MYNN
geneOn this page
Also known as SBBIZ1ZBTB31ZNF902
Summary
MYNN (myoneurin, HGNC:14955) is a protein-coding gene on chromosome 3q26.2, encoding Myoneurin (Q9NPC7).
This gene encodes a member of the BTB/POZ and zinc finger domain-containing protein family that are involved in the control of gene expression. Alternative splicing results in multiple transcript variants and a pseudogene has been identified on chromosome 14.
Source: NCBI Gene 55892 — RefSeq curated summary.
At a glance
- GWAS associations: 16
- Clinical variants (ClinVar): 57 total
- Druggable target: yes
- MANE Select transcript:
NM_018657
Identifiers
Gene identifiers
| Field | Value |
|---|---|
| HGNC ID | HGNC:14955 |
| Approved symbol | MYNN |
| Name | myoneurin |
| Location | 3q26.2 |
| Locus type | gene with protein product |
| Status | Approved |
| Aliases | SBBIZ1, ZBTB31, ZNF902 |
| Ensembl gene | ENSG00000085274 |
| Ensembl biotype | protein_coding |
| OMIM | 606042 |
| Entrez | 55892 |
Gene structure
Transcript identifiers
Ensembl transcripts: 19 — 17 protein_coding, 2 nonsense_mediated_decay
ENST00000349841, ENST00000356716, ENST00000544106, ENST00000602391, ENST00000602751, ENST00000900706, ENST00000900707, ENST00000900708, ENST00000900709, ENST00000900710, ENST00000900711, ENST00000938902, ENST00000938903, ENST00000938904, ENST00000938905, ENST00000938906, ENST00000941309, ENST00000941310, ENST00000941311
RefSeq mRNA: 3 — MANE Select: NM_018657
NM_001185118, NM_001185119, NM_018657
CCDS: CCDS3207, CCDS54671
Canonical transcript exons
ENST00000349841 — 8 exons
| Exon | Start | End |
|---|---|---|
| ENSE00001015017 | 169778768 | 169779561 |
| ENSE00001366820 | 169774265 | 169774561 |
| ENSE00001421558 | 169786416 | 169789716 |
| ENSE00003324590 | 169773396 | 169773462 |
| ENSE00003464361 | 169780590 | 169780749 |
| ENSE00003513468 | 169784622 | 169784708 |
| ENSE00003628147 | 169783477 | 169783560 |
| ENSE00003641936 | 169782465 | 169782643 |
Expression profiles
Bgee: expression breadth ubiquitous, 274 present calls, max score 96.59.
FANTOM5 (CAGE): breadth ubiquitous, TPM avg 19.7830 / max 211.4608, expressed in 1782 samples.
FANTOM5 promoters (4 alternative TSS)
| Promoter ID | TPM avg | Samples expressed |
|---|---|---|
| 39678 | 16.4487 | 1755 |
| 39675 | 2.5720 | 1331 |
| 39676 | 0.5352 | 320 |
| 39677 | 0.2271 | 80 |
Top tissues by expression
285 total, by Bgee expression score (0-100, higher = more expressed):
| Tissue | Anatomy ID | Expression score | Quality |
|---|---|---|---|
| buccal mucosa cell | CL:0002336 | 96.59 | gold quality |
| secondary oocyte | CL:0000655 | 96.23 | gold quality |
| male germ line stem cell (sensu Vertebrata) in testis | CL:0000089 ∩ UBERON:0000473 | 89.20 | gold quality |
| calcaneal tendon | UBERON:0003701 | 88.83 | gold quality |
| oocyte | CL:0000023 | 88.10 | gold quality |
| esophagus squamous epithelium | UBERON:0006920 | 86.49 | gold quality |
| ventricular zone | UBERON:0003053 | 85.72 | gold quality |
| amniotic fluid | UBERON:0000173 | 85.66 | gold quality |
| ganglionic eminence | UBERON:0004023 | 85.66 | gold quality |
| cortical plate | UBERON:0005343 | 85.33 | gold quality |
| hindlimb stylopod muscle | UBERON:0004252 | 85.03 | gold quality |
| gastrocnemius | UBERON:0001388 | 84.90 | gold quality |
| hair follicle | UBERON:0002073 | 84.75 | silver quality |
| islet of Langerhans | UBERON:0000006 | 84.73 | gold quality |
| muscle of leg | UBERON:0001383 | 84.72 | gold quality |
| cartilage tissue | UBERON:0002418 | 84.45 | gold quality |
| parietal pleura | UBERON:0002400 | 84.29 | gold quality |
| squamous epithelium | UBERON:0006914 | 84.19 | gold quality |
| body of pancreas | UBERON:0001150 | 83.86 | gold quality |
| stromal cell of endometrium | CL:0002255 | 83.54 | gold quality |
| pancreas | UBERON:0001264 | 83.35 | gold quality |
| tendon | UBERON:0000043 | 83.34 | gold quality |
| germinal epithelium of ovary | UBERON:0001304 | 83.34 | gold quality |
| pleura | UBERON:0000977 | 83.26 | gold quality |
| rectum | UBERON:0001052 | 83.23 | gold quality |
| epithelial cell of pancreas | CL:0000083 | 83.19 | gold quality |
| sperm | CL:0000019 | 82.95 | gold quality |
| muscle organ | UBERON:0001630 | 82.94 | gold quality |
| endometrium | UBERON:0001295 | 82.90 | gold quality |
| adrenal tissue | UBERON:0018303 | 82.88 | gold quality |
Single-cell (SCXA)
Detected in 1 experiment(s), a significant marker in 1.
| Experiment | Marker? | Max mean expression |
|---|---|---|
| E-ANND-3 | no | 0.00 |
Regulation
Is transcription factor: no
miRNA regulators (miRDB)
151 targeting MYNN, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):
| miRNA | Max score | Avg score | miRNA target_count |
|---|---|---|---|
| HSA-MIR-3163 | 100.00 | 77.23 | 8605 |
| HSA-MIR-5692A | 100.00 | 74.40 | 6850 |
| HSA-MIR-3646 | 100.00 | 73.56 | 5283 |
| HSA-MIR-4283 | 100.00 | 66.42 | 2097 |
| HSA-MIR-1277-5P | 100.00 | 73.95 | 5056 |
| HSA-MIR-4533 | 100.00 | 69.48 | 2758 |
| HSA-MIR-4262 | 100.00 | 73.26 | 3931 |
| HSA-MIR-3120-5P | 100.00 | 65.56 | 965 |
| HSA-MIR-4692 | 100.00 | 67.32 | 2066 |
| HSA-MIR-548AW | 99.99 | 72.57 | 3559 |
| HSA-MIR-548C-3P | 99.99 | 74.01 | 7587 |
| HSA-MIR-4282 | 99.99 | 75.36 | 6408 |
| HSA-MIR-34A-5P | 99.99 | 71.21 | 1784 |
| HSA-MIR-449A | 99.99 | 71.05 | 1776 |
| HSA-MIR-181A-5P | 99.99 | 72.96 | 2995 |
| HSA-MIR-181B-5P | 99.99 | 72.97 | 2996 |
| HSA-MIR-181C-5P | 99.99 | 72.95 | 2996 |
| HSA-MIR-181D-5P | 99.99 | 73.04 | 2997 |
| HSA-MIR-3662 | 99.99 | 73.82 | 5684 |
| HSA-MIR-4803 | 99.98 | 71.99 | 3117 |
| HSA-MIR-12136 | 99.98 | 72.81 | 5713 |
| HSA-MIR-4775 | 99.98 | 75.00 | 6394 |
| HSA-MIR-34C-5P | 99.97 | 70.45 | 1577 |
| HSA-MIR-449B-5P | 99.97 | 70.26 | 1580 |
| HSA-MIR-1468-3P | 99.96 | 72.74 | 3797 |
| HSA-MIR-5688 | 99.96 | 73.23 | 4504 |
| HSA-MIR-495-3P | 99.96 | 72.81 | 4197 |
| HSA-MIR-548AJ-3P | 99.96 | 73.38 | 5345 |
| HSA-MIR-548X-3P | 99.96 | 73.38 | 5345 |
| HSA-MIR-548AT-5P | 99.96 | 70.83 | 2666 |
Literature-anchored findings (GeneRIF, showing 2)
- there may exist an association between a combination of MYNN rs10936599 and TERC rs2293607 polymorphisms and development of bladder cancer in Turkish population. (PMID:30120764)
- Comprehensive characterization of coding and non-coding single nucleotide polymorphisms of the Myoneurin (MYNN) gene using molecular dynamics simulation and docking approaches. (PMID:38165846)
Cross-species orthologs
2 orthologs
| Organism | Symbol | Gene ID |
|---|---|---|
| mus_musculus | Mynn | ENSMUSG00000037730 |
| rattus_norvegicus | Mynn | ENSRNOG00000027923 |
Paralogs (51): WIZ (ENSG00000011451), ZNF416 (ENSG00000083817), PRDM4 (ENSG00000110851), PRDM2 (ENSG00000116731), ZBTB17 (ENSG00000116809), ZNF644 (ENSG00000122482), GZF1 (ENSG00000125812), ZNF426 (ENSG00000130818), ZNF287 (ENSG00000141040), ZNF697 (ENSG00000143067), ZNF687 (ENSG00000143373), ZNF214 (ENSG00000149050), ZNF547 (ENSG00000152433), ZNF776 (ENSG00000152443), ZNF230 (ENSG00000159882), ZNF222 (ENSG00000159885), ZNF233 (ENSG00000159915), ZNF333 (ENSG00000160961), ZNF319 (ENSG00000166188), ZNF592 (ENSG00000166716), ZNF646 (ENSG00000167395), ZNF507 (ENSG00000168813), ZNF768 (ENSG00000169957), ZNF417 (ENSG00000173480), ZNF408 (ENSG00000175213), ZBTB41 (ENSG00000177888), ZNF223 (ENSG00000178386), ZNF852 (ENSG00000178917), ZNF784 (ENSG00000179922), ZNF572 (ENSG00000180938), ZNF707 (ENSG00000181135), ZNF746 (ENSG00000181220), ZNF467 (ENSG00000181444), ZNF530 (ENSG00000183647), ZNF17 (ENSG00000186272), ZNF527 (ENSG00000189164), ZKSCAN7 (ENSG00000196345), ZNF34 (ENSG00000196378), ZNF774 (ENSG00000196391), ZNF777 (ENSG00000196453)
Protein
Protein identifiers
Myoneurin — Q9NPC7 (reviewed: Q9NPC7)
Alternative names: Zinc finger and BTB domain-containing protein 31
All UniProt accessions (2): Q9NPC7, R4GMT1
UniProt curated annotations — full annotation on UniProt →
Subcellular location. Nucleus.
Tissue specificity. Mainly expressed in the neuromuscular system. Located in and around synaptic myonuclei in adult muscle. Expression is dysregulated after nerve injury. Also found in the testis, ovary and placenta.
Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.
Isoforms (4)
| UniProt ID | Names | Canonical? |
|---|---|---|
| Q9NPC7-1 | 1 | yes |
| Q9NPC7-2 | 2 | |
| Q9NPC7-3 | 3 | |
| Q9NPC7-4 | 4, m4b |
RefSeq proteins (3): NP_001172047, NP_001172048, NP_061127* (*=MANE)
Domains & families (InterPro)
| ID | Name | Type |
|---|---|---|
| IPR000210 | BTB/POZ_dom | Domain |
| IPR011333 | SKP1/BTB/POZ_sf | Homologous_superfamily |
| IPR013087 | Znf_C2H2_type | Domain |
| IPR036236 | Znf_C2H2_sf | Homologous_superfamily |
Pfam: PF00096, PF00651, PF13912
UniProt features (35 total): zinc finger region 8, helix 6, splice variant 5, compositionally biased region 3, region of interest 2, short sequence motif 2, sequence conflict 2, strand 2, turn 2, chain 1, domain 1, modified residue 1
Structure
Experimental structures (PDB)
1 structures.
| PDB | Method | Resolution (Å) |
|---|---|---|
| 2VPK | X-RAY DIFFRACTION | 2 |
Predicted structure (AlphaFold)
| Model | pLDDT | Fraction very-high |
|---|---|---|
| AF-Q9NPC7-F1 | 64.90 | 0.29 |
Functional residue map
Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.
Post-translational modifications (1): 289
Function
Pathways and Gene Ontology
Reactome pathways
0 pathways
MSigDB gene sets: 137 (showing top):
RNGTGGGC_UNKNOWN, GOBP_RESPONSE_TO_PEPTIDE, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN, chr3q26, YY1_Q6, YY1_02, SLEBOS_HEAD_AND_NECK_CANCER_WITH_HPV_UP, DODD_NASOPHARYNGEAL_CARCINOMA_UP, BERTUCCI_MEDULLARY_VS_DUCTAL_BREAST_CANCER_UP, MODULE_544, DING_LUNG_CANCER_EXPRESSION_BY_COPY_NUMBER, ACEVEDO_LIVER_CANCER_UP, TGCCTTA_MIR124A, GCCATNTTG_YY1_Q6
GO Biological Process (2): regulation of transcription by RNA polymerase II (GO:0006357), cellular response to leukemia inhibitory factor (GO:1990830)
GO Molecular Function (6): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872)
GO Cellular Component (2): nucleoplasm (GO:0005654), nucleus (GO:0005634)
GO top-level categories
Rollup of top GO terms by namespace:
| Category | Terms |
|---|---|
| RNA polymerase II transcription regulatory region sequence-specific DNA binding | 2 |
| regulation of DNA-templated transcription | 1 |
| transcription by RNA polymerase II | 1 |
| cellular response to cytokine stimulus | 1 |
| response to leukemia inhibitory factor | 1 |
| cis-regulatory region sequence-specific DNA binding | 1 |
| chromatin | 1 |
| DNA-binding transcription factor activity | 1 |
| regulation of transcription by RNA polymerase II | 1 |
| transition metal ion binding | 1 |
| nucleic acid binding | 1 |
| binding | 1 |
| cation binding | 1 |
| nuclear lumen | 1 |
| cellular anatomical structure | 1 |
| intracellular membrane-bounded organelle | 1 |
Protein interactions and networks
STRING
1478 interactions, top by confidence (×1000):
| Protein A | Protein B | Partner UniProt | Score |
|---|---|---|---|
| MYNN | LRRC34 | Q8IZ02 | 810 |
| MYNN | ACTRT3 | Q9BYD9 | 722 |
| MYNN | LRRIQ4 | A6NIV6 | 721 |
| MYNN | LRRC31 | Q6UY01 | 583 |
| MYNN | RHPN2 | Q8IUC4 | 517 |
| MYNN | PREPL | Q4J6C6 | 453 |
| MYNN | ZNF800 | Q2TB10 | 439 |
| MYNN | CUEDC2 | Q9H467 | 436 |
| MYNN | GPR160 | Q9UJ42 | 435 |
| MYNN | DARS2 | Q6PI48 | 423 |
| MYNN | FBXO28 | Q9NVF7 | 416 |
| MYNN | ECH1 | Q13011 | 405 |
| MYNN | FAM170A | A1A519 | 399 |
| MYNN | ZBTB24 | O43167 | 396 |
| MYNN | OLIG3 | Q7RTU3 | 387 |
IntAct
54 interactions, top by confidence:
| A | B | Type | Score |
|---|---|---|---|
| ANP32B | MYNN | psi-mi:“MI:0915”(physical association) | 0.560 |
| FDXACB1 | MYNN | psi-mi:“MI:0915”(physical association) | 0.560 |
| CALR | MYNN | psi-mi:“MI:0915”(physical association) | 0.560 |
| SERPINH1 | MYNN | psi-mi:“MI:0915”(physical association) | 0.560 |
| MYNN | CDH1 | psi-mi:“MI:0915”(physical association) | 0.560 |
| DLST | MYNN | psi-mi:“MI:0915”(physical association) | 0.560 |
| DMWD | MYNN | psi-mi:“MI:0915”(physical association) | 0.560 |
| MYNN | psi-mi:“MI:0915”(physical association) | 0.560 | |
| GRN | MYNN | psi-mi:“MI:0915”(physical association) | 0.560 |
| PRKN | MYNN | psi-mi:“MI:0915”(physical association) | 0.560 |
| MYNN | TGFBR2 | psi-mi:“MI:0915”(physical association) | 0.560 |
| CDK5R1 | MYNN | psi-mi:“MI:0915”(physical association) | 0.560 |
| KIF1B | MYNN | psi-mi:“MI:0915”(physical association) | 0.560 |
| MYNN | JPH3 | psi-mi:“MI:0915”(physical association) | 0.560 |
| MYNN | NEK7 | psi-mi:“MI:0915”(physical association) | 0.560 |
BioGRID (16): MYNN (Affinity Capture-MS), MYNN (Affinity Capture-MS), ANP32B (Two-hybrid), FDXACB1 (Two-hybrid), MYNN (Proximity Label-MS), MYNN (Affinity Capture-MS), MYNN (Affinity Capture-MS), MYNN (Two-hybrid), MYNN (Cross-Linking-MS (XL-MS)), NEK1 (Cross-Linking-MS (XL-MS)), MYNN (Affinity Capture-RNA), MYNN (Affinity Capture-MS), MYNN (Two-hybrid), MYNN (Affinity Capture-RNA), MYNN (Affinity Capture-MS)
ESM2 similar proteins: A1L1J6, A2ANX9, A7Y7X5, E9Q8T2, G5E8B9, O15060, O43167, O43829, O62836, O95625, P08048, P0C6P6, P10925, P17010, P17012, P20662, P52739, Q01611, Q08376, Q0VCB0, Q2FAY8, Q3TTC2, Q4V8R6, Q52V16, Q5DU09, Q5PPG4, Q5R5M1, Q5R5N5, Q5RAU9, Q5SVQ8, Q6B4Z5, Q6GNP2, Q6INV8, Q7TS63, Q7ZVR6, Q80V63, Q80X44, Q811F1, Q8K3J5, Q92010
Diamond homologs: A0JN76, A1L2U9, A1YEX3, A1YPR0, A2AAX3, B1WAZ8, B1WBS3, B1WBU4, B2RXF5, D3ZA50, O14867, O15062, O15156, O15209, O43167, O43298, O43829, O88282, O88939, O93567, O95365, P24278, P41182, P41183, P52739, P97302, P97303, Q08376, Q0IH98, Q0IJ29, Q0P4X6, Q0VCJ6, Q13105, Q14526, Q1H9T6, Q1L8W0, Q2T9Z7, Q3B725, Q3B7N9, Q3SWU4
SIGNOR signaling
0 interactions.
Disease & clinical
Clinical variants and AI predictions
ClinVar
57 variants total. Per-class counts are floors (≥ shown; pagination cap):
| Classification | Count (floor) |
|---|---|
| Pathogenic | 0 |
| Likely pathogenic | 0 |
| Uncertain significance | 45 |
| Likely benign | 0 |
| Benign | 0 |
Top pathogenic / likely-pathogenic (0)
SpliceAI
1029 predictions. Top by Δscore:
| Variant | Effect | Δscore |
|---|---|---|
| 3:169778766:A:AG | acceptor_gain | 1.0000 |
| 3:169778767:G:GG | acceptor_gain | 1.0000 |
| 3:169779542:GCAT:G | donor_gain | 1.0000 |
| 3:169780587:TAG:T | acceptor_loss | 1.0000 |
| 3:169780588:A:AG | acceptor_gain | 1.0000 |
| 3:169780588:AG:A | acceptor_gain | 1.0000 |
| 3:169780588:AGGT:A | acceptor_gain | 1.0000 |
| 3:169780589:G:GA | acceptor_gain | 1.0000 |
| 3:169780589:GG:G | acceptor_gain | 1.0000 |
| 3:169780589:GGT:G | acceptor_gain | 1.0000 |
| 3:169780589:GGTG:G | acceptor_gain | 1.0000 |
| 3:169780589:GGTGA:G | acceptor_gain | 1.0000 |
| 3:169780698:AT:A | donor_gain | 1.0000 |
| 3:169780750:G:GA | donor_loss | 1.0000 |
| 3:169780751:T:A | donor_loss | 1.0000 |
| 3:169784616:TTTCA:T | acceptor_loss | 1.0000 |
| 3:169784617:TTCAG:T | acceptor_loss | 1.0000 |
| 3:169784618:TCA:T | acceptor_loss | 1.0000 |
| 3:169784619:CA:C | acceptor_loss | 1.0000 |
| 3:169784620:A:AG | acceptor_gain | 1.0000 |
| 3:169784620:AG:A | acceptor_gain | 1.0000 |
| 3:169784621:G:A | acceptor_loss | 1.0000 |
| 3:169784621:G:GG | acceptor_gain | 1.0000 |
| 3:169784621:GG:G | acceptor_gain | 1.0000 |
| 3:169784621:GGA:G | acceptor_gain | 1.0000 |
| 3:169784683:G:GT | donor_gain | 1.0000 |
| 3:169784707:TGGT:T | donor_loss | 1.0000 |
| 3:169784709:G:GG | donor_gain | 1.0000 |
| 3:169784709:GT:G | donor_loss | 1.0000 |
| 3:169784710:T:A | donor_loss | 1.0000 |
AlphaMissense
4049 scored. Top likely-pathogenic:
| Variant | Protein change | am_pathogenicity |
|---|---|---|
| 3:169779495:T:C | C332R | 1.000 |
| 3:169779516:T:C | F339L | 1.000 |
| 3:169779517:T:C | F339S | 1.000 |
| 3:169779518:T:A | F339L | 1.000 |
| 3:169779518:T:G | F339L | 1.000 |
| 3:169779535:T:C | L345P | 1.000 |
| 3:169779545:T:A | H348Q | 1.000 |
| 3:169779545:T:G | H348Q | 1.000 |
| 3:169779557:T:A | H352Q | 1.000 |
| 3:169779557:T:G | H352Q | 1.000 |
| 3:169780628:T:C | F367L | 1.000 |
| 3:169780629:T:C | F367S | 1.000 |
| 3:169780630:T:A | F367L | 1.000 |
| 3:169780630:T:G | F367L | 1.000 |
| 3:169780694:T:C | C389R | 1.000 |
| 3:169780703:T:C | C392R | 1.000 |
| 3:169780715:T:C | F396L | 1.000 |
| 3:169780716:T:C | F396S | 1.000 |
| 3:169780717:T:A | F396L | 1.000 |
| 3:169780717:T:G | F396L | 1.000 |
| 3:169780734:T:C | L402P | 1.000 |
| 3:169782493:T:C | C417R | 1.000 |
| 3:169782502:T:C | C420R | 1.000 |
| 3:169782514:T:C | F424L | 1.000 |
| 3:169782515:T:C | F424S | 1.000 |
| 3:169782516:T:A | F424L | 1.000 |
| 3:169782516:T:G | F424L | 1.000 |
| 3:169782533:T:C | L430P | 1.000 |
| 3:169782541:C:A | H433N | 1.000 |
| 3:169782541:C:G | H433D | 1.000 |
dbSNP variants (sampled 300 via entrez): RS1000107656 (3:169781869 A>G), RS1000135495 (3:169778972 A>C,G), RS1000176719 (3:169789834 A>G), RS1000184827 (3:169775623 C>G,T), RS1000214547 (3:169775942 G>T), RS1000434071 (3:169790117 C>T), RS1000550070 (3:169777484 T>C,G), RS1000747482 (3:169780526 C>A,G,T), RS1001215006 (3:169784501 A>G), RS1001359775 (3:169784095 C>G), RS1001374430 (3:169776772 C>T), RS1001731438 (3:169785006 T>G), RS1001967208 (3:169771708 C>G), RS1002123681 (3:169776982 G>A,C), RS1002236020 (3:169776608 A>C)
Disease associations
OMIM: gene MIM:606042 | disease phenotypes:
GenCC curated gene-disease
Mondo (0):
Orphanet (0):
HPO phenotypes
0 total (0 of 0 shown, HPO-id order):
GWAS associations
16 associations (top):
| Study | Trait | p-value |
|---|---|---|
| GCST000843_3 | Colorectal cancer | 3.000000e-08 |
| GCST001198_51 | Multiple sclerosis | 7.000000e-07 |
| GCST002140_2 | Multiple myeloma | 9.000000e-14 |
| GCST002243_3 | Bladder cancer | 5.000000e-09 |
| GCST002299_1 | Chronic lymphocytic leukemia | 2.000000e-09 |
| GCST002922_5 | Multiple myeloma and monoclonal gammopathy | 7.000000e-06 |
| GCST004744_12 | Lung adenocarcinoma | 5.000000e-06 |
| GCST005996_58 | Red blood cell count | 4.000000e-08 |
| GCST007552_26 | Colorectal cancer | 2.000000e-06 |
| GCST007856_90 | Colorectal cancer or advanced adenoma | 8.000000e-06 |
| GCST008834_3 | Non-small cell lung cancer | 2.000000e-10 |
| GCST009869_52 | Colorectal cancer | 9.000000e-06 |
| GCST010303_21 | Nevus count or cutaneous melanoma | 5.000000e-16 |
| GCST010304_1 | Cutaneous malignant melanoma | 4.000000e-11 |
| GCST011956_77 | Systemic lupus erythematosus | 2.000000e-11 |
| GCST012396_4 | Multiple myeloma | 3.000000e-08 |
EFO canonical traits (2, from GWAS)
| EFO ID | Trait name |
|---|---|
| EFO:0004305 | erythrocyte count |
| EFO:0004632 | nevus count |
Drugs & pharmacology
Drug and pharmacology data
Is drug target: yes
ChEMBL targets (1): CHEMBL5069362 (SINGLE PROTEIN)
PharmGKB: 1 entry (VIP=true, CPIC=false)
CTD chemical–gene interactions
38 total (human), top 30 by PubMed support.
| Chemical | Actions (top 5) | PubMed papers |
|---|---|---|
| Valproic Acid | affects expression, affects cotreatment, decreases expression | 4 |
| Formaldehyde | increases expression | 2 |
| 3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide | decreases expression | 1 |
| TAK-243 | increases sumoylation | 1 |
| dicrotophos | decreases expression | 1 |
| methylmercuric chloride | decreases expression, increases expression | 1 |
| triphenyl phosphate | affects expression | 1 |
| tris(1,3-dichloro-2-propyl)phosphate | increases expression | 1 |
| sodium arsenite | increases expression | 1 |
| butyraldehyde | increases expression | 1 |
| cupric oxide | increases expression | 1 |
| celastrol | decreases expression | 1 |
| di-n-butylphosphoric acid | affects expression | 1 |
| cylindrospermopsin | increases expression | 1 |
| CGP 52608 | affects binding, increases reaction | 1 |
| gedunin | decreases expression | 1 |
| 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide | affects cotreatment, decreases expression | 1 |
| abrine | increases expression | 1 |
| dorsomorphin | affects cotreatment, decreases expression | 1 |
| (4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) | increases expression | 1 |
| jinfukang | decreases expression | 1 |
| Resveratrol | affects cotreatment, increases expression | 1 |
| Sunitinib | increases expression | 1 |
| Benzene | decreases expression | 1 |
| Calcitriol | decreases expression, affects cotreatment | 1 |
| Demecolcine | decreases expression | 1 |
| Doxorubicin | decreases expression | 1 |
| Ethyl Methanesulfonate | increases expression | 1 |
| Folic Acid | increases expression | 1 |
| Gold | decreases expression | 1 |
ChEMBL screening assays
2 unique, capped per target: 2 binding
Representative assays (with source publication via chembl_document):
| Assay ID | Type | Description | Source paper |
|---|---|---|---|
| CHEMBL5059495 | Binding | Proteomics fold change data (SUDHL4 cells, 1h) | Data for DCP probe CCT369260 |
Cellosaurus cell lines
1 cell lines: 1 transformed cell line
First 10 cell lines (id-ordered, not curated):
| Cellosaurus | Name | Category | Sex |
|---|---|---|---|
| CVCL_HC85 | HEK293 eGFP-MYNN | Transformed cell line | Female |
Clinical trials (associated diseases)
0 trials via MONDO — disease-level, not drug-specific.
Related Atlas pages
- Disease cohort memberships (association, not causation — diseases whose associated-gene cohort lists this gene; a subset are also under Associated diseases): B-cell chronic lymphocytic leukemia, colorectal adenoma, cutaneous melanoma, lung adenocarcinoma, monoclonal gammopathy, non-small cell lung carcinoma, plasma cell myeloma, urinary bladder carcinoma