NACC2

Summary

NACC2 (NACC family member 2, HGNC:23846) is a protein-coding gene on chromosome 9q34.3, encoding Nucleus accumbens-associated protein 2 (Q96BF6). Functions as a transcriptional repressor through its association with the NuRD complex.

Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; histone deacetylase binding activity; and protein homodimerization activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage; and protein homooligomerization. Located in chromatin; mitochondrion; and nucleolus.

Source: NCBI Gene 138151 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 67 total
• MANE Select transcript: NM_144653

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:23846
Approved symbol	NACC2
Name	NACC family member 2
Location	9q34.3
Locus type	gene with protein product
Status	Approved
Aliases	MGC23427, BEND9, BTBD31
Ensembl gene	ENSG00000148411
Ensembl biotype	protein_coding
OMIM	615786
Entrez	138151

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 3 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000277554, ENST00000371753, ENST00000467669, ENST00000930481

RefSeq mRNA: 1 — MANE Select: NM_144653 NM_144653

CCDS: CCDS6993

Canonical transcript exons

ENST00000277554 — 6 exons

Exon	Start	End
ENSE00001352850	136095189	136095289
ENSE00003889367	136013864	136013969
ENSE00003890139	136006537	136012024
ENSE00003893831	136013199	136013296
ENSE00003893876	136049636	136050580
ENSE00003894415	136016265	136016429

Expression profiles

Bgee: expression breadth ubiquitous, 289 present calls, max score 99.07.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 10.4305 / max 69.0075, expressed in 1751 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
103117	6.8099	1687
103118	1.9037	1219
103116	1.7170	1091

Top tissues by expression

296 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
dorsal motor nucleus of vagus nerve	UBERON:0002870	99.07	gold quality
inferior olivary complex	UBERON:0002127	98.76	gold quality
medial globus pallidus	UBERON:0002477	98.61	gold quality
globus pallidus	UBERON:0001875	98.37	gold quality
lateral globus pallidus	UBERON:0002476	97.93	gold quality
endothelial cell	CL:0000115	97.58	gold quality
inferior vagus X ganglion	UBERON:0005363	97.52	gold quality
cranial nerve II	UBERON:0000941	97.48	gold quality
lateral nuclear group of thalamus	UBERON:0002736	97.31	gold quality
medulla oblongata	UBERON:0001896	96.92	gold quality
choroid plexus epithelium	UBERON:0003911	96.92	gold quality
substantia nigra pars reticulata	UBERON:0001966	96.81	gold quality
subthalamic nucleus	UBERON:0001906	96.79	gold quality
substantia nigra pars compacta	UBERON:0001965	96.67	gold quality
postcentral gyrus	UBERON:0002581	96.38	gold quality
CA1 field of hippocampus	UBERON:0003881	96.31	gold quality
superior vestibular nucleus	UBERON:0007227	96.12	gold quality
dorsal plus ventral thalamus	UBERON:0001897	95.94	gold quality
parietal lobe	UBERON:0001872	95.66	gold quality
entorhinal cortex	UBERON:0002728	95.57	gold quality
spinal cord	UBERON:0002240	95.56	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	95.50	gold quality
pons	UBERON:0000988	95.49	gold quality
blood vessel layer	UBERON:0004797	95.47	gold quality
seminal vesicle	UBERON:0000998	95.36	gold quality
saphenous vein	UBERON:0007318	95.17	gold quality
ventral tegmental area	UBERON:0002691	95.16	gold quality
temporal lobe	UBERON:0001871	94.47	gold quality
midbrain	UBERON:0001891	94.47	gold quality
amygdala	UBERON:0001876	94.35	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.94
E-MTAB-6142	no	43.96

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

1 targets.

Target	Regulation
MDM2	Repression

JASPAR motifs

Motif	Name	Family
MA2507.1	NACC2	Other factors with up to three adjacent zinc fingers
MA2559.1	NACC2	Other factors with up to three adjacent zinc fingers

JASPAR matrix evidence (PMIDs): PMID:35144965

Upstream regulators (CollecTRI, top): TP53

miRNA regulators (miRDB)

228 targeting NACC2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-126-5P	100.00	72.71	3180
HSA-MIR-4476	100.00	68.18	2030
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-MIR-5193	100.00	67.26	1744
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-5196-5P	100.00	67.98	2761
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-7110-3P	100.00	73.18	2486
HSA-MIR-4747-5P	100.00	67.90	2681
HSA-MIR-6798-5P	100.00	65.77	699
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-4776-3P	100.00	68.73	1340
HSA-MIR-3120-5P	100.00	65.56	965
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-4514	99.99	67.10	1870
HSA-MIR-3667-3P	99.99	67.17	1636
HSA-MIR-6870-5P	99.99	68.55	2115
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997

Literature-anchored findings (GeneRIF, showing 2)

• RBB is a novel transcriptional repressor and an important regulator of p53 pathway. (PMID:22926524)
• NACC2, a molecular effector of miR-132 regulation at the interface between adult neurogenesis and Alzheimer’s disease. (PMID:39256511)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Nacc2	ENSMUSG00000026932
rattus_norvegicus	Nacc2	ENSRNOG00000018231

Paralogs (28): ZNF280C (ENSG00000056277), ZBTB25 (ENSG00000089775), PRDM13 (ENSG00000112238), BCL6 (ENSG00000113916), FEZF1 (ENSG00000128610), ZBTB46 (ENSG00000130584), PRDM12 (ENSG00000130711), ZNF280D (ENSG00000137871), FEZF2 (ENSG00000153266), ZBTB7B (ENSG00000160685), NACC1 (ENSG00000160877), BCL6B (ENSG00000161940), GFI1 (ENSG00000162676), GFI1B (ENSG00000165702), ZBTB49 (ENSG00000168826), ZNF280A (ENSG00000169548), ZNF581 (ENSG00000171425), ZNF524 (ENSG00000171443), ZBTB26 (ENSG00000171448), ZBTB21 (ENSG00000173276), ZNF683 (ENSG00000176083), ZBTB33 (ENSG00000177485), ZBTB3 (ENSG00000185670), ZBTB6 (ENSG00000186130), ZBTB14 (ENSG00000198081), ZBTB12 (ENSG00000204366), ZNF580 (ENSG00000213015), ZNF280B (ENSG00000275004)

Protein

Protein identifiers

Nucleus accumbens-associated protein 2 — Q96BF6 (reviewed: Q96BF6)

Alternative names: BTB/POZ domain-containing protein 14A, Repressor with BTB domain and BEN domain

All UniProt accessions (1): Q96BF6

UniProt curated annotations — full annotation on UniProt →

Function. Functions as a transcriptional repressor through its association with the NuRD complex. Recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53.

Subunit / interactions. Homooligomer; mediated by the BTB domain. Interacts with the NuRD complex. Interacts (via C-terminal part) with HDAC2. Interacts (via BTB domain) with MTA1, MTA2 and MTA3.

Subcellular location. Nucleus.

RefSeq proteins (1): NP_653254* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000210	BTB/POZ_dom	Domain
IPR011333	SKP1/BTB/POZ_sf	Homologous_superfamily
IPR018379	BEN_domain	Domain
IPR050457	ZnFinger_BTB_dom_contain	Family

Pfam: PF00651, PF10523

UniProt features (12 total): cross-link 5, domain 2, region of interest 2, compositionally biased region 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96BF6-F1	61.41	0.27

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (5): 429, 456, 174, 217, 299

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 241 (showing top): GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP, GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_UP, TGACCTY_ERR1_Q2, SENESE_HDAC1_AND_HDAC2_TARGETS_DN, ONKEN_UVEAL_MELANOMA_UP, GOBP_APOPTOTIC_SIGNALING_PATHWAY, GOBP_REGULATION_OF_RESPONSE_TO_STRESS, GOBP_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE, GOBP_DNA_DAMAGE_RESPONSE, CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_5, YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_13, GOBP_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY, GOBP_POSITIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION, GOBP_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE, GOBP_PROTEIN_HOMOOLIGOMERIZATION

GO Biological Process (8): negative regulation of transcription by RNA polymerase II (GO:0000122), regulation of transcription by RNA polymerase II (GO:0006357), negative regulation of cell population proliferation (GO:0008285), protein-containing complex localization (GO:0031503), negative regulation of DNA-templated transcription (GO:0045892), protein homooligomerization (GO:0051260), positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage (GO:1902231), regulation of cell population proliferation (GO:0042127)

GO Molecular Function (8): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227), protein homodimerization activity (GO:0042803), histone deacetylase binding (GO:0042826), protein-containing complex binding (GO:0044877), DNA binding (GO:0003677), protein binding (GO:0005515)

GO Cellular Component (5): chromatin (GO:0000785), nucleus (GO:0005634), nucleolus (GO:0005730), mitochondrion (GO:0005739), nuclear lumen (GO:0031981)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA polymerase II transcription regulatory region sequence-specific DNA binding	3
regulation of transcription by RNA polymerase II	2
transcription by RNA polymerase II	2
regulation of DNA-templated transcription	2
cell population proliferation	2
binding	2
intracellular membrane-bounded organelle	2
negative regulation of DNA-templated transcription	1
regulation of cell population proliferation	1
negative regulation of cellular process	1
macromolecule localization	1
DNA-templated transcription	1
negative regulation of RNA biosynthetic process	1
protein complex oligomerization	1
intrinsic apoptotic signaling pathway in response to DNA damage	1
regulation of intrinsic apoptotic signaling pathway in response to DNA damage	1
positive regulation of intrinsic apoptotic signaling pathway	1
regulation of cellular process	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
negative regulation of transcription by RNA polymerase II	1
DNA-binding transcription factor activity, RNA polymerase II-specific	1
DNA-binding transcription repressor activity	1
identical protein binding	1
protein dimerization activity	1
enzyme binding	1
nucleic acid binding	1
chromosome	1
cellular anatomical structure	1
nuclear lumen	1
intracellular membraneless organelle	1
cytoplasm	1
nucleus	1
intracellular organelle lumen	1

Protein interactions and networks

STRING

788 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
NACC2	PPP1R26	Q5T8A7	511
NACC2	HINFP	Q9BQA5	497
NACC2	ETV6	P41212	474
NACC2	BEND3	Q5T5X7	463
NACC2	QKI	Q96PU8	444
NACC2	BEND6	Q5SZJ8	431
NACC2	RB1CC1	Q8TDY2	428
NACC2	RBL2	Q08999	428
NACC2	RB1	P06400	416
NACC2	MORC3	Q14149	408
NACC2	TRIM27	P14373	401
NACC2	ID2	Q02363	390
NACC2	DGCR8	Q8WYQ5	389
NACC2	BTBD1	Q9H0C5	379
NACC2	GPR37L1	O60883	379
NACC2	BEND7	Q8N7W2	379

IntAct

34 interactions, top by confidence:

A	B	Type	Score
RFXANK	RFXAP	psi-mi:“MI:0914”(association)	0.780
VHL	NACC2	psi-mi:“MI:0915”(physical association)	0.560
FOXP3	FOXP2	psi-mi:“MI:0914”(association)	0.530
HSPB8	VWA8	psi-mi:“MI:0914”(association)	0.530
DNAJB8	DNAJB6	psi-mi:“MI:0914”(association)	0.530
RPP21	POP7	psi-mi:“MI:0914”(association)	0.530
EPS8	NACC2	psi-mi:“MI:0915”(physical association)	0.370
ZBTB34	CHEK1	psi-mi:“MI:0914”(association)	0.350
BCAN	HSPA5	psi-mi:“MI:0914”(association)	0.350
NACC2	FHL2	psi-mi:“MI:0914”(association)	0.350
B4GALT2	LENG9	psi-mi:“MI:0914”(association)	0.350
BORCS8	SH3PXD2B	psi-mi:“MI:0914”(association)	0.350
NPAS1	CIBAR1	psi-mi:“MI:0914”(association)	0.350
INF2	PIPSL	psi-mi:“MI:0914”(association)	0.350
SENP3	IPO5	psi-mi:“MI:0914”(association)	0.350
TPGS1	PIK3R2	psi-mi:“MI:0914”(association)	0.350
PPARD	ACACB	psi-mi:“MI:0914”(association)	0.350
C6orf141	ZNF195	psi-mi:“MI:0914”(association)	0.350
DNAJB6	SCAMP1	psi-mi:“MI:0914”(association)	0.350
DHDH	ZNF185	psi-mi:“MI:0914”(association)	0.350
NCAPH2	FANCA	psi-mi:“MI:0914”(association)	0.350
SOHLH1	FANCA	psi-mi:“MI:0914”(association)	0.350
TFPT	CCP110	psi-mi:“MI:0914”(association)	0.350
DCTN3	RPS6KA4	psi-mi:“MI:0914”(association)	0.350
AANAT	UBB	psi-mi:“MI:0914”(association)	0.350
TWIST2	TCF3	psi-mi:“MI:0914”(association)	0.350
CIB3	PCK1	psi-mi:“MI:0914”(association)	0.350
C11orf71	MNAT1	psi-mi:“MI:0914”(association)	0.350

BioGRID (61): NACC2 (Affinity Capture-MS), NACC2 (Affinity Capture-RNA), NACC2 (Affinity Capture-RNA), NACC2 (Positive Genetic), NACC1 (Affinity Capture-MS), NACC2 (Affinity Capture-MS), NACC2 (Affinity Capture-MS), OSBPL1A (Affinity Capture-MS), FHL2 (Affinity Capture-MS), GOPC (Affinity Capture-MS), FEM1A (Affinity Capture-MS), TRAPPC9 (Affinity Capture-MS), NACC2 (Affinity Capture-MS), NACC2 (Affinity Capture-MS), NACC2 (Affinity Capture-MS)

ESM2 similar proteins: A6QPM3, A7X8B3, A7X8B5, A7X8B7, A7X8B9, A7X8C2, A7X8C4, A7X8C7, A7X8C9, A7X8D2, A7X8D4, A7XW16, A7XW20, A7XW25, E9Q3T6, E9Q6W4, J7FCF0, O14512, O42406, O70361, O75626, O95863, O97775, O97952, O97960, P06186, P06401, P07812, P10275, P41182, P41183, Q02085, Q0VDT2, Q3UZD5, Q562B4, Q5IS79, Q5U5Q3, Q60688, Q62233, Q6F2E4

Diamond homologs: A0JN76, A1L2U9, A1YPR0, B1WAZ8, B1WBS3, B1WBU4, B2RXF5, E1B932, G5E8B9, O14867, O15062, O43167, O43298, O88282, O88939, O93567, O95365, O95625, P10074, P28575, P41182, P41183, P52739, P97302, P97303, Q0IH98, Q0IJ29, Q0P4X6, Q0VCJ6, Q13105, Q14526, Q1H9T6, Q1L8W0, Q3B725, Q3B7M1, Q3B7N9, Q3SWU4, Q3ZB90, Q503R4, Q53G59

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

67 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	54
Likely benign	4
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

1940 predictions. Top by Δscore:

Variant	Effect	Δscore
9:136011658:T:TA	donor_gain	1.0000
9:136012023:CA:C	acceptor_gain	1.0000
9:136012025:C:CC	acceptor_gain	1.0000
9:136013194:CTTAC:C	donor_loss	1.0000
9:136013196:TAC:T	donor_loss	1.0000
9:136013197:A:AC	donor_gain	1.0000
9:136013197:ACA:A	donor_loss	1.0000
9:136013198:C:CA	donor_gain	1.0000
9:136013198:CA:C	donor_gain	1.0000
9:136013198:CAT:C	donor_gain	1.0000
9:136013198:CATT:C	donor_gain	1.0000
9:136013198:CATTT:C	donor_gain	1.0000
9:136013292:TGTTC:T	acceptor_gain	1.0000
9:136013294:TTC:T	acceptor_gain	1.0000
9:136013295:TC:T	acceptor_gain	1.0000
9:136013296:CC:C	acceptor_gain	1.0000
9:136013297:C:CC	acceptor_gain	1.0000
9:136013297:CTG:C	acceptor_loss	1.0000
9:136013300:G:C	acceptor_gain	1.0000
9:136013300:G:GC	acceptor_gain	1.0000
9:136013310:C:CT	acceptor_gain	1.0000
9:136013310:C:T	acceptor_gain	1.0000
9:136013311:G:T	acceptor_gain	1.0000
9:136016260:CTCA:C	donor_loss	1.0000
9:136016262:CAC:C	donor_loss	1.0000
9:136016264:C:CT	donor_loss	1.0000
9:136016266:TGCC:T	donor_gain	1.0000
9:136016428:CA:C	acceptor_gain	1.0000
9:136049630:CGTTA:C	donor_loss	1.0000
9:136049631:GTTAC:G	donor_loss	1.0000

AlphaMissense

3812 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
9:136011927:C:A	W451C	1.000
9:136011927:C:G	W451C	1.000
9:136011929:A:G	W451R	1.000
9:136011929:A:T	W451R	1.000
9:136011943:C:G	R446P	1.000
9:136011944:G:T	R446S	1.000
9:136011946:C:G	R445P	1.000
9:136011947:G:T	R445S	1.000
9:136011949:G:T	A444D	1.000
9:136011951:G:C	N443K	1.000
9:136011951:G:T	N443K	1.000
9:136011952:T:A	N443I	1.000
9:136011953:T:C	N443D	1.000
9:136011955:G:A	T442I	1.000
9:136011957:G:C	C441W	1.000
9:136011958:C:A	C441F	1.000
9:136011958:C:G	C441S	1.000
9:136011958:C:T	C441Y	1.000
9:136011959:A:G	C441R	1.000
9:136011959:A:T	C441S	1.000
9:136011960:C:A	M440I	1.000
9:136011960:C:G	M440I	1.000
9:136011960:C:T	M440I	1.000
9:136011961:A:C	M440R	1.000
9:136011961:A:G	M440T	1.000
9:136011961:A:T	M440K	1.000
9:136011963:G:C	D439E	1.000
9:136011963:G:T	D439E	1.000
9:136011964:T:A	D439V	1.000
9:136011964:T:C	D439G	1.000

dbSNP variants (sampled 300 via entrez): RS1000031585 (9:136041058 G>A), RS1000087747 (9:136070164 G>T), RS1000097752 (9:136021135 G>A,C), RS1000154102 (9:136056199 C>T), RS1000214021 (9:136058625 G>A,C), RS1000226889 (9:136086693 C>A), RS1000234340 (9:136020363 G>A), RS1000239619 (9:136060211 T>C), RS1000278031 (9:136096078 C>T), RS1000281676 (9:136082586 C>T), RS1000283833 (9:136051659 G>A), RS1000328751 (9:136070033 A>C), RS1000332775 (9:136030334 G>A), RS1000333882 (9:136091082 T>C), RS1000359894 (9:136090459 G>A)

Disease associations

OMIM: gene MIM:615786 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST004131_21	Inflammatory bowel disease	5.000000e-36
GCST004132_11	Crohn’s disease	6.000000e-30
GCST004133_17	Ulcerative colitis	2.000000e-16
GCST012796_7	Sjögren’s syndrome	5.000000e-06

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

55 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
methylmercuric chloride	increases expression, affects cotreatment	3
Benzo(a)pyrene	increases expression, affects methylation, decreases methylation	3
Valproic Acid	increases methylation, decreases expression, increases expression	3
bisphenol A	affects cotreatment, affects methylation, decreases methylation, increases expression	2
entinostat	increases expression, affects cotreatment	2
Acetaminophen	decreases expression	2
Air Pollutants	affects cotreatment, decreases expression, increases abundance, affects expression	2
Ozone	affects expression, affects cotreatment, decreases expression, increases abundance	2
bisphenol F	affects cotreatment, increases expression	1
TAK-243	increases sumoylation	1
dicrotophos	increases expression	1
triphenyl phosphate	affects expression	1
alpha-pinene	affects cotreatment, decreases expression, increases abundance	1
propionaldehyde	increases expression	1
pirinixic acid	affects binding, decreases expression, increases activity	1
testosterone undecanoate	affects cotreatment, decreases expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
butyraldehyde	increases expression	1
aflatoxin B2	decreases methylation	1
methacrylaldehyde	affects cotreatment, decreases expression, increases abundance	1
cylindrospermopsin	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
abrine	decreases expression	1
dorsomorphin	affects cotreatment, increases expression	1
PCI 5002	affects cotreatment, increases expression	1
Temozolomide	increases expression	1
Sunitinib	decreases expression	1
Fulvestrant	affects cotreatment, affects methylation	1
Leflunomide	decreases expression	1
Acrolein	affects cotreatment, decreases expression, increases abundance	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.