MZT1

Summary

MZT1 (mitotic spindle organizing protein 1, HGNC:33830) is a protein-coding gene on chromosome 13q21.33, encoding Mitotic-spindle organizing protein 1 (Q08AG7). Required for the recruitment and the assembly of the gamma-tubulin ring complex (gTuRC) at the centrosome. It is a common-essential gene (DepMap: required in 92.8% of cancer cell lines).

Involved in gamma-tubulin complex localization. Located in centrosome and spindle. Part of gamma-tubulin ring complex.

Source: NCBI Gene 440145 — RefSeq curated summary.

At a glance

• GWAS associations: 13
• Clinical variants (ClinVar): 17 total
• Cancer dependency (DepMap): dependent in 92.8% of screened cell lines (common-essential)
• MANE Select transcript: NM_001071775

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33830
Approved symbol	MZT1
Name	mitotic spindle organizing protein 1
Location	13q21.33
Locus type	gene with protein product
Status	Approved
Aliases	LOC440145, FLJ21869, MGC150539, RP11-11C5.2, MOZART1
Ensembl gene	ENSG00000204899
Ensembl biotype	protein_coding
OMIM	613448
Entrez	440145

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000377818

RefSeq mRNA: 1 — MANE Select: NM_001071775 NM_001071775

CCDS: CCDS31990

Canonical transcript exons

ENST00000377818 — 3 exons

Exon	Start	End
ENSE00001475211	72708367	72710345
ENSE00001475212	72718952	72719097
ENSE00001829898	72727524	72727629

Expression profiles

Bgee: expression breadth ubiquitous, 250 present calls, max score 96.27.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 35.7108 / max 465.3557, expressed in 1811 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
137577	33.4581	1810
137579	1.3286	640
137578	0.5792	372
137580	0.3449	190

Top tissues by expression

255 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cerebellar vermis	UBERON:0004720	96.27	gold quality
lateral globus pallidus	UBERON:0002476	95.54	gold quality
lateral nuclear group of thalamus	UBERON:0002736	95.01	gold quality
nucleus accumbens	UBERON:0001882	94.58	gold quality
caudate nucleus	UBERON:0001873	93.60	gold quality
putamen	UBERON:0001874	93.19	gold quality
ventricular zone	UBERON:0003053	93.10	gold quality
tibialis anterior	UBERON:0001385	92.72	silver quality
oviduct epithelium	UBERON:0004804	92.38	gold quality
left ventricle myocardium	UBERON:0006566	92.19	gold quality
deltoid	UBERON:0001476	91.91	gold quality
cardiac muscle of right atrium	UBERON:0003379	91.22	gold quality
Brodmann (1909) area 46	UBERON:0006483	91.22	gold quality
secondary oocyte	CL:0000655	90.73	gold quality
buccal mucosa cell	CL:0002336	90.58	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	90.23	gold quality
postcentral gyrus	UBERON:0002581	90.13	gold quality
quadriceps femoris	UBERON:0001377	89.86	gold quality
upper arm skin	UBERON:0004263	89.82	silver quality
biceps brachii	UBERON:0001507	89.81	gold quality
globus pallidus	UBERON:0001875	89.77	gold quality
medial globus pallidus	UBERON:0002477	89.65	gold quality
ganglionic eminence	UBERON:0004023	89.62	gold quality
parietal lobe	UBERON:0001872	89.44	gold quality
vastus lateralis	UBERON:0001379	89.39	gold quality
Brodmann (1909) area 9	UBERON:0013540	89.39	gold quality
cerebellum	UBERON:0002037	89.28	gold quality
islet of Langerhans	UBERON:0000006	89.24	gold quality
cerebellar cortex	UBERON:0002129	89.21	gold quality
cerebellar hemisphere	UBERON:0002245	89.18	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-CURD-88	yes	3.95
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

155 targeting MZT1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-485-3P	99.98	70.68	1585
HSA-MIR-539-3P	99.98	70.74	1616
HSA-MIR-548AN	99.97	70.91	2817
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-507	99.97	70.11	1915
HSA-MIR-3688-3P	99.97	72.02	2834
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-9-3P	99.96	70.88	2068
HSA-MIR-548AJ-3P	99.96	73.38	5345
HSA-MIR-548X-3P	99.96	73.38	5345
HSA-MIR-1250-3P	99.96	70.04	4038
HSA-MIR-551B-5P	99.96	71.28	3493
HSA-MIR-4666A-3P	99.96	71.71	3434

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 92.8% of screened cell lines, common-essential.

Literature-anchored findings (GeneRIF, showing 3)

• MZT1 is a ‘priming factor’ for gamma-tubulin ring complex that allows spatial regulation of nucleation. (PMID:27852835)
• NMR secondary structure and interactions of recombinant human MOZART1 protein with its binding partner, GCP3, has been presented. (PMID:28851027)
• MZT Proteins Form Multi-Faceted Structural Modules in the gamma-Tubulin Ring Complex. (PMID:32610146)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	mzt1	ENSDARG00000096668
mus_musculus	Mzt1	ENSMUSG00000033186
rattus_norvegicus	Mzt1	ENSRNOG00000068487

Protein

Protein identifiers

Mitotic-spindle organizing protein 1 — Q08AG7 (reviewed: Q08AG7)

Alternative names: Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1

All UniProt accessions (1): Q08AG7

UniProt curated annotations — full annotation on UniProt →

Function. Required for the recruitment and the assembly of the gamma-tubulin ring complex (gTuRC) at the centrosome. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.

Subunit / interactions. Associates with the gamma-tubulin ring complex (gTuRC) consisting of TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6 and gamma-tubulin TUBG1 or TUBG2; within the complex, interacts with TUBGCP3 and TUBGCP6 to form a luminal bridge with actin that stabilizes the initial structure during complex assembly. Interacts with TUBG1.

Subcellular location. Cytoplasm. Cytoskeleton. Microtubule organizing center. Centrosome. Spindle.

Similarity. Belongs to the MOZART1 family.

RefSeq proteins (1): NP_001065243* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR022214	MZT1	Family

Pfam: PF12554

UniProt features (8 total): helix 3, initiator methionine 1, chain 1, modified residue 1, sequence variant 1, turn 1

Structure

Experimental structures (PDB)

26 structures.

PDB	Method	Resolution (Å)
6L81	X-RAY DIFFRACTION	2.2
6M33	X-RAY DIFFRACTION	3.29
8RX1	ELECTRON MICROSCOPY	3.57
6X0U	ELECTRON MICROSCOPY	3.6
7AS4	ELECTRON MICROSCOPY	4.13
9QVN	ELECTRON MICROSCOPY	4.7
7QJ0	ELECTRON MICROSCOPY	5.32
9QVM	ELECTRON MICROSCOPY	6.8
7QJ1	ELECTRON MICROSCOPY	7
8VRD	ELECTRON MICROSCOPY	7
7QJD	ELECTRON MICROSCOPY	7.1
7QJ3	ELECTRON MICROSCOPY	7.6
8VRJ	ELECTRON MICROSCOPY	7.7
7QJ6	ELECTRON MICROSCOPY	7.8
7QJ9	ELECTRON MICROSCOPY	8.1
8VRK	ELECTRON MICROSCOPY	8.5
7QJ2	ELECTRON MICROSCOPY	8.6
7QJ5	ELECTRON MICROSCOPY	8.7
7QJ7	ELECTRON MICROSCOPY	8.7
7QJ8	ELECTRON MICROSCOPY	8.7
7QJ4	ELECTRON MICROSCOPY	9
7QJA	ELECTRON MICROSCOPY	9.2
7QJB	ELECTRON MICROSCOPY	9.2
7QJC	ELECTRON MICROSCOPY	16.1
9I8G	ELECTRON MICROSCOPY	22.4
9I8H	ELECTRON MICROSCOPY	23.2

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q08AG7-F1	93.00	0.85

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 2

Function

Pathways and Gene Ontology

Reactome pathways

9 pathways

ID	Pathway
R-HSA-380270	Recruitment of mitotic centrosome proteins and complexes
R-HSA-380320	Recruitment of NuMA to mitotic centrosomes
R-HSA-1640170	Cell Cycle
R-HSA-380287	Centrosome maturation
R-HSA-453274	Mitotic G2-G2/M phases
R-HSA-68877	Mitotic Prometaphase
R-HSA-68886	M Phase
R-HSA-69275	G2/M Transition
R-HSA-69278	Cell Cycle, Mitotic

MSigDB gene sets: 170 (showing top): chr13q21, GOBP_CHROMOSOME_ORGANIZATION, GOBP_MICROTUBULE_NUCLEATION, GOCC_MICROTUBULE_ORGANIZING_CENTER, PATIL_LIVER_CANCER, WEI_MYCN_TARGETS_WITH_E_BOX, GOBP_MITOTIC_SPINDLE_ASSEMBLY, GOBP_ORGANELLE_FISSION, GOCC_CENTROSOME, GOBP_MITOTIC_NUCLEAR_DIVISION, GOBP_ORGANELLE_ASSEMBLY, GOBP_MITOTIC_CELL_CYCLE, FISCHER_DREAM_TARGETS, GOBP_SPINDLE_ASSEMBLY, LINDVALL_IMMORTALIZED_BY_TERT_DN

GO Biological Process (3): gamma-tubulin complex localization (GO:0033566), microtubule nucleation by interphase microtubule organizing center (GO:0051415), mitotic spindle assembly (GO:0090307)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (7): gamma-tubulin ring complex (GO:0000931), centrosome (GO:0005813), spindle (GO:0005819), cytosol (GO:0005829), interphase microtubule organizing center (GO:0031021), cytoplasm (GO:0005737), cytoskeleton (GO:0005856)

Reactome top-level categories

Rollup of top-7 pathways:

Category	Pathways
Cell Cycle, Mitotic	2
Centrosome maturation	1
Mitotic Prometaphase	1
G2/M Transition	1
M Phase	1
Mitotic G2-G2/M phases	1
Cell Cycle	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
microtubule organizing center	2
intracellular membraneless organelle	2
cellular anatomical structure	2
protein-containing complex localization	1
microtubule nucleation by microtubule organizing center	1
mitotic sister chromatid segregation	1
mitotic spindle organization	1
spindle assembly	1
mitotic nuclear division	1
binding	1
gamma-tubulin complex	1
gamma-tubulin small complex	1
centriole	1
microtubule cytoskeleton	1
cytoplasm	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

1857 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MZT1	MZT2A	Q6P582	995
MZT1	B8ZZ87	B8ZZ87	989
MZT1	TUBGCP3	Q96CW5	951
MZT1	TUBG1	P23258	905
MZT1	NEDD1	Q8NHV4	894
MZT1	TUBGCP6	Q96RT7	869
MZT1	TUBGCP4	Q9UGJ1	865
MZT1	TUBGCP5	Q96RT8	820
MZT1	TUBGCP2	Q9BSJ2	763
MZT1	NME7	Q9Y5B8	735
MZT1	ERC2	O15083	721
MZT1	CDK5RAP2	Q96SN8	699
MZT1	PIBF1	Q8WXW3	603
MZT1	BORA	Q6PGQ7	602
MZT1	MTO1	Q9Y2Z2	536

IntAct

36 interactions, top by confidence:

A	B	Type	Score
MZT1	TUBG1	psi-mi:“MI:0915”(physical association)	0.770
Mzt2	TUBG1	psi-mi:“MI:0914”(association)	0.560
TRIM72	MZT1	psi-mi:“MI:0915”(physical association)	0.560
CYGB	MZT1	psi-mi:“MI:0915”(physical association)	0.560
MZT1	CINP	psi-mi:“MI:0915”(physical association)	0.560
MZT1	CYGB	psi-mi:“MI:0915”(physical association)	0.560
MZT1	TRIM72	psi-mi:“MI:0915”(physical association)	0.560
MZT1	PCNT	psi-mi:“MI:0914”(association)	0.530
TUBG2	TXNDC9	psi-mi:“MI:0914”(association)	0.530
Tubg1	BDP1	psi-mi:“MI:0914”(association)	0.350
Tubgcp6	MRE11	psi-mi:“MI:0914”(association)	0.350
Tubg1	RTL8C	psi-mi:“MI:0914”(association)	0.350
SCAF11	MRPL3	psi-mi:“MI:0914”(association)	0.350
Tubgcp5	TUBG1	psi-mi:“MI:0914”(association)	0.350
TUBGCP2	WWP2	psi-mi:“MI:0914”(association)	0.350
TUBGCP4	PZP	psi-mi:“MI:0914”(association)	0.350
TUBGCP5	DNAJC6	psi-mi:“MI:0914”(association)	0.350
MZT1	ZC3H18	psi-mi:“MI:0914”(association)	0.350
Lgals3bp	CS	psi-mi:“MI:0914”(association)	0.350
Tubg1	ZC3H18	psi-mi:“MI:0914”(association)	0.350
NEDD1	ATP5MF-PTCD1	psi-mi:“MI:0914”(association)	0.350
NEDD1	DERL1	psi-mi:“MI:0914”(association)	0.350
MAPK1	SEC16A	psi-mi:“MI:0914”(association)	0.350
MZT1	TUBGCP6	psi-mi:“MI:0914”(association)	0.350
CCP110	A2ML1	psi-mi:“MI:0914”(association)	0.350
CCP110	KIF2A	psi-mi:“MI:0914”(association)	0.350
FAM187B	DCTN3	psi-mi:“MI:0914”(association)	0.350

BioGRID (92): APOB (Affinity Capture-MS), CENPF (Affinity Capture-MS), FMR1 (Affinity Capture-MS), LGALS3BP (Affinity Capture-MS), RBBP6 (Affinity Capture-MS), SRSF7 (Affinity Capture-MS), TUBG1 (Affinity Capture-MS), USP11 (Affinity Capture-MS), RGS19 (Affinity Capture-MS), TUBGCP3 (Affinity Capture-MS), SRSF10 (Affinity Capture-MS), TUBGCP2 (Affinity Capture-MS), EXOSC7 (Affinity Capture-MS), ZC3H13 (Affinity Capture-MS), ZC3H3 (Affinity Capture-MS)

ESM2 similar proteins: A1CQI3, A3KNK7, A7RWP6, B2RYZ5, B5FXZ4, B5XC71, B5XGH3, O12940, O35094, O35226, O35685, O35857, O88746, P0C8Y1, P55035, P55036, Q08AG7, Q0VFD6, Q16186, Q17QG2, Q1DRC2, Q1RMG8, Q2UF96, Q3KPT5, Q58DA0, Q5BDL9, Q5R762, Q5RGJ6, Q5RJU0, Q5U4M5, Q5ZIN1, Q60482, Q63525, Q640V2, Q64537, Q6DH42, Q6GLP4, Q6GN67, Q6P877, Q7ZVK4

Diamond homologs: A1CQI3, A4QYG1, A6S6H9, A7EXZ2, A9NKD9, B5FXZ4, P0C8Y1, P0CF96, P0CP04, P0CP05, Q08AG7, Q0VFD6, Q1DRC2, Q2GVR6, Q5BDL9, Q5U4M5, Q8BUR9, Q9C9T3, Q9M0N8

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 37 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Recruitment of mitotic centrosome proteins and complexes	10	56.6×	1e-13
Recruitment of NuMA to mitotic centrosomes	10	48.5×	4e-13
Loss of Nlp from mitotic centrosomes	5	33.0×	2e-05
Loss of proteins required for interphase microtubule organization from the centrosome	5	33.0×	2e-05
AURKA Activation by TPX2	5	31.7×	2e-05
Regulation of PLK1 Activity at G2/M Transition	5	26.4×	5e-05
Anchoring of the basal body to the plasma membrane	5	23.6×	8e-05
M Phase	5	13.8×	9e-04

GO biological processes:

GO term	Partners	Fold	FDR
microtubule nucleation	8	172.2×	1e-14
cytoplasmic microtubule organization	6	71.2×	1e-08
mitotic cell cycle	8	36.9×	3e-09

Disease & clinical

Clinical variants and AI predictions

ClinVar

17 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	11
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

462 predictions. Top by Δscore:

Variant	Effect	Δscore
13:72719093:CAGAA:C	acceptor_gain	1.0000
13:72719094:AGAA:A	acceptor_gain	1.0000
13:72719095:GAA:G	acceptor_gain	1.0000
13:72719095:GAAC:G	acceptor_loss	1.0000
13:72719096:AA:A	acceptor_gain	1.0000
13:72719096:AAC:A	acceptor_loss	1.0000
13:72719097:ACT:A	acceptor_loss	1.0000
13:72719098:C:CC	acceptor_gain	1.0000
13:72719099:T:C	acceptor_loss	1.0000
13:72727521:CAC:C	donor_loss	1.0000
13:72727522:A:AC	donor_gain	1.0000
13:72727522:ACCGT:A	donor_gain	1.0000
13:72727523:C:CC	donor_gain	1.0000
13:72727523:C:G	donor_loss	1.0000
13:72727523:CCGT:C	donor_gain	1.0000
13:72727523:CCGTC:C	donor_gain	1.0000
13:72710344:GCC:G	acceptor_loss	0.9900
13:72710345:CCT:C	acceptor_loss	0.9900
13:72710346:CTA:C	acceptor_loss	0.9900
13:72710347:T:A	acceptor_loss	0.9900
13:72718946:TCCAA:T	donor_loss	0.9900
13:72718947:CCAA:C	donor_loss	0.9900
13:72718948:CAACC:C	donor_loss	0.9900
13:72718949:AAC:A	donor_loss	0.9900
13:72718950:A:AT	donor_loss	0.9900
13:72710342:CAGC:C	acceptor_gain	0.9800
13:72719108:A:AC	acceptor_gain	0.9800
13:72719108:A:C	acceptor_gain	0.9800
13:72727522:AC:A	donor_gain	0.9800
13:72727523:CC:C	donor_gain	0.9800

AlphaMissense

522 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
13:72719036:A:C	C47W	1.000
13:72718974:C:G	R68P	0.999
13:72718977:A:G	L67P	0.999
13:72718998:A:G	L60S	0.999
13:72719007:G:T	P57Q	0.999
13:72719016:C:A	G54V	0.999
13:72719028:A:G	L50P	0.999
13:72719037:C:T	C47Y	0.999
13:72719038:A:G	C47R	0.999
13:72719061:A:G	L39S	0.999
13:72719083:A:G	S32P	0.999
13:72718986:A:T	I64N	0.998
13:72718989:A:T	V63D	0.998
13:72719016:C:T	G54E	0.998
13:72719017:C:G	G54R	0.998
13:72719017:C:T	G54R	0.998
13:72719019:T:G	Q53P	0.998
13:72719024:A:C	C51W	0.998
13:72719025:C:T	C51Y	0.998
13:72719028:A:T	L50H	0.998
13:72719046:A:G	L44P	0.998
13:72719046:A:T	L44Q	0.998
13:72719073:A:G	L35S	0.998
13:72718969:C:G	A70P	0.997
13:72718986:A:C	I64S	0.997
13:72718996:A:G	S61P	0.997
13:72719007:G:C	P57R	0.997
13:72719022:T:A	E52V	0.997
13:72719031:C:G	R49P	0.997
13:72719034:A:T	V48E	0.997

dbSNP variants (sampled 300 via entrez): RS1000268547 (13:72716598 T>C), RS1000326468 (13:72708874 T>C), RS1000368767 (13:72729530 C>A,T), RS1000543475 (13:72710952 A>G), RS1000959611 (13:72723217 C>T), RS1001013345 (13:72728397 T>C), RS1001062856 (13:72710702 T>C), RS1001197540 (13:72709531 T>C), RS1001328189 (13:72721220 C>T), RS1001343427 (13:72710464 A>T), RS1001602682 (13:72722059 C>T), RS1001649340 (13:72708816 A>T), RS1001658729 (13:72715572 G>A), RS1001849320 (13:72728317 G>A,T), RS1001860895 (13:72724399 A>G)

Disease associations

OMIM: gene MIM:613448 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

13 associations (top):

Study	Trait	p-value
GCST001636_3	Obsessive-compulsive disorder	5.000000e-06
GCST007576_205	Chronotype	4.000000e-09
GCST009391_1202	Metabolite levels	6.000000e-06
GCST009391_1463	Metabolite levels	2.000000e-06
GCST009391_1475	Metabolite levels	4.000000e-06
GCST009391_1494	Metabolite levels	2.000000e-06
GCST009391_1509	Metabolite levels	2.000000e-06
GCST009391_1615	Metabolite levels	3.000000e-06
GCST009391_1674	Metabolite levels	5.000000e-08
GCST009391_1829	Metabolite levels	8.000000e-06
GCST009391_1833	Metabolite levels	2.000000e-06
GCST009391_1869	Metabolite levels	8.000000e-07
GCST010216_1	Diastolic blood pressure	5.000000e-06

EFO canonical traits (11, from GWAS)

EFO ID	Trait name
EFO:0008328	chronotype measurement
EFO:0010418	triacylglycerol 52:6 measurement
EFO:0010406	triacylglycerol 48:3 measurement
EFO:0010407	triacylglycerol 48:4 measurement
EFO:0010416	triacylglycerol 52:4 measurement
EFO:0010417	triacylglycerol 52:5 measurement
EFO:0010378	phosphatidylcholine 34:4 measurement
EFO:0010340	cholesteryl ester 14:0 measurement
EFO:0010411	triacylglycerol 50:4 measurement
EFO:0010412	triacylglycerol 50:5 measurement
EFO:0006945	diastolic blood pressure change measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

29 total (human), top 29 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Air Pollutants	decreases expression, increases abundance	2
Smoke	decreases expression, increases abundance	2
Testosterone	affects cotreatment, decreases expression	2
Tetrachlorodibenzodioxin	decreases expression	2
Valproic Acid	decreases expression, decreases methylation	2
Aflatoxin B1	affects expression, increases methylation	2
Particulate Matter	decreases expression, increases abundance, affects cotreatment	2
GSK-J4	increases expression	1
dicrotophos	decreases expression	1
geldanamycin	increases expression	1
mono-(2-ethylhexyl)phthalate	decreases expression	1
sodium arsenite	decreases expression	1
2,3-bis(3’-hydroxybenzyl)butyrolactone	affects cotreatment, increases expression	1
K 7174	increases expression	1
jinfukang	decreases expression	1
Resveratrol	increases expression	1
Temozolomide	decreases expression	1
Sunitinib	decreases expression	1
Ethanol	decreases expression, increases abundance, affects cotreatment	1
Calcitriol	decreases expression, affects cotreatment	1
Coumestrol	affects cotreatment, increases expression	1
Gasoline	affects cotreatment, decreases expression, increases abundance	1
Lead	affects expression	1
Polycyclic Aromatic Hydrocarbons	affects cotreatment, decreases expression, increases abundance	1
Theophylline	decreases expression	1
Tretinoin	decreases expression	1
Cyclosporine	increases expression	1
Okadaic Acid	increases expression	1
Lactic Acid	decreases expression	1

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B1Y4	Abcam HeLa MZT1 KO	Cancer cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.