NAPA

Summary

NAPA (NSF attachment protein alpha, HGNC:7641) is a protein-coding gene on chromosome 19q13.33, encoding Alpha-soluble NSF attachment protein (P54920). Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

This gene encodes a member of the soluble NSF attachment protein (SNAP) family. SNAP proteins play a critical role in the docking and fusion of vesicles to target membranes as part of the 20S NSF-SNAP-SNARE complex. The encoded protein plays a role in the completion of membrane fusion by mediating the interaction of N-ethylmaleimide-sensitive factor (NSF) with the vesicle-associated and membrane-associated SNAP receptor (SNARE) complex, and stimulating the ATPase activity of NSF. Alternatively spliced transcript variants have been observed for this gene.

Source: NCBI Gene 8775 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 57 total
• Druggable target: yes
• MANE Select transcript: NM_003827

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:7641
Approved symbol	NAPA
Name	NSF attachment protein alpha
Location	19q13.33
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000105402
Ensembl biotype	protein_coding
OMIM	603215
Entrez	8775

Gene structure

Transcript identifiers

Ensembl transcripts: 22 — 8 retained_intron, 6 protein_coding, 4 protein_coding_CDS_not_defined, 4 nonsense_mediated_decay

ENST00000263354, ENST00000593761, ENST00000593785, ENST00000593905, ENST00000594001, ENST00000594155, ENST00000594217, ENST00000594288, ENST00000594740, ENST00000595227, ENST00000595826, ENST00000596892, ENST00000597118, ENST00000597160, ENST00000597271, ENST00000597274, ENST00000597778, ENST00000598615, ENST00000601208, ENST00000601927, ENST00000602082, ENST00000602174

RefSeq mRNA: 1 — MANE Select: NM_003827 NM_003827

CCDS: CCDS12702

Canonical transcript exons

ENST00000263354 — 11 exons

Exon	Start	End
ENSE00001274857	47514843	47515063
ENSE00003023433	47487637	47488389
ENSE00003494573	47503423	47503502
ENSE00003622084	47489711	47489761
ENSE00003633141	47493119	47493174
ENSE00003641533	47500633	47500749
ENSE00003645772	47495550	47495596
ENSE00003658999	47492015	47492119
ENSE00003688395	47493416	47493493
ENSE00003790248	47492961	47493045
ENSE00003791605	47490788	47490856

Expression profiles

Bgee: expression breadth ubiquitous, 144 present calls, max score 99.31.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 105.9360 / max 749.0327, expressed in 1828 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
181783	103.8062	1828
181775	0.8494	327
181779	0.4636	28
181782	0.3815	184
181778	0.2134	12
181781	0.1819	79
181777	0.0280	13
181776	0.0120	6

Top tissues by expression

145 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right hemisphere of cerebellum	UBERON:0014890	99.31	gold quality
cerebellum	UBERON:0002037	99.28	gold quality
cerebellar cortex	UBERON:0002129	99.28	gold quality
cerebellar hemisphere	UBERON:0002245	99.27	gold quality
primary visual cortex	UBERON:0002436	99.17	gold quality
superior frontal gyrus	UBERON:0002661	99.11	gold quality
prefrontal cortex	UBERON:0000451	99.01	gold quality
right frontal lobe	UBERON:0002810	99.00	gold quality
frontal cortex	UBERON:0001870	98.99	gold quality
frontal lobe	UBERON:0016525	98.99	gold quality
Brodmann (1909) area 9	UBERON:0013540	98.87	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	98.86	gold quality
right adrenal gland	UBERON:0001233	98.84	gold quality
right adrenal gland cortex	UBERON:0035827	98.84	gold quality
left adrenal gland cortex	UBERON:0035825	98.81	gold quality
left adrenal gland	UBERON:0001234	98.79	gold quality
cerebral cortex	UBERON:0000956	98.75	gold quality
pituitary gland	UBERON:0000007	98.69	gold quality
skin of leg	UBERON:0001511	98.62	gold quality
adenohypophysis	UBERON:0002196	98.62	gold quality
anterior cingulate cortex	UBERON:0009835	98.62	gold quality
zone of skin	UBERON:0000014	98.56	gold quality
prostate gland	UBERON:0002367	98.54	gold quality
brain	UBERON:0000955	98.51	gold quality
apex of heart	UBERON:0002098	98.51	gold quality
skin of abdomen	UBERON:0001416	98.50	gold quality
Ammon’s horn	UBERON:0001954	98.50	gold quality
telencephalon	UBERON:0001893	98.46	gold quality
metanephros cortex	UBERON:0010533	98.32	gold quality
left uterine tube	UBERON:0001303	98.29	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

58 targeting NAPA, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6870-5P	99.99	68.55	2115
HSA-MIR-4723-5P	99.97	68.70	2034
HSA-MIR-5698	99.97	68.49	2029
HSA-MIR-7111-5P	99.97	68.48	2062
HSA-MIR-185-3P	99.95	67.01	1743
HSA-MIR-4525	99.94	64.38	675
HSA-MIR-5010-5P	99.94	64.11	705
HSA-MIR-6753-3P	99.93	66.57	637
HSA-MIR-7107-3P	99.93	66.73	627
HSA-MIR-4731-5P	99.89	67.23	2537
HSA-MIR-4492	99.87	68.25	3611
HSA-MIR-3151-5P	99.86	63.83	1069
HSA-MIR-6842-5P	99.80	67.54	1587
HSA-MIR-7110-5P	99.80	67.84	1712
HSA-MIR-6739-5P	99.80	67.87	2806
HSA-MIR-6817-3P	99.79	68.35	2126
HSA-MIR-548AJ-5P	99.78	71.12	3085
HSA-MIR-548F-5P	99.78	71.02	3093
HSA-MIR-548G-5P	99.78	71.12	3085
HSA-MIR-548X-5P	99.78	71.12	3085
HSA-MIR-6733-5P	99.74	67.94	2759
HSA-MIR-4422	99.72	72.07	2908
HSA-MIR-6752-5P	99.59	67.32	1243
HSA-MIR-6751-5P	99.56	64.99	1145
HSA-MIR-3153	99.55	67.59	2337
HSA-MIR-6081	99.48	66.07	1446
HSA-MIR-1275	99.47	67.90	2749
HSA-MIR-4498	99.47	67.42	2360
HSA-MIR-330-3P	99.41	69.95	2521
HSA-MIR-6731-5P	99.28	67.42	2375

Literature-anchored findings (GeneRIF, showing 10)

• alpha-SNAP plays a key role in the acrosome reaction. (PMID:15542541)
• G alpha12 interaction with alphaSNAP induces VE-cadherin localization at endothelial junctions and regulates barrier function (PMID:15980433)
• Results suggest that the combinational SNARE proteins VAMP8 and Vti1b mediate the fusion of antimicrobial and canonical autophagosomes with lysosomes, an essential event for autophagic degradation. (PMID:20089838)
• The most N-terminal part of BKV agnoprotein is involved in the interaction with alpha-SNAP (PMID:21931730)
• a novel role for alphaSNAP in promoting epithelial cell survival by unique mechanisms involving regulation of Bcl-2 expression and Golgi biogenesis (PMID:22194596)
• novel roles for alphaSNAP in promoting the formation of epithelial adherens junctions and tight junctions by controlling golgi-dependent expression and trafficking of junctional proteins. (PMID:22485163)
• Study revealed a novel role for alphaSNAP as a negative regulator of autophagy that acts by enhancing mTOR signaling and regulating the integrity of the Golgi complex. (PMID:23187805)
• data implicates beta1 integrin, FAK, and paxillin in mediating the observed pro-adhesive effects of alphaSNAP. These results reveal novel roles for alphaSNAP in regulating ECM adhesion and motility of epithelial cells. (PMID:24311785)
• alphaSNAP is mainly expressed in the neuron brain tissue of patients with temporal lobe epilepsy. Its blood levels were significantly lower in these patients. alphaSNAP levels may increase epilepsy susceptibility. (PMID:26156199)
• High affinity associations with alpha-SNAP enable calcium entry via Orai1 channels. (PMID:34653219)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	napab	ENSDARG00000020405
danio_rerio	napaa	ENSDARG00000067605
mus_musculus	Napa	ENSMUSG00000006024
rattus_norvegicus	Napa	ENSRNOG00000001494
drosophila_melanogaster	alphaSnap	FBGN0250791
caenorhabditis_elegans		WBGENE00017016

Paralogs (2): NAPB (ENSG00000125814), NAPG (ENSG00000134265)

Protein

Protein identifiers

Alpha-soluble NSF attachment protein — P54920 (reviewed: P54920)

Alternative names: N-ethylmaleimide-sensitive factor attachment protein alpha

All UniProt accessions (10): P54920, M0QZM9, M0QZN5, M0R027, M0R031, M0R058, M0R0I4, M0R0Y2, M0R213, M0R2M1

UniProt curated annotations — full annotation on UniProt →

Function. Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. Together with GNA12 promotes CDH5 localization to plasma membrane.

Subunit / interactions. Interacts with PRKCABP, and disrupts the interaction between GRIA2 and PRKCABP, leading to the internalization of GRIA2. Found in a complex with VAMP8. Component of a SNARE-like complex that contains at least ZW10, USE1L, RINT1, STX18 and NAPA/SNAP-alpha. Interacts with VTI1A. Interacts with STX12. Interacts with GNA12 (via N-terminus); the interaction promotes CDH5 localization to plasma membrane.

Subcellular location. Cell membrane.

Similarity. Belongs to the SNAP family.

RefSeq proteins (1): NP_003818* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000744	NSF_attach	Family
IPR011990	TPR-like_helical_dom_sf	Homologous_superfamily

Pfam: PF14938

UniProt features (8 total): modified residue 4, mutagenesis site 2, chain 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P54920-F1	89.06	0.67

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (4): 1, 26, 29, 195

Mutagenesis-validated functional residues (2):

Position	Phenotype
122	does not affect interaction with gna12.
140	increases interaction with gna12.

Function

Pathways and Gene Ontology

Reactome pathways

16 pathways

ID	Pathway
R-HSA-204005	COPII-mediated vesicle transport
R-HSA-432722	Golgi Associated Vesicle Biogenesis
R-HSA-6807878	COPI-mediated anterograde transport
R-HSA-6811434	COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-6811438	Intra-Golgi traffic
R-HSA-6811440	Retrograde transport at the Trans-Golgi-Network
R-HSA-199977	ER to Golgi Anterograde Transport
R-HSA-199991	Membrane Trafficking
R-HSA-199992	trans-Golgi Network Vesicle Budding
R-HSA-392499	Metabolism of proteins
R-HSA-446203	Asparagine N-linked glycosylation
R-HSA-5653656	Vesicle-mediated transport
R-HSA-597592	Post-translational protein modification
R-HSA-6811442	Intra-Golgi and retrograde Golgi-to-ER traffic
R-HSA-8856688	Golgi-to-ER retrograde transport
R-HSA-948021	Transport to the Golgi and subsequent modification

MSigDB gene sets: 223 (showing top): GOBP_APICAL_PROTEIN_LOCALIZATION, MODY_HIPPOCAMPUS_POSTNATAL, GOBP_INTRACELLULAR_PROTEIN_TRANSPORT, GOCC_SECRETORY_GRANULE, ASTON_MAJOR_DEPRESSIVE_DISORDER_DN, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GOBP_MEMBRANE_FUSION, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP, IVANOVA_HEMATOPOIESIS_LATE_PROGENITOR, GOBP_NEUROTRANSMITTER_TRANSPORT, GOBP_NEUROGENESIS, CREBP1_Q2, GOBP_VESICLE_MEDIATED_TRANSPORT, REACTOME_MEMBRANE_TRAFFICKING, GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS

GO Biological Process (13): intracellular protein transport (GO:0006886), intra-Golgi vesicle-mediated transport (GO:0006891), brain development (GO:0007420), regulation of synaptic vesicle priming (GO:0010807), synaptic vesicle priming (GO:0016082), neuron differentiation (GO:0030182), synaptic transmission, glutamatergic (GO:0035249), SNARE complex disassembly (GO:0035494), apical protein localization (GO:0045176), membrane fusion (GO:0061025), protein transport (GO:0015031), vesicle-mediated transport (GO:0016192), protein-containing complex disassembly (GO:0032984)

GO Molecular Function (5): SNARE binding (GO:0000149), soluble NSF attachment protein activity (GO:0005483), syntaxin binding (GO:0019905), protein-containing complex binding (GO:0044877), protein binding (GO:0005515)

GO Cellular Component (10): cytosol (GO:0005829), membrane (GO:0016020), neuromuscular junction (GO:0031594), presynaptic active zone membrane (GO:0048787), synaptobrevin 2-SNAP-25-syntaxin-1a complex (GO:0070044), extracellular exosome (GO:0070062), postsynapse (GO:0098794), glutamatergic synapse (GO:0098978), plasma membrane (GO:0005886), presynapse (GO:0098793)

Reactome top-level categories

Rollup of top-10 pathways:

Category	Pathways
Intra-Golgi and retrograde Golgi-to-ER traffic	3
Membrane Trafficking	3
ER to Golgi Anterograde Transport	2
trans-Golgi Network Vesicle Budding	1
Golgi-to-ER retrograde transport	1
Transport to the Golgi and subsequent modification	1
Vesicle-mediated transport	1
Post-translational protein modification	1
Metabolism of proteins	1
Asparagine N-linked glycosylation	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	4
synapse	4
intracellular protein localization	3
transport	2
binding	2
protein transport	1
intracellular transport	1
Golgi vesicle transport	1
central nervous system development	1
animal organ development	1
head development	1
synaptic vesicle priming	1
regulation of protein-containing complex assembly	1
synaptic vesicle exocytosis	1
protein-containing complex assembly	1
exocytic process	1
cell differentiation	1
generation of neurons	1
chemical synaptic transmission	1
vesicle-mediated transport	1
protein-containing complex disassembly	1
membrane organization	1
establishment of protein localization	1
cellular process	1
cellular component disassembly	1
protein-containing complex organization	1
protein binding	1
protein-macromolecule adaptor activity	1
SNARE binding	1
cytoplasm	1
presynaptic membrane	1
presynaptic active zone	1
synaptic membrane	1
SNARE complex	1
extracellular vesicle	1
membrane	1
cell periphery	1

Protein interactions and networks

STRING

1420 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
NAPA	NSF	P46459	991
NAPA	NAPG	Q99747	974
NAPA	VAMP2	P19065	950
NAPA	SNAP25	P13795	891
NAPA	STX18	Q9P2W9	890
NAPA	STX1A	Q16623	888
NAPA	VAMP7	P51809	863
NAPA	STX6	O43752	845
NAPA	SNAP23	O00161	828
NAPA	STX10	O60499	819
NAPA	STX2	P32856	802
NAPA	SEC22B	O75396	789
NAPA	STXBP5	Q5T5C0	789
NAPA	STX4	Q12846	781
NAPA	SNAP29	O95721	773

IntAct

159 interactions, top by confidence:

A	B	Type	Score
STX11	SNAP23	psi-mi:“MI:0914”(association)	0.900
RINT1	NBAS	psi-mi:“MI:0914”(association)	0.830
GOSR2	BET1	psi-mi:“MI:0914”(association)	0.810
STX18	NBAS	psi-mi:“MI:0914”(association)	0.810
NAPA	SNAP23	psi-mi:“MI:0914”(association)	0.780
SNAP23	NAPA	psi-mi:“MI:0915”(physical association)	0.780
STX4	NAPA	psi-mi:“MI:0915”(physical association)	0.780
NAPA	SNAP23	psi-mi:“MI:0915”(physical association)	0.780
NAPA	STX4	psi-mi:“MI:0915”(physical association)	0.780
NSF	NAPA	psi-mi:“MI:0915”(physical association)	0.740
STX5	NAPA	psi-mi:“MI:0915”(physical association)	0.740
STX5	GOSR2	psi-mi:“MI:0914”(association)	0.670
STX6	GOSR2	psi-mi:“MI:0914”(association)	0.670
BNIP1	NBAS	psi-mi:“MI:0914”(association)	0.640
NAPG	NSF	psi-mi:“MI:0914”(association)	0.640
SEC22B	ZW10	psi-mi:“MI:0914”(association)	0.640
NIPAL1	ESYT2	psi-mi:“MI:0914”(association)	0.640
USE1	NBAS	psi-mi:“MI:0914”(association)	0.640
STX7	SNAP23	psi-mi:“MI:0914”(association)	0.640
STX12	SNAP23	psi-mi:“MI:0914”(association)	0.640
VPS45	STX16	psi-mi:“MI:0914”(association)	0.620
BET1	NSF	psi-mi:“MI:0914”(association)	0.570
HTT	NAPA	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (360): Nsf (Affinity Capture-Western), NAPA (Affinity Capture-MS), NAPA (Affinity Capture-MS), NAPA (Affinity Capture-MS), NAPA (Affinity Capture-MS), NAPA (Affinity Capture-MS), NAPA (Affinity Capture-MS), NAPA (Affinity Capture-MS), NAPA (Affinity Capture-MS), NAPA (Affinity Capture-MS), RTN4 (Two-hybrid), NAPA (Two-hybrid), NAPA (Two-hybrid), NAPA (Two-hybrid), NAPA (Two-hybrid)

ESM2 similar proteins: B0BNG0, F8RP11, J9VSG5, O35814, O54981, O89079, P31948, P50502, P50503, P54920, P54921, P81125, P85969, Q0JL44, Q15006, Q2UF96, Q3ZBZ8, Q43468, Q4IBU4, Q4QR29, Q4R8N7, Q4WTC0, Q4X0I8, Q5E993, Q5R882, Q5RF31, Q5XEP2, Q5ZIK9, Q5ZLF0, Q60445, Q60864, Q62018, Q6DEU9, Q6INS3, Q6PD62, Q6TGY8, Q7S8M1, Q7ZWU1, Q8AVU9, Q8IZP2

Diamond homologs: O90758, P28663, P54920, P54921, P81125, P81126, P85969, P93798, Q23983, Q9DB05, Q9H115, Q9J5J0, P32602, P78603, Q54NP6, Q75D68, Q9LXZ5, Q9M5P8, Q9P4D0, Q9P4X4, Q9P6A5, Q9SPE6

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 137 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Intra-Golgi traffic	12	32.1×	5e-13
Retrograde transport at the Trans-Golgi-Network	10	22.6×	3e-09
COPII-mediated vesicle transport	8	13.5×	8e-06
trans-Golgi Network Vesicle Budding	5	13.1×	2e-03
Intra-Golgi and retrograde Golgi-to-ER traffic	12	13.0×	1e-08
COPI-dependent Golgi-to-ER retrograde traffic	10	11.4×	1e-06
Golgi Associated Vesicle Biogenesis	5	10.3×	4e-03
Translocation of SLC2A4 (GLUT4) to the plasma membrane	6	9.6×	2e-03

GO biological processes:

GO term	Partners	Fold	FDR
vesicle fusion	14	69.1×	1e-20
obsolete vesicle docking	10	62.8×	6e-14
membrane fusion	7	35.8×	5e-08
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	11	30.4×	1e-11
intra-Golgi vesicle-mediated transport	6	25.9×	6e-06
Golgi to plasma membrane protein transport	6	25.9×	6e-06
retrograde transport, endosome to Golgi	11	18.5×	2e-09
exocytosis	12	14.9×	3e-09

Disease & clinical

Clinical variants and AI predictions

ClinVar

57 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	41
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

1968 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:47493016:G:T	A169D	1.000
19:47493453:G:T	A128D	1.000
19:47493474:G:T	A121D	1.000
19:47500683:G:T	A82D	1.000
19:47503442:T:A	K53N	1.000
19:47503442:T:G	K53N	1.000
19:47488324:C:A	K284N	0.999
19:47488324:C:G	K284N	0.999
19:47488337:A:G	L280P	0.999
19:47492045:G:C	C212W	0.999
19:47492047:A:G	C212R	0.999
19:47492056:C:G	A209P	0.999
19:47492076:G:T	A202D	0.999
19:47492088:A:G	L198P	0.999
19:47492115:C:T	G189E	0.999
19:47492116:C:A	G189W	0.999
19:47492116:C:G	G189R	0.999
19:47492116:C:T	G189R	0.999
19:47492980:G:T	A181D	0.999
19:47492981:C:G	A181P	0.999
19:47493040:G:T	A161D	0.999
19:47493041:C:G	A161P	0.999
19:47493126:A:G	S157P	0.999
19:47493150:C:G	A149P	0.999
19:47493173:G:T	A141D	0.999
19:47493174:C:G	A141P	0.999
19:47493454:C:G	A128P	0.999
19:47493475:C:G	A121P	0.999
19:47493477:G:T	A120E	0.999
19:47493485:G:C	F117L	0.999

dbSNP variants (sampled 300 via entrez): RS1000165342 (19:47511624 G>A,C), RS1000218032 (19:47511277 A>G), RS1000302129 (19:47511919 C>T), RS1000449976 (19:47510500 T>A,G), RS1000453849 (19:47505757 C>A), RS1000509745 (19:47512976 C>T), RS1000656199 (19:47516143 T>C), RS1000673580 (19:47512232 C>T), RS1000963528 (19:47501349 A>C,G), RS1000983768 (19:47496227 G>A,T), RS1001019696 (19:47495846 C>G), RS1001084468 (19:47500050 G>A,C,T), RS1001226069 (19:47510889 C>A,G), RS1001310563 (19:47501163 T>C), RS1001312698 (19:47493847 A>T)

Disease associations

OMIM: gene MIM:603215 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6066865 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

35 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	affects binding, increases reaction, decreases expression	2
Valproic Acid	increases expression, increases methylation	2
aristolochic acid I	increases expression	1
GSK-J4	increases expression	1
triphenyl phosphate	affects expression	1
beta-lapachone	increases expression	1
sodium arsenite	increases expression	1
perfluorooctanoic acid	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	affects expression, affects reaction	1
CGP 52608	affects binding, increases reaction	1
monomethylarsonous acid	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
dimethylarsinous acid	increases expression	1
bisphenol B	increases expression	1
bisphenol S	increases expression	1
LDN 193189	affects cotreatment, increases expression	1
bisphenol AF	increases expression	1
Sunitinib	increases expression	1
Chelating Agents	affects binding, decreases expression	1
Copper	affects binding, decreases expression	1
Diazinon	increases methylation	1
Doxorubicin	decreases expression	1
Furaldehyde	affects localization, increases expression, affects cotreatment	1
Glucose	decreases expression	1
Ivermectin	decreases expression	1
Selenium	increases expression	1
Silicon Dioxide	decreases expression	1
Smoke	decreases expression	1
Sodium Chloride	affects cotreatment, affects localization, increases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5651864	Binding	Binding affinity to human NAPA incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.