NALCN-AS1

Summary

NALCN-AS1 (NALCN antisense RNA 1, HGNC:42743) is a long non-coding RNA gene on chromosome 13q32.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:42743
Approved symbol	NALCN-AS1
Name	NALCN antisense RNA 1
Location	13q32.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000233009
Ensembl biotype	lncRNA
Entrez	100885778
RNAcentral	URS000075D232 — lncRNA, 2861 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000457843, ENST00000787138

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000457843 — 8 exons

Exon	Start	End
ENSE00001593136	101057694	101059286
ENSE00001596773	101049280	101049365
ENSE00001597756	100708325	100708393
ENSE00001608042	101056950	101057432
ENSE00001669265	100740557	100740628
ENSE00001678459	101013218	101013350
ENSE00001681416	101024679	101024798
ENSE00001769530	101055157	101055446

Expression profiles

Bgee: expression breadth broad, 82 present calls, max score 58.66.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0452 / max 10.2409, expressed in 15 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
135883	0.0452	15

Top tissues by expression

82 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ventricular zone	UBERON:0003053	58.66	silver quality
urinary bladder	UBERON:0001255	53.39	gold quality
right lung	UBERON:0002167	52.33	gold quality
right ovary	UBERON:0002118	51.97	gold quality
prefrontal cortex	UBERON:0000451	51.44	gold quality
superior frontal gyrus	UBERON:0002661	50.58	gold quality
placenta	UBERON:0001987	50.45	gold quality
primary visual cortex	UBERON:0002436	50.07	gold quality
cerebellum	UBERON:0002037	49.89	silver quality
cerebellar cortex	UBERON:0002129	49.83	silver quality
small intestine Peyer’s patch	UBERON:0003454	49.71	gold quality
cerebellar hemisphere	UBERON:0002245	49.68	silver quality
tibial artery	UBERON:0007610	49.62	gold quality
popliteal artery	UBERON:0002250	49.57	gold quality
apex of heart	UBERON:0002098	49.01	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	48.97	silver quality
liver	UBERON:0002107	48.87	silver quality
muscle of leg	UBERON:0001383	48.81	silver quality
right hemisphere of cerebellum	UBERON:0014890	48.80	silver quality
islet of Langerhans	UBERON:0000006	47.62	gold quality
ovary	UBERON:0000992	47.32	gold quality
frontal cortex	UBERON:0001870	47.20	gold quality
gall bladder	UBERON:0002110	47.01	gold quality
ascending aorta	UBERON:0001496	46.80	gold quality
descending thoracic aorta	UBERON:0002345	46.63	gold quality
thoracic aorta	UBERON:0001515	46.61	gold quality
Brodmann (1909) area 9	UBERON:0013540	46.56	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	46.50	gold quality
left ovary	UBERON:0002119	46.15	gold quality
lung	UBERON:0002048	45.62	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.79

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.