MYNN

gene
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Also known as SBBIZ1ZBTB31ZNF902

Summary

MYNN (myoneurin, HGNC:14955) is a protein-coding gene on chromosome 3q26.2, encoding Myoneurin (Q9NPC7).

This gene encodes a member of the BTB/POZ and zinc finger domain-containing protein family that are involved in the control of gene expression. Alternative splicing results in multiple transcript variants and a pseudogene has been identified on chromosome 14.

Source: NCBI Gene 55892 — RefSeq curated summary.

At a glance

  • GWAS associations: 16
  • Clinical variants (ClinVar): 57 total
  • Druggable target: yes
  • MANE Select transcript: NM_018657

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:14955
Approved symbolMYNN
Namemyoneurin
Location3q26.2
Locus typegene with protein product
StatusApproved
AliasesSBBIZ1, ZBTB31, ZNF902
Ensembl geneENSG00000085274
Ensembl biotypeprotein_coding
OMIM606042
Entrez55892

Gene structure

Transcript identifiers

Ensembl transcripts: 19 — 17 protein_coding, 2 nonsense_mediated_decay

ENST00000349841, ENST00000356716, ENST00000544106, ENST00000602391, ENST00000602751, ENST00000900706, ENST00000900707, ENST00000900708, ENST00000900709, ENST00000900710, ENST00000900711, ENST00000938902, ENST00000938903, ENST00000938904, ENST00000938905, ENST00000938906, ENST00000941309, ENST00000941310, ENST00000941311

RefSeq mRNA: 3 — MANE Select: NM_018657 NM_001185118, NM_001185119, NM_018657

CCDS: CCDS3207, CCDS54671

Canonical transcript exons

ENST00000349841 — 8 exons

ExonStartEnd
ENSE00001015017169778768169779561
ENSE00001366820169774265169774561
ENSE00001421558169786416169789716
ENSE00003324590169773396169773462
ENSE00003464361169780590169780749
ENSE00003513468169784622169784708
ENSE00003628147169783477169783560
ENSE00003641936169782465169782643

Expression profiles

Bgee: expression breadth ubiquitous, 274 present calls, max score 96.59.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 19.7830 / max 211.4608, expressed in 1782 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter IDTPM avgSamples expressed
3967816.44871755
396752.57201331
396760.5352320
396770.227180

Top tissues by expression

285 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
buccal mucosa cellCL:000233696.59gold quality
secondary oocyteCL:000065596.23gold quality
male germ line stem cell (sensu Vertebrata) in testisCL:0000089 ∩ UBERON:000047389.20gold quality
calcaneal tendonUBERON:000370188.83gold quality
oocyteCL:000002388.10gold quality
esophagus squamous epitheliumUBERON:000692086.49gold quality
ventricular zoneUBERON:000305385.72gold quality
amniotic fluidUBERON:000017385.66gold quality
ganglionic eminenceUBERON:000402385.66gold quality
cortical plateUBERON:000534385.33gold quality
hindlimb stylopod muscleUBERON:000425285.03gold quality
gastrocnemiusUBERON:000138884.90gold quality
hair follicleUBERON:000207384.75silver quality
islet of LangerhansUBERON:000000684.73gold quality
muscle of legUBERON:000138384.72gold quality
cartilage tissueUBERON:000241884.45gold quality
parietal pleuraUBERON:000240084.29gold quality
squamous epitheliumUBERON:000691484.19gold quality
body of pancreasUBERON:000115083.86gold quality
stromal cell of endometriumCL:000225583.54gold quality
pancreasUBERON:000126483.35gold quality
tendonUBERON:000004383.34gold quality
germinal epithelium of ovaryUBERON:000130483.34gold quality
pleuraUBERON:000097783.26gold quality
rectumUBERON:000105283.23gold quality
epithelial cell of pancreasCL:000008383.19gold quality
spermCL:000001982.95gold quality
muscle organUBERON:000163082.94gold quality
endometriumUBERON:000129582.90gold quality
adrenal tissueUBERON:001830382.88gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

ExperimentMarker?Max mean expression
E-ANND-3no0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

151 targeting MYNN, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNAMax scoreAvg scoremiRNA target_count
HSA-MIR-3163100.0077.238605
HSA-MIR-5692A100.0074.406850
HSA-MIR-3646100.0073.565283
HSA-MIR-4283100.0066.422097
HSA-MIR-1277-5P100.0073.955056
HSA-MIR-4533100.0069.482758
HSA-MIR-4262100.0073.263931
HSA-MIR-3120-5P100.0065.56965
HSA-MIR-4692100.0067.322066
HSA-MIR-548AW99.9972.573559
HSA-MIR-548C-3P99.9974.017587
HSA-MIR-428299.9975.366408
HSA-MIR-34A-5P99.9971.211784
HSA-MIR-449A99.9971.051776
HSA-MIR-181A-5P99.9972.962995
HSA-MIR-181B-5P99.9972.972996
HSA-MIR-181C-5P99.9972.952996
HSA-MIR-181D-5P99.9973.042997
HSA-MIR-366299.9973.825684
HSA-MIR-480399.9871.993117
HSA-MIR-1213699.9872.815713
HSA-MIR-477599.9875.006394
HSA-MIR-34C-5P99.9770.451577
HSA-MIR-449B-5P99.9770.261580
HSA-MIR-1468-3P99.9672.743797
HSA-MIR-568899.9673.234504
HSA-MIR-495-3P99.9672.814197
HSA-MIR-548AJ-3P99.9673.385345
HSA-MIR-548X-3P99.9673.385345
HSA-MIR-548AT-5P99.9670.832666

Literature-anchored findings (GeneRIF, showing 2)

  • there may exist an association between a combination of MYNN rs10936599 and TERC rs2293607 polymorphisms and development of bladder cancer in Turkish population. (PMID:30120764)
  • Comprehensive characterization of coding and non-coding single nucleotide polymorphisms of the Myoneurin (MYNN) gene using molecular dynamics simulation and docking approaches. (PMID:38165846)

Cross-species orthologs

2 orthologs

OrganismSymbolGene ID
mus_musculusMynnENSMUSG00000037730
rattus_norvegicusMynnENSRNOG00000027923

Paralogs (51): WIZ (ENSG00000011451), ZNF416 (ENSG00000083817), PRDM4 (ENSG00000110851), PRDM2 (ENSG00000116731), ZBTB17 (ENSG00000116809), ZNF644 (ENSG00000122482), GZF1 (ENSG00000125812), ZNF426 (ENSG00000130818), ZNF287 (ENSG00000141040), ZNF697 (ENSG00000143067), ZNF687 (ENSG00000143373), ZNF214 (ENSG00000149050), ZNF547 (ENSG00000152433), ZNF776 (ENSG00000152443), ZNF230 (ENSG00000159882), ZNF222 (ENSG00000159885), ZNF233 (ENSG00000159915), ZNF333 (ENSG00000160961), ZNF319 (ENSG00000166188), ZNF592 (ENSG00000166716), ZNF646 (ENSG00000167395), ZNF507 (ENSG00000168813), ZNF768 (ENSG00000169957), ZNF417 (ENSG00000173480), ZNF408 (ENSG00000175213), ZBTB41 (ENSG00000177888), ZNF223 (ENSG00000178386), ZNF852 (ENSG00000178917), ZNF784 (ENSG00000179922), ZNF572 (ENSG00000180938), ZNF707 (ENSG00000181135), ZNF746 (ENSG00000181220), ZNF467 (ENSG00000181444), ZNF530 (ENSG00000183647), ZNF17 (ENSG00000186272), ZNF527 (ENSG00000189164), ZKSCAN7 (ENSG00000196345), ZNF34 (ENSG00000196378), ZNF774 (ENSG00000196391), ZNF777 (ENSG00000196453)

Protein

Protein identifiers

MyoneurinQ9NPC7 (reviewed: Q9NPC7)

Alternative names: Zinc finger and BTB domain-containing protein 31

All UniProt accessions (2): Q9NPC7, R4GMT1

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Nucleus.

Tissue specificity. Mainly expressed in the neuromuscular system. Located in and around synaptic myonuclei in adult muscle. Expression is dysregulated after nerve injury. Also found in the testis, ovary and placenta.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

Isoforms (4)

UniProt IDNamesCanonical?
Q9NPC7-11yes
Q9NPC7-22
Q9NPC7-33
Q9NPC7-44, m4b

RefSeq proteins (3): NP_001172047, NP_001172048, NP_061127* (*=MANE)

Domains & families (InterPro)

IDNameType
IPR000210BTB/POZ_domDomain
IPR011333SKP1/BTB/POZ_sfHomologous_superfamily
IPR013087Znf_C2H2_typeDomain
IPR036236Znf_C2H2_sfHomologous_superfamily

Pfam: PF00096, PF00651, PF13912

UniProt features (35 total): zinc finger region 8, helix 6, splice variant 5, compositionally biased region 3, region of interest 2, short sequence motif 2, sequence conflict 2, strand 2, turn 2, chain 1, domain 1, modified residue 1

Structure

Experimental structures (PDB)

1 structures.

PDBMethodResolution (Å)
2VPKX-RAY DIFFRACTION2

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-Q9NPC7-F164.900.29

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 289

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 137 (showing top): RNGTGGGC_UNKNOWN, GOBP_RESPONSE_TO_PEPTIDE, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN, chr3q26, YY1_Q6, YY1_02, SLEBOS_HEAD_AND_NECK_CANCER_WITH_HPV_UP, DODD_NASOPHARYNGEAL_CARCINOMA_UP, BERTUCCI_MEDULLARY_VS_DUCTAL_BREAST_CANCER_UP, MODULE_544, DING_LUNG_CANCER_EXPRESSION_BY_COPY_NUMBER, ACEVEDO_LIVER_CANCER_UP, TGCCTTA_MIR124A, GCCATNTTG_YY1_Q6

GO Biological Process (2): regulation of transcription by RNA polymerase II (GO:0006357), cellular response to leukemia inhibitory factor (GO:1990830)

GO Molecular Function (6): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (2): nucleoplasm (GO:0005654), nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
RNA polymerase II transcription regulatory region sequence-specific DNA binding2
regulation of DNA-templated transcription1
transcription by RNA polymerase II1
cellular response to cytokine stimulus1
response to leukemia inhibitory factor1
cis-regulatory region sequence-specific DNA binding1
chromatin1
DNA-binding transcription factor activity1
regulation of transcription by RNA polymerase II1
transition metal ion binding1
nucleic acid binding1
binding1
cation binding1
nuclear lumen1
cellular anatomical structure1
intracellular membrane-bounded organelle1

Protein interactions and networks

STRING

1478 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
MYNNLRRC34Q8IZ02810
MYNNACTRT3Q9BYD9722
MYNNLRRIQ4A6NIV6721
MYNNLRRC31Q6UY01583
MYNNRHPN2Q8IUC4517
MYNNPREPLQ4J6C6453
MYNNZNF800Q2TB10439
MYNNCUEDC2Q9H467436
MYNNGPR160Q9UJ42435
MYNNDARS2Q6PI48423
MYNNFBXO28Q9NVF7416
MYNNECH1Q13011405
MYNNFAM170AA1A519399
MYNNZBTB24O43167396
MYNNOLIG3Q7RTU3387

IntAct

54 interactions, top by confidence:

ABTypeScore
ANP32BMYNNpsi-mi:“MI:0915”(physical association)0.560
FDXACB1MYNNpsi-mi:“MI:0915”(physical association)0.560
CALRMYNNpsi-mi:“MI:0915”(physical association)0.560
SERPINH1MYNNpsi-mi:“MI:0915”(physical association)0.560
MYNNCDH1psi-mi:“MI:0915”(physical association)0.560
DLSTMYNNpsi-mi:“MI:0915”(physical association)0.560
DMWDMYNNpsi-mi:“MI:0915”(physical association)0.560
MYNNpsi-mi:“MI:0915”(physical association)0.560
GRNMYNNpsi-mi:“MI:0915”(physical association)0.560
PRKNMYNNpsi-mi:“MI:0915”(physical association)0.560
MYNNTGFBR2psi-mi:“MI:0915”(physical association)0.560
CDK5R1MYNNpsi-mi:“MI:0915”(physical association)0.560
KIF1BMYNNpsi-mi:“MI:0915”(physical association)0.560
MYNNJPH3psi-mi:“MI:0915”(physical association)0.560
MYNNNEK7psi-mi:“MI:0915”(physical association)0.560

BioGRID (16): MYNN (Affinity Capture-MS), MYNN (Affinity Capture-MS), ANP32B (Two-hybrid), FDXACB1 (Two-hybrid), MYNN (Proximity Label-MS), MYNN (Affinity Capture-MS), MYNN (Affinity Capture-MS), MYNN (Two-hybrid), MYNN (Cross-Linking-MS (XL-MS)), NEK1 (Cross-Linking-MS (XL-MS)), MYNN (Affinity Capture-RNA), MYNN (Affinity Capture-MS), MYNN (Two-hybrid), MYNN (Affinity Capture-RNA), MYNN (Affinity Capture-MS)

ESM2 similar proteins: A1L1J6, A2ANX9, A7Y7X5, E9Q8T2, G5E8B9, O15060, O43167, O43829, O62836, O95625, P08048, P0C6P6, P10925, P17010, P17012, P20662, P52739, Q01611, Q08376, Q0VCB0, Q2FAY8, Q3TTC2, Q4V8R6, Q52V16, Q5DU09, Q5PPG4, Q5R5M1, Q5R5N5, Q5RAU9, Q5SVQ8, Q6B4Z5, Q6GNP2, Q6INV8, Q7TS63, Q7ZVR6, Q80V63, Q80X44, Q811F1, Q8K3J5, Q92010

Diamond homologs: A0JN76, A1L2U9, A1YEX3, A1YPR0, A2AAX3, B1WAZ8, B1WBS3, B1WBU4, B2RXF5, D3ZA50, O14867, O15062, O15156, O15209, O43167, O43298, O43829, O88282, O88939, O93567, O95365, P24278, P41182, P41183, P52739, P97302, P97303, Q08376, Q0IH98, Q0IJ29, Q0P4X6, Q0VCJ6, Q13105, Q14526, Q1H9T6, Q1L8W0, Q2T9Z7, Q3B725, Q3B7N9, Q3SWU4

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

57 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic0
Likely pathogenic0
Uncertain significance45
Likely benign0
Benign0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1029 predictions. Top by Δscore:

VariantEffectΔscore
3:169778766:A:AGacceptor_gain1.0000
3:169778767:G:GGacceptor_gain1.0000
3:169779542:GCAT:Gdonor_gain1.0000
3:169780587:TAG:Tacceptor_loss1.0000
3:169780588:A:AGacceptor_gain1.0000
3:169780588:AG:Aacceptor_gain1.0000
3:169780588:AGGT:Aacceptor_gain1.0000
3:169780589:G:GAacceptor_gain1.0000
3:169780589:GG:Gacceptor_gain1.0000
3:169780589:GGT:Gacceptor_gain1.0000
3:169780589:GGTG:Gacceptor_gain1.0000
3:169780589:GGTGA:Gacceptor_gain1.0000
3:169780698:AT:Adonor_gain1.0000
3:169780750:G:GAdonor_loss1.0000
3:169780751:T:Adonor_loss1.0000
3:169784616:TTTCA:Tacceptor_loss1.0000
3:169784617:TTCAG:Tacceptor_loss1.0000
3:169784618:TCA:Tacceptor_loss1.0000
3:169784619:CA:Cacceptor_loss1.0000
3:169784620:A:AGacceptor_gain1.0000
3:169784620:AG:Aacceptor_gain1.0000
3:169784621:G:Aacceptor_loss1.0000
3:169784621:G:GGacceptor_gain1.0000
3:169784621:GG:Gacceptor_gain1.0000
3:169784621:GGA:Gacceptor_gain1.0000
3:169784683:G:GTdonor_gain1.0000
3:169784707:TGGT:Tdonor_loss1.0000
3:169784709:G:GGdonor_gain1.0000
3:169784709:GT:Gdonor_loss1.0000
3:169784710:T:Adonor_loss1.0000

AlphaMissense

4049 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
3:169779495:T:CC332R1.000
3:169779516:T:CF339L1.000
3:169779517:T:CF339S1.000
3:169779518:T:AF339L1.000
3:169779518:T:GF339L1.000
3:169779535:T:CL345P1.000
3:169779545:T:AH348Q1.000
3:169779545:T:GH348Q1.000
3:169779557:T:AH352Q1.000
3:169779557:T:GH352Q1.000
3:169780628:T:CF367L1.000
3:169780629:T:CF367S1.000
3:169780630:T:AF367L1.000
3:169780630:T:GF367L1.000
3:169780694:T:CC389R1.000
3:169780703:T:CC392R1.000
3:169780715:T:CF396L1.000
3:169780716:T:CF396S1.000
3:169780717:T:AF396L1.000
3:169780717:T:GF396L1.000
3:169780734:T:CL402P1.000
3:169782493:T:CC417R1.000
3:169782502:T:CC420R1.000
3:169782514:T:CF424L1.000
3:169782515:T:CF424S1.000
3:169782516:T:AF424L1.000
3:169782516:T:GF424L1.000
3:169782533:T:CL430P1.000
3:169782541:C:AH433N1.000
3:169782541:C:GH433D1.000

dbSNP variants (sampled 300 via entrez): RS1000107656 (3:169781869 A>G), RS1000135495 (3:169778972 A>C,G), RS1000176719 (3:169789834 A>G), RS1000184827 (3:169775623 C>G,T), RS1000214547 (3:169775942 G>T), RS1000434071 (3:169790117 C>T), RS1000550070 (3:169777484 T>C,G), RS1000747482 (3:169780526 C>A,G,T), RS1001215006 (3:169784501 A>G), RS1001359775 (3:169784095 C>G), RS1001374430 (3:169776772 C>T), RS1001731438 (3:169785006 T>G), RS1001967208 (3:169771708 C>G), RS1002123681 (3:169776982 G>A,C), RS1002236020 (3:169776608 A>C)

Disease associations

OMIM: gene MIM:606042 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

16 associations (top):

StudyTraitp-value
GCST000843_3Colorectal cancer3.000000e-08
GCST001198_51Multiple sclerosis7.000000e-07
GCST002140_2Multiple myeloma9.000000e-14
GCST002243_3Bladder cancer5.000000e-09
GCST002299_1Chronic lymphocytic leukemia2.000000e-09
GCST002922_5Multiple myeloma and monoclonal gammopathy7.000000e-06
GCST004744_12Lung adenocarcinoma5.000000e-06
GCST005996_58Red blood cell count4.000000e-08
GCST007552_26Colorectal cancer2.000000e-06
GCST007856_90Colorectal cancer or advanced adenoma8.000000e-06
GCST008834_3Non-small cell lung cancer2.000000e-10
GCST009869_52Colorectal cancer9.000000e-06
GCST010303_21Nevus count or cutaneous melanoma5.000000e-16
GCST010304_1Cutaneous malignant melanoma4.000000e-11
GCST011956_77Systemic lupus erythematosus2.000000e-11
GCST012396_4Multiple myeloma3.000000e-08

EFO canonical traits (2, from GWAS)

EFO IDTrait name
EFO:0004305erythrocyte count
EFO:0004632nevus count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL5069362 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

38 total (human), top 30 by PubMed support.

ChemicalActions (top 5)PubMed papers
Valproic Acidaffects expression, affects cotreatment, decreases expression4
Formaldehydeincreases expression2
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamidedecreases expression1
TAK-243increases sumoylation1
dicrotophosdecreases expression1
methylmercuric chloridedecreases expression, increases expression1
triphenyl phosphateaffects expression1
tris(1,3-dichloro-2-propyl)phosphateincreases expression1
sodium arseniteincreases expression1
butyraldehydeincreases expression1
cupric oxideincreases expression1
celastroldecreases expression1
di-n-butylphosphoric acidaffects expression1
cylindrospermopsinincreases expression1
CGP 52608affects binding, increases reaction1
gedunindecreases expression1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamideaffects cotreatment, decreases expression1
abrineincreases expression1
dorsomorphinaffects cotreatment, decreases expression1
(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)increases expression1
jinfukangdecreases expression1
Resveratrolaffects cotreatment, increases expression1
Sunitinibincreases expression1
Benzenedecreases expression1
Calcitrioldecreases expression, affects cotreatment1
Demecolcinedecreases expression1
Doxorubicindecreases expression1
Ethyl Methanesulfonateincreases expression1
Folic Acidincreases expression1
Golddecreases expression1

ChEMBL screening assays

2 unique, capped per target: 2 binding

Representative assays (with source publication via chembl_document):

Assay IDTypeDescriptionSource paper
CHEMBL5059495BindingProteomics fold change data (SUDHL4 cells, 1h)Data for DCP probe CCT369260

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

CellosaurusNameCategorySex
CVCL_HC85HEK293 eGFP-MYNNTransformed cell lineFemale

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.