MYOPARR

Summary

MYOPARR (myogenin promoter associated myogenic regulatory antisense long non coding RNA, HGNC:54178) is a long non-coding RNA gene on chromosome 1q32.1.

Predicted to enable RNA polymerase II core promoter sequence-specific DNA binding activity. Predicted to be involved in myoblast fate specification. Predicted to act upstream of or within with a positive effect on gene expression. Predicted to act upstream of or within protein-containing complex assembly and skeletal muscle fiber development.

Source: NCBI Gene 114004358 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 1 total

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:54178
Approved symbol	MYOPARR
Name	myogenin promoter associated myogenic regulatory antisense long non coding RNA
Location	1q32.1
Locus type	RNA, long non-coding
Status	Approved
Entrez	114004358
RNAcentral	URS0000E42B0E — lncRNA, 2245 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Myoparr is a novel key regulator of muscle development (PMID:30622218)

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

1 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000969987 (1:203083154 T>C), RS1000978200 (1:203082691 G>A,C,T), RS1001020440 (1:203088220 A>G), RS1001073571 (1:203088577 G>T), RS1001283955 (1:203083130 T>C), RS1001634508 (1:203085895 G>C), RS1001748892 (1:203086061 A>C,G), RS1002634532 (1:203087155 C>A,T), RS1004670351 (1:203088123 G>A,T), RS1004696246 (1:203087705 A>G), RS1004828345 (1:203083073 T>C,G), RS1005138847 (1:203082797 C>T), RS1005300107 (1:203086657 C>G), RS1005535632 (1:203086686 G>T), RS1005599377 (1:203087100 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 0 entries

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.