NAB1

Summary

NAB1 (NGFI-A binding protein 1, HGNC:7626) is a protein-coding gene on chromosome 2q32.2, encoding NGFI-A-binding protein 1 (Q13506). Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2.

Predicted to enable transcription coregulator activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to act upstream of or within endochondral ossification; nervous system development; and regulation of epidermis development. Predicted to be located in nucleoplasm. Predicted to be active in nucleus.

Source: NCBI Gene 4664 — RefSeq curated summary.

At a glance

• GWAS associations: 21
• Clinical variants (ClinVar): 64 total
• MANE Select transcript: NM_005966

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:7626
Approved symbol	NAB1
Name	NGFI-A binding protein 1
Location	2q32.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000138386
Ensembl biotype	protein_coding
OMIM	600800
Entrez	4664

Gene structure

Transcript identifiers

Ensembl transcripts: 63 — 62 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000337386, ENST00000409581, ENST00000409641, ENST00000416973, ENST00000423076, ENST00000423376, ENST00000426601, ENST00000434473, ENST00000448811, ENST00000484774, ENST00000903108, ENST00000903109, ENST00000903110, ENST00000903111, ENST00000903112, ENST00000903113, ENST00000903114, ENST00000903115, ENST00000903116, ENST00000903117, ENST00000903118, ENST00000903119, ENST00000903120, ENST00000903121, ENST00000903122, ENST00000903123, ENST00000903124, ENST00000903125, ENST00000903126, ENST00000903127, ENST00000903128, ENST00000903129, ENST00000903130, ENST00000903131, ENST00000903132, ENST00000903133, ENST00000903134, ENST00000903135, ENST00000903136, ENST00000903137, ENST00000903138, ENST00000903139, ENST00000920767, ENST00000920768, ENST00000920769, ENST00000920770, ENST00000920771, ENST00000920772, ENST00000920773, ENST00000920774, ENST00000920775, ENST00000960766, ENST00000960767, ENST00000960768, ENST00000960769, ENST00000960770, ENST00000960771, ENST00000960772, ENST00000960773, ENST00000960774, ENST00000960775, ENST00000960776, ENST00000960777

RefSeq mRNA: 5 — MANE Select: NM_005966 NM_001321312, NM_001321313, NM_001321314, NM_001321315, NM_005966

CCDS: CCDS2307, CCDS82545

Canonical transcript exons

ENST00000337386 — 10 exons

Exon	Start	End
ENSE00000934468	190687201	190687317
ENSE00000934471	190673101	190673152
ENSE00000934472	190670326	190670459
ENSE00000934473	190659158	190659995
ENSE00001129482	190685476	190685638
ENSE00001300540	190655977	190656153
ENSE00001323207	190649846	190649982
ENSE00001827629	190690245	190692766
ENSE00001829865	190649083	190649360
ENSE00003505637	190683738	190683827

Expression profiles

Bgee: expression breadth ubiquitous, 290 present calls, max score 96.55.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 6.9239 / max 82.7082, expressed in 1705 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
24311	4.8562	1591
24310	1.1739	684
24312	0.5933	291
24313	0.3005	102

Top tissues by expression

295 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ganglionic eminence	UBERON:0004023	96.55	gold quality
skin of hip	UBERON:0001554	96.40	gold quality
upper leg skin	UBERON:0004262	96.20	gold quality
calcaneal tendon	UBERON:0003701	94.88	gold quality
endothelial cell	CL:0000115	94.64	gold quality
choroid plexus epithelium	UBERON:0003911	94.59	gold quality
cortical plate	UBERON:0005343	94.26	gold quality
ventricular zone	UBERON:0003053	93.54	gold quality
colonic epithelium	UBERON:0000397	93.35	gold quality
cranial nerve II	UBERON:0000941	93.22	gold quality
tendon of biceps brachii	UBERON:0008188	93.19	gold quality
tendon	UBERON:0000043	93.17	gold quality
gingiva	UBERON:0001828	93.16	gold quality
gingival epithelium	UBERON:0001949	93.12	gold quality
right coronary artery	UBERON:0001625	92.71	gold quality
mucosa of paranasal sinus	UBERON:0005030	92.57	gold quality
parietal pleura	UBERON:0002400	92.52	gold quality
cerebellar vermis	UBERON:0004720	92.50	gold quality
germinal epithelium of ovary	UBERON:0001304	92.47	gold quality
bronchial epithelial cell	CL:0002328	92.30	gold quality
skin of abdomen	UBERON:0001416	92.25	gold quality
oral cavity	UBERON:0000167	92.21	gold quality
hair follicle	UBERON:0002073	92.21	gold quality
pleura	UBERON:0000977	92.11	gold quality
embryo	UBERON:0000922	92.00	gold quality
descending thoracic aorta	UBERON:0002345	91.85	gold quality
zone of skin	UBERON:0000014	91.84	gold quality
popliteal artery	UBERON:0002250	91.76	gold quality
tibial artery	UBERON:0007610	91.76	gold quality
sural nerve	UBERON:0015488	91.71	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

1 targets.

Target	Regulation
MSLN	Unknown

Upstream regulators (CollecTRI, top): EGR2

miRNA regulators (miRDB)

185 targeting NAB1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-3064-3P	100.00	70.09	1254
HSA-MIR-200B-3P	100.00	73.31	2693
HSA-MIR-200C-3P	100.00	73.35	2685
HSA-MIR-429	100.00	73.44	2698
HSA-MIR-4476	100.00	68.18	2030
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-MIR-656-3P	100.00	72.15	2788
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-126-5P	100.00	72.71	3180
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-4534	99.99	66.58	1907
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-4482-3P	99.98	72.50	3147
HSA-MIR-3692-3P	99.98	70.27	2139
HSA-MIR-302C-5P	99.97	72.56	3642
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-3065-5P	99.97	71.56	3281
HSA-MIR-548AJ-3P	99.96	73.38	5345

Literature-anchored findings (GeneRIF, showing 5)

• mutations in the human NABI gene are most likely not involved in the pathogenesis of peripheral neuropathies. (PMID:12030330)
• Methylation pattern of the corresponding NGFI-A binding site in the human glucocorticoid receptor exon 1-F specific promoter in post mortem hippocampal tissue. (PMID:17853270)
• Data show that the suppressive effect of valproic acid on chondrocytes is not due to reduced expression or recruitment of Egr-1 to the mPGES-1 promoter and involves upregulation of NAB1. (PMID:21239760)
• These data suggest that type I IFN stimulation induces a rapid recruitment of a repressive Egr3/Nab1 complex that silences transcription from the ifngr1 promoter. (PMID:23935197)
• N6-Methyladenosine modified circ-NAB1 modulates cell cycle and epithelial-mesenchymal transition via CDKN3 in endometrial cancer. (PMID:38814199)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	nab1b	ENSDARG00000040700
danio_rerio	nab1a	ENSDARG00000042940
mus_musculus	Nab1	ENSMUSG00000002881
rattus_norvegicus	Nab1	ENSRNOG00000012959
drosophila_melanogaster	nab	FBGN0259986
caenorhabditis_elegans		WBGENE00003107

Paralogs (1): NAB2 (ENSG00000166886)

Protein

Protein identifiers

NGFI-A-binding protein 1 — Q13506 (reviewed: Q13506)

Alternative names: EGR-1-binding protein 1, Transcriptional regulatory protein p54

All UniProt accessions (8): Q13506, B8ZZS2, C9J3V0, C9JFF6, C9JID4, C9JJ42, C9JL92, H0Y4C5

UniProt curated annotations — full annotation on UniProt →

Function. Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2.

Subunit / interactions. Homomultimers may associate with EGR1 bound to DNA.

Subcellular location. Nucleus.

Tissue specificity. Isoform Short is found in myeloid leukemia cell line KG-1.

Domain organisation. The NAB conserved domain 1 (NCD1) interacts with EGR1 inhibitory domain and mediates multimerization. The NAB conserved domain 2 (NCD2) is necessary for transcriptional repression.

Similarity. Belongs to the NAB family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q13506-1	Long	yes
Q13506-2	Short

RefSeq proteins (5): NP_001308241, NP_001308242, NP_001308243, NP_001308244, NP_005957* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR006986	Nab1_C	Domain
IPR006988	Nab_N	Domain
IPR006989	NAB_co-repressor_dom	Domain
IPR038398	NCD2_sf	Homologous_superfamily
IPR039040	NAB_fam	Family

Pfam: PF04902, PF04904, PF04905

UniProt features (37 total): cross-link 14, helix 8, region of interest 5, modified residue 4, sequence conflict 2, chain 1, splice variant 1, strand 1, compositionally biased region 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
2YUF	SOLUTION NMR

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q13506-F1	64.90	0.32

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (18): 407, 126, 129, 143, 212, 333, 333, 355, 369, 373, 454, 465, 477, 480, 480, 172, 183, 328

Function

Pathways and Gene Ontology

Reactome pathways

9 pathways

ID	Pathway
R-HSA-9031628	NGF-stimulated transcription
R-HSA-9619665	EGR2 and SOX10-mediated initiation of Schwann cell myelination
R-HSA-1266738	Developmental Biology
R-HSA-162582	Signal Transduction
R-HSA-166520	Signaling by NTRKs
R-HSA-187037	Signaling by NTRK1 (TRKA)
R-HSA-198725	Nuclear Events (kinase and transcription factor activation)
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases
R-HSA-9675108	Nervous system development

MSigDB gene sets: 326 (showing top): GGGACCA_MIR133A_MIR133B, JI_RESPONSE_TO_FSH_UP, GCM_GSPT1, GOBP_SKELETAL_SYSTEM_DEVELOPMENT, GOBP_REGULATION_OF_EPIDERMIS_DEVELOPMENT, GOZGIT_ESR1_TARGETS_DN, GCM_ZNF198, GOBP_NEUROGENESIS, HEIDENBLAD_AMPLICON_8Q24_DN, GOBP_REPLACEMENT_OSSIFICATION, GOBP_ANIMAL_ORGAN_MORPHOGENESIS, GOBP_BONE_DEVELOPMENT, WANG_RESPONSE_TO_BEXAROTENE_DN, GOBP_ENSHEATHMENT_OF_NEURONS, SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_UP

GO Biological Process (6): endochondral ossification (GO:0001958), regulation of DNA-templated transcription (GO:0006355), Schwann cell differentiation (GO:0014037), myelination (GO:0042552), regulation of epidermis development (GO:0045682), negative regulation of DNA-templated transcription (GO:0045892)

GO Molecular Function (1): transcription coregulator activity (GO:0003712)

GO Cellular Component (2): nucleus (GO:0005634), nucleoplasm (GO:0005654)

Reactome top-level categories

Rollup of top-7 pathways:

Category	Pathways
Nuclear Events (kinase and transcription factor activation)	1
Nervous system development	1
Signaling by Receptor Tyrosine Kinases	1
Signaling by NTRKs	1
Signaling by NTRK1 (TRKA)	1
Signal Transduction	1
Developmental Biology	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
DNA-templated transcription	2
replacement ossification	1
endochondral bone morphogenesis	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
peripheral nervous system development	1
glial cell differentiation	1
axon ensheathment	1
epidermis development	1
regulation of developmental process	1
regulation of DNA-templated transcription	1
negative regulation of RNA biosynthetic process	1
transcription regulator activity	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
cellular anatomical structure	1

Protein interactions and networks

STRING

626 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
NAB1	EGR2	P11161	957
NAB1	EGR3	Q06889	950
NAB1	EGR1	P18146	941
NAB1	EGR4	Q05215	880
NAB1	STAT2	P52630	584
NAB1	STAT4	Q14765	569
NAB1	STAT6	P42226	518
NAB1	STAT1	P42224	478
NAB1	NGF	P01138	472
NAB1	ANKRD36	A6QL64	444
NAB1	FKBP14	Q9NWM8	425
NAB1	PPRC1	Q5VV67	424
NAB1	NEMP2	A6NFY4	413
NAB1	TCF3	P15883	408
NAB1	MFSD6	Q6ZSS7	399

IntAct

14 interactions, top by confidence:

A	B	Type	Score
NAB1	SDHA	psi-mi:“MI:0915”(physical association)	0.400
NAB1	POU2AF1	psi-mi:“MI:0915”(physical association)	0.370
Ppp2r1a	CCHCR1	psi-mi:“MI:0914”(association)	0.350
Racgap1	DDX3X	psi-mi:“MI:0914”(association)	0.350
Mkln1	NNT	psi-mi:“MI:0914”(association)	0.350
CPAP	CCP110	psi-mi:“MI:0914”(association)	0.350
NAB2	GLS	psi-mi:“MI:0914”(association)	0.350
AKTIP	PGGT1B	psi-mi:“MI:0914”(association)	0.350
EGR1	NAB1	psi-mi:“MI:0914”(association)	0.350
EEF1AKMT3	SMCHD1	psi-mi:“MI:0914”(association)	0.350
PRICKLE4	USO1	psi-mi:“MI:0914”(association)	0.350
MVK	NAB1	psi-mi:“MI:0914”(association)	0.350
NAB1	gptB	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (43): NAB1 (Affinity Capture-RNA), NAB1 (Affinity Capture-RNA), NAB1 (Affinity Capture-RNA), NAB1 (Affinity Capture-RNA), NAB1 (Affinity Capture-MS), NAB1 (Synthetic Growth Defect), NAB1 (Affinity Capture-MS), NAB1 (Affinity Capture-MS), NAB1 (Affinity Capture-MS), NAB1 (Affinity Capture-MS), NAB1 (Affinity Capture-MS), NAB1 (Affinity Capture-MS), NAB1 (Affinity Capture-MS), NAB1 (Affinity Capture-RNA), NAB1 (Affinity Capture-MS)

ESM2 similar proteins: A0FIN4, A2VD01, A9ZLX4, D2HNW6, D4A7U2, O88974, O94988, P10914, P14316, P15314, P16236, P17433, P17947, P23570, P23906, P49140, Q00IB7, Q13506, Q13905, Q15047, Q1LY51, Q3B7M3, Q3SZP0, Q3TTA7, Q3UWM4, Q4V7W5, Q5HYC2, Q5RJA1, Q5XJV7, Q61122, Q62722, Q6A098, Q6AI12, Q6BDS1, Q6DFR2, Q6GQL0, Q6PKU1, Q6ZMT4, Q6ZNC4, Q80TJ7

Diamond homologs: O35589, Q13506, Q15742, Q59E55, Q61122, Q61127, Q62722, Q22002

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

64 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	52
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1155 predictions. Top by Δscore:

Variant	Effect	Δscore
2:190670306:ACTCT:A	acceptor_gain	1.0000
2:190670310:T:TA	acceptor_gain	1.0000
2:190670315:T:TA	acceptor_gain	1.0000
2:190670316:G:A	acceptor_gain	1.0000
2:190670320:A:AG	acceptor_gain	1.0000
2:190670321:T:G	acceptor_gain	1.0000
2:190670321:TCCA:T	acceptor_loss	1.0000
2:190670323:CA:C	acceptor_loss	1.0000
2:190670324:A:AG	acceptor_gain	1.0000
2:190670324:AGCT:A	acceptor_loss	1.0000
2:190670325:G:GG	acceptor_gain	1.0000
2:190670325:GC:G	acceptor_gain	1.0000
2:190670325:GCT:G	acceptor_gain	1.0000
2:190670325:GCTC:G	acceptor_gain	1.0000
2:190670325:GCTCA:G	acceptor_gain	1.0000
2:190670455:ACCAA:A	donor_gain	1.0000
2:190670456:CCAA:C	donor_gain	1.0000
2:190670457:CAA:C	donor_gain	1.0000
2:190670458:AA:A	donor_gain	1.0000
2:190670459:AGTA:A	donor_loss	1.0000
2:190670460:G:GG	donor_gain	1.0000
2:190670460:GT:G	donor_loss	1.0000
2:190670464:G:GG	donor_gain	1.0000
2:190685467:A:AG	acceptor_gain	1.0000
2:190685470:TACTA:T	acceptor_loss	1.0000
2:190685471:ACTAG:A	acceptor_loss	1.0000
2:190685472:CTAGC:C	acceptor_loss	1.0000
2:190685473:TAGC:T	acceptor_loss	1.0000
2:190685473:TAGCA:T	acceptor_gain	1.0000
2:190685474:A:AG	acceptor_gain	1.0000

AlphaMissense

3194 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:190659204:G:A	G10R	1.000
2:190659204:G:C	G10R	1.000
2:190659217:T:A	L14Q	1.000
2:190659217:T:C	L14P	1.000
2:190659226:T:A	I17K	1.000
2:190659226:T:G	I17R	1.000
2:190659229:T:C	L18S	1.000
2:190659244:T:A	L23Q	1.000
2:190659244:T:C	L23P	1.000
2:190659265:T:C	F30S	1.000
2:190659276:G:A	G34S	1.000
2:190659276:G:C	G34R	1.000
2:190659276:G:T	G34C	1.000
2:190659277:G:A	G34D	1.000
2:190659277:G:T	G34V	1.000
2:190659279:G:C	G35R	1.000
2:190659279:G:T	G35C	1.000
2:190659280:G:A	G35D	1.000
2:190659280:G:T	G35V	1.000
2:190659282:G:C	D36H	1.000
2:190659282:G:T	D36Y	1.000
2:190659283:A:C	D36A	1.000
2:190659283:A:G	D36G	1.000
2:190659283:A:T	D36V	1.000
2:190659284:T:A	D36E	1.000
2:190659284:T:G	D36E	1.000
2:190659285:G:C	D37H	1.000
2:190659286:A:C	D37A	1.000
2:190659286:A:G	D37G	1.000
2:190659286:A:T	D37V	1.000

dbSNP variants (sampled 300 via entrez): RS1000001698 (2:190676069 T>A), RS1000037170 (2:190676458 G>A), RS1000067459 (2:190647508 CTT>C), RS1000088218 (2:190662474 A>T), RS1000093194 (2:190647805 C>T), RS1000095308 (2:190683513 G>A), RS1000360898 (2:190667222 A>G), RS1000485622 (2:190672528 C>T), RS1000633112 (2:190678007 G>A), RS1000687189 (2:190664232 G>A,T), RS1000724138 (2:190664841 C>G), RS1000745785 (2:190665954 C>G), RS1000789156 (2:190650076 A>G), RS1000973373 (2:190688435 T>C), RS1001032137 (2:190679940 G>A)

Disease associations

OMIM: gene MIM:600800 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

21 associations (top):

Study	Trait	p-value
GCST003129_7	Primary biliary cholangitis	2.000000e-14
GCST003518_14	Daytime sleep phenotypes	3.000000e-06
GCST003654_5	Bone mineral density (Ward’s triangle area)	7.000000e-07
GCST006052_5	Polymyositis	4.000000e-06
GCST006979_50	Heel bone mineral density	5.000000e-14
GCST007094_193	Diastolic blood pressure	2.000000e-06
GCST007095_1	Systolic blood pressure	9.000000e-06
GCST007095_94	Systolic blood pressure	3.000000e-07
GCST007096_38	Pulse pressure	1.000000e-10
GCST007097_55	Pulse pressure	3.000000e-06
GCST007097_56	Pulse pressure	1.000000e-06
GCST007099_203	Systolic blood pressure	5.000000e-13
GCST007267_293	Systolic blood pressure	3.000000e-09
GCST007278_7	Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies)	7.000000e-11
GCST009131_4	Systemic sclerosis	5.000000e-09
GCST009597_200	Multiple sclerosis	6.000000e-06
GCST009873_29	Autoimmune traits (pleiotropy)	2.000000e-08
GCST009877_13	Rheumatoid arthritis	1.000000e-08
GCST011096_35	Systemic lupus erythematosus	1.000000e-13
GCST011097_1	Systemic lupus erythematosus	7.000000e-09
GCST90011866_10	Systemic lupus erythematosus	3.000000e-06

EFO canonical traits (6, from GWAS)

EFO ID	Trait name
EFO:0007828	daytime rest measurement
EFO:0007785	femoral neck bone mineral density
EFO:0009270	heel bone mineral density
EFO:0006336	diastolic blood pressure
EFO:0006335	systolic blood pressure
EFO:0005763	pulse pressure measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

47 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	increases abundance, decreases expression, affects cotreatment	3
entinostat	decreases expression, affects cotreatment	2
Arsenic	affects cotreatment, decreases expression, increases abundance	2
Tamoxifen	affects expression, affects cotreatment, increases expression	2
Cadmium Chloride	decreases expression	2
aristolochic acid I	decreases expression	1
FR900359	affects phosphorylation	1
bisphenol F	affects cotreatment, increases expression	1
TAK-243	decreases sumoylation	1
dicrotophos	decreases expression	1
methylmercuric chloride	increases expression	1
cobaltous chloride	decreases expression	1
manganese chloride	affects cotreatment, decreases expression, increases abundance	1
coumarin	increases phosphorylation	1
beta-methylcholine	affects expression	1
CGP 52608	affects binding, increases reaction	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
abrine	increases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
Resveratrol	affects cotreatment, increases expression	1
Temozolomide	decreases expression	1
Sunitinib	increases expression	1
Zoledronic Acid	increases expression	1
Air Pollutants	increases abundance, decreases expression	1
Benzene	increases expression	1
Benzo(a)pyrene	decreases methylation	1
Caffeine	affects phosphorylation	1
Cisplatin	affects response to substance	1
Coumestrol	increases expression, affects cotreatment	1
Demecolcine	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.