MYOSLID

Summary

MYOSLID (myocardin-induced smooth muscle lncRNA, inducer of differentiation, HGNC:51821) is a long non-coding RNA gene on chromosome 2q33.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51821
Approved symbol	MYOSLID
Name	myocardin-induced smooth muscle lncRNA, inducer of differentiation
Location	2q33.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000229647
Ensembl biotype	lncRNA
OMIM	618976
Entrez	105373853
RNAcentral	URS0000BC4586 — lncRNA, 991 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 26 — 26 lncRNA

ENST00000430494, ENST00000435643, ENST00000440326, ENST00000454444, ENST00000656422, ENST00000661935, ENST00000666421, ENST00000758487, ENST00000758488, ENST00000758489, ENST00000758490, ENST00000758491, ENST00000758492, ENST00000758493, ENST00000758494, ENST00000758495, ENST00000758496, ENST00000758497, ENST00000758498, ENST00000758499, ENST00000758500, ENST00000758501, ENST00000758502, ENST00000758503, ENST00000758504, ENST00000758505

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000430494 — 3 exons

Exon	Start	End
ENSE00001622468	207240201	207240299
ENSE00004110450	207239325	207240086
ENSE00004110489	207245289	207245892

Expression profiles

Bgee: expression breadth ubiquitous, 127 present calls, max score 80.99.

FANTOM5 (CAGE): breadth broad, TPM avg 1.8056 / max 104.6901, expressed in 528 samples.

FANTOM5 promoters (9 alternative TSS)

Promoter ID	TPM avg	Samples expressed
24859	0.5997	232
24857	0.3606	109
24860	0.1861	78
24858	0.1805	95
24861	0.1566	62
24856	0.1193	46
24864	0.1133	54
24863	0.0474	12
24862	0.0421	14

Top tissues by expression

127 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	80.99	gold quality
monocyte	CL:0000576	77.15	gold quality
leukocyte	CL:0000738	76.02	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	73.94	gold quality
stromal cell of endometrium	CL:0002255	68.52	gold quality
blood	UBERON:0000178	67.21	gold quality
bone marrow cell	CL:0002092	65.88	silver quality
granulocyte	CL:0000094	65.08	gold quality
lower esophagus mucosa	UBERON:0035834	63.27	gold quality
sural nerve	UBERON:0015488	63.17	silver quality
smooth muscle tissue	UBERON:0001135	63.01	gold quality
ganglionic eminence	UBERON:0004023	63.00	gold quality
popliteal artery	UBERON:0002250	62.42	gold quality
tibial artery	UBERON:0007610	62.40	gold quality
tonsil	UBERON:0002372	62.18	gold quality
bone marrow	UBERON:0002371	62.14	gold quality
islet of Langerhans	UBERON:0000006	60.99	gold quality
calcaneal tendon	UBERON:0003701	60.48	gold quality
esophagus mucosa	UBERON:0002469	60.07	gold quality
right coronary artery	UBERON:0001625	59.94	gold quality
left coronary artery	UBERON:0001626	59.01	gold quality
cortical plate	UBERON:0005343	58.01	silver quality
lymph node	UBERON:0000029	57.99	gold quality
gall bladder	UBERON:0002110	57.90	gold quality
thoracic aorta	UBERON:0001515	57.73	gold quality
descending thoracic aorta	UBERON:0002345	57.72	gold quality
ascending aorta	UBERON:0001496	57.65	gold quality
esophagus	UBERON:0001043	56.70	gold quality
skeletal muscle tissue	UBERON:0001134	56.62	silver quality
myometrium	UBERON:0001296	56.48	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.12

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• MYOSLID, the first human vascular smooth mcell-selective and serum response factor/CArG-dependent lncRNA, is a novel modulator in amplifying the VSMC differentiation program, likely through feed-forward actions of both MKL1 and transforming growth factor-beta/SMAD pathways. (PMID:27444199)
• The knockdown of MYOSLID in Oral squamous cell carcinoma cell line significantly inhibited cell migration and invasion compared to those in the control cells. In addition, the knockdown of MYOSLID significantly reduced Slug, PDPN and LAMB3 expression levels. (PMID:31238980)
• The lncRNA MYOSLID-miR-29c-3p-MCL-1 axis plays a key role in the development of gastric cancer (PMID:31497917)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.