MYLK-AS1

Summary

MYLK-AS1 (MYLK antisense RNA 1, HGNC:42440) is a long non-coding RNA gene on chromosome 3q21.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:42440
Approved symbol	MYLK-AS1
Name	MYLK antisense RNA 1
Location	3q21.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000239523
Ensembl biotype	lncRNA
Entrez	100506826
RNAcentral	URS000075C578 — lncRNA, 814 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 162 — 162 lncRNA

ENST00000463408, ENST00000470449, ENST00000485162, ENST00000510827, ENST00000515464, ENST00000657993, ENST00000662316, ENST00000664237, ENST00000664745, ENST00000665710, ENST00000685086, ENST00000685242, ENST00000685586, ENST00000685895, ENST00000686121, ENST00000686858, ENST00000687610, ENST00000687846, ENST00000691647, ENST00000692354, ENST00000701230, ENST00000701243, ENST00000701259, ENST00000701396, ENST00000701664, ENST00000702298, ENST00000703248, ENST00000715826, ENST00000715827, ENST00000756470, ENST00000756471, ENST00000756472, ENST00000756473, ENST00000756474, ENST00000756475, ENST00000756476, ENST00000756477, ENST00000756478, ENST00000756479, ENST00000756480, ENST00000756481, ENST00000756482, ENST00000756483, ENST00000756484, ENST00000756485, ENST00000756486, ENST00000756487, ENST00000756488, ENST00000756489, ENST00000756490, ENST00000756491, ENST00000756492, ENST00000756493, ENST00000756494, ENST00000756495, ENST00000756496, ENST00000756497, ENST00000756498, ENST00000756499, ENST00000756500, ENST00000756501, ENST00000756502, ENST00000756503, ENST00000756504, ENST00000756505, ENST00000756506, ENST00000756507, ENST00000756508, ENST00000756509, ENST00000756510, ENST00000756511, ENST00000756512, ENST00000756513, ENST00000756514, ENST00000756515, ENST00000756516, ENST00000756517, ENST00000756518, ENST00000756519, ENST00000756520, ENST00000756521, ENST00000756522, ENST00000756523, ENST00000756524, ENST00000756525, ENST00000756526, ENST00000756527, ENST00000756528, ENST00000756529, ENST00000756530, ENST00000756531, ENST00000756532, ENST00000756533, ENST00000756534, ENST00000756535, ENST00000756536, ENST00000756537, ENST00000756538, ENST00000756539, ENST00000756540, ENST00000756541, ENST00000756542, ENST00000756543, ENST00000756544, ENST00000756545, ENST00000756546, ENST00000756547, ENST00000756548, ENST00000756549, ENST00000756550, ENST00000756551, ENST00000756552, ENST00000756553, ENST00000756554, ENST00000756555, ENST00000756556, ENST00000756557, ENST00000756558, ENST00000756559, ENST00000756560, ENST00000756561, ENST00000756562, ENST00000756563, ENST00000756564, ENST00000756565, ENST00000756566, ENST00000756567, ENST00000756568, ENST00000756569, ENST00000756570, ENST00000756571, ENST00000756572, ENST00000756573, ENST00000756574, ENST00000756575, ENST00000756576, ENST00000756577, ENST00000756578, ENST00000756579, ENST00000756580, ENST00000756581, ENST00000756582, ENST00000756583, ENST00000756584, ENST00000756585, ENST00000756586, ENST00000756587, ENST00000756588, ENST00000756589, ENST00000756590, ENST00000756591, ENST00000756593, ENST00000756594, ENST00000756595, ENST00000756596, ENST00000756597, ENST00000756598, ENST00000756599, ENST00000756600, ENST00000756601, ENST00000756602, ENST00000756603

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000463408 — 2 exons

Exon	Start	End
ENSE00004106628	123585553	123585794
ENSE00004106710	123629494	123630828

Expression profiles

Bgee: expression breadth ubiquitous, 168 present calls, max score 96.56.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 4.2402 / max 54.7987, expressed in 1383 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
38285	4.2402	1383

Top tissues by expression

248 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
esophagogastric junction muscularis propria	UBERON:0035841	96.56	gold quality
lower esophagus muscularis layer	UBERON:0035833	96.42	gold quality
lower esophagus	UBERON:0013473	96.40	gold quality
muscle layer of sigmoid colon	UBERON:0035805	96.39	gold quality
left uterine tube	UBERON:0001303	94.69	gold quality
lower esophagus mucosa	UBERON:0035834	94.12	gold quality
body of uterus	UBERON:0009853	91.92	gold quality
right testis	UBERON:0004534	91.05	gold quality
left testis	UBERON:0004533	90.58	gold quality
testis	UBERON:0000473	88.07	gold quality
esophagus	UBERON:0001043	87.88	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	87.21	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	86.61	gold quality
prostate gland	UBERON:0002367	85.99	gold quality
ascending aorta	UBERON:0001496	85.48	gold quality
mucosa of transverse colon	UBERON:0004991	85.41	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	84.97	gold quality
ectocervix	UBERON:0012249	84.72	gold quality
thoracic aorta	UBERON:0001515	84.60	gold quality
transverse colon	UBERON:0001157	84.15	gold quality
descending thoracic aorta	UBERON:0002345	84.12	gold quality
colon	UBERON:0001155	83.17	gold quality
endocervix	UBERON:0000458	82.88	gold quality
spinal cord	UBERON:0002240	82.47	gold quality
right atrium auricular region	UBERON:0006631	82.37	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	81.89	gold quality
spleen	UBERON:0002106	81.88	gold quality
right ovary	UBERON:0002118	81.66	gold quality
myometrium	UBERON:0001296	81.65	gold quality
large intestine	UBERON:0000059	81.60	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.33

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• LncRNA MYLK-AS1 facilitates tumor progression and angiogenesis by targeting miR-424-5p/E2F7 axis and activating VEGFR-2 signaling pathway in hepatocellular carcinoma. (PMID:33168027)
• LncRNA MYLK-AS1 acts as an oncogene by epigenetically silencing large tumor suppressor 2 (LATS2) in gastric cancer. (PMID:34181498)
• Novel Long Noncoding RNAs, LINC01093 and MYLK-AS1, Serve as Potential Diagnostic and Prognostic Biomarkers or Hepatocellular Carcinoma. (PMID:37527208)
• LncRNA MYLK antisense RNA 1 activates cell division cycle 42/Neutal Wiskott-Aldrich syndrome protein pathway via microRNA-101-5p to accelerate epithelial-to-mesenchymal transition of colon cancer cells. (PMID:37950620)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.