N4BP2

Summary

N4BP2 (NEDD4 binding protein 2, HGNC:29851) is a protein-coding gene on chromosome 4p14, encoding NEDD4-binding protein 2 (Q86UW6). Has 5’-polynucleotide kinase and nicking endonuclease activity.

This gene encodes a protein containing a polynucleotide kinase domain (PNK) near the N-terminal region, and a Small MutS Related (Smr) domain near the C-terminal region. The encoded protein can bind to both B-cell leukemia/lymphoma 3 (BCL-3) and neural precursor cell expressed, developmentally downregulated 4, (Nedd4) proteins. This protein binds and hydrolyzes ATP, may function as a 5’-polynucleotide kinase, and has the capacity to be a ubiquitylation substrate. This protein may play a role in transcription-coupled DNA repair or genetic recombination. Alternative splicing results in multiple transcript variants encoding different isoforms.

Source: NCBI Gene 55728 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 246 total
• Cancer driver (intOGen): loss-of-function (tumor-suppressor-like) across 3 cancer types
• MANE Select transcript: NM_018177

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:29851
Approved symbol	N4BP2
Name	NEDD4 binding protein 2
Location	4p14
Locus type	gene with protein product
Status	Approved
Aliases	B3BP
Ensembl gene	ENSG00000078177
Ensembl biotype	protein_coding
OMIM	619139
Entrez	55728

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 7 protein_coding, 2 nonsense_mediated_decay

ENST00000261435, ENST00000511480, ENST00000513269, ENST00000515550, ENST00000706658, ENST00000913248, ENST00000913249, ENST00000913250, ENST00000913251

RefSeq mRNA: 2 — MANE Select: NM_018177 NM_001318359, NM_018177

CCDS: CCDS3457

Canonical transcript exons

ENST00000261435 — 18 exons

Exon	Start	End
ENSE00001077370	40097227	40097569
ENSE00001489911	40073455	40073551
ENSE00003996490	40106900	40107024
ENSE00003996493	40102075	40103218
ENSE00003996494	40126134	40126330
ENSE00003996495	40131801	40131919
ENSE00003996496	40113432	40113508
ENSE00003996497	40154192	40158252
ENSE00003996499	40152780	40152903
ENSE00003996500	40112084	40112172
ENSE00003996501	40144632	40144800
ENSE00003996502	40119932	40122309
ENSE00003996503	40124160	40124205
ENSE00003996504	40136944	40137082
ENSE00003996505	40117869	40118024
ENSE00003996506	40142673	40142861
ENSE00003996507	40123127	40123212
ENSE00003996508	40056850	40057030

Expression profiles

Bgee: expression breadth ubiquitous, 227 present calls, max score 94.76.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 10.9728 / max 274.0797, expressed in 1658 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
47395	10.9728	1658

Top tissues by expression

248 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
tibia	UBERON:0000979	94.76	gold quality
epithelial cell of pancreas	CL:0000083	93.17	gold quality
amniotic fluid	UBERON:0000173	85.75	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	85.24	gold quality
secondary oocyte	CL:0000655	85.04	gold quality
corpus epididymis	UBERON:0004359	84.69	gold quality
thymus	UBERON:0002370	84.00	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.84	gold quality
placenta	UBERON:0001987	83.63	gold quality
calcaneal tendon	UBERON:0003701	83.20	gold quality
parietal pleura	UBERON:0002400	82.66	gold quality
bone marrow cell	CL:0002092	82.44	gold quality
visceral pleura	UBERON:0002401	82.24	gold quality
oocyte	CL:0000023	81.87	gold quality
oral cavity	UBERON:0000167	81.40	gold quality
oviduct epithelium	UBERON:0004804	81.08	gold quality
ventricular zone	UBERON:0003053	80.63	gold quality
palpebral conjunctiva	UBERON:0001812	80.62	gold quality
mucosa of paranasal sinus	UBERON:0005030	80.55	gold quality
adrenal tissue	UBERON:0018303	80.49	gold quality
caput epididymis	UBERON:0004358	80.47	gold quality
ganglionic eminence	UBERON:0004023	80.29	gold quality
bone marrow	UBERON:0002371	79.75	gold quality
germinal epithelium of ovary	UBERON:0001304	79.64	gold quality
pigmented layer of retina	UBERON:0001782	79.54	gold quality
retina	UBERON:0000966	79.52	gold quality
bronchial epithelial cell	CL:0002328	79.21	gold quality
superficial temporal artery	UBERON:0001614	79.17	gold quality
tonsil	UBERON:0002372	79.15	gold quality
esophagus squamous epithelium	UBERON:0006920	78.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.36

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

216 targeting N4BP2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-MIR-98-3P	100.00	74.08	3907
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-3120-5P	100.00	65.56	965
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-200B-3P	100.00	73.31	2693
HSA-MIR-200C-3P	100.00	73.35	2685
HSA-MIR-429	100.00	73.44	2698
HSA-MIR-518D-5P	100.00	67.51	979
HSA-MIR-518E-5P	100.00	67.66	954
HSA-MIR-518F-5P	100.00	67.51	979
HSA-MIR-519A-5P	100.00	67.66	954
HSA-MIR-519B-5P	100.00	67.66	954
HSA-MIR-519C-5P	100.00	67.66	954
HSA-MIR-520C-5P	100.00	67.51	979
HSA-MIR-522-5P	100.00	67.66	954
HSA-MIR-523-5P	100.00	67.66	954
HSA-MIR-526A-5P	100.00	67.51	979
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242

Literature-anchored findings (GeneRIF, showing 5)

• B3BP is a 5’-polynucleotide kinase (PMID:12730195)
• These data suggest that haplotype blocks ATTA and GTTG of N4BP2 is correlation with the risk of sporadic nasopharyngeal carcinoma in the Southern Chinese population. (PMID:17626640)
• The solution structure of the functionally active Smr domain of the Bcl3-binding protein (also known as Nedd4-binding protein 2), a protein with unknown function that lacks other domains present in MutS proteins, is determined. (PMID:18804481)
• the N-terminal extended region of the Smr domain in the native B3bp may function as a regulatory region for the nicking endonuclease (PMID:22072629)
• We found that a burden of low-frequency coding variants in N4BP2, CDSN, PRTG, and AHRR were associated with increased risk of Nonsyndromic cleft lip with or without cleft palate (NSCL/P) . Low-frequency variants in other genes were associated with decreased risk of NSCL/P. These results demonstrate that low-frequency variants contribute to the genetic etiology of NSCL/P (PMID:28425186)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	N4bp2	ENSMUSG00000037795
rattus_norvegicus	N4bp2	ENSRNOG00000027152

Paralogs (2): N4BP2L1 (ENSG00000139597), N4BP2L2 (ENSG00000244754)

Protein

Protein identifiers

NEDD4-binding protein 2 — Q86UW6 (reviewed: Q86UW6)

Alternative names: BCL-3-binding protein

All UniProt accessions (4): Q86UW6, D6R9J2, D6RC09, H0YA93

UniProt curated annotations — full annotation on UniProt →

Function. Has 5’-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination. May play a role in the non-stop mRNA decay pathway (NSD), which specifically targets and degrades mRNAs that lack a proper stop codon.

Subunit / interactions. Binds NEDD4. Binds BCL3 and CREBBP.

Subcellular location. Cytoplasm.

Post-translational modifications. Ubiquitinated; this targets the protein for degradation by the proteasome.

Domain organisation. The Smr domain has nicking endonuclease activity, but no significant double strand cleavage or exonuclease activity.

Isoforms (2)

UniProt ID	Names	Canonical?
Q86UW6-1	1	yes
Q86UW6-2	2

RefSeq proteins (2): NP_001305288, NP_060647* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR002625	Smr_dom	Domain
IPR003892	CUE	Domain
IPR009060	UBA-like_sf	Homologous_superfamily
IPR013899	DUF1771	Domain
IPR027417	P-loop_NTPase	Homologous_superfamily
IPR036063	Smr_dom_sf	Homologous_superfamily
IPR041801	N4BP2_CUE	Domain
IPR052772	Endo/PolyKinase_Domain-Protein	Family
IPR056718	DUF7816	Domain
IPR056719	DUF7817	Domain
IPR056720	DUF7818	Domain

Pfam: PF01713, PF08590, PF13671, PF25124, PF25125, PF25126

UniProt features (40 total): sequence conflict 7, region of interest 7, sequence variant 5, strand 5, helix 4, compositionally biased region 3, domain 2, coiled-coil region 2, modified residue 2, chain 1, binding site 1, splice variant 1

Structure

Experimental structures (PDB)

4 structures.

PDB	Method	Resolution (Å)
3FAU	X-RAY DIFFRACTION	1.9
3BHB	X-RAY DIFFRACTION	2.2
2D9I	SOLUTION NMR
2VKC	SOLUTION NMR

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q86UW6-F1	49.36	0.16

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (1): 447–454

Post-translational modifications (2): 906, 1210

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 193 (showing top): GSE18804_SPLEEN_MACROPHAGE_VS_BRAIN_TUMORAL_MACROPHAGE_DN, GOMF_ENDONUCLEASE_ACTIVITY, GOMF_NUCLEASE_ACTIVITY, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, KAUFFMANN_DNA_REPAIR_GENES, MODULE_239, ZHANG_BREAST_CANCER_PROGENITORS_UP, PITX2_Q2, GOMF_DNA_ENDONUCLEASE_ACTIVITY, SENESE_HDAC3_TARGETS_DN, NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_UP, LEE_RECENT_THYMIC_EMIGRANT, GOBP_DNA_METABOLIC_PROCESS, GOMF_UBIQUITIN_LIKE_PROTEIN_BINDING, NUYTTEN_NIPP1_TARGETS_DN

GO Biological Process (2): nuclear-transcribed mRNA catabolic process, non-stop decay (GO:0070481), DNA metabolic process (GO:0006259)

GO Molecular Function (8): endonuclease activity (GO:0004519), DNA endonuclease activity (GO:0004520), ATP binding (GO:0005524), hydrolase activity (GO:0016787), ubiquitin binding (GO:0043130), ATP-dependent polydeoxyribonucleotide 5’-hydroxyl-kinase activity (GO:0046404), nucleotide binding (GO:0000166), protein binding (GO:0005515)

GO Cellular Component (2): cytosol (GO:0005829), cytoplasm (GO:0005737)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
nuclear-transcribed mRNA catabolic process	1
nucleic acid metabolic process	1
nuclease activity	1
endonuclease activity	1
DNA nuclease activity	1
adenyl ribonucleotide binding	1
purine ribonucleoside triphosphate binding	1
catalytic activity	1
ubiquitin-like protein binding	1
ATP-dependent polynucleotide 5’-hydroxyl-kinase activity	1
nucleoside phosphate binding	1
heterocyclic compound binding	1
binding	1
cytoplasm	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

912 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
N4BP2	PLXNA4	Q9HCM2	591
N4BP2	BCL3	P20749	558
N4BP2	ZNF567	Q8N184	543
N4BP2	KLHL5	Q96PQ7	489
N4BP2	CHD9	Q3L8U1	466
N4BP2	TMEM156	Q8N614	453
N4BP2	RBM47	A0AV96	450
N4BP2	SPDYE16	A6NNV3	447
N4BP2	A0A0J9YYB4	A0A0J9YYB4	441
N4BP2	LIAS	O43766	439
N4BP2	PDE10A	Q9Y233	439
N4BP2	PDS5A	Q29RF7	437
N4BP2	ZWILCH	Q9H900	425
N4BP2	BCL2	P10415	416
N4BP2	ETFB	P38117	413

IntAct

43 interactions, top by confidence:

A	B	Type	Score
DYNLL1	BLTP3B	psi-mi:“MI:0914”(association)	0.730
DYNLL2	BLTP3B	psi-mi:“MI:0914”(association)	0.640
SF3B1	SAP18	psi-mi:“MI:0914”(association)	0.640
FAM136A	RBFOX3	psi-mi:“MI:0914”(association)	0.640
FAM98A	HERC2	psi-mi:“MI:0914”(association)	0.640
RACK1	RIOK3	psi-mi:“MI:0914”(association)	0.640
DISC1	AP4M1	psi-mi:“MI:0914”(association)	0.530
FAM136A	PIK3C2A	psi-mi:“MI:0914”(association)	0.530
N4BP2	PLEC	psi-mi:“MI:0915”(physical association)	0.400
CEP63	CIBAR1	psi-mi:“MI:0914”(association)	0.350
RTCB	MCRIP1	psi-mi:“MI:0914”(association)	0.350
SF3B3	ATXN7	psi-mi:“MI:0914”(association)	0.350
VPS35	KIF2A	psi-mi:“MI:0914”(association)	0.350
hspa1a_hspa1b_human-1	SHTN1	psi-mi:“MI:0914”(association)	0.350
DUSP16	MEIOC	psi-mi:“MI:0914”(association)	0.350
SNAPC4	PIK3C2A	psi-mi:“MI:0914”(association)	0.350
NAA11	DVL2	psi-mi:“MI:0914”(association)	0.350
CCT8L2	DVL2	psi-mi:“MI:0914”(association)	0.350
NPAS1	CIBAR1	psi-mi:“MI:0914”(association)	0.350
FAM98A	CASC3	psi-mi:“MI:0914”(association)	0.350
NPHP4	ARHGAP32	psi-mi:“MI:0914”(association)	0.350
RPGRIP1L	ILVBL	psi-mi:“MI:2364”(proximity)	0.270
HOOK2	SEC16A	psi-mi:“MI:2364”(proximity)	0.270
YWHAG	E2F8	psi-mi:“MI:2364”(proximity)	0.270
AGGF1	BLTP3B	psi-mi:“MI:2364”(proximity)	0.270

BioGRID (104): N4BP2 (Proximity Label-MS), N4BP2 (Affinity Capture-MS), N4BP2 (Affinity Capture-MS), CREBBP (Affinity Capture-Western), N4BP2 (Two-hybrid), N4BP2 (Affinity Capture-MS), N4BP2 (Affinity Capture-MS), N4BP2 (Affinity Capture-RNA), N4BP2 (Affinity Capture-Western), BCL3 (Reconstituted Complex), N4BP2 (Proximity Label-MS), N4BP2 (Proximity Label-MS), N4BP2 (Proximity Label-MS), N4BP2 (Proximity Label-MS), N4BP2 (Proximity Label-MS)

ESM2 similar proteins: A1L2H3, A2AKX3, A5D8S0, B0S6S9, D3Z987, E1BC15, O43303, O60673, O95405, P56715, Q03188, Q2M2Z5, Q3MHH3, Q3V089, Q569L8, Q5BQN8, Q5CZC0, Q5DTT3, Q5R9I1, Q5VWN6, Q61493, Q641I1, Q6NS59, Q6NSW3, Q6ZP01, Q6ZU52, Q7TSH4, Q7Z333, Q7Z3T8, Q80U44, Q80U59, Q86UW6, Q86WS4, Q86XD8, Q8IXS0, Q8MJ03, Q8MJ04, Q8MJ06, Q8N1H7, Q8N7Z5

Diamond homologs: O64843, Q6NQH9, Q86UW6, Q9LYE5, Q9UTP4, O74840, Q08954, Q29S05, Q3V2Q8, Q5TBK1, Q66H65, Q8JZS6, Q92802, P13233

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 58 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
mRNA Splicing	6	17.3×	2e-04
Anchoring of the basal body to the plasma membrane	5	14.9×	1e-03
Processing of Capped Intron-Containing Pre-mRNA	6	13.0×	4e-04
Mitotic Prometaphase	5	9.1×	8e-03
Metabolism of RNA	8	8.8×	3e-04
mRNA Splicing - Major Pathway	6	8.6×	3e-03

Disease & clinical

Cancer significance

From intOGen — cancer-driver classification: loss-of-function (tumor-suppressor-like) across 3 cancer types — CHOL, HCC, UTUC.

Clinical variants and AI predictions

ClinVar

246 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	210
Likely benign	22
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

4436 predictions. Top by Δscore:

Variant	Effect	Δscore
4:40057027:GCAG:G	donor_gain	1.0000
4:40057028:CAG:C	donor_loss	1.0000
4:40057029:AG:A	donor_loss	1.0000
4:40057030:GG:G	donor_loss	1.0000
4:40057031:G:GA	donor_loss	1.0000
4:40057032:T:G	donor_loss	1.0000
4:40073453:A:AG	acceptor_gain	1.0000
4:40073454:G:GG	acceptor_gain	1.0000
4:40073548:GACA:G	donor_gain	1.0000
4:40073552:G:GG	donor_gain	1.0000
4:40102062:T:A	acceptor_gain	1.0000
4:40102072:CA:C	acceptor_loss	1.0000
4:40102073:A:AG	acceptor_gain	1.0000
4:40102073:AGTT:A	acceptor_gain	1.0000
4:40102074:G:GA	acceptor_gain	1.0000
4:40102074:GTT:G	acceptor_gain	1.0000
4:40102074:GTTG:G	acceptor_gain	1.0000
4:40106894:TCACA:T	acceptor_loss	1.0000
4:40106895:CACA:C	acceptor_loss	1.0000
4:40106896:ACAG:A	acceptor_gain	1.0000
4:40106897:CA:C	acceptor_loss	1.0000
4:40106898:A:AG	acceptor_gain	1.0000
4:40106898:AG:A	acceptor_gain	1.0000
4:40106899:G:GA	acceptor_loss	1.0000
4:40106899:G:GG	acceptor_gain	1.0000
4:40106899:GG:G	acceptor_gain	1.0000
4:40107022:GTG:G	donor_gain	1.0000
4:40107025:G:GG	donor_gain	1.0000
4:40107025:GTA:G	donor_loss	1.0000
4:40107026:T:TC	donor_loss	1.0000

AlphaMissense

11831 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
4:40144735:T:C	L1693P	1.000
4:40103170:T:C	L442P	0.999
4:40103179:T:C	L445P	0.999
4:40103184:G:C	G447R	0.999
4:40103203:A:T	K453I	0.999
4:40106937:A:C	S471R	0.999
4:40106939:T:A	S471R	0.999
4:40106939:T:G	S471R	0.999
4:40106952:T:C	F476L	0.999
4:40106954:T:A	F476L	0.999
4:40106954:T:G	F476L	0.999
4:40107022:G:C	R499P	0.999
4:40112123:T:A	I513K	0.999
4:40112126:A:T	D514V	0.999
4:40112130:T:A	N515K	0.999
4:40112130:T:G	N515K	0.999
4:40112146:T:A	W521R	0.999
4:40112146:T:C	W521R	0.999
4:40112165:T:A	V527D	0.999
4:40113480:T:A	W546R	0.999
4:40113480:T:C	W546R	0.999
4:40113502:T:C	L553P	0.999
4:40117871:G:C	R556P	0.999
4:40122274:T:C	L1388P	0.999
4:40123195:T:A	W1423R	0.999
4:40123195:T:C	W1423R	0.999
4:40131859:T:C	L1529P	0.999
4:40142805:G:C	A1640P	0.999
4:40144735:T:A	L1693H	0.999
4:40144744:T:C	L1696P	0.999

dbSNP variants (sampled 300 via entrez): RS10000000 (4:40087276 A>G,T), RS1000008879 (4:40094660 A>C,G), RS1000018253 (4:40087304 G>A,C), RS1000065117 (4:40070934 C>A,T), RS1000067958 (4:40180603 A>G), RS1000074447 (4:40130000 T>C), RS1000112863 (4:40148214 C>T), RS10001172 (4:40156957 T>C), RS1000120019 (4:40181010 C>T), RS1000126162 (4:40143341 T>A), RS1000146222 (4:40133080 C>T), RS1000153325 (4:40160631 G>A), RS1000203254 (4:40094156 A>C), RS1000222404 (4:40181079 G>A), RS1000224156 (4:40058668 G>A)

Disease associations

OMIM: gene MIM:619139 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST001501_3	Platelet thrombus formation	1.000000e-06

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

47 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, decreases expression	4
Cyclosporine	increases expression	4
Benzo(a)pyrene	decreases expression, increases methylation	3
sodium arsenite	decreases expression, increases expression	2
Air Pollutants	decreases expression, increases abundance, increases expression	2
Aflatoxin B1	affects expression, decreases expression, decreases methylation	2
Cadmium Chloride	increases abundance, increases expression, decreases expression	2
Particulate Matter	increases expression, decreases expression, increases abundance	2
aristolochic acid I	decreases expression	1
FR900359	increases phosphorylation	1
myristicin	decreases expression	1
triphenyl phosphate	affects expression	1
trichostatin A	affects expression	1
aflatoxin B2	decreases methylation	1
cyanoginosin LR	increases expression	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	decreases expression	1
2-palmitoylglycerol	increases expression	1
monomethylarsonous acid	decreases expression	1
erucylphospho-N,N,N-trimethylpropylammonium	increases expression	1
ICG 001	increases expression	1
abrine	decreases expression	1
bisphenol S	affects cotreatment, decreases methylation	1
jinfukang	decreases expression	1
riccardin D	increases expression	1
NSC 689534	affects binding, increases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1
Resveratrol	affects cotreatment, increases expression	1
Sunitinib	increases expression	1
Fulvestrant	affects cotreatment, decreases methylation	1

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_E2D0	HAP1 N4BP2 (-) 1	Cancer cell line	Male
CVCL_E2D1	HAP1 N4BP2 (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.