MYOM2

Summary

MYOM2 (myomesin 2, HGNC:7614) is a protein-coding gene on chromosome 8p23.3, encoding Myomesin-2 (P54296). Major component of the vertebrate myofibrillar M band.

The giant protein titin, together with its associated proteins, interconnects the major structure of sarcomeres, the M bands and Z discs. The C-terminal end of the titin string extends into the M line, where it binds tightly to M-band constituents of apparent molecular masses of 190 kD and 165 kD. The predicted MYOM2 protein contains 1,465 amino acids. Like MYOM1, MYOM2 has a unique N-terminal domain followed by 12 repeat domains with strong homology to either fibronectin type III or immunoglobulin C2 domains. Protein sequence comparisons suggested that the MYOM2 protein and bovine M protein are identical.

Source: NCBI Gene 9172 — RefSeq curated summary.

At a glance

• GWAS associations: 15
• Clinical variants (ClinVar): 521 total
• MANE Select transcript: NM_003970

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:7614
Approved symbol	MYOM2
Name	myomesin 2
Location	8p23.3
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000036448
Ensembl biotype	protein_coding
OMIM	603509
Entrez	9172

Gene structure

Transcript identifiers

Ensembl transcripts: 37 — 24 protein_coding, 11 protein_coding_CDS_not_defined, 2 retained_intron

ENST00000262113, ENST00000517520, ENST00000518203, ENST00000518513, ENST00000518803, ENST00000519372, ENST00000519518, ENST00000519631, ENST00000520072, ENST00000520298, ENST00000520779, ENST00000523438, ENST00000523443, ENST00000612167, ENST00000621894, ENST00000887731, ENST00000887732, ENST00000887733, ENST00000887734, ENST00000887735, ENST00000887736, ENST00000953567, ENST00000953568, ENST00000953569, ENST00000953570, ENST00000953571, ENST00000953572, ENST00000953573, ENST00000953574, ENST00000953575, ENST00000953576, ENST00000953577, ENST00000953578, ENST00000953579, ENST00000953580, ENST00000953581, ENST00000953582

RefSeq mRNA: 1 — MANE Select: NM_003970 NM_003970

CCDS: CCDS5957

Canonical transcript exons

ENST00000262113 — 37 exons

Exon	Start	End
ENSE00000364514	2093970	2094091
ENSE00000677580	2059153	2059245
ENSE00000677581	2069278	2069366
ENSE00000677582	2069447	2069497
ENSE00000677583	2072345	2072509
ENSE00000677606	2076141	2076282
ENSE00000677608	2078734	2078933
ENSE00000677611	2079560	2079613
ENSE00000677681	2096247	2096434
ENSE00000677787	2106491	2106597
ENSE00000677788	2108786	2108830
ENSE00000677789	2109395	2109531
ENSE00001086499	2052158	2052313
ENSE00001086505	2057348	2057486
ENSE00001135752	2050755	2050873
ENSE00001186264	2057623	2057780
ENSE00001262708	2073339	2073500
ENSE00001262753	2144664	2145456
ENSE00001365011	2045046	2045168
ENSE00003496398	2143401	2143456
ENSE00003507826	2100876	2101054
ENSE00003517897	2102667	2102781
ENSE00003518905	2085263	2085390
ENSE00003547374	2092346	2092520
ENSE00003559400	2129127	2129232
ENSE00003572125	2116216	2116275
ENSE00003572680	2115960	2116104
ENSE00003588420	2098857	2098983
ENSE00003603537	2124179	2124217
ENSE00003616988	2090008	2090191
ENSE00003633340	2123252	2123365
ENSE00003649138	2106242	2106398
ENSE00003664925	2142375	2142397
ENSE00003665049	2117885	2117952
ENSE00003672390	2123555	2123642
ENSE00003673343	2140723	2140886
ENSE00003682047	2141141	2141177

Expression profiles

Bgee: expression breadth ubiquitous, 142 present calls, max score 99.77.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 7.2799 / max 1069.6911, expressed in 1017 samples.

FANTOM5 promoters (10 alternative TSS)

Promoter ID	TPM avg	Samples expressed
87208	2.8222	94
87215	2.3009	917
87209	1.0792	66
87213	0.6840	57
87216	0.1136	39
87217	0.1097	27
87214	0.0583	22
87212	0.0442	20
205033	0.0420	19
87211	0.0258	11

Top tissues by expression

142 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
apex of heart	UBERON:0002098	99.77	gold quality
hindlimb stylopod muscle	UBERON:0004252	99.47	gold quality
cardiac atrium	UBERON:0002081	99.37	gold quality
right atrium auricular region	UBERON:0006631	99.37	gold quality
heart left ventricle	UBERON:0002084	99.29	gold quality
skeletal muscle tissue	UBERON:0001134	99.11	gold quality
gastrocnemius	UBERON:0001388	99.05	gold quality
muscle organ	UBERON:0001630	98.12	gold quality
skeletal muscle organ	UBERON:0014892	98.12	gold quality
muscle of leg	UBERON:0001383	98.08	gold quality
heart	UBERON:0000948	96.19	gold quality
granulocyte	CL:0000094	94.96	gold quality
Brodmann (1909) area 9	UBERON:0013540	91.80	gold quality
muscle tissue	UBERON:0002385	91.49	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	91.43	gold quality
right frontal lobe	UBERON:0002810	90.93	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	90.65	gold quality
right testis	UBERON:0004534	90.45	gold quality
left testis	UBERON:0004533	90.32	gold quality
testis	UBERON:0000473	90.19	gold quality
anterior cingulate cortex	UBERON:0009835	89.76	gold quality
superior frontal gyrus	UBERON:0002661	89.70	gold quality
cerebral cortex	UBERON:0000956	89.13	gold quality
primary visual cortex	UBERON:0002436	88.92	gold quality
nucleus accumbens	UBERON:0001882	88.83	gold quality
frontal cortex	UBERON:0001870	88.56	gold quality
frontal lobe	UBERON:0016525	88.56	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	88.28	gold quality
temporal lobe	UBERON:0001871	87.30	gold quality
putamen	UBERON:0001874	87.21	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.21
E-MTAB-11268	no	2197.00
E-ENAD-17	no	86.80

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): MEF2C, SIM2

miRNA regulators (miRDB)

19 targeting MYOM2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-551B-5P	99.96	71.28	3493
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-6835-3P	99.93	70.49	2904
HSA-MIR-548E-5P	99.89	72.73	4486
HSA-MIR-629-3P	99.85	67.99	1875
HSA-MIR-6833-5P	99.50	68.93	1161
HSA-MIR-4774-3P	98.90	67.82	737
HSA-MIR-6867-3P	98.12	66.07	1305
HSA-MIR-876-5P	97.99	68.49	1345
HSA-MIR-4287	97.55	67.24	1247
HSA-MIR-4685-3P	97.55	67.35	1255
HSA-MIR-4690-3P	97.02	64.72	981
HSA-MIR-5685	97.02	64.34	1004
HSA-MIR-3167	96.81	67.09	1236
HSA-MIR-137-5P	94.03	60.01	43
HSA-MIR-483-5P	93.53	65.81	111
HSA-MIR-196B-3P	85.79	67.95	91

Literature-anchored findings (GeneRIF, showing 3)

• Results identify muscle-type creatine kinase as a binding partner of a central portion of myomesin and the closely related M-protein. (PMID:12972258)
• a direct interaction of dysferlin with Trim72/MG53, AHNAK, cytoplasmic dynein, myomesin-2 and calsequestrin-1, but not with caveolin-3 or dystrophin, is reported. (PMID:23792176)
• Identification of MYOM2 as a candidate gene in hypertrophic cardiomyopathy and Tetralogy of Fallot, and its functional evaluation in the Drosophila heart. (PMID:33033063)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	myom2a	ENSDARG00000075433
danio_rerio		ENSDARG00000110698
mus_musculus	Myom2	ENSMUSG00000031461
rattus_norvegicus	Myom2	ENSRNOG00000011754
drosophila_melanogaster	mtgo	FBGN0259735
caenorhabditis_elegans		WBGENE00007944

Paralogs (11): FNDC3B (ENSG00000075420), MYBPC2 (ENSG00000086967), MYOM1 (ENSG00000101605), FNDC3A (ENSG00000102531), OBSL1 (ENSG00000124006), MYBPH (ENSG00000133055), MYBPC3 (ENSG00000134571), MYOM3 (ENSG00000142661), IGSF22 (ENSG00000179057), MYBPC1 (ENSG00000196091), MYBPHL (ENSG00000221986)

Protein

Protein identifiers

Myomesin-2 — P54296 (reviewed: P54296)

Alternative names: 165 kDa connectin-associated protein, 165 kDa titin-associated protein, M-protein, Myomesin family member 2

All UniProt accessions (2): E7EWH9, P54296

UniProt curated annotations — full annotation on UniProt →

Function. Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.

Subunit / interactions. Interacts with TTN/titin.

Subcellular location. Cytoplasm. Myofibril. Sarcomere. M line.

RefSeq proteins (1): NP_003961* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003598	Ig_sub2	Domain
IPR003599	Ig_sub	Domain
IPR003961	FN3_dom	Domain
IPR007110	Ig-like_dom	Domain
IPR013098	Ig_I-set	Domain
IPR013783	Ig-like_fold	Homologous_superfamily
IPR036116	FN3_sf	Homologous_superfamily
IPR036179	Ig-like_dom_sf	Homologous_superfamily
IPR050964	Striated_Muscle_Regulatory	Family

Pfam: PF00041, PF07679

UniProt features (29 total): sequence variant 11, domain 10, sequence conflict 4, region of interest 2, chain 1, compositionally biased region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P54296-F1	77.47	0.26

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 148 (showing top): GOBP_STRIATED_MUSCLE_CELL_DIFFERENTIATION, ACEVEDO_NORMAL_TISSUE_ADJACENT_TO_LIVER_TUMOR_DN, MEF2_02, MODULE_329, GOBP_SARCOMERE_ORGANIZATION, GOBP_CELLULAR_COMPONENT_ASSEMBLY_INVOLVED_IN_MORPHOGENESIS, GOBP_MUSCLE_STRUCTURE_DEVELOPMENT, GOBP_MUSCLE_CONTRACTION, MODULE_202, ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_DN, GOBP_ACTOMYOSIN_STRUCTURE_ORGANIZATION, GOBP_ORGANELLE_ASSEMBLY, GNF2_IL2RB, GOBP_MUSCLE_SYSTEM_PROCESS, GOMF_STRUCTURAL_CONSTITUENT_OF_MUSCLE

GO Biological Process (3): extraocular skeletal muscle development (GO:0002074), muscle contraction (GO:0006936), sarcomere organization (GO:0045214)

GO Molecular Function (4): structural constituent of muscle (GO:0008307), kinase binding (GO:0019900), structural molecule activity (GO:0005198), protein binding (GO:0005515)

GO Cellular Component (4): mitochondrion (GO:0005739), M band (GO:0031430), myosin filament (GO:0032982), cytoplasm (GO:0005737)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
skeletal muscle tissue development	1
camera-type eye development	1
skeletal muscle organ development	1
muscle system process	1
myofibril assembly	1
actomyosin structure organization	1
structural molecule activity	1
enzyme binding	1
molecular_function	1
binding	1
cytoplasm	1
intracellular membrane-bounded organelle	1
A band	1
myosin complex	1
supramolecular fiber	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

2270 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MYOM2	PLG	P00747	988
MYOM2	RIGI	O95786	983
MYOM2	ALB	P02768	980
MYOM2	TRAF3	Q13114	961
MYOM2	FN1	P02751	958
MYOM2	TBK1	Q9UHD2	951
MYOM2	CD46	P15529	948
MYOM2	IKBKB	O14920	915
MYOM2	TTN	Q8WZ42	872
MYOM2	GP5	P40197	853
MYOM2	IKBKE	Q14164	853
MYOM2	ERVW-1	Q9UQF0	836
MYOM2	MAG	P20916	813
MYOM2	MAVS	Q7Z434	811
MYOM2	IFIH1	Q9BYX4	808

IntAct

33 interactions, top by confidence:

A	B	Type	Score
EHMT2	WIZ	psi-mi:“MI:0914”(association)	0.730
MYOM2	DYSF	psi-mi:“MI:2364”(proximity)	0.450
RYR1	MYOM2	psi-mi:“MI:2364”(proximity)	0.450
ACTN2	MYOM2	psi-mi:“MI:2364”(proximity)	0.450
MYOM2	TTN	psi-mi:“MI:2364”(proximity)	0.450
HSPB2	MYOM2	psi-mi:“MI:0915”(physical association)	0.370
PCNA	MYOM2	psi-mi:“MI:0915”(physical association)	0.370
ATXN1		psi-mi:“MI:0914”(association)	0.350
M		psi-mi:“MI:0914”(association)	0.350
C1QTNF7	AGRN	psi-mi:“MI:0914”(association)	0.350
RSPH6A	ATP2A1	psi-mi:“MI:0914”(association)	0.350
LATS1	ATP2A1	psi-mi:“MI:0914”(association)	0.350
TSPAN33	ATP2A1	psi-mi:“MI:0914”(association)	0.350
MFGE8	MYH7B	psi-mi:“MI:0914”(association)	0.350
MRPS23	MYH7B	psi-mi:“MI:0914”(association)	0.350
FMR1	MYOM2	psi-mi:“MI:0915”(physical association)	0.000
ANKRD1	MYOM2	psi-mi:“MI:0915”(physical association)	0.000
DYSF	MYOM2	psi-mi:“MI:0915”(physical association)	0.000
MYOM2	MYBPC2	psi-mi:“MI:0915”(physical association)	0.000
MYBPC2	MYOM2	psi-mi:“MI:0915”(physical association)	0.000
MYOM2	ACTN2	psi-mi:“MI:0915”(physical association)	0.000
MYOM2	JMJD1C	psi-mi:“MI:0915”(physical association)	0.000
MYOM2	MYH7	psi-mi:“MI:0915”(physical association)	0.000
MYOM2	MYOM2	psi-mi:“MI:0915”(physical association)	0.000
MYOM2	NEB	psi-mi:“MI:0915”(physical association)	0.000
MYOM2	RPS6	psi-mi:“MI:0915”(physical association)	0.000
MYOM2	RYR1	psi-mi:“MI:0915”(physical association)	0.000
SEC31A	MYOM2	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (34): MYOM2 (Two-hybrid), MYOM2 (Affinity Capture-MS), MYOM2 (Two-hybrid), MYOM2 (Two-hybrid), MYOM2 (Two-hybrid), SEC31A (Two-hybrid), TNNT1 (Two-hybrid), JMJD1C (Two-hybrid), MYOM2 (Two-hybrid), ACTN2 (Two-hybrid), MYH7 (Two-hybrid), NEB (Two-hybrid), RPS6 (Two-hybrid), RYR1 (Two-hybrid), TAF1 (Two-hybrid)

ESM2 similar proteins: A0A087WV53, A2AAJ9, A2ABU4, A2RUH7, E7F6H7, O00423, O01761, O14576, O54785, O70468, O88485, O88599, P16419, P22607, P26453, P52179, P53670, P53671, P54296, P56741, P70402, Q00872, Q02173, Q05623, Q05BC3, Q0DYP5, Q13203, Q14168, Q14324, Q14896, Q29RQ3, Q32L23, Q4V8C3, Q5FW53, Q5PQM4, Q5VST9, Q5VTT5, Q5XI81, Q5XKE0, Q60992

Diamond homologs: A0A087WV53, A2AAJ9, A2ASS6, A2RUH7, O75147, O94856, O94898, P05548, P52179, P54296, P97685, Q00872, Q23551, Q52KR2, Q5VST9, Q62234, Q80W87, Q810U3, Q8WX93, Q92626, A2ABU4, O88599, P12960, P14781, P28685, P68500, P70402, P97527, P97528, Q02173, Q07409, Q12860, Q13203, Q14896, Q28106, Q2EY15, Q2VWP7, Q2VWP9, Q589G5, Q5PQM4

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
PRKACA	down-regulates	MYOM2	phosphorylation

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 29 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Striated Muscle Contraction	5	73.5×	1e-06
Muscle contraction	5	18.4×	6e-04

GO biological processes:

GO term	Partners	Fold	FDR
sarcomere organization	5	70.9×	2e-06

Disease & clinical

Clinical variants and AI predictions

ClinVar

521 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	380
Likely benign	54
Benign	62

Top pathogenic / likely-pathogenic (0)

SpliceAI

5645 predictions. Top by Δscore:

Variant	Effect	Δscore
8:2045167:GG:G	donor_gain	1.0000
8:2045168:GG:G	donor_gain	1.0000
8:2050754:GGA:G	acceptor_gain	1.0000
8:2050874:G:GG	donor_gain	1.0000
8:2057344:GCAG:G	acceptor_loss	1.0000
8:2057345:CA:C	acceptor_loss	1.0000
8:2057346:A:AG	acceptor_gain	1.0000
8:2057347:G:GA	acceptor_loss	1.0000
8:2057347:G:GG	acceptor_gain	1.0000
8:2057483:GATG:G	donor_gain	1.0000
8:2057724:G:GT	donor_gain	1.0000
8:2057778:GTG:G	donor_gain	1.0000
8:2069364:GAA:G	donor_gain	1.0000
8:2069367:G:GG	donor_gain	1.0000
8:2072343:A:AG	acceptor_gain	1.0000
8:2072344:G:GG	acceptor_gain	1.0000
8:2072507:ATGG:A	donor_loss	1.0000
8:2072508:TGGTG:T	donor_loss	1.0000
8:2072509:GGT:G	donor_loss	1.0000
8:2072511:T:A	donor_loss	1.0000
8:2073335:TCA:T	acceptor_loss	1.0000
8:2073336:CA:C	acceptor_loss	1.0000
8:2073337:A:AG	acceptor_gain	1.0000
8:2073337:A:AT	acceptor_loss	1.0000
8:2073338:G:GG	acceptor_gain	1.0000
8:2073338:GAC:G	acceptor_gain	1.0000
8:2073498:GAG:G	donor_gain	1.0000
8:2073501:G:A	donor_loss	1.0000
8:2076132:T:TA	acceptor_gain	1.0000
8:2076136:CCAAG:C	acceptor_loss	1.0000

AlphaMissense

9652 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
8:2057779:T:A	W187R	0.999
8:2057779:T:C	W187R	0.999
8:2076227:T:A	W403R	0.999
8:2076227:T:C	W403R	0.999
8:2085337:T:A	W531R	0.999
8:2085337:T:C	W531R	0.999
8:2090114:G:C	R584P	0.999
8:2092411:T:A	W632R	0.999
8:2092411:T:C	W632R	0.999
8:2096370:G:C	R750P	0.999
8:2098891:T:C	F783S	0.999
8:2123285:T:A	W1163R	0.999
8:2123285:T:C	W1163R	0.999
8:2140785:T:C	L1288P	0.999
8:2140823:T:G	Y1301D	0.999
8:2144715:T:A	W1378R	0.999
8:2144715:T:C	W1378R	0.999
8:2144829:T:G	Y1416D	0.999
8:2144849:T:A	N1422K	0.999
8:2144849:T:G	N1422K	0.999
8:2059233:T:C	L214P	0.998
8:2069303:T:G	Y227D	0.998
8:2072497:T:A	W316R	0.998
8:2072497:T:C	W316R	0.998
8:2078835:T:C	F455S	0.998
8:2078838:G:C	R456P	0.998
8:2090111:T:C	F583S	0.998
8:2092413:G:C	W632C	0.998
8:2092413:G:T	W632C	0.998
8:2094011:T:C	F682S	0.998

dbSNP variants (sampled 300 via entrez): RS1000004793 (8:2123907 A>C), RS1000031197 (8:2084752 C>A,T), RS1000041717 (8:2056345 C>G), RS1000104683 (8:2109129 A>G), RS1000158061 (8:2052370 G>C,T), RS1000164179 (8:2116648 T>G), RS1000181852 (8:2064475 C>T), RS1000191810 (8:2068166 C>T), RS1000218966 (8:2053187 A>G), RS1000231558 (8:2139670 G>A), RS1000240801 (8:2056194 A>G), RS1000256028 (8:2135462 A>C), RS1000261661 (8:2077035 G>C), RS1000268515 (8:2110738 C>T), RS1000279573 (8:2052485 T>A,C)

Disease associations

OMIM: gene MIM:603509 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

15 associations (top):

Study	Trait	p-value
GCST002579_3	Heschl’s gyrus morphology	4.000000e-06
GCST002671_9	Toenail selenium levels	2.000000e-06
GCST002875_176	Diisocyanate-induced asthma	3.000000e-06
GCST007844_12	Ankylosing spondylitis	6.000000e-06
GCST009391_1268	Metabolite levels	8.000000e-06
GCST009391_1275	Metabolite levels	2.000000e-06
GCST009391_1540	Metabolite levels	3.000000e-06
GCST009391_479	Metabolite levels	4.000000e-06
GCST009391_568	Metabolite levels	8.000000e-06
GCST009391_788	Metabolite levels	7.000000e-07
GCST009391_876	Metabolite levels	3.000000e-06
GCST009391_922	Metabolite levels	2.000000e-06
GCST009391_932	Metabolite levels	6.000000e-06
GCST009796_1	Opioid use cessation	4.000000e-06
GCST012489_33	Heel bone mineral density x serum urate levels interaction	4.000000e-08

EFO canonical traits (13, from GWAS)

EFO ID	Trait name
EFO:0006995	response to diisocyanate
EFO:0010545	uridine diphosphate measurement
EFO:0010546	uridine measurement
EFO:0010510	NG-monomethyl-arginine measurement
EFO:0010389	phosphatidylcholine 40:6 measurement
EFO:0010498	hydroxyproline measurement
EFO:0010395	sphingomyelin 22:0 measurement
EFO:0010403	triacylglycerol 48:0 measurement
EFO:0010443	triacylglycerol 58:9 measurement
EFO:0010401	triacylglycerol 46:1 measurement
EFO:0009937	Opioid use measurement
EFO:0004531	urate measurement
EFO:0009270	heel bone mineral density

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB clinical annotations

1 annotations.

Variant	Type	Level	Drugs	Phenotypes
rs17064642	Efficacy	3	aspirin;clopidogrel	Acute coronary syndrome;Major Adverse Cardiac Events (MACE)

PharmGKB variants

1 variants.

Variant	Genes	Level	Score	#Clin annots	Drugs
rs17064642	MYOM2	3	4.00	1	aspirin;clopidogrel

CTD chemical–gene interactions

30 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	decreases expression, decreases methylation, increases mutagenesis, affects methylation	4
Doxorubicin	decreases expression	3
Daunorubicin	decreases expression	2
Mitoxantrone	decreases expression	2
urushiol	decreases expression	1
methyleugenol	decreases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	increases methylation, affects cotreatment	1
quercitrin	increases expression	1
mono-(2-ethylhexyl)phthalate	decreases methylation, increases abundance	1
sodium arsenite	affects methylation	1
benzo(e)pyrene	affects methylation	1
aflatoxin B2	increases methylation	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	increases expression	1
monomethylarsonous acid	increases expression	1
jinfukang	increases expression	1
Sunitinib	decreases expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Choline	affects expression	1
Diethylhexyl Phthalate	decreases methylation, increases abundance	1
Etoposide	decreases expression	1
Methapyrilene	affects methylation	1
Methylcholanthrene	affects binding, increases reaction	1
Valproic Acid	increases methylation	1
Aflatoxin B1	decreases expression	1
Cadmium Chloride	decreases expression	1
Thapsigargin	decreases expression	1
Okadaic Acid	decreases expression	1
Acrylamide	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.