MZT2B
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Also known as FLJ14346MOZART2B
Summary
MZT2B (mitotic spindle organizing protein 2B, HGNC:25886) is a protein-coding gene on chromosome 2q21.1, encoding Mitotic-spindle organizing protein 2B (Q6NZ67). Required for the recruitment and the assembly of the gamma-tubulin ring complex (gTuRC) at the centrosome.
Located in cytosol; microtubule cytoskeleton; and nucleoplasm. Part of gamma-tubulin ring complex.
Source: NCBI Gene 80097 — RefSeq curated summary.
At a glance
- Clinical variants (ClinVar): 81 total — 1 pathogenic, 1 likely-pathogenic
- Phenotypes (HPO): 1
- MANE Select transcript:
NM_025029
Identifiers
Gene identifiers
| Field | Value |
|---|---|
| HGNC ID | HGNC:25886 |
| Approved symbol | MZT2B |
| Name | mitotic spindle organizing protein 2B |
| Location | 2q21.1 |
| Locus type | gene with protein product |
| Status | Approved |
| Aliases | FLJ14346, MOZART2B |
| Ensembl gene | ENSG00000152082 |
| Ensembl biotype | protein_coding |
| OMIM | 613450 |
| Entrez | 80097 |
Gene structure
Transcript identifiers
Ensembl transcripts: 12 — 9 protein_coding, 2 retained_intron, 1 protein_coding_CDS_not_defined
ENST00000281871, ENST00000409255, ENST00000425361, ENST00000455239, ENST00000457492, ENST00000480182, ENST00000485869, ENST00000491178, ENST00000651060, ENST00000916358, ENST00000916359, ENST00000948926
RefSeq mRNA: 3 — MANE Select: NM_025029
NM_001330282, NM_001330284, NM_025029
CCDS: CCDS2157, CCDS82511
Canonical transcript exons
ENST00000281871 — 3 exons
| Exon | Start | End |
|---|---|---|
| ENSE00001587901 | 130182262 | 130182452 |
| ENSE00002522165 | 130182627 | 130182775 |
| ENSE00003556139 | 130190469 | 130190727 |
Expression profiles
Bgee: expression breadth ubiquitous, 285 present calls, max score 99.38.
FANTOM5 (CAGE): breadth ubiquitous, TPM avg 95.4046 / max 531.0295, expressed in 1827 samples.
FANTOM5 promoters (3 alternative TSS)
| Promoter ID | TPM avg | Samples expressed |
|---|---|---|
| 22497 | 93.9484 | 1827 |
| 22496 | 1.2633 | 749 |
| 22495 | 0.1929 | 63 |
Top tissues by expression
288 total, by Bgee expression score (0-100, higher = more expressed):
| Tissue | Anatomy ID | Expression score | Quality |
|---|---|---|---|
| apex of heart | UBERON:0002098 | 99.38 | gold quality |
| anterior cingulate cortex | UBERON:0009835 | 99.31 | gold quality |
| cingulate cortex | UBERON:0003027 | 99.30 | gold quality |
| amygdala | UBERON:0001876 | 99.27 | gold quality |
| endocervix | UBERON:0000458 | 99.20 | gold quality |
| right testis | UBERON:0004534 | 99.20 | gold quality |
| right frontal lobe | UBERON:0002810 | 99.16 | gold quality |
| left testis | UBERON:0004533 | 99.16 | gold quality |
| left ovary | UBERON:0002119 | 99.14 | gold quality |
| body of pancreas | UBERON:0001150 | 99.11 | gold quality |
| right ovary | UBERON:0002118 | 99.06 | gold quality |
| left lobe of thyroid gland | UBERON:0001120 | 99.05 | gold quality |
| Brodmann (1909) area 9 | UBERON:0013540 | 99.03 | gold quality |
| prefrontal cortex | UBERON:0000451 | 99.02 | gold quality |
| left uterine tube | UBERON:0001303 | 99.02 | gold quality |
| nucleus accumbens | UBERON:0001882 | 99.02 | gold quality |
| esophagogastric junction muscularis propria | UBERON:0035841 | 99.01 | gold quality |
| muscle layer of sigmoid colon | UBERON:0035805 | 98.99 | gold quality |
| right lobe of thyroid gland | UBERON:0001119 | 98.98 | gold quality |
| mucosa of stomach | UBERON:0001199 | 98.97 | gold quality |
| heart left ventricle | UBERON:0002084 | 98.97 | gold quality |
| lower esophagus | UBERON:0013473 | 98.97 | gold quality |
| lower esophagus muscularis layer | UBERON:0035833 | 98.97 | gold quality |
| lower esophagus mucosa | UBERON:0035834 | 98.97 | gold quality |
| body of stomach | UBERON:0001161 | 98.96 | gold quality |
| mucosa of transverse colon | UBERON:0004991 | 98.94 | gold quality |
| cardiac ventricle | UBERON:0002082 | 98.93 | gold quality |
| right atrium auricular region | UBERON:0006631 | 98.92 | gold quality |
| body of uterus | UBERON:0009853 | 98.92 | gold quality |
| left adrenal gland cortex | UBERON:0035825 | 98.91 | gold quality |
Single-cell (SCXA)
Detected in 9 experiment(s), a significant marker in 6.
| Experiment | Marker? | Max mean expression |
|---|---|---|
| E-MTAB-5061 | yes | 344.54 |
| E-CURD-46 | yes | 19.67 |
| E-ANND-3 | yes | 16.15 |
| E-MTAB-10553 | yes | 7.32 |
| E-CURD-88 | yes | 5.35 |
| E-CURD-122 | yes | 4.69 |
| E-MTAB-7008 | no | 115.28 |
| E-GEOD-124858 | no | 52.66 |
| E-GEOD-125970 | no | 15.79 |
Regulation
Is transcription factor: no
miRNA regulators (miRDB)
4 targeting MZT2B, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):
| miRNA | Max score | Avg score | miRNA target_count |
|---|---|---|---|
| HSA-MIR-4731-5P | 99.89 | 67.23 | 2537 |
| HSA-MIR-12135 | 98.99 | 70.26 | 1814 |
| HSA-MIR-6810-5P | 98.29 | 66.21 | 975 |
| HSA-MIR-4330 | 95.44 | 66.39 | 993 |
Literature-anchored findings (GeneRIF, showing 1)
- MZT Proteins Form Multi-Faceted Structural Modules in the gamma-Tubulin Ring Complex. (PMID:32610146)
Cross-species orthologs
3 orthologs
| Organism | Symbol | Gene ID |
|---|---|---|
| danio_rerio | mzt2b | ENSDARG00000057928 |
| mus_musculus | Mzt2 | ENSMUSG00000022671 |
| rattus_norvegicus | Mzt2b | ENSRNOG00000066842 |
Paralogs (1): MZT2A (ENSG00000173272)
Protein
Protein identifiers
Mitotic-spindle organizing protein 2B — Q6NZ67 (reviewed: Q6NZ67)
Alternative names: Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2B
All UniProt accessions (6): Q6NZ67, A0A494C0V9, B8ZZ87, H7BZ50, H7C173, H7C293
UniProt curated annotations — full annotation on UniProt →
Function. Required for the recruitment and the assembly of the gamma-tubulin ring complex (gTuRC) at the centrosome. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.
Subunit / interactions. Associates with the gamma-tubulin ring complex (gTuRC) consisting of TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6 and gamma-tubulin TUBG1 or TUBG2; within the complex, interacts with TUBGCP2; the interaction plays a role in gTuRC activation. Interacts with TUBG1.
Subcellular location. Cytoplasm. Cytoskeleton. Microtubule organizing center. Centrosome. Spindle.
Similarity. Belongs to the MOZART2 family.
RefSeq proteins (3): NP_001317211, NP_001317213, NP_079305* (*=MANE)
Domains & families (InterPro)
| ID | Name | Type |
|---|---|---|
| IPR024332 | MOZART2 | Family |
Pfam: PF12926
UniProt features (8 total): compositionally biased region 2, modified residue 2, sequence variant 2, chain 1, region of interest 1
Structure
Experimental structures (PDB)
1 structures.
| PDB | Method | Resolution (Å) |
|---|---|---|
| 9QVM | ELECTRON MICROSCOPY | 6.8 |
Predicted structure (AlphaFold)
| Model | pLDDT | Fraction very-high |
|---|---|---|
| AF-Q6NZ67-F1 | 64.86 | 0.22 |
Functional residue map
Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.
Post-translational modifications (2): 34, 152
Function
Pathways and Gene Ontology
Reactome pathways
9 pathways
| ID | Pathway |
|---|---|
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes |
| R-HSA-1640170 | Cell Cycle |
| R-HSA-380287 | Centrosome maturation |
| R-HSA-453274 | Mitotic G2-G2/M phases |
| R-HSA-68877 | Mitotic Prometaphase |
| R-HSA-68886 | M Phase |
| R-HSA-69275 | G2/M Transition |
| R-HSA-69278 | Cell Cycle, Mitotic |
MSigDB gene sets: 136 (showing top):
STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN, GOBP_MICROTUBULE_NUCLEATION, GOCC_MICROTUBULE_ORGANIZING_CENTER, GOCC_CENTROSOME, CREB_Q3, GOBP_MICROTUBULE_POLYMERIZATION, GOCC_SPINDLE, GOCC_GAMMA_TUBULIN_COMPLEX, KIM_WT1_TARGETS_DN, CHEN_METABOLIC_SYNDROM_NETWORK, TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C, GOBP_MICROTUBULE_CYTOSKELETON_ORGANIZATION, KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3, GOBP_PROTEIN_POLYMERIZATION, GOBP_SUPRAMOLECULAR_FIBER_ORGANIZATION
GO Biological Process (0):
GO Molecular Function (1): protein binding (GO:0005515)
GO Cellular Component (7): gamma-tubulin ring complex (GO:0000931), nucleoplasm (GO:0005654), centrosome (GO:0005813), spindle (GO:0005819), cytosol (GO:0005829), cytoplasm (GO:0005737), cytoskeleton (GO:0005856)
Reactome top-level categories
Rollup of top-7 pathways:
| Category | Pathways |
|---|---|
| Cell Cycle, Mitotic | 2 |
| Centrosome maturation | 1 |
| Mitotic Prometaphase | 1 |
| G2/M Transition | 1 |
| M Phase | 1 |
| Mitotic G2-G2/M phases | 1 |
| Cell Cycle | 1 |
GO top-level categories
Rollup of top GO terms by namespace:
| Category | Terms |
|---|---|
| cellular anatomical structure | 3 |
| intracellular membraneless organelle | 2 |
| binding | 1 |
| gamma-tubulin complex | 1 |
| gamma-tubulin small complex | 1 |
| nuclear lumen | 1 |
| centriole | 1 |
| microtubule organizing center | 1 |
| microtubule cytoskeleton | 1 |
| cytoplasm | 1 |
| intracellular anatomical structure | 1 |
Protein interactions and networks
STRING
0 interactions, top by confidence (×1000):
IntAct
104 interactions, top by confidence:
| A | B | Type | Score |
|---|---|---|---|
| CSNK1A1 | FAM83G | psi-mi:“MI:0914”(association) | 0.900 |
| ODAD1 | HGS | psi-mi:“MI:0914”(association) | 0.850 |
| TUBGCP5 | TUBG1 | psi-mi:“MI:0914”(association) | 0.840 |
| MZT2B | TUBG1 | psi-mi:“MI:0914”(association) | 0.770 |
| TUBG1 | MZT2B | psi-mi:“MI:0915”(physical association) | 0.770 |
| Mzt2 | TUBG1 | psi-mi:“MI:0914”(association) | 0.560 |
| APLNR | METTL15 | psi-mi:“MI:0914”(association) | 0.530 |
| NPY2R | RTL8C | psi-mi:“MI:0914”(association) | 0.530 |
| SPINT2 | UPK3BL1 | psi-mi:“MI:0914”(association) | 0.530 |
| TUBG2 | TXNDC9 | psi-mi:“MI:0914”(association) | 0.530 |
| SLCO1B1 | SYNGR2 | psi-mi:“MI:0914”(association) | 0.530 |
| MZT1 | PCNT | psi-mi:“MI:0914”(association) | 0.530 |
| TXNDC12 | TUBG1 | psi-mi:“MI:0914”(association) | 0.530 |
| CXCR4 | TMEM120B | psi-mi:“MI:0914”(association) | 0.530 |
| FBXW11 | AHCYL1 | psi-mi:“MI:0914”(association) | 0.530 |
| TUBG2 | TCP1 | psi-mi:“MI:0914”(association) | 0.530 |
| NEDD1 | CEP290 | psi-mi:“MI:0914”(association) | 0.480 |
| Tubgcp3 | psi-mi:“MI:0915”(physical association) | 0.400 | |
| Mzt2 | psi-mi:“MI:0915”(physical association) | 0.400 | |
| Tubgcp2 | TUBG1 | psi-mi:“MI:0915”(physical association) | 0.400 |
| Tubg1 | psi-mi:“MI:0915”(physical association) | 0.400 |
BioGRID (137): MZT2B (Affinity Capture-MS), TUBGCP2 (Affinity Capture-MS), TUBG1 (Affinity Capture-MS), TUBGCP5 (Affinity Capture-MS), TUBGCP3 (Affinity Capture-MS), TUBGCP6 (Affinity Capture-MS), TUBGCP4 (Affinity Capture-MS), NME7 (Affinity Capture-MS), MZT2B (Affinity Capture-MS), MZT2B (Co-fractionation), MZT2B (Biochemical Activity), MZT2B (Affinity Capture-MS), MZT2B (Affinity Capture-MS), MZT2B (Affinity Capture-MS), MZT2B (Affinity Capture-MS)
ESM2 similar proteins: A4D2P6, A5PJV8, A6NFD8, D4AE48, O00268, O00287, O35274, O35779, O43566, P04198, P12755, P55199, Q08DA0, Q0D2I5, Q2KJ58, Q504T8, Q5XKK7, Q60698, Q61976, Q6NZ67, Q6P582, Q6R891, Q6T4P5, Q7Z6J2, Q80YR4, Q86UD0, Q86UK7, Q8BXL9, Q8CEG5, Q8R4T5, Q8TF61, Q8VCG9, Q969F2, Q969G9, Q96HZ4, Q96SB3, Q99PV5, Q9BQ61, Q9BUN5, Q9BZE9
Diamond homologs: A5PJV8, Q28DB1, Q6DC17, Q6NZ67, Q6P582, Q9CQ25
SIGNOR signaling
0 interactions.
Enriched among interaction partners
Reactome pathways and GO biological processes over-represented among this gene’s 129 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.
Reactome pathways:
| Pathway | Partners | Fold | FDR |
|---|---|---|---|
| Transport of vitamins, nucleosides, and related molecules | 6 | 20.9× | 8e-05 |
| Recruitment of mitotic centrosome proteins and complexes | 11 | 19.2× | 6e-09 |
| Recruitment of NuMA to mitotic centrosomes | 11 | 16.4× | 2e-08 |
| Centrosome maturation | 5 | 16.3× | 2e-03 |
| Regulation of PLK1 Activity at G2/M Transition | 6 | 9.8× | 4e-03 |
| G alpha (i) signalling events | 10 | 5.0× | 4e-03 |
GO biological processes:
| GO term | Partners | Fold | FDR |
|---|---|---|---|
| microtubule nucleation | 8 | 47.1× | 3e-09 |
| cytoplasmic microtubule organization | 7 | 22.7× | 8e-06 |
| adenylate cyclase-modulating G protein-coupled receptor signaling pathway | 5 | 15.9× | 2e-03 |
| mitotic cell cycle | 7 | 8.8× | 2e-03 |
| G protein-coupled receptor signaling pathway | 13 | 4.4× | 2e-03 |
Disease & clinical
Clinical variants and AI predictions
ClinVar
81 variants total. Per-class counts are floors (≥ shown; pagination cap):
| Classification | Count (floor) |
|---|---|
| Pathogenic | 1 |
| Likely pathogenic | 1 |
| Uncertain significance | 59 |
| Likely benign | 12 |
| Benign | 4 |
Top pathogenic / likely-pathogenic (2)
| Variant ID | HGVS | Classification |
|---|---|---|
| 4279388 | GRCh37/hg19 2q21.1(chr2:130904460-131041207)x1 | Pathogenic |
| 183299 | NM_207312.3(TUBA3E):c.643C>T (p.Arg215Cys) | Likely pathogenic |
SpliceAI
709 predictions. Top by Δscore:
| Variant | Effect | Δscore |
|---|---|---|
| 2:130182446:TGTTC:T | donor_gain | 1.0000 |
| 2:130182448:TTC:T | donor_gain | 1.0000 |
| 2:130182453:G:GG | donor_gain | 1.0000 |
| 2:130182447:GTTCA:G | donor_gain | 0.9900 |
| 2:130182452:AG:A | donor_loss | 0.9900 |
| 2:130182454:T:G | donor_loss | 0.9900 |
| 2:130182771:CCGAG:C | donor_loss | 0.9900 |
| 2:130182772:CGAG:C | donor_loss | 0.9900 |
| 2:130182773:GAGGT:G | donor_loss | 0.9900 |
| 2:130182774:AG:A | donor_loss | 0.9900 |
| 2:130182775:GG:G | donor_loss | 0.9900 |
| 2:130182776:G:A | donor_loss | 0.9900 |
| 2:130182777:T:G | donor_loss | 0.9900 |
| 2:130183667:G:T | donor_gain | 0.9900 |
| 2:130190463:CCTCA:C | acceptor_loss | 0.9900 |
| 2:130190464:CTCA:C | acceptor_loss | 0.9900 |
| 2:130190465:TCAGG:T | acceptor_loss | 0.9900 |
| 2:130190467:A:AC | acceptor_loss | 0.9900 |
| 2:130190467:A:AG | acceptor_gain | 0.9900 |
| 2:130190467:AG:A | acceptor_gain | 0.9900 |
| 2:130190468:G:GG | acceptor_gain | 0.9900 |
| 2:130190468:GG:G | acceptor_gain | 0.9900 |
| 2:130190468:GGGA:G | acceptor_gain | 0.9900 |
| 2:130182399:GCT:G | donor_gain | 0.9800 |
| 2:130182442:G:GT | donor_gain | 0.9800 |
| 2:130182455:GA:G | donor_loss | 0.9800 |
| 2:130182553:T:TA | donor_gain | 0.9800 |
| 2:130182625:AG:A | acceptor_gain | 0.9800 |
| 2:130182626:GG:G | acceptor_gain | 0.9800 |
| 2:130190466:CAGGG:C | acceptor_gain | 0.9800 |
AlphaMissense
998 scored. Top likely-pathogenic:
| Variant | Protein change | am_pathogenicity |
|---|---|---|
| 2:130182641:T:C | L62P | 0.999 |
| 2:130182671:T:A | V72D | 0.999 |
| 2:130182683:T:A | L76H | 0.999 |
| 2:130182410:T:C | L43P | 0.998 |
| 2:130182644:T:C | L63P | 0.998 |
| 2:130182683:T:C | L76P | 0.998 |
| 2:130182401:T:C | L40P | 0.997 |
| 2:130182449:T:C | F56S | 0.997 |
| 2:130182641:T:A | L62Q | 0.997 |
| 2:130182662:C:A | P69H | 0.997 |
| 2:130182668:C:A | A71D | 0.997 |
| 2:130182448:T:C | F56L | 0.996 |
| 2:130182450:C:A | F56L | 0.996 |
| 2:130182450:C:G | F56L | 0.996 |
| 2:130182629:T:C | I58T | 0.996 |
| 2:130182650:T:C | L65P | 0.996 |
| 2:130182653:A:T | N66I | 0.996 |
| 2:130182662:C:G | P69R | 0.996 |
| 2:130182662:C:T | P69L | 0.996 |
| 2:130182401:T:A | L40Q | 0.995 |
| 2:130182410:T:A | L43Q | 0.995 |
| 2:130182629:T:G | I58S | 0.995 |
| 2:130182632:T:C | L59P | 0.995 |
| 2:130182680:T:G | M75R | 0.995 |
| 2:130182683:T:G | L76R | 0.995 |
| 2:130182418:G:C | A46P | 0.994 |
| 2:130182627:G:C | K57N | 0.994 |
| 2:130182627:G:T | K57N | 0.994 |
| 2:130182661:C:A | P69T | 0.994 |
| 2:130182421:G:C | A47P | 0.993 |
dbSNP variants (sampled 300 via entrez): RS1000136066 (2:130180891 G>T), RS1000227143 (2:130193270 A>T), RS1000510490 (2:130194562 G>C), RS1000536099 (2:130182056 G>A,C), RS1000711336 (2:130186299 A>G), RS1001043467 (2:130181863 T>A,C), RS1001308731 (2:130186057 C>G), RS1001412457 (2:130185672 C>G,T), RS1001758608 (2:130181300 C>A,G,T), RS1001839542 (2:130190162 A>G), RS1002147837 (2:130182399 G>A), RS1002231239 (2:130203312 C>T), RS1003011961 (2:130196529 C>A,T), RS1003107553 (2:130190922 C>T), RS1003273172 (2:130187918 C>G)
Disease associations
OMIM: gene MIM:613450 | disease phenotypes: MIM:607432
GenCC curated gene-disease
Mondo (2): lissencephaly spectrum disorders (MONDO:0018838), neurodevelopmental disorder (MONDO:0700092)
Orphanet (1): Lissencephaly (Orphanet:48471)
HPO phenotypes
1 total (1 of 1 shown, HPO-id order):
| HPO | Term |
|---|---|
| HP:0001339 | Lissencephaly |
GWAS associations
0 associations (top):
MeSH disease descriptors (2)
| Descriptor | Name | Tree numbers |
|---|---|---|
| D054082 | Lissencephaly | C10.500.507.450.499; C16.131.666.507.450.499 |
| D065886 | Neurodevelopmental Disorders | F03.625 |
Drugs & pharmacology
Drug and pharmacology data
Is drug target: no
PharmGKB: 1 entry (VIP=true, CPIC=false)
CTD chemical–gene interactions
21 total (human), top 21 by PubMed support.
| Chemical | Actions (top 5) | PubMed papers |
|---|---|---|
| sodium arsenite | affects expression, affects binding, increases reaction, decreases expression | 3 |
| Valproic Acid | affects expression, decreases expression | 3 |
| FR900359 | increases phosphorylation | 1 |
| methylmercuric chloride | increases expression | 1 |
| bisphenol A | affects expression | 1 |
| glycidyl methacrylate | increases expression | 1 |
| lead acetate | increases expression, affects cotreatment | 1 |
| tris(2-butoxyethyl) phosphate | affects expression | 1 |
| zinc protoporphyrin | affects cotreatment, increases expression | 1 |
| butyraldehyde | decreases expression | 1 |
| (+)-JQ1 compound | decreases expression | 1 |
| Benzo(a)pyrene | affects expression | 1 |
| Cisplatin | decreases expression | 1 |
| Lead | increases expression | 1 |
| Lipopolysaccharides | affects expression, affects response to substance | 1 |
| Smoke | decreases expression | 1 |
| Tetrachlorodibenzodioxin | affects expression | 1 |
| Thiram | decreases expression | 1 |
| Tobacco Smoke Pollution | increases expression | 1 |
| Tretinoin | decreases expression | 1 |
| Cyclosporine | decreases expression | 1 |
Cellosaurus cell lines
1 cell lines: 1 transformed cell line
First 10 cell lines (id-ordered, not curated):
| Cellosaurus | Name | Category | Sex |
|---|---|---|---|
| CVCL_B3BQ | Abcam HEK293T MZT2B KO | Transformed cell line | Female |
Clinical trials (associated diseases)
202 trials via MONDO — disease-level, not drug-specific.
| Trial | Phase | Status | Title |
|---|---|---|---|
| NCT04586348 | PHASE4 | UNKNOWN | Prenatal Iodine Supplementation and Early Childhood Neurodevelopment |
| NCT04873115 | PHASE4 | UNKNOWN | Double-blind, Placebo-controlled, Randomized Clinical Trial Comparing the Efficacy and Safety of Sialanar Plus orAl rehabiLitation Against Placebo Plus Oral Rehabilitation for chIldren and Adolescents With seVere Sialorrhoea and Neurodisabilties, |
| NCT02559102 | PHASE3 | COMPLETED | Dexmedetomidine Sedation Versus General Anaesthesia for Inguinal Hernia Surgery in Infants |
| NCT02757079 | PHASE3 | COMPLETED | Study of the Efficacy and Safety of NPC-15 for Sleep Disorders of Children With Neurodevelopmental Disorders |
| NCT06915480 | PHASE3 | RECRUITING | Reducing Missed Appointments |
| NCT07377032 | PHASE3 | RECRUITING | TAP-GRIN: Interventional Study on Patients With GRIN-related Neurodevelopmental Disorders |
| NCT02909959 | PHASE2 | COMPLETED | Sulforaphane for the Treatment of Young Men With Autism Spectrum Disorder |
| NCT06081348 | PHASE2 | RECRUITING | Sertraline vs. Placebo in the Treatment of Anxiety in Children and AdoLescents With NeurodevelopMental Disorders |
| NCT06352372 | PHASE2 | COMPLETED | Safety and Efficacy of tPBM for Epileptiform Activity in Autism |
| NCT00503191 | PHASE1 | COMPLETED | NeuroModulation Technique Treatment of Autism |
| NCT04475848 | PHASE1 | COMPLETED | A Study to Investigate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Food Effect of RO6953958 in Healthy Participants |
| NCT06300398 | PHASE1 | COMPLETED | IAMA-6 Oral Dose Study in Healthy Adults |
| NCT01783041 | PHASE2/PHASE3 | COMPLETED | Effect of Early L-Carnitine Supplementation on Neurodevelopmental Outcomes in Very Preterm Infants |
| NCT05767385 | PHASE2/PHASE3 | RECRUITING | Fetal Cerebrovascular Autoregulation in Congenital Heart Disease and Association With Neonatal Neurobehavior |
| NCT05675098 | EARLY_PHASE1 | NOT_YET_RECRUITING | Central Nervous System Stimulants and Physical Function in Children With Cerebral Palsy |
| NCT00783783 | Not specified | COMPLETED | CYP2D6 Pharmacogenetics in Risperidone-Treated Children |
| NCT01778504 | Not specified | RECRUITING | Studying Childhood-onset Behavioral, Psychiatric, and Developmental Disorders |
| NCT01850784 | Not specified | UNKNOWN | High Energy Formula Feeding in Infants With Congenital Heart Disease |
| NCT01922791 | Not specified | COMPLETED | Nutrition and Pregnancy Intervention Study |
| NCT01942525 | Not specified | UNKNOWN | Influence of Intrauterine Growth Restriction on Amplitude-integrated EEG in Preterm Infants |
| NCT02003170 | Not specified | COMPLETED | Etiology and Early Diagnosis of Neurodevelopmental Disorders |
| NCT02118649 | Not specified | ACTIVE_NOT_RECRUITING | Enhancing Behavior and Brain Response to Visual Targets Using a Computer Game |
| NCT02557191 | Not specified | TERMINATED | Biomarkers, Neurodevelopment and Preterm Infants |
| NCT02690675 | Not specified | COMPLETED | Iron Supplement Effect on Child Development |
| NCT02694003 | Not specified | COMPLETED | Better Nights, Better Days for Children With Neurodevelopment Disorders |
| NCT02792894 | Not specified | COMPLETED | Family Networks (FaNs) for Children With Developmental Disorders and Delays |
| NCT02871674 | Not specified | UNKNOWN | Good Night Project: Behavioural Sleep Interventions for Children With ADHD: A Randomised Controlled Trial |
| NCT02887157 | Not specified | COMPLETED | Analyzing Retinal Microanatomy in ROP |
| NCT02898298 | Not specified | COMPLETED | Positive Emotion Regulation Training in Children, Adolescents and Young Adults With and Without Developmental Disorder |
| NCT02912780 | Not specified | UNKNOWN | Introduction of Microsystems in a Level 3 Neonatal Intensive Care Unit |
| NCT03023293 | Not specified | COMPLETED | n-3 PUFAs, Irisin and Maternal Glucose Metabolism From Pregnancy to Postpartum |
| NCT03023644 | Not specified | COMPLETED | Improving Neurodevelopmental Outcomes in Children With Congenital Heart Disease: An Intervention Study |
| NCT03032991 | Not specified | UNKNOWN | Early Biomarkers of Neurodevelopment in Offspring of Diabetic Mothers |
| NCT03088189 | Not specified | TERMINATED | Effect of Parental Peri-conceptional Vitamin B12 Supplementation on Infant Neurocognitive Development in Offspring |
| NCT03096028 | Not specified | COMPLETED | Developmental Origins of Mental Health Disorders |
| NCT03148782 | Not specified | COMPLETED | Brain Plasticity Underlying Acquisition of New Organizational Skills in Children-R61 Phase |
| NCT03172104 | Not specified | COMPLETED | Neurobehavioural Development of Infants Born <30 Weeks Gestational Age Between Birth and Five Years of Age |
| NCT03222375 | Not specified | RECRUITING | SQUED™ Series 28.1 Home-use and Treatment of Autowave Reverberator of Autism |
| NCT03229928 | Not specified | COMPLETED | Clinical Testing of a Real-Time Behavior Measurement Tool: Measuring Outcomes for CHAnge |
| NCT03232489 | Not specified | UNKNOWN | Study for the Evaluation of the Feasibility of Applying Advanced MRI Scanning in Pediatric Clinical Practice |
Related Atlas pages
- Disease cohort memberships (association, not causation — diseases whose associated-gene cohort lists this gene; a subset are also under Associated diseases): lissencephaly spectrum disorders