.0000
7:101616219:C:CG	donor_gain	1.0000
7:101616219:CA:C	donor_gain	1.0000
7:101616219:CACA:C	donor_gain	1.0000
7:101616219:CACAT:C	donor_gain	1.0000
7:101616222:ATCGG:A	donor_gain	1.0000
7:101616309:CACA:C	acceptor_gain	1.0000
7:101616312:A:C	acceptor_gain	1.0000
7:101622091:CTCA:C	donor_loss	1.0000
7:101622092:TCAC:T	donor_loss	1.0000
7:101622093:CACCC:C	donor_loss	1.0000
7:101622094:AC:A	donor_gain	1.0000
7:101622094:ACCCT:A	donor_loss	1.0000
7:101622095:C:CA	donor_loss	1.0000
7:101622095:CC:C	donor_gain	1.0000
7:101622196:GCGGC:G	acceptor_gain	1.0000
7:101622197:CGGC:C	acceptor_gain	1.0000
7:101622197:CGGCC:C	acceptor_gain	1.0000
7:101622198:GGC:G	acceptor_gain	1.0000
7:101622199:GC:G	acceptor_gain	1.0000
7:101622199:GCCTG:G	acceptor_loss	1.0000
7:101622200:CCTG:C	acceptor_gain	1.0000
7:101622201:C:CC	acceptor_gain	1.0000
7:101622202:T:A	acceptor_loss	1.0000
7:101622203:G:C	acceptor_gain	1.0000
7:101622210:G:C	acceptor_gain	1.0000
7:101622210:G:GC	acceptor_gain	1.0000

AlphaMissense

1500 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
7:101622122:A:G	L143P	0.999
7:101623067:G:C	F93L	0.999
7:101623067:G:T	F93L	0.999
7:101623069:A:G	F93L	0.999
7:101613508:G:C	C216W	0.998
7:101613696:A:G	L183P	0.998
7:101622124:G:C	F142L	0.998
7:101622124:G:T	F142L	0.998
7:101622125:A:G	F142S	0.998
7:101622126:A:G	F142L	0.998
7:101622140:A:T	I137N	0.998
7:101623020:A:G	L109S	0.998
7:101623035:A:T	I104N	0.998
7:101616232:A:T	V174D	0.997
7:101616265:A:G	F163S	0.997
7:101616277:A:T	I159N	0.997
7:101622133:G:C	F139L	0.997
7:101622133:G:T	F139L	0.997
7:101622135:A:G	F139L	0.997
7:101622136:G:C	N138K	0.997
7:101622136:G:T	N138K	0.997
7:101623023:T:G	D108A	0.997
7:101613500:A:T	I219N	0.996
7:101613509:C:T	C216Y	0.996
7:101613512:A:G	L215P	0.996
7:101613696:A:T	L183H	0.996
7:101616269:C:G	A162P	0.996
7:101622134:A:G	F139S	0.996
7:101623023:T:C	D108G	0.996
7:101623047:C:G	R100P	0.996

dbSNP variants (sampled 300 via entrez): RS1000192276 (7:101626330 C>T), RS1000304101 (7:101614663 G>A), RS1000307995 (7:101629835 G>A), RS1000319216 (7:101621587 T>G), RS1000445194 (7:101630019 A>G), RS1000605210 (7:101626506 G>T), RS1000634153 (7:101622587 C>T), RS1000863710 (7:101617676 A>G), RS1000908005 (7:101627395 A>G), RS1001309487 (7:101628563 G>A), RS1001317160 (7:101617378 G>A), RS1001604937 (7:101623711 A>C), RS1001895221 (7:101628822 C>T), RS1002177254 (7:101628724 G>A,T), RS1002310129 (7:101623872 T>A,C)

Disease associations

OMIM: gene MIM:617177 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST002549_10	Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels)	1.000000e-06
GCST003264_251	Post bronchodilator FEV1/FVC ratio	4.000000e-06
GCST008062_64	Blood urea nitrogen levels	4.000000e-16

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0005658	response to selective serotonin reuptake inhibitor
EFO:0004713	FEV/FVC ratio

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

12 total (human), top 12 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
entinostat	increases expression, affects cotreatment	2
perfluorotetradecanoic acid	decreases expression	1
perfluorooctanoic acid	decreases expression	1
perfluorobutyric acid	decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	increases expression, affects cotreatment	1
Grape Seed Proanthocyanidins	affects cotreatment, increases expression	1
dorsomorphin	affects cotreatment, increases expression	1
Benzo(a)pyrene	affects methylation, increases methylation	1
Catechin	affects cotreatment, increases expression	1
Estradiol	affects binding, increases expression	1
Tetrachlorodibenzodioxin	increases expression	1
Aflatoxin B1	increases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.