NABP2

Summary

NABP2 (nucleic acid binding protein 2, HGNC:28412) is a protein-coding gene on chromosome 12q13.3, encoding SOSS complex subunit B1 (Q9BQ15). Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint.

Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2B, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).

Source: NCBI Gene 79035 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 23 total
• Druggable target: yes
• MANE Select transcript: NM_024068

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28412
Approved symbol	NABP2
Name	nucleic acid binding protein 2
Location	12q13.3
Locus type	gene with protein product
Status	Approved
Aliases	MGC2731, SSB1, hSSB1, SOSS-B1
Ensembl gene	ENSG00000139579
Ensembl biotype	protein_coding
OMIM	612104
Entrez	79035

Gene structure

Transcript identifiers

Ensembl transcripts: 15 — 14 protein_coding, 1 retained_intron

ENST00000267023, ENST00000341463, ENST00000380198, ENST00000399713, ENST00000447747, ENST00000479016, ENST00000882054, ENST00000882055, ENST00000934237, ENST00000934238, ENST00000934239, ENST00000934240, ENST00000934241, ENST00000934242, ENST00000959362

RefSeq mRNA: 1 — MANE Select: NM_024068 NM_024068

CCDS: CCDS8911

Canonical transcript exons

ENST00000267023 — 7 exons

Exon	Start	End
ENSE00000938855	56226179	56226260
ENSE00000938856	56226356	56226419
ENSE00001417709	56224342	56224441
ENSE00001481497	56229014	56229854
ENSE00001554507	56224834	56224935
ENSE00003586500	56225624	56225695
ENSE00003677734	56225373	56225511

Expression profiles

Bgee: expression breadth ubiquitous, 261 present calls, max score 92.57.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 37.6751 / max 186.0038, expressed in 1821 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
126090	35.0034	1815
126088	2.2460	1116
126089	0.4258	199

Top tissues by expression

280 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
prefrontal cortex	UBERON:0000451	92.57	gold quality
right frontal lobe	UBERON:0002810	92.52	gold quality
anterior cingulate cortex	UBERON:0009835	92.51	gold quality
cingulate cortex	UBERON:0003027	92.47	gold quality
right adrenal gland	UBERON:0001233	92.18	gold quality
ganglionic eminence	UBERON:0004023	91.97	gold quality
nucleus accumbens	UBERON:0001882	91.85	gold quality
left adrenal gland	UBERON:0001234	91.81	gold quality
gastrocnemius	UBERON:0001388	91.81	gold quality
mucosa of transverse colon	UBERON:0004991	91.71	gold quality
left adrenal gland cortex	UBERON:0035825	91.67	gold quality
right adrenal gland cortex	UBERON:0035827	91.53	gold quality
muscle of leg	UBERON:0001383	91.35	gold quality
caudate nucleus	UBERON:0001873	91.34	gold quality
putamen	UBERON:0001874	91.33	gold quality
adrenal cortex	UBERON:0001235	91.23	gold quality
islet of Langerhans	UBERON:0000006	91.05	gold quality
amygdala	UBERON:0001876	90.73	gold quality
hindlimb stylopod muscle	UBERON:0004252	90.54	gold quality
ventricular zone	UBERON:0003053	90.49	gold quality
adrenal gland	UBERON:0002369	90.21	gold quality
neocortex	UBERON:0001950	90.20	gold quality
frontal cortex	UBERON:0001870	90.17	gold quality
stromal cell of endometrium	CL:0002255	89.99	gold quality
Brodmann (1909) area 9	UBERON:0013540	89.97	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	89.95	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	89.93	gold quality
body of pancreas	UBERON:0001150	89.38	gold quality
cerebellar hemisphere	UBERON:0002245	89.35	gold quality
cerebellar cortex	UBERON:0002129	89.29	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ENAD-17	no	253.96
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

34 targeting NABP2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4476	100.00	68.18	2030
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-MIR-4510	100.00	66.60	2050
HSA-MIR-6127	100.00	66.76	2188
HSA-MIR-6129	100.00	66.46	2080
HSA-MIR-6130	100.00	66.69	2012
HSA-MIR-6133	100.00	66.48	2064
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-6764-5P	99.75	67.89	2304
HSA-MIR-4306	99.72	70.50	3630
HSA-MIR-4729	99.69	72.18	4233
HSA-MIR-7150	99.62	66.80	1322
HSA-MIR-1915-3P	99.58	66.79	1988
HSA-MIR-543	99.52	69.03	2595
HSA-MIR-185-5P	99.35	68.60	2497
HSA-MIR-504-3P	99.30	67.18	1745
HSA-MIR-5693	99.24	66.67	1106
HSA-MIR-7151-3P	99.04	69.72	2370
HSA-MIR-4744	99.01	69.91	1581
HSA-MIR-1207-3P	98.99	66.22	1532
HSA-MIR-181A-2-3P	98.91	67.60	1168
HSA-MIR-4764-5P	98.88	65.53	894
HSA-MIR-4742-3P	98.73	69.82	1803
HSA-MIR-583	98.71	67.44	1791
HSA-MIR-619-5P	98.57	64.97	1988
HSA-MIR-5089-5P	98.45	66.06	1388
HSA-MIR-4778-5P	97.96	68.06	1634
HSA-MIR-4769-3P	97.95	68.17	1002
HSA-MIR-6817-5P	97.95	67.86	1026
HSA-MIR-4638-3P	97.90	65.75	905

Literature-anchored findings (GeneRIF, showing 13)

• Cells deficient in hSSB1 exhibit increased radiosensitivity, defective checkpoint activation and enhanced genomic instability coupled with a diminished capacity for DNA repair. (PMID:18449195)
• hSSB1 and hSSB2 form two separate complexes with similar structures, and both complexes participate in DNA damage response. (PMID:19605351)
• INTS3 controls the SSB1-mediated DNA damage response. (PMID:19786574)
• SOSS complexes, containing SSB1, do not localize with Replication Protein A (RPA) to replication sites in human cells, yet have a strong effect on double-strand break resection and homologous recombination. (PMID:23178594)
• Identification of EEf1E1 and OBFC2B as novel BRCA1-partner genes in the DNA double-strand break repair pathway. (PMID:24104880)
• The findings demonstrate the importance of hSSB1 in maintaining and repairing DNA replication forks and for overall genomic stability. (PMID:24753408)
• In the absence of hSSB1, human 8-oxoguanine glycosylase 1 does not localize to chromatin, resulting in the accumulation of 8-oxoguanine in the genome. (PMID:26261212)
• findings demonstrate a novel hSSB1 regulatory mechanism for the repair of damaged DNA (PMID:27273218)
• the detailed molecular mechanism in solution of ssDNA binding by hSSB1, a major player in the maintenance of genomic stability, is reported. (PMID:27387285)
• Our data highlights that BLM helicase and hSSB1 function in a dynamic complex in cells and that this complex is likely required for BLM protein stability and function. (PMID:28506294)
• Genome-wide association study in the Taiwan Biobank identifies four novel genes for human height: NABP2, RASA2, RNF41 and SLC39A5. (PMID:34270706)
• Mechanisms of SSBP1 variants in mitochondrial disease: Molecular dynamics simulations reveal stable tetramers with altered DNA binding surfaces. (PMID:34464898)
• hSSB1 (NABP2/OBFC2B) modulates the DNA damage and androgen-induced transcriptional response in prostate cancer. (PMID:36811381)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	nabp2	ENSDARG00000090976
mus_musculus	Nabp2	ENSMUSG00000025374
rattus_norvegicus	Nabp2	ENSRNOG00000023480

Paralogs (1): NABP1 (ENSG00000173559)

Protein

Protein identifiers

SOSS complex subunit B1 — Q9BQ15 (reviewed: Q9BQ15)

Alternative names: Nucleic acid-binding protein 2, Oligonucleotide/oligosaccharide-binding fold-containing protein 2B, Sensor of single-strand DNA complex subunit B1, Sensor of ssDNA subunit B1, Single-stranded DNA-binding protein 1

All UniProt accessions (3): Q9BQ15, C9JMP5, C9JT95

UniProt curated annotations — full annotation on UniProt →

Function. Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.

Subunit / interactions. Component of the SOSS complex, composed of SOSS-B (SOSS-B1/NABP2 or SOSS-B2/NABP1), SOSS-A/INTS3 and SOSS-C/INIP. SOSS complexes containing SOSS-B1/NABP2 are more abundant than complexes containing SOSS-B2/NABP1. Directly interacts with ATM, SOSS-A/INTS3 and RAD51. Interacts with INTS7.

Subcellular location. Nucleus.

Post-translational modifications. Phosphorylated by ATM in response to DNA damage. Phosphorylation prevents degradation by the proteasome, hence stabilization of the protein and accumulation within cells. Ubiquitinated in a FBXL5-dependent manner, leading to proteasomal degradation.

Similarity. Belongs to the SOSS-B family. SOSS-B1 subfamily.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9BQ15-1	1	yes
Q9BQ15-2	2

RefSeq proteins (1): NP_076973* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR012340	NA-bd_OB-fold	Homologous_superfamily
IPR048970	OB_Ssb-like	Domain
IPR051231	SOSS-B	Family

Pfam: PF21473

UniProt features (18 total): strand 7, helix 2, compositionally biased region 2, mutagenesis site 2, chain 1, DNA-binding region 1, region of interest 1, modified residue 1, splice variant 1

Structure

Experimental structures (PDB)

6 structures.

PDB	Method	Resolution (Å)
4OWT	X-RAY DIFFRACTION	2
4OWW	X-RAY DIFFRACTION	2.3
4OWX	X-RAY DIFFRACTION	2.3
5D8F	X-RAY DIFFRACTION	2.35
5D8E	X-RAY DIFFRACTION	3
8RBZ	ELECTRON MICROSCOPY	3.7

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9BQ15-F1	77.84	0.53

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 117

Mutagenesis-validated functional residues (2):

Position	Phenotype
117	loss of phosphorylation by atm.
117	enhances atm-dependent signaling.

Function

Pathways and Gene Ontology

Reactome pathways

3 pathways

ID	Pathway
R-HSA-6807505	RNA polymerase II transcribes snRNA genes
R-HSA-73857	RNA Polymerase II Transcription
R-HSA-74160	Gene expression (Transcription)

MSigDB gene sets: 178 (showing top): E2F_Q4, GOBP_CHROMOSOME_ORGANIZATION, GOBP_RESPONSE_TO_IONIZING_RADIATION, E2F4DP1_01, GOBP_TELOMERE_CAPPING, GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_CHROMOSOME, GOBP_CELL_CYCLE_PHASE_TRANSITION, GOBP_TELOMERE_ORGANIZATION, TAL1ALPHAE47_01, GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ORGANELLE, LHX3_01, GOBP_POSITIVE_REGULATION_OF_ORGANELLE_ORGANIZATION, GOBP_MITOTIC_G2_M_TRANSITION_CHECKPOINT, GOBP_REGULATION_OF_CELL_CYCLE_G2_M_PHASE_TRANSITION, PAX8_B

GO Biological Process (7): double-strand break repair via homologous recombination (GO:0000724), DNA repair (GO:0006281), DNA damage response (GO:0006974), response to ionizing radiation (GO:0010212), mitotic G2/M transition checkpoint (GO:0044818), establishment of protein localization to telomere (GO:0070200), positive regulation of telomere capping (GO:1904355)

GO Molecular Function (5): DNA binding (GO:0003677), single-stranded DNA binding (GO:0003697), DNA polymerase binding (GO:0070182), G-rich strand telomeric DNA binding (GO:0098505), protein binding (GO:0005515)

GO Cellular Component (6): chromosome, telomeric region (GO:0000781), nucleus (GO:0005634), nucleoplasm (GO:0005654), cytosol (GO:0005829), site of double-strand break (GO:0035861), SOSS complex (GO:0070876)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
RNA Polymerase II Transcription	1
Gene expression (Transcription)	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
recombinational repair	1
double-strand break repair	1
DNA metabolic process	1
DNA damage response	1
cellular response to stress	1
response to radiation	1
mitotic cell cycle checkpoint signaling	1
negative regulation of G2/M transition of mitotic cell cycle	1
establishment of protein localization to chromosome	1
telomere capping	1
positive regulation of telomere maintenance	1
regulation of telomere capping	1
nucleic acid binding	1
DNA binding	1
enzyme binding	1
single-stranded telomeric DNA binding	1
binding	1
chromosomal region	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
cytoplasm	1
site of DNA damage	1
nuclear protein-containing complex	1

Protein interactions and networks

STRING

732 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
NABP2	INTS3	Q68E01	894
NABP2	INIP	Q9NRY2	867
NABP2	ATM	Q13315	697
NABP2	SSBP1	Q04837	505
NABP2	LRRC40	Q9H9A6	456
NABP2	SHISA4	Q96DD7	453
NABP2	MNMIP1	A4FU49	445
NABP2	SNAPC3	Q92966	438
NABP2	UBE2V2	Q15819	435
NABP2	LEPROTL1	O95214	426
NABP2	TERT	O14746	424
NABP2	INTS6	Q9UL03	419
NABP2	NAIF1	Q69YI7	419
NABP2	KLHL15	Q96M94	413
NABP2	ABRAXAS1	Q6UWZ7	411

IntAct

46 interactions, top by confidence:

A	B	Type	Score
PPP2R1A	STRN	psi-mi:“MI:0914”(association)	0.880
PPP2R1A	STRN	psi-mi:“MI:2364”(proximity)	0.880
NABP2	INTS3	psi-mi:“MI:0914”(association)	0.810
INTS3	NABP2	psi-mi:“MI:0915”(physical association)	0.810
INTS3	NABP2	psi-mi:“MI:0407”(direct interaction)	0.810
NABP2	INTS3	psi-mi:“MI:0915”(physical association)	0.810
BLM	RPA2	psi-mi:“MI:0914”(association)	0.640
INIP	INTS3	psi-mi:“MI:0914”(association)	0.630
INTS3	NABP1	psi-mi:“MI:0914”(association)	0.620
CDKN1A	NABP2	psi-mi:“MI:0915”(physical association)	0.620
CDKN1A	NABP2	psi-mi:“MI:0403”(colocalization)	0.620
NABP2	CDKN1A	psi-mi:“MI:0915”(physical association)	0.620
NABP2	CDKN1A	psi-mi:“MI:0407”(direct interaction)	0.620
ATM	NABP2	psi-mi:“MI:0915”(physical association)	0.600
NABP2	ATM	psi-mi:“MI:0915”(physical association)	0.600
ATM	NABP2	psi-mi:“MI:0217”(phosphorylation reaction)	0.600
BLM	NABP2	psi-mi:“MI:0915”(physical association)	0.540
NABP2	BLM	psi-mi:“MI:0914”(association)	0.540
NABP2	BLM	psi-mi:“MI:0403”(colocalization)	0.540
SUPT5H	POLR2D	psi-mi:“MI:0914”(association)	0.530
RAD51	NABP2	psi-mi:“MI:0915”(physical association)	0.460
NABP2	RAD51	psi-mi:“MI:0403”(colocalization)	0.460

BioGRID (111): SKP1 (Affinity Capture-Western), CUL1 (Affinity Capture-Western), NABP2 (Affinity Capture-Western), FBXL5 (Affinity Capture-Western), FBXL5 (Reconstituted Complex), NABP2 (Affinity Capture-MS), INIP (Co-fractionation), INTS3 (Co-fractionation), MTCH1 (Affinity Capture-MS), EDRF1 (Affinity Capture-MS), VPS41 (Affinity Capture-MS), VPS4A (Affinity Capture-MS), LUC7L3 (Affinity Capture-MS), GATAD2A (Affinity Capture-MS), CENPJ (Affinity Capture-MS)

ESM2 similar proteins: A5D7P8, A6QLK2, F1LQ48, O55047, O95628, P25916, P35226, P59326, P97855, Q08CW1, Q0VCY1, Q0VCZ3, Q12906, Q13148, Q13283, Q1ECX4, Q32KX7, Q32LC7, Q3SWT1, Q3ZBD9, Q4R5D9, Q5FVP2, Q5PRC7, Q5R601, Q5R8L2, Q5RB87, Q5SDR3, Q5U2U0, Q5ZLN5, Q64213, Q66K94, Q6DE02, Q6NRF9, Q86UE8, Q8BGW5, Q8BT14, Q8C0V0, Q8R2Y9, Q90ZY6, Q91YT7

Diamond homologs: A5D7P8, A6QLK2, Q3SWT1, Q54X41, Q5FVP2, Q5PRC7, Q66K94, Q6DE02, Q6NRF9, Q8BGW5, Q8R2Y9, Q96AH0, Q9BQ15, Q9VM17

SIGNOR signaling

5 interactions.

A	Effect	B	Mechanism
FBXL5	“down-regulates quantity by destabilization”	NABP2	binding
“Cullin 1-RBX1-Skp1”	“down-regulates quantity by destabilization”	NABP2	polyubiquitination
ATM	“up-regulates activity”	NABP2	phosphorylation

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 34 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
TP53 Regulates Transcription of DNA Repair Genes	5	34.9×	3e-05
Meiotic recombination	6	29.9×	5e-06
RNA polymerase II transcribes snRNA genes	5	29.7×	4e-05
G2/M DNA damage checkpoint	5	23.1×	8e-05
Processing of DNA double-strand break ends	5	22.0×	8e-05
Transcriptional Regulation by TP53	8	19.1×	9e-07
Estrogen-dependent gene expression	5	14.5×	3e-04
Diseases of signal transduction by growth factor receptors and second messengers	6	13.1×	1e-04

GO biological processes:

GO term	Partners	Fold	FDR
response to ionizing radiation	5	62.3×	2e-06
double-strand break repair via homologous recombination	8	37.8×	8e-09
DNA damage response	9	14.6×	1e-06
DNA repair	6	11.6×	6e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

23 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	14
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

736 predictions. Top by Δscore:

Variant	Effect	Δscore
12:56225361:T:TA	acceptor_gain	1.0000
12:56225366:C:CA	acceptor_gain	1.0000
12:56225369:TCA:T	acceptor_loss	1.0000
12:56225370:CA:C	acceptor_loss	1.0000
12:56225371:A:AG	acceptor_gain	1.0000
12:56225371:A:G	acceptor_loss	1.0000
12:56225371:AG:A	acceptor_gain	1.0000
12:56225371:AGGCC:A	acceptor_gain	1.0000
12:56225372:G:C	acceptor_loss	1.0000
12:56225372:G:GA	acceptor_gain	1.0000
12:56225372:GG:G	acceptor_gain	1.0000
12:56225372:GGC:G	acceptor_gain	1.0000
12:56225372:GGCC:G	acceptor_gain	1.0000
12:56225372:GGCCG:G	acceptor_gain	1.0000
12:56225507:AAAGG:A	donor_gain	1.0000
12:56225508:AAGG:A	donor_gain	1.0000
12:56225509:AGG:A	donor_gain	1.0000
12:56225509:AGGG:A	donor_loss	1.0000
12:56225510:GG:G	donor_gain	1.0000
12:56225510:GGG:G	donor_gain	1.0000
12:56225511:GG:G	donor_gain	1.0000
12:56225511:GGT:G	donor_loss	1.0000
12:56225512:G:GG	donor_gain	1.0000
12:56225619:CATA:C	acceptor_loss	1.0000
12:56225621:TA:T	acceptor_loss	1.0000
12:56225622:A:AG	acceptor_gain	1.0000
12:56225622:A:C	acceptor_loss	1.0000
12:56225623:G:GG	acceptor_gain	1.0000
12:56225691:GGAGA:G	donor_gain	1.0000
12:56225692:GAGA:G	donor_gain	1.0000

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000092052 (12:56227004 G>A), RS1000585678 (12:56221599 T>C), RS1001123944 (12:56221792 T>C), RS1001575802 (12:56224593 T>A,C,G), RS1001938558 (12:56228052 C>T), RS1002043517 (12:56221266 T>C), RS1002370987 (12:56227722 G>A,T), RS1002581621 (12:56226505 C>A), RS1003140091 (12:56224622 G>A,T), RS1003633951 (12:56225849 G>C), RS1004036966 (12:56227680 G>A), RS1004089163 (12:56227930 C>T), RS1004199387 (12:56221427 C>T), RS1005044246 (12:56228934 T>C), RS1005096750 (12:56229389 A>G)

Disease associations

OMIM: gene MIM:612104 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST010002_217	Refractive error	6.000000e-174

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL4742316 (PROTEIN-PROTEIN INTERACTION)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

26 total (human), top 26 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
(+)-JQ1 compound	decreases expression	4
sodium arsenite	decreases expression, increases abundance, increases expression	3
cobaltous chloride	decreases expression	2
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	decreases reaction, increases acetylation, decreases expression, increases ubiquitination	2
Smoke	decreases expression, increases abundance	2
Cyclosporine	decreases expression, increases expression	2
Cadmium Chloride	decreases expression, increases abundance	2
aristolochic acid I	increases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	increases expression	1
trichostatin A	increases acetylation, decreases ubiquitination, increases reaction	1
di-n-butylphosphoric acid	affects expression	1
14-deoxy-11,12-didehydroandrographolide	decreases expression	1
Air Pollutants	decreases expression, increases abundance	1
Arsenic	increases abundance, decreases expression	1
Vehicle Emissions	affects expression, increases abundance	1
Cadmium	decreases expression, increases abundance	1
Etoposide	decreases reaction, increases acetylation	1
Lead	affects expression	1
Methyl Methanesulfonate	increases expression	1
Niacinamide	increases acetylation, decreases ubiquitination, increases reaction	1
Thiram	decreases expression	1
Tobacco Smoke Pollution	increases expression	1
Valproic Acid	affects expression	1
Okadaic Acid	increases expression	1
Particulate Matter	affects expression, increases abundance	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL4713758	Binding	Protac activity at CRBN/NABP2 in human BxPC-3 cells assessed as NABP2 degradation incubated for 16 hrs by proteomic analysis	Discovery of a Napabucasin PROTAC as an Effective Degrader of the E3 Ligase ZFP91. — J Med Chem

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B3BR	Abcam HEK293T NABP2 KO	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.