MZT2B

gene
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Also known as FLJ14346MOZART2B

Summary

MZT2B (mitotic spindle organizing protein 2B, HGNC:25886) is a protein-coding gene on chromosome 2q21.1, encoding Mitotic-spindle organizing protein 2B (Q6NZ67). Required for the recruitment and the assembly of the gamma-tubulin ring complex (gTuRC) at the centrosome.

Located in cytosol; microtubule cytoskeleton; and nucleoplasm. Part of gamma-tubulin ring complex.

Source: NCBI Gene 80097 — RefSeq curated summary.

At a glance

  • Clinical variants (ClinVar): 81 total — 1 pathogenic, 1 likely-pathogenic
  • Phenotypes (HPO): 1
  • MANE Select transcript: NM_025029

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:25886
Approved symbolMZT2B
Namemitotic spindle organizing protein 2B
Location2q21.1
Locus typegene with protein product
StatusApproved
AliasesFLJ14346, MOZART2B
Ensembl geneENSG00000152082
Ensembl biotypeprotein_coding
OMIM613450
Entrez80097

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 9 protein_coding, 2 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000281871, ENST00000409255, ENST00000425361, ENST00000455239, ENST00000457492, ENST00000480182, ENST00000485869, ENST00000491178, ENST00000651060, ENST00000916358, ENST00000916359, ENST00000948926

RefSeq mRNA: 3 — MANE Select: NM_025029 NM_001330282, NM_001330284, NM_025029

CCDS: CCDS2157, CCDS82511

Canonical transcript exons

ENST00000281871 — 3 exons

ExonStartEnd
ENSE00001587901130182262130182452
ENSE00002522165130182627130182775
ENSE00003556139130190469130190727

Expression profiles

Bgee: expression breadth ubiquitous, 285 present calls, max score 99.38.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 95.4046 / max 531.0295, expressed in 1827 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter IDTPM avgSamples expressed
2249793.94841827
224961.2633749
224950.192963

Top tissues by expression

288 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
apex of heartUBERON:000209899.38gold quality
anterior cingulate cortexUBERON:000983599.31gold quality
cingulate cortexUBERON:000302799.30gold quality
amygdalaUBERON:000187699.27gold quality
endocervixUBERON:000045899.20gold quality
right testisUBERON:000453499.20gold quality
right frontal lobeUBERON:000281099.16gold quality
left testisUBERON:000453399.16gold quality
left ovaryUBERON:000211999.14gold quality
body of pancreasUBERON:000115099.11gold quality
right ovaryUBERON:000211899.06gold quality
left lobe of thyroid glandUBERON:000112099.05gold quality
Brodmann (1909) area 9UBERON:001354099.03gold quality
prefrontal cortexUBERON:000045199.02gold quality
left uterine tubeUBERON:000130399.02gold quality
nucleus accumbensUBERON:000188299.02gold quality
esophagogastric junction muscularis propriaUBERON:003584199.01gold quality
muscle layer of sigmoid colonUBERON:003580598.99gold quality
right lobe of thyroid glandUBERON:000111998.98gold quality
mucosa of stomachUBERON:000119998.97gold quality
heart left ventricleUBERON:000208498.97gold quality
lower esophagusUBERON:001347398.97gold quality
lower esophagus muscularis layerUBERON:003583398.97gold quality
lower esophagus mucosaUBERON:003583498.97gold quality
body of stomachUBERON:000116198.96gold quality
mucosa of transverse colonUBERON:000499198.94gold quality
cardiac ventricleUBERON:000208298.93gold quality
right atrium auricular regionUBERON:000663198.92gold quality
body of uterusUBERON:000985398.92gold quality
left adrenal gland cortexUBERON:003582598.91gold quality

Single-cell (SCXA)

Detected in 9 experiment(s), a significant marker in 6.

ExperimentMarker?Max mean expression
E-MTAB-5061yes344.54
E-CURD-46yes19.67
E-ANND-3yes16.15
E-MTAB-10553yes7.32
E-CURD-88yes5.35
E-CURD-122yes4.69
E-MTAB-7008no115.28
E-GEOD-124858no52.66
E-GEOD-125970no15.79

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

4 targeting MZT2B, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNAMax scoreAvg scoremiRNA target_count
HSA-MIR-4731-5P99.8967.232537
HSA-MIR-1213598.9970.261814
HSA-MIR-6810-5P98.2966.21975
HSA-MIR-433095.4466.39993

Literature-anchored findings (GeneRIF, showing 1)

  • MZT Proteins Form Multi-Faceted Structural Modules in the gamma-Tubulin Ring Complex. (PMID:32610146)

Cross-species orthologs

3 orthologs

OrganismSymbolGene ID
danio_reriomzt2bENSDARG00000057928
mus_musculusMzt2ENSMUSG00000022671
rattus_norvegicusMzt2bENSRNOG00000066842

Paralogs (1): MZT2A (ENSG00000173272)

Protein

Protein identifiers

Mitotic-spindle organizing protein 2BQ6NZ67 (reviewed: Q6NZ67)

Alternative names: Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2B

All UniProt accessions (6): Q6NZ67, A0A494C0V9, B8ZZ87, H7BZ50, H7C173, H7C293

UniProt curated annotations — full annotation on UniProt →

Function. Required for the recruitment and the assembly of the gamma-tubulin ring complex (gTuRC) at the centrosome. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.

Subunit / interactions. Associates with the gamma-tubulin ring complex (gTuRC) consisting of TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6 and gamma-tubulin TUBG1 or TUBG2; within the complex, interacts with TUBGCP2; the interaction plays a role in gTuRC activation. Interacts with TUBG1.

Subcellular location. Cytoplasm. Cytoskeleton. Microtubule organizing center. Centrosome. Spindle.

Similarity. Belongs to the MOZART2 family.

RefSeq proteins (3): NP_001317211, NP_001317213, NP_079305* (*=MANE)

Domains & families (InterPro)

IDNameType
IPR024332MOZART2Family

Pfam: PF12926

UniProt features (8 total): compositionally biased region 2, modified residue 2, sequence variant 2, chain 1, region of interest 1

Structure

Experimental structures (PDB)

1 structures.

PDBMethodResolution (Å)
9QVMELECTRON MICROSCOPY6.8

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-Q6NZ67-F164.860.22

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 34, 152

Function

Pathways and Gene Ontology

Reactome pathways

9 pathways

IDPathway
R-HSA-380270Recruitment of mitotic centrosome proteins and complexes
R-HSA-380320Recruitment of NuMA to mitotic centrosomes
R-HSA-1640170Cell Cycle
R-HSA-380287Centrosome maturation
R-HSA-453274Mitotic G2-G2/M phases
R-HSA-68877Mitotic Prometaphase
R-HSA-68886M Phase
R-HSA-69275G2/M Transition
R-HSA-69278Cell Cycle, Mitotic

MSigDB gene sets: 136 (showing top): STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN, GOBP_MICROTUBULE_NUCLEATION, GOCC_MICROTUBULE_ORGANIZING_CENTER, GOCC_CENTROSOME, CREB_Q3, GOBP_MICROTUBULE_POLYMERIZATION, GOCC_SPINDLE, GOCC_GAMMA_TUBULIN_COMPLEX, KIM_WT1_TARGETS_DN, CHEN_METABOLIC_SYNDROM_NETWORK, TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C, GOBP_MICROTUBULE_CYTOSKELETON_ORGANIZATION, KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3, GOBP_PROTEIN_POLYMERIZATION, GOBP_SUPRAMOLECULAR_FIBER_ORGANIZATION

GO Biological Process (0):

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (7): gamma-tubulin ring complex (GO:0000931), nucleoplasm (GO:0005654), centrosome (GO:0005813), spindle (GO:0005819), cytosol (GO:0005829), cytoplasm (GO:0005737), cytoskeleton (GO:0005856)

Reactome top-level categories

Rollup of top-7 pathways:

CategoryPathways
Cell Cycle, Mitotic2
Centrosome maturation1
Mitotic Prometaphase1
G2/M Transition1
M Phase1
Mitotic G2-G2/M phases1
Cell Cycle1

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
cellular anatomical structure3
intracellular membraneless organelle2
binding1
gamma-tubulin complex1
gamma-tubulin small complex1
nuclear lumen1
centriole1
microtubule organizing center1
microtubule cytoskeleton1
cytoplasm1
intracellular anatomical structure1

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

104 interactions, top by confidence:

ABTypeScore
CSNK1A1FAM83Gpsi-mi:“MI:0914”(association)0.900
ODAD1HGSpsi-mi:“MI:0914”(association)0.850
TUBGCP5TUBG1psi-mi:“MI:0914”(association)0.840
MZT2BTUBG1psi-mi:“MI:0914”(association)0.770
TUBG1MZT2Bpsi-mi:“MI:0915”(physical association)0.770
Mzt2TUBG1psi-mi:“MI:0914”(association)0.560
APLNRMETTL15psi-mi:“MI:0914”(association)0.530
NPY2RRTL8Cpsi-mi:“MI:0914”(association)0.530
SPINT2UPK3BL1psi-mi:“MI:0914”(association)0.530
TUBG2TXNDC9psi-mi:“MI:0914”(association)0.530
SLCO1B1SYNGR2psi-mi:“MI:0914”(association)0.530
MZT1PCNTpsi-mi:“MI:0914”(association)0.530
TXNDC12TUBG1psi-mi:“MI:0914”(association)0.530
CXCR4TMEM120Bpsi-mi:“MI:0914”(association)0.530
FBXW11AHCYL1psi-mi:“MI:0914”(association)0.530
TUBG2TCP1psi-mi:“MI:0914”(association)0.530
NEDD1CEP290psi-mi:“MI:0914”(association)0.480
Tubgcp3psi-mi:“MI:0915”(physical association)0.400
Mzt2psi-mi:“MI:0915”(physical association)0.400
Tubgcp2TUBG1psi-mi:“MI:0915”(physical association)0.400
Tubg1psi-mi:“MI:0915”(physical association)0.400

BioGRID (137): MZT2B (Affinity Capture-MS), TUBGCP2 (Affinity Capture-MS), TUBG1 (Affinity Capture-MS), TUBGCP5 (Affinity Capture-MS), TUBGCP3 (Affinity Capture-MS), TUBGCP6 (Affinity Capture-MS), TUBGCP4 (Affinity Capture-MS), NME7 (Affinity Capture-MS), MZT2B (Affinity Capture-MS), MZT2B (Co-fractionation), MZT2B (Biochemical Activity), MZT2B (Affinity Capture-MS), MZT2B (Affinity Capture-MS), MZT2B (Affinity Capture-MS), MZT2B (Affinity Capture-MS)

ESM2 similar proteins: A4D2P6, A5PJV8, A6NFD8, D4AE48, O00268, O00287, O35274, O35779, O43566, P04198, P12755, P55199, Q08DA0, Q0D2I5, Q2KJ58, Q504T8, Q5XKK7, Q60698, Q61976, Q6NZ67, Q6P582, Q6R891, Q6T4P5, Q7Z6J2, Q80YR4, Q86UD0, Q86UK7, Q8BXL9, Q8CEG5, Q8R4T5, Q8TF61, Q8VCG9, Q969F2, Q969G9, Q96HZ4, Q96SB3, Q99PV5, Q9BQ61, Q9BUN5, Q9BZE9

Diamond homologs: A5PJV8, Q28DB1, Q6DC17, Q6NZ67, Q6P582, Q9CQ25

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 129 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

PathwayPartnersFoldFDR
Transport of vitamins, nucleosides, and related molecules620.9×8e-05
Recruitment of mitotic centrosome proteins and complexes1119.2×6e-09
Recruitment of NuMA to mitotic centrosomes1116.4×2e-08
Centrosome maturation516.3×2e-03
Regulation of PLK1 Activity at G2/M Transition69.8×4e-03
G alpha (i) signalling events105.0×4e-03

GO biological processes:

GO termPartnersFoldFDR
microtubule nucleation847.1×3e-09
cytoplasmic microtubule organization722.7×8e-06
adenylate cyclase-modulating G protein-coupled receptor signaling pathway515.9×2e-03
mitotic cell cycle78.8×2e-03
G protein-coupled receptor signaling pathway134.4×2e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

81 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic1
Likely pathogenic1
Uncertain significance59
Likely benign12
Benign4

Top pathogenic / likely-pathogenic (2)

Variant IDHGVSClassification
4279388GRCh37/hg19 2q21.1(chr2:130904460-131041207)x1Pathogenic
183299NM_207312.3(TUBA3E):c.643C>T (p.Arg215Cys)Likely pathogenic

SpliceAI

709 predictions. Top by Δscore:

VariantEffectΔscore
2:130182446:TGTTC:Tdonor_gain1.0000
2:130182448:TTC:Tdonor_gain1.0000
2:130182453:G:GGdonor_gain1.0000
2:130182447:GTTCA:Gdonor_gain0.9900
2:130182452:AG:Adonor_loss0.9900
2:130182454:T:Gdonor_loss0.9900
2:130182771:CCGAG:Cdonor_loss0.9900
2:130182772:CGAG:Cdonor_loss0.9900
2:130182773:GAGGT:Gdonor_loss0.9900
2:130182774:AG:Adonor_loss0.9900
2:130182775:GG:Gdonor_loss0.9900
2:130182776:G:Adonor_loss0.9900
2:130182777:T:Gdonor_loss0.9900
2:130183667:G:Tdonor_gain0.9900
2:130190463:CCTCA:Cacceptor_loss0.9900
2:130190464:CTCA:Cacceptor_loss0.9900
2:130190465:TCAGG:Tacceptor_loss0.9900
2:130190467:A:ACacceptor_loss0.9900
2:130190467:A:AGacceptor_gain0.9900
2:130190467:AG:Aacceptor_gain0.9900
2:130190468:G:GGacceptor_gain0.9900
2:130190468:GG:Gacceptor_gain0.9900
2:130190468:GGGA:Gacceptor_gain0.9900
2:130182399:GCT:Gdonor_gain0.9800
2:130182442:G:GTdonor_gain0.9800
2:130182455:GA:Gdonor_loss0.9800
2:130182553:T:TAdonor_gain0.9800
2:130182625:AG:Aacceptor_gain0.9800
2:130182626:GG:Gacceptor_gain0.9800
2:130190466:CAGGG:Cacceptor_gain0.9800

AlphaMissense

998 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
2:130182641:T:CL62P0.999
2:130182671:T:AV72D0.999
2:130182683:T:AL76H0.999
2:130182410:T:CL43P0.998
2:130182644:T:CL63P0.998
2:130182683:T:CL76P0.998
2:130182401:T:CL40P0.997
2:130182449:T:CF56S0.997
2:130182641:T:AL62Q0.997
2:130182662:C:AP69H0.997
2:130182668:C:AA71D0.997
2:130182448:T:CF56L0.996
2:130182450:C:AF56L0.996
2:130182450:C:GF56L0.996
2:130182629:T:CI58T0.996
2:130182650:T:CL65P0.996
2:130182653:A:TN66I0.996
2:130182662:C:GP69R0.996
2:130182662:C:TP69L0.996
2:130182401:T:AL40Q0.995
2:130182410:T:AL43Q0.995
2:130182629:T:GI58S0.995
2:130182632:T:CL59P0.995
2:130182680:T:GM75R0.995
2:130182683:T:GL76R0.995
2:130182418:G:CA46P0.994
2:130182627:G:CK57N0.994
2:130182627:G:TK57N0.994
2:130182661:C:AP69T0.994
2:130182421:G:CA47P0.993

dbSNP variants (sampled 300 via entrez): RS1000136066 (2:130180891 G>T), RS1000227143 (2:130193270 A>T), RS1000510490 (2:130194562 G>C), RS1000536099 (2:130182056 G>A,C), RS1000711336 (2:130186299 A>G), RS1001043467 (2:130181863 T>A,C), RS1001308731 (2:130186057 C>G), RS1001412457 (2:130185672 C>G,T), RS1001758608 (2:130181300 C>A,G,T), RS1001839542 (2:130190162 A>G), RS1002147837 (2:130182399 G>A), RS1002231239 (2:130203312 C>T), RS1003011961 (2:130196529 C>A,T), RS1003107553 (2:130190922 C>T), RS1003273172 (2:130187918 C>G)

Disease associations

OMIM: gene MIM:613450 | disease phenotypes: MIM:607432

GenCC curated gene-disease

Mondo (2): lissencephaly spectrum disorders (MONDO:0018838), neurodevelopmental disorder (MONDO:0700092)

Orphanet (1): Lissencephaly (Orphanet:48471)

HPO phenotypes

1 total (1 of 1 shown, HPO-id order):

HPOTerm
HP:0001339Lissencephaly

GWAS associations

0 associations (top):

MeSH disease descriptors (2)

DescriptorNameTree numbers
D054082LissencephalyC10.500.507.450.499; C16.131.666.507.450.499
D065886Neurodevelopmental DisordersF03.625

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

21 total (human), top 21 by PubMed support.

ChemicalActions (top 5)PubMed papers
sodium arseniteaffects expression, affects binding, increases reaction, decreases expression3
Valproic Acidaffects expression, decreases expression3
FR900359increases phosphorylation1
methylmercuric chlorideincreases expression1
bisphenol Aaffects expression1
glycidyl methacrylateincreases expression1
lead acetateincreases expression, affects cotreatment1
tris(2-butoxyethyl) phosphateaffects expression1
zinc protoporphyrinaffects cotreatment, increases expression1
butyraldehydedecreases expression1
(+)-JQ1 compounddecreases expression1
Benzo(a)pyreneaffects expression1
Cisplatindecreases expression1
Leadincreases expression1
Lipopolysaccharidesaffects expression, affects response to substance1
Smokedecreases expression1
Tetrachlorodibenzodioxinaffects expression1
Thiramdecreases expression1
Tobacco Smoke Pollutionincreases expression1
Tretinoindecreases expression1
Cyclosporinedecreases expression1

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

CellosaurusNameCategorySex
CVCL_B3BQAbcam HEK293T MZT2B KOTransformed cell lineFemale

Clinical trials (associated diseases)

202 trials via MONDO — disease-level, not drug-specific.

TrialPhaseStatusTitle
NCT04586348PHASE4UNKNOWNPrenatal Iodine Supplementation and Early Childhood Neurodevelopment
NCT04873115PHASE4UNKNOWNDouble-blind, Placebo-controlled, Randomized Clinical Trial Comparing the Efficacy and Safety of Sialanar Plus orAl rehabiLitation Against Placebo Plus Oral Rehabilitation for chIldren and Adolescents With seVere Sialorrhoea and Neurodisabilties,
NCT02559102PHASE3COMPLETEDDexmedetomidine Sedation Versus General Anaesthesia for Inguinal Hernia Surgery in Infants
NCT02757079PHASE3COMPLETEDStudy of the Efficacy and Safety of NPC-15 for Sleep Disorders of Children With Neurodevelopmental Disorders
NCT06915480PHASE3RECRUITINGReducing Missed Appointments
NCT07377032PHASE3RECRUITINGTAP-GRIN: Interventional Study on Patients With GRIN-related Neurodevelopmental Disorders
NCT02909959PHASE2COMPLETEDSulforaphane for the Treatment of Young Men With Autism Spectrum Disorder
NCT06081348PHASE2RECRUITINGSertraline vs. Placebo in the Treatment of Anxiety in Children and AdoLescents With NeurodevelopMental Disorders
NCT06352372PHASE2COMPLETEDSafety and Efficacy of tPBM for Epileptiform Activity in Autism
NCT00503191PHASE1COMPLETEDNeuroModulation Technique Treatment of Autism
NCT04475848PHASE1COMPLETEDA Study to Investigate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Food Effect of RO6953958 in Healthy Participants
NCT06300398PHASE1COMPLETEDIAMA-6 Oral Dose Study in Healthy Adults
NCT01783041PHASE2/PHASE3COMPLETEDEffect of Early L-Carnitine Supplementation on Neurodevelopmental Outcomes in Very Preterm Infants
NCT05767385PHASE2/PHASE3RECRUITINGFetal Cerebrovascular Autoregulation in Congenital Heart Disease and Association With Neonatal Neurobehavior
NCT05675098EARLY_PHASE1NOT_YET_RECRUITINGCentral Nervous System Stimulants and Physical Function in Children With Cerebral Palsy
NCT00783783Not specifiedCOMPLETEDCYP2D6 Pharmacogenetics in Risperidone-Treated Children
NCT01778504Not specifiedRECRUITINGStudying Childhood-onset Behavioral, Psychiatric, and Developmental Disorders
NCT01850784Not specifiedUNKNOWNHigh Energy Formula Feeding in Infants With Congenital Heart Disease
NCT01922791Not specifiedCOMPLETEDNutrition and Pregnancy Intervention Study
NCT01942525Not specifiedUNKNOWNInfluence of Intrauterine Growth Restriction on Amplitude-integrated EEG in Preterm Infants
NCT02003170Not specifiedCOMPLETEDEtiology and Early Diagnosis of Neurodevelopmental Disorders
NCT02118649Not specifiedACTIVE_NOT_RECRUITINGEnhancing Behavior and Brain Response to Visual Targets Using a Computer Game
NCT02557191Not specifiedTERMINATEDBiomarkers, Neurodevelopment and Preterm Infants
NCT02690675Not specifiedCOMPLETEDIron Supplement Effect on Child Development
NCT02694003Not specifiedCOMPLETEDBetter Nights, Better Days for Children With Neurodevelopment Disorders
NCT02792894Not specifiedCOMPLETEDFamily Networks (FaNs) for Children With Developmental Disorders and Delays
NCT02871674Not specifiedUNKNOWNGood Night Project: Behavioural Sleep Interventions for Children With ADHD: A Randomised Controlled Trial
NCT02887157Not specifiedCOMPLETEDAnalyzing Retinal Microanatomy in ROP
NCT02898298Not specifiedCOMPLETEDPositive Emotion Regulation Training in Children, Adolescents and Young Adults With and Without Developmental Disorder
NCT02912780Not specifiedUNKNOWNIntroduction of Microsystems in a Level 3 Neonatal Intensive Care Unit
NCT03023293Not specifiedCOMPLETEDn-3 PUFAs, Irisin and Maternal Glucose Metabolism From Pregnancy to Postpartum
NCT03023644Not specifiedCOMPLETEDImproving Neurodevelopmental Outcomes in Children With Congenital Heart Disease: An Intervention Study
NCT03032991Not specifiedUNKNOWNEarly Biomarkers of Neurodevelopment in Offspring of Diabetic Mothers
NCT03088189Not specifiedTERMINATEDEffect of Parental Peri-conceptional Vitamin B12 Supplementation on Infant Neurocognitive Development in Offspring
NCT03096028Not specifiedCOMPLETEDDevelopmental Origins of Mental Health Disorders
NCT03148782Not specifiedCOMPLETEDBrain Plasticity Underlying Acquisition of New Organizational Skills in Children-R61 Phase
NCT03172104Not specifiedCOMPLETEDNeurobehavioural Development of Infants Born <30 Weeks Gestational Age Between Birth and Five Years of Age
NCT03222375Not specifiedRECRUITINGSQUED™ Series 28.1 Home-use and Treatment of Autowave Reverberator of Autism
NCT03229928Not specifiedCOMPLETEDClinical Testing of a Real-Time Behavior Measurement Tool: Measuring Outcomes for CHAnge
NCT03232489Not specifiedUNKNOWNStudy for the Evaluation of the Feasibility of Applying Advanced MRI Scanning in Pediatric Clinical Practice
  • Disease cohort memberships (association, not causation — diseases whose associated-gene cohort lists this gene; a subset are also under Associated diseases): lissencephaly spectrum disorders