MYRIP

Summary

MYRIP (myosin VIIA and Rab interacting protein, HGNC:19156) is a protein-coding gene on chromosome 3p22.1, encoding Rab effector MyRIP (Q8NFW9). Rab effector protein involved in melanosome transport.

Predicted to enable actin binding activity; myosin binding activity; and protein kinase A binding activity. Predicted to be involved in positive regulation of insulin secretion. Predicted to be located in several cellular components, including cytoplasmic vesicle; perinuclear region of cytoplasm; and photoreceptor outer segment. Predicted to be part of exocyst. Predicted to be active in cortical actin cytoskeleton.

Source: NCBI Gene 25924 — RefSeq curated summary.

At a glance

• GWAS associations: 5
• Clinical variants (ClinVar): 52 total
• MANE Select transcript: NM_015460

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:19156
Approved symbol	MYRIP
Name	myosin VIIA and Rab interacting protein
Location	3p22.1
Locus type	gene with protein product
Status	Approved
Aliases	DKFZp586F1018, exophilin-8, SLAC2-C, SLAC2C
Ensembl gene	ENSG00000170011
Ensembl biotype	protein_coding
OMIM	611790
Entrez	25924

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 9 protein_coding, 3 protein_coding_CDS_not_defined, 2 nonsense_mediated_decay

ENST00000302541, ENST00000396217, ENST00000425621, ENST00000444716, ENST00000458292, ENST00000458441, ENST00000459828, ENST00000475082, ENST00000482033, ENST00000539167, ENST00000866103, ENST00000866104, ENST00000966123, ENST00000966124

RefSeq mRNA: 5 — MANE Select: NM_015460 NM_001284423, NM_001284424, NM_001284425, NM_001284426, NM_015460

CCDS: CCDS2689, CCDS68390, CCDS68391, CCDS68392

Canonical transcript exons

ENST00000302541 — 17 exons

Exon	Start	End
ENSE00001813396	40258134	40260321
ENSE00001889127	39809609	39809916
ENSE00003465544	40250439	40250499
ENSE00003500639	40250222	40250326
ENSE00003505407	40182220	40182373
ENSE00003524887	40044050	40044271
ENSE00003554558	40251881	40251999
ENSE00003557154	40167159	40167239
ENSE00003559920	40151048	40151184
ENSE00003560710	39900787	39900926
ENSE00003570864	40209854	40210093
ENSE00003591457	40244446	40244607
ENSE00003603494	40162730	40162810
ENSE00003606608	40166846	40166943
ENSE00003677798	40169950	40170093
ENSE00003685136	40189826	40190463
ENSE00003691666	40233859	40234053

Expression profiles

Bgee: expression breadth ubiquitous, 261 present calls, max score 97.81.

FANTOM5 (CAGE): breadth broad, TPM avg 3.1187 / max 151.3854, expressed in 449 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
36165	1.7215	378
36163	0.3309	133
36167	0.3302	158
36164	0.2821	159
36169	0.2703	54
36166	0.0945	39
36168	0.0776	35
202731	0.0117	5

Top tissues by expression

292 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
pigmented layer of retina	UBERON:0001782	97.81	gold quality
retina	UBERON:0000966	97.78	gold quality
endothelial cell	CL:0000115	97.41	gold quality
substantia nigra pars compacta	UBERON:0001965	95.42	gold quality
choroid plexus epithelium	UBERON:0003911	95.22	gold quality
Brodmann (1909) area 23	UBERON:0013554	92.95	gold quality
parotid gland	UBERON:0001831	92.09	gold quality
substantia nigra pars reticulata	UBERON:0001966	92.08	gold quality
entorhinal cortex	UBERON:0002728	91.31	gold quality
amygdala	UBERON:0001876	91.05	gold quality
orbitofrontal cortex	UBERON:0004167	91.04	gold quality
temporal lobe	UBERON:0001871	90.69	gold quality
superior frontal gyrus	UBERON:0002661	88.08	gold quality
cingulate cortex	UBERON:0003027	87.74	gold quality
anterior cingulate cortex	UBERON:0009835	87.74	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	87.12	gold quality
postcentral gyrus	UBERON:0002581	86.56	gold quality
prefrontal cortex	UBERON:0000451	86.22	gold quality
parietal lobe	UBERON:0001872	86.05	gold quality
frontal cortex	UBERON:0001870	85.98	gold quality
neocortex	UBERON:0001950	85.96	gold quality
cerebral cortex	UBERON:0000956	85.92	gold quality
Brodmann (1909) area 10	UBERON:0013541	85.46	gold quality
CA1 field of hippocampus	UBERON:0003881	85.37	gold quality
superior vestibular nucleus	UBERON:0007227	85.14	gold quality
primary visual cortex	UBERON:0002436	84.89	gold quality
Brodmann (1909) area 9	UBERON:0013540	84.88	gold quality
paraflocculus	UBERON:0005351	84.60	gold quality
right frontal lobe	UBERON:0002810	84.51	gold quality
frontal pole	UBERON:0002795	84.37	gold quality

Single-cell (SCXA)

Detected in 4 experiment(s), a significant marker in 4.

Experiment	Marker?	Max mean expression
E-HCAD-35	yes	69.95
E-CURD-119	yes	21.15
E-HCAD-25	yes	7.88
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): GATA3

miRNA regulators (miRDB)

146 targeting MYRIP, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-4789-3P	99.99	70.75	2484
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-4500	99.99	72.72	2367
HSA-MIR-34A-5P	99.99	71.21	1784
HSA-MIR-449A	99.99	71.05	1776
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-8068	99.98	73.85	2376
HSA-LET-7A-5P	99.98	72.29	1790
HSA-LET-7B-5P	99.98	72.31	1790
HSA-LET-7C-5P	99.98	72.29	1790
HSA-LET-7E-5P	99.98	72.29	1790
HSA-LET-7F-5P	99.98	72.56	1784
HSA-LET-7G-5P	99.98	72.37	1784
HSA-LET-7I-5P	99.98	72.37	1788
HSA-MIR-98-5P	99.98	72.33	1787
HSA-MIR-1250-3P	99.96	70.04	4038
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-1468-3P	99.96	72.74	3797
HSA-MIR-96-5P	99.95	72.80	2140
HSA-MIR-545-3P	99.95	70.74	2783
HSA-MIR-141-3P	99.94	72.79	2421
HSA-MIR-200A-3P	99.94	72.68	2420
HSA-MIR-101-3P	99.94	75.03	2230
HSA-MIR-9983-3P	99.94	71.48	3631
HSA-MIR-335-3P	99.93	73.36	4958

Literature-anchored findings (GeneRIF, showing 9)

• a molecular complex composed of Rab27A, MyRIP and myosin VIIa bridges retinal melanosomes to the actin cytoskeleton and thereby mediates the local trafficking of these organelles (PMID:11964381)
• Slac2-c/MyRIP contains an N-terminal Slp homology domain (SHD) and functions as a linker protein that interacts with myosin Rab27A/B, VIIa/Va, and actin. (PMID:12221080)
• Slac2c/MyRIP is part of a complex mediating the interaction of secretory granules with cortical actin cytoskeleton (PMID:14517322)
• During primate spermiogenesis, dynein, myosin Va, MyRIP and Rab27b that compose microtubule-based and actin-based vesicle transport systems are actually present in the manchette and might possibly be involved in intramanchette transport. (PMID:18478159)
• Rab27a and MyRIP regulate the amount and multimeric state of VWF released from endothelial cells. (PMID:19270261)
• A new potentially protective effect was identified at rs2679798 in MYRIP. (PMID:20861866)
• A Rab27a/MyRIP/myosin Va complex is involved in linking von-Willebrand factor (Vwf) to the peripheral actin cytoskeleton of endothelial cells to allow full maturation and prevent premature secretion of vWF. (PMID:21740491)
• Myrip couples the retention of secretory granules in the cell cortex, their transport to the plasma membrane, and their attachment to the plasma membrane, thus promoting secretion. (PMID:22396429)
• The role of MyRIP in Ca(2+)-driven exocytosis requires both MyoVa- and actin-binding potential. (PMID:26675235)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	myripb	ENSDARG00000038814
danio_rerio	myripa	ENSDARG00000075706
mus_musculus	Myrip	ENSMUSG00000041794
rattus_norvegicus	Myrip	ENSRNOG00000018797

Paralogs (2): MLPH (ENSG00000115648), MOBP (ENSG00000168314)

Protein

Protein identifiers

Rab effector MyRIP — Q8NFW9 (reviewed: Q8NFW9)

Alternative names: Exophilin-8, Myosin-VIIa- and Rab-interacting protein, Synaptotagmin-like protein lacking C2 domains C

All UniProt accessions (2): Q8NFW9, F8WFC5

UniProt curated annotations — full annotation on UniProt →

Function. Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Functions as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release.

Subunit / interactions. Binds MYO5A, MYO7A and F-actin. Binds RAB27A that has been activated by GTP-binding via its N-terminus. Interacts with PRKAR2A. Interacts with components of the exocyst complex, including EXOC3 and EXOC4.

Subcellular location. Cytoplasm. Perinuclear region. Cytoplasmic vesicle. Secretory vesicle.

Tissue specificity. Detected in brain, skin, heart, adrenal medulla, pancreas, intestine, liver, kidney, muscle and testis.

Isoforms (6)

UniProt ID	Names	Canonical?
Q8NFW9-1	1	yes
Q8NFW9-2	2
Q8NFW9-3	3
Q8NFW9-4	4
Q8NFW9-5	5
Q8NFW9-6	6

RefSeq proteins (5): NP_001271352, NP_001271353, NP_001271354, NP_001271355, NP_056275* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR006788	Myrip/Melanophilin	Domain
IPR010911	Rab_BD	Domain
IPR011011	Znf_FYVE_PHD	Homologous_superfamily
IPR013083	Znf_RING/FYVE/PHD	Homologous_superfamily
IPR041282	FYVE_2	Domain
IPR051745	Intracell_Transport_Effector	Family

Pfam: PF02318, PF04698

UniProt features (35 total): region of interest 8, compositionally biased region 7, splice variant 7, sequence conflict 5, sequence variant 3, modified residue 2, chain 1, domain 1, zinc finger region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NFW9-F1	58.10	0.22

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 298, 350

Function

Pathways and Gene Ontology

Reactome pathways

7 pathways

ID	Pathway
R-HSA-264876	Insulin processing
R-HSA-9824585	Regulation of MITF-M-dependent genes involved in pigmentation
R-HSA-1266738	Developmental Biology
R-HSA-2980736	Peptide hormone metabolism
R-HSA-392499	Metabolism of proteins
R-HSA-9730414	MITF-M-regulated melanocyte development
R-HSA-9856651	MITF-M-dependent gene expression

MSigDB gene sets: 199 (showing top): GSE18804_SPLEEN_MACROPHAGE_VS_BRAIN_TUMORAL_MACROPHAGE_UP, GOBP_INTRACELLULAR_PROTEIN_TRANSPORT, GOCC_SECRETORY_GRANULE, ATACCTC_MIR202, GOBP_INSULIN_SECRETION, GOBP_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION, GOBP_REGULATION_OF_HORMONE_LEVELS, GOBP_HORMONE_TRANSPORT, GOMF_GTPASE_BINDING, GOBP_CELL_CELL_SIGNALING, GTGCCTT_MIR506, CAIRO_HEPATOBLASTOMA_CLASSES_DN, GOBP_POSITIVE_REGULATION_OF_INSULIN_SECRETION, GOBP_REGULATION_OF_PROTEIN_SECRETION, MISSIAGLIA_REGULATED_BY_METHYLATION_UP

GO Biological Process (2): intracellular protein transport (GO:0006886), positive regulation of insulin secretion (GO:0032024)

GO Molecular Function (7): actin binding (GO:0003779), zinc ion binding (GO:0008270), myosin binding (GO:0017022), small GTPase binding (GO:0031267), protein kinase A binding (GO:0051018), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (12): exocyst (GO:0000145), photoreceptor outer segment (GO:0001750), cytosol (GO:0005829), transport vesicle (GO:0030133), cortical actin cytoskeleton (GO:0030864), dense core granule (GO:0031045), melanosome (GO:0042470), synapse (GO:0045202), perinuclear region of cytoplasm (GO:0048471), cytoplasm (GO:0005737), actin cytoskeleton (GO:0015629), cytoplasmic vesicle (GO:0031410)

Reactome top-level categories

Rollup of top-5 pathways:

Category	Pathways
Peptide hormone metabolism	1
MITF-M-dependent gene expression	1
Metabolism of proteins	1
Developmental Biology	1
MITF-M-regulated melanocyte development	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	4
cytoplasm	3
cytoskeletal protein binding	2
intracellular protein localization	1
protein transport	1
intracellular transport	1
insulin secretion	1
positive regulation of protein secretion	1
regulation of insulin secretion	1
positive regulation of peptide hormone secretion	1
transition metal ion binding	1
GTPase binding	1
protein binding	1
binding	1
cation binding	1
cell cortex	1
vesicle tethering complex	1
photoreceptor cell cilium	1
endomembrane system	1
cytoplasmic vesicle	1
actin cytoskeleton	1
cortical cytoskeleton	1
secretory granule	1
pigment granule	1
cell junction	1
intracellular anatomical structure	1
cytoskeleton	1
intracellular vesicle	1

Protein interactions and networks

STRING

612 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MYRIP	RAB27A	P51159	997
MYRIP	MYO5A	Q9Y4I1	988
MYRIP	MYO7A	P78427	978
MYRIP	RAB27B	O00194	957
MYRIP	SYTL1	Q8IYJ3	903
MYRIP	EXOC3	O60645	900
MYRIP	EXOC4	Q96A65	890
MYRIP	SYTL2	Q9HCH5	662
MYRIP	PRKACB	P22694	594
MYRIP	PRKACA	P17612	593
MYRIP	PRKACG	P22612	591
MYRIP	UNC13D	Q70J99	529
MYRIP	RIMBP2	O15034	513
MYRIP	STX4	Q12846	479
MYRIP	CAV1	Q03135	458

IntAct

22 interactions, top by confidence:

A	B	Type	Score
MYRIP	C1orf216	psi-mi:“MI:0915”(physical association)	0.720
C1orf216	MYRIP	psi-mi:“MI:0915”(physical association)	0.720
RAB27B	MYRIP	psi-mi:“MI:0915”(physical association)	0.560
RAB27A	MYRIP	psi-mi:“MI:0915”(physical association)	0.560
OIP5	MYRIP	psi-mi:“MI:0915”(physical association)	0.560
MYRIP	Dlg4	psi-mi:“MI:0407”(direct interaction)	0.440
MYRIP	CAV1	psi-mi:“MI:0915”(physical association)	0.400
GRB2	MYRIP	psi-mi:“MI:0915”(physical association)	0.400
MYRIP	NCK1	psi-mi:“MI:0915”(physical association)	0.400
PIK3R1	MYRIP	psi-mi:“MI:0915”(physical association)	0.400
C1orf216	MYRIP	psi-mi:“MI:0915”(physical association)	0.000
RAB27B	MYRIP	psi-mi:“MI:0915”(physical association)	0.000
RAB27A	MYRIP	psi-mi:“MI:0915”(physical association)	0.000
MYRIP	OIP5	psi-mi:“MI:0915”(physical association)	0.000
VPS26C	MYRIP	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (10): C1orf216 (Two-hybrid), MYRIP (Affinity Capture-RNA), MYRIP (Affinity Capture-Western), MYRIP (Two-hybrid), MYRIP (Two-hybrid), MYRIP (Two-hybrid), MYRIP (Two-hybrid), MYRIP (Two-hybrid), MYRIP (Cross-Linking-MS (XL-MS)), PDCD11 (Cross-Linking-MS (XL-MS))

ESM2 similar proteins: A0A1L8HBI7, A0A1L8HJK9, A0A1L8HTT5, A6NP61, A8T6P4, C0SPG1, C3VD30, F1N4E5, K7SGN7, O35144, O35253, O70240, O88406, O88566, Q15554, Q1XFL1, Q3ZC82, Q4KLH3, Q5HZN9, Q5JTV8, Q5PQX1, Q5R7A3, Q62315, Q68DK7, Q6P1H6, Q6PDM1, Q6PG95, Q6ZPF3, Q76N89, Q7T3T8, Q7T3T9, Q7T3U0, Q7TNY7, Q7TP65, Q7TSX9, Q80SU3, Q80VM8, Q86XL3, Q8IVF5, Q8K3I4

Diamond homologs: A8T6P4, M3WHG5, Q13875, Q63327, Q7TNY7, Q8K3I4, Q8NFW9, Q8VHQ7, Q91V27, Q96C24, Q9BV36, Q9D2P8, Q9R0Q1, A0FGR8, A0FGR9, A6QP06, A8KBH6, O00443, O00750, O54880, P97610, Q22366, Q3TZZ7, Q4VX76, Q58D79, Q5DTI8, Q5FWL4, Q5M7N9, Q5RAY1, Q61194, Q768S4, Q7ZWU7, Q80T23, Q812E4, Q86UR5, Q8IV01, Q8IYJ3, Q8TDW5, Q920N7, Q99N48

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

52 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	43
Likely benign	2
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

4189 predictions. Top by Δscore:

Variant	Effect	Δscore
3:39813310:GC:G	donor_gain	1.0000
3:39813311:C:G	donor_gain	1.0000
3:39893264:G:GT	donor_gain	1.0000
3:39900776:T:TA	acceptor_gain	1.0000
3:39900782:CCCA:C	acceptor_loss	1.0000
3:39900784:CAGGT:C	acceptor_loss	1.0000
3:39900785:A:AC	acceptor_loss	1.0000
3:39900786:G:GT	acceptor_loss	1.0000
3:39900922:CTAAG:C	donor_loss	1.0000
3:39900923:TAAG:T	donor_loss	1.0000
3:39900924:AAGGT:A	donor_loss	1.0000
3:39900928:T:A	donor_loss	1.0000
3:39923687:G:GT	donor_gain	1.0000
3:40044026:A:AG	acceptor_gain	1.0000
3:40044027:T:G	acceptor_gain	1.0000
3:40044035:A:AG	acceptor_gain	1.0000
3:40044035:ACCTT:A	acceptor_gain	1.0000
3:40044036:C:G	acceptor_gain	1.0000
3:40044039:T:TA	acceptor_gain	1.0000
3:40044040:G:A	acceptor_gain	1.0000
3:40044047:CA:C	acceptor_loss	1.0000
3:40044047:CAGTG:C	acceptor_gain	1.0000
3:40044048:A:AG	acceptor_gain	1.0000
3:40044048:AGT:A	acceptor_gain	1.0000
3:40044048:AGTG:A	acceptor_gain	1.0000
3:40044049:G:GA	acceptor_gain	1.0000
3:40044049:GT:G	acceptor_gain	1.0000
3:40044049:GTG:G	acceptor_gain	1.0000
3:40044049:GTGA:G	acceptor_gain	1.0000
3:40044049:GTGAG:G	acceptor_gain	1.0000

AlphaMissense

5630 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
3:39900869:T:A	V18D	0.999
3:39900899:T:C	L28P	0.999
3:40167217:T:C	L236P	0.999
3:39900845:T:C	L10S	0.998
3:39900881:T:A	V22D	0.998
3:39900890:A:C	D25A	0.998
3:39900890:A:T	D25V	0.998
3:39900901:C:A	R29S	0.998
3:40044130:G:A	C64Y	0.998
3:40044131:C:G	C64W	0.998
3:40044249:T:C	C104R	0.998
3:40151073:T:A	W120R	0.998
3:40151073:T:C	W120R	0.998
3:40151100:T:C	F129L	0.998
3:40151102:C:A	F129L	0.998
3:40151102:C:G	F129L	0.998
3:40151109:T:C	F132L	0.998
3:40151111:T:A	F132L	0.998
3:40151111:T:G	F132L	0.998
3:40166887:G:C	A198P	0.998
3:40166888:C:A	A198D	0.998
3:40166908:G:C	A205P	0.998
3:40167184:T:C	L225P	0.998
3:39900890:A:G	D25G	0.997
3:39900891:C:A	D25E	0.997
3:39900891:C:G	D25E	0.997
3:39900902:G:C	R29P	0.997
3:39900920:G:C	R35P	0.997
3:40044129:T:C	C64R	0.997
3:40044180:T:C	C81R	0.997

dbSNP variants (sampled 300 via entrez): RS1000005579 (3:40145706 T>C), RS1000014941 (3:39935929 C>T), RS1000015530 (3:40059465 G>A), RS1000033379 (3:40192375 A>G,T), RS1000038786 (3:39836844 C>A), RS1000059526 (3:40068400 G>A), RS1000073976 (3:39943258 T>G), RS1000077708 (3:40209425 A>G), RS1000084825 (3:39959506 C>T), RS1000091523 (3:40133955 C>A,T), RS1000092137 (3:39837110 A>G), RS1000102501 (3:40259544 C>T), RS1000103866 (3:40112820 A>G), RS1000106457 (3:40192676 C>T), RS1000107369 (3:39934358 A>C)

Disease associations

OMIM: gene MIM:611790 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

5 associations (top):

Study	Trait	p-value
GCST000081_1	Sleep-related phenotypes	1.000000e-07
GCST000905_1	Information processing speed	9.000000e-06
GCST001693_1	Acute lymphoblastic leukemia (childhood)	2.000000e-07
GCST007470_4	Rapid automatized naming of letters	8.000000e-06
GCST009200_3	Whole brain grey matter density	7.000000e-06

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0004363	information processing speed
EFO:0005301	reading and spelling ability
EFO:0010306	Grey matter density measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

35 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects methylation, decreases expression, increases methylation	4
Valproic Acid	increases expression, decreases expression	4
Aflatoxin B1	decreases expression, decreases methylation	4
Estradiol	decreases expression, affects cotreatment, increases expression	2
Nickel	decreases expression	2
FR900359	increases phosphorylation	1
bisphenol F	decreases methylation	1
methyleugenol	decreases expression	1
pirinixic acid	affects binding, decreases expression, increases activity	1
bisphenol A	affects cotreatment, increases methylation, decreases methylation	1
methylselenic acid	decreases expression	1
ethyl-p-hydroxybenzoate	increases expression	1
terbufos	increases methylation	1
trichostatin A	increases expression	1
arsenite	increases methylation	1
sulforaphane	decreases expression	1
ferrous chloride	decreases expression	1
aflatoxin B2	increases methylation	1
perfluorooctane sulfonic acid	decreases expression	1
CGP 52608	affects binding, increases reaction	1
prothioconazole	increases expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Acetaminophen	decreases expression	1
Arsenic	affects methylation	1
Cadmium	increases abundance, increases expression	1
Fonofos	increases methylation	1
Methapyrilene	decreases expression	1
Parathion	increases methylation	1
Phenobarbital	affects expression	1
Phthalic Acids	increases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.